{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:40:08Z","timestamp":1790430008758,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty patients with early and continuously treated phenylketonuria (PKU) between 8 and 20 years of age were compared with 30 controls, matched individually for age, sex, and educational level of both parents, on behaviour rating scales for parents and teachers as well as a school achievement scale. PKU patients, as a group, demonstrated more problems in task\u2010oriented behaviour and average academic performance than did matched controls. Interestingly, whereas male PKU patients were rated significantly lower on introversion by their teachers, female patients were rated significantly higher on introversion and lower on extraversion than matched controls. This sex difference was also reflected in the relationship between measures of dietary control and the behaviour clusters, suggesting that male and female patients respond differently to elevated Phe levels or the stress associated with PKU. The teacher rating on average academic performance of the PKU patients was associated with recent level of dietary control, which suggests that it might be improved by more strict adherence to the diet. In addition, academic performance correlated negatively with the behaviour cluster negative task orientation. Further studies are recommended to obtain a more complete evaluation of this relationship and to replicate the current findings on larger samples.<\/jats:p>","DOI":"10.1023\/a:1005669610722","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T23:07:17Z","timestamp":1040512037000},"page":"548-562","source":"Crossref","is-referenced-by-count":58,"title":["Behaviour and school achievement in patients with early and continuously treated phenylketonuria"],"prefix":"10.1002","volume":"23","author":[{"given":"B. A.","family":"Stemerdink","sequence":"first","affiliation":[{"name":"Department of Developmental and Experimental Clinical Psychology State University Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Kalverboer","sequence":"additional","affiliation":[{"name":"Department of Developmental and Experimental Clinical Psychology State University Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"van der Meere","sequence":"additional","affiliation":[{"name":"Department of Developmental and Experimental Clinical Psychology State University Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W.","family":"van der Molen","sequence":"additional","affiliation":[{"name":"Department of Developmental Psychology University of Amsterdam  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Free University Hospital  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. W. A.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Child Psychology University Hospital of Nijmegen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M. E.","family":"Slijper","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H.","family":"Verkerk","sequence":"additional","affiliation":[{"name":"TNO Prevention and Health  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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