{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:08:22Z","timestamp":1793210902364,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are two mechanisms for glucose transport across cell membranes. In the intestine and renal proximal tubule, glucose is transported against a concentration gradient by a secondary active transport mechanism in which glucose is cotransported with sodium ions. In all other cells, glucose transport is mediated by one or more of the members of the closely related GLUT family of glucose transporters. The pattern of expression of the GLUT transporters in different tissues is related to the different roles of glucose metabolism in different tissues. Primary defects in glucose transport all appear to be extremely rare and not all possible deficiencies have been identified. Deficiency of the secondary active sodium\/glucose transporters result in glucose\/galactose malabsorption or congenital renal glycosuri\u00e4GLUT1 deficiency produces a seizure disorder with low glucose concentration in cerebrospinal fluid and GLUT2 deficiency is the basis of the Fanconi\u2013Bickel syndrome, which resembles type I glycogen storage disease.<\/jats:p>","DOI":"10.1023\/a:1005632012591","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T23:07:17Z","timestamp":1040512037000},"page":"237-246","source":"Crossref","is-referenced-by-count":179,"title":["Glucose transporters: Structure, function and consequences of deficiency"],"prefix":"10.1002","volume":"23","author":[{"given":"G. K.","family":"Brown","sequence":"first","affiliation":[{"name":"Genetics Unit Department of Biochemistry  South Parks Road Oxford OX1 3QU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.8.976"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42067-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39029-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.41.10.1320"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4088"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85561-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109053251006"},{"key":"e_1_2_1_9_1","first-page":"51","article-title":"Glucose transport protein deficiency: an emerging syndrome with therapeutic implications","volume":"10","author":"De Vivo DC","year":"1995","journal-title":"Int Pediatr"},{"key":"e_1_2_1_10_1","first-page":"3561","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Desjeux J\u2010F","year":"1995"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116747"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402546"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111429"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1427"},{"key":"e_1_2_1_15_1","first-page":"60","volume":"245","author":"Garvey WT","year":"1989","journal-title":"Pretranslational suppression of aninsulin\u2010responsive glucose transporter in rats with diabetes mellitusff Science"},{"key":"e_1_2_1_16_1","first-page":"1072","article-title":"Pretranslational suppression of a glucose transporter protein causes insulin resistance inadipocytes from patients with non\u2010insulin\u2010dependent diabetes mellitus and obesity","volume":"87","author":"Garvey WT","year":"1991","journal-title":"J ClinInvest"},{"key":"e_1_2_1_17_1","first-page":"1512","article-title":"Glycemic improvement in diabetic db\/db miceby overexpression of the human insulin\u2010regulatable glucose transporter (GLUT4)","volume":"95","author":"Gibbs EM","year":"1995","journal-title":"J ClinInvest"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00235a004"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12317"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/338083a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(94)90007-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/377151a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050068"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"13276","DOI":"10.1016\/S0021-9258(19)38295-X","article-title":"Human facilitative glucose transportersff Isolation, functional characterization, and gene localization of cDNAs encoding an isoform(GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusualglucose transporter pseudogene\u2010like sequence (GLUT6)","volume":"265","author":"Kayano T","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1959"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022544131826"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401365"},{"key":"e_1_2_1_28_1","first-page":"137","article-title":"Genetic analyses of glucose transporter genes inFrench non\u2010insulin\u2010dependent diabetic families","volume":"23","author":"Lesage S","year":"1997","journal-title":"Diabetes Metab"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31672-1"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.13.7926364"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.3.1505464"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70132-X"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950211"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb18550.x"},{"key":"e_1_2_1_35_1","first-page":"8514","article-title":"Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes","volume":"268","author":"Nishimura H","year":"1993","journal-title":"J BiolChem"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.16.070196.001315"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114883"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-2-771"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2930119"},{"key":"e_1_2_1_40_1","first-page":"1831","article-title":"Peripheral but not hepatic insulin resistance inmice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene","volume":"100","author":"Rossetti L","year":"1997","journal-title":"J ClinInvest"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050937"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-188"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720238.x"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350507"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1096"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2542"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115858"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)43974-9"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36592-4"},{"key":"e_1_2_1_50_1","first-page":"F406","article-title":"Heterogeneity of sodium\u2010dependent D\u2010glucose transport alongthe proximal tubule: evidence from vesicle studies","volume":"242","author":"Turner RJ","year":"1982","journal-title":"Am J Physiol"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.4.E716"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62010240.x"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(98)00021-2"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2860173"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.7.885"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1023%2FA%3A1005632012591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1023\/A%3A1005632012591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T23:37:25Z","timestamp":1694821045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1023\/A%3A1005632012591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1023\/A:1005632012591"],"URL":"https:\/\/doi.org\/10.1023\/a:1005632012591","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}