{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:21:34Z","timestamp":1753888894061,"version":"3.41.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1023\/a:1005670404456","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T18:07:17Z","timestamp":1040494037000},"page":"2282-2289","source":"Crossref","is-referenced-by-count":10,"title":["Evidence for a Na+\u2013H+ Exchange Across Human Colonic Basolateral Plasma Membranes Purified from Organ Donor Colons"],"prefix":"10.1007","volume":"45","author":[{"given":"Sangeeta","family":"Tyagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virendra","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waddah A.","family":"Alrefai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder K.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnamurthy","family":"Ramaswamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep K.","family":"Dudeja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"298149_CR1","first-page":"141","volume-title":"The Large Intestine: Physiology, Pathophysiology, and Disease","author":"HJ Binder","year":"1991","unstructured":"Binder HJ, Sandle GI, Rajenderan VM: Colonic fluid and electrolyte transport in health and disease. In The Large Intestine: Physiology, Pathophysiology, and Disease. SF Phillips (ed). New York, Raven Press, 1991, pp 141-168"},{"key":"298149_CR2","first-page":"2133","volume-title":"Physiology of the Gastrontestinal Tract","author":"HJ Binder","year":"1994","unstructured":"Binder HJ, Sandle GI: Electrolyte Transport in the Mammalian Colon. In Physiology of the Gastrontestinal Tract, 3rd ed. LR Johnson (ed). New York, Raven Press, 1994, pp 2133-2171","edition":"3rd ed."},{"key":"298149_CR3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-642-77118-7_6","volume":"16","author":"VM Rajendran","year":"1993","unstructured":"Rajendran VM, Binder HJ: Ion transport in rat colon. Adv Comp Environ Physiol 16:113-137 1993","journal-title":"Adv Comp Environ Physiol"},{"key":"298149_CR4","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1172\/JCI104634","volume":"41","author":"R Levitan","year":"1962","unstructured":"Levitan R, Fordtran JS, Burrows BA, Ingelfinger FJ: Water and salt absorption in the human colon. J Clin Invest 41:1754-1759, 1962","journal-title":"J Clin Invest"},{"key":"298149_CR5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0016-5085(82)80015-2","volume":"83","author":"GR Davis","year":"1982","unstructured":"Davis GR, Santa Ana CA, Morawski SG, Fordtran JS: Permeability characteristics of human jejunum, ileum, proximal colon and distal colon: results of potential difference measurements and unidirectional fluxes. Gastroenterology 83:844-850, 1982","journal-title":"Gastroenterology"},{"key":"298149_CR6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0016-5085(69)80071-5","volume":"56","author":"GJ Devroede","year":"1969","unstructured":"Devroede GJ, Phillips SF: Conservation of sodium, chloride, and water by the human colon. Gastroenterology 56:101-109, 1969","journal-title":"Gastroenterology"},{"key":"298149_CR7","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(78)90700-X","volume":"74","author":"PC Hawker","year":"1978","unstructured":"Hawker PC, Mashiter KE, Tumberg LA: Mechanisms of transport of Na1, Cl2 and K1 in the human colon. Gastroenterology 74:1241-1247, 1978","journal-title":"Gastroenterology"},{"key":"298149_CR8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0016-5085(87)90904-8","volume":"93","author":"JH Sellin","year":"1987","unstructured":"Sellin JH, De Soignie R: Ion transport in human colon in vitro. Gastroenterology 93:441-448, 1987","journal-title":"Gastroenterology"},{"key":"298149_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00581912","volume":"410","author":"GI Sandle","year":"1987","unstructured":"Sandle GI, Mcglone F: Segmental variability of membrane conductances in rat and human colonic epithelia. Pfleugers Arch 410:173-180, 1987","journal-title":"Pfleugers Arch"},{"key":"298149_CR10","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0006-291X(90)92042-X","volume":"167","author":"JM Harig","year":"1990","unstructured":"Harig JM, Dudeja PK, Knaup SM, Shoshara J, Ramaswamy K, Brasitus TA: Apical plasma membrane vesicles formed from organ donor colon demonstrate Na1 and H1 conductances and Na-\/H- exchange. Biochem Biophys Res Commun 167:438-443, 1990","journal-title":"Biochem Biophys Res Commun"},{"key":"298149_CR11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0016-5085(94)94837-2","volume":"106","author":"PK Dudeja","year":"1994","unstructured":"Dudeja PK, Harig JM, Baldwin ML, Cragoe JEJ, Ramaswamy K, Brasitus TA: Na1 transport in human proximal colonic apical membrane vesicles. Gastroenterology 106:125-133, 1994","journal-title":"Gastroenterology"},{"key":"298149_CR12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0005-2736(94)90334-4","volume":"1193","author":"PK Dudeja","year":"1994","unstructured":"Dudeja PK, Baldwin ML, Harig JM, Cragoe EJ, Jr. Ramaswamy K, Brasitus TA: Mechanisms of Na1 transport in human distal colonic apical membrane vesicles. Biochim Biophys Acta 1193:67-76, 1994","journal-title":"Biochim Biophys Acta"},{"key":"298149_CR13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0005-2736(95)00257-X","volume":"1280","author":"RJ Mahajan","year":"1996","unstructured":"Mahajan RJ, Baldwin ML, Harig JM, Ramaswamy K, Dudeja PK: Chloride transport in human proximal colonic apical membrane vesicles. Biochim Biophys Acta 1280:12-18, 1996","journal-title":"Biochim Biophys Acta"},{"key":"298149_CR14","first-page":"A208","volume":"102","author":"PK Dudeja","year":"1992","unstructured":"Dudeja PK, Harig JM, Ramswamy K, Prell M, Brasitus TA: Evidence for a carrier mediated Cl-\/HCO-3 2 exchange process in human distal colonic apical membrane vesicles. Gastroenterology 102:A208, 1992","journal-title":"Gastroenterology"},{"key":"298149_CR15","first-page":"G624","volume":"257","author":"PK Dudeja","year":"1989","unstructured":"Dudeja PK, Foster ES, Brasitus TA: Na+\/H+ antiporter of rat colonic basolateral membrane vesicles. Am J Physiol 257:G624-G632, 1989","journal-title":"Am J Physiol"},{"key":"298149_CR16","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI115444","volume":"88","author":"VM Rajendran","year":"1991","unstructured":"Rajendran VM, Oesterlin M, Binder HJ: Sodium uptake across basolateral membrane of rat distal colon. J Clin Invest 88:1379-1385, 1991","journal-title":"J Clin Invest"},{"issue":"2","key":"298149_CR17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01869471","volume":"110","author":"H Wiener","year":"1989","unstructured":"Wiener H, Van-Os CH: Rabbit distal colon epithelium: II Characterization of (Na+, K+, Cl-) cotransport and [3H]-bumetanide binding. J Membr Biol 110(2):163-174, 1989","journal-title":"J Membr Biol"},{"key":"298149_CR18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976","journal-title":"Anal Biochem"},{"key":"298149_CR19","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1016\/S0021-9258(19)45187-9","volume":"247","author":"GJ Siegel","year":"1972","unstructured":"Siegel GJ, Goodman BG: Sodium-potassium-activated adenosine triphosphatase: potassium regulation of enzyme phosphorylation. Sodium-stimulated potassium-inhibited, uridine triphosphate hydrolysis. J Biol Chem 247:3630-3637, 1972","journal-title":"J Biol Chem"},{"key":"298149_CR20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0005-2736(84)90093-2","volume":"773","author":"TA Brasitus","year":"1984","unstructured":"Brasitus TA, Keresztes RS: Protein-lipid interactions in antipodal plasma membranes of rat colonocytes. Biochim Biophys Acta 773:290-300, 1984","journal-title":"Biochim Biophys Acta"},{"key":"298149_CR21","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.1074\/jbc.272.36.22373","volume":"272","author":"J Orlowski","year":"1997","unstructured":"Orlowski J, Grinstein S: Na+\/H+ Exchangers of mammalian cells. J Biol Chem 272:22373-22376, 1997","journal-title":"J Biol Chem"},{"key":"298149_CR22","first-page":"G781","volume":"250","author":"ES Foster","year":"1986","unstructured":"Foster ES, Dudeja PK, Brasitus TA: Na+\/H+ exchange in rat colonic brush-border vesicles. Am J Physiol 250:G781-G787, 1986","journal-title":"Am J Physiol"},{"key":"298149_CR23","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1073\/pnas.85.18.6797","volume":"85","author":"JG Haggerty","year":"1988","unstructured":"Haggerty JG, Agarwal N, Reilly RF, Adelberg EA, Slayman CW: Pharmacologically different Na+\/H+ antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1). Proc Natl Acad Sci USA 85:6797-6801, 1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"298149_CR24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0016-5085(88)90495-7","volume":"95","author":"K Kekuchi","year":"1988","unstructured":"Kekuchi K, Abumrad MM, Ghishan FK: Na+\/H+ exchange by brush border membrane vesicles of human jejunal small intestine. Gastroenterology 95:388-393, 1988","journal-title":"Gastroenterology"},{"key":"298149_CR25","first-page":"G802","volume":"259","author":"RG Knickelbein","year":"1990","unstructured":"Knickelbein RG, Aronson PS, Dobbins JW. Characterization of Na+\/H+ exchangers on villus cells in rabbit ileum. Am J Physiol 259:G802-G806, 1990","journal-title":"Am J Physiol"},{"key":"298149_CR26","first-page":"G504","volume":"245","author":"R Knickelbein","year":"1983","unstructured":"Knickelbein R, Aronson PS, Atherton W, Dobbins JW: Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na+\/H+ exchange. Am J Physiol 245:G504-G510, 1983","journal-title":"Am J Physiol"},{"key":"298149_CR27","first-page":"G45","volume":"27","author":"S Acra","year":"1993","unstructured":"Acra S, Dykes W, Nylander W, Ghishan FK: Characterization of a distinct Na+\/H+ exchanger in basolateral membrane of human jejunum. Am J Physiol 27:G45-G50, 1993","journal-title":"Am J Physiol"},{"key":"298149_CR28","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/0016-5085(92)91440-F","volume":"103","author":"Z Zamir","year":"1992","unstructured":"Zamir Z, Barry JA, Ramaswamy K: Sodium transport in human intestinal basolateral membrane vesicles. Gastroenterology 103:1817-1822, 1992","journal-title":"Gastroenterology"},{"key":"298149_CR29","first-page":"G206","volume":"255","author":"JG Kleinman","year":"1988","unstructured":"Kleinman JG, Harig JM, Barry JA, Ramaswamy K: Na1 and H1 transport in human jejunal brush-border membrane vesicles. Am J Physiol 255:G206-G211, 1988","journal-title":"Am J Physiol"},{"key":"298149_CR30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0005-2736(89)90028-X","volume":"981","author":"K Ramaswamy","year":"1989","unstructured":"Ramaswamy K, Harig JM, Kleinman JG, Harris MS, Barry JA: Sodium-proton exchange in human ileal brush border membrane vesicles. Biochem Biophys Acta 981:193-199, 1989","journal-title":"Biochem Biophys Acta"},{"key":"298149_CR31","doi-asserted-by":"crossref","first-page":"9331","DOI":"10.1016\/S0021-9258(19)50428-8","volume":"267","author":"J Orlowski","year":"1992","unstructured":"Orlowski J, Kandasamy RA, Shull GE: Molecular cloning of putative members of the Na+\/H+ exchanger gene family. J Biol Chem 267:9331-9339, 1992","journal-title":"J Biol Chem"},{"key":"298149_CR32","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1016\/S0021-9258(19)50429-X","volume":"267","author":"CM Tse","year":"1992","unstructured":"Tse CM, Brant SR, Walker MS, Pouyssegur J, Donowitz M: Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+\/H+ exchanger isoform (NHE 3). J Biol Chem 267:9340-9346, 1992","journal-title":"J Biol Chem"},{"key":"298149_CR33","first-page":"93","volume":"135","author":"M Tse","year":"1993","unstructured":"Tse M, Levine S, Yun C, Brant S, Counillon LT, Pouyssegur J, Donowitz M: Structure\/function studies of the epithelial isoforms of the mammalian Na+\/H+ exchanger gene family. J Membr Biol 135:93-108, 1993","journal-title":"J Membr Biol"},{"key":"298149_CR34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0888-7543(95)80002-4","volume":"25","author":"CA Klanke","year":"1995","unstructured":"Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird M, Kandasamy RA, Orlows KJ, Oterud BE, Lippert M: Molecular cloning and physical and genetic mapping of a novel human Na+\/H+ exchanger (NHE5\/SLC9A5) to chromosome 16q22.1. Genomics 25:615-622, 1995","journal-title":"Genomics"},{"key":"298149_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00352346","volume":"5","author":"C Szpirer","year":"1994","unstructured":"Szpirer C, Szpirer J, Riviere M, Levan G, Orlowski J: Chromosomal assignment of four genes encoding Na\/H exchanger isoforms in human and rat. Mammal Genome 5:153-159, 1994","journal-title":"Mammal Genome"},{"issue":"12","key":"298149_CR36","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1074\/jbc.273.12.6951","volume":"273","author":"M Numata","year":"1998","unstructured":"Numata M, Petrecca K, Lake N, Orlowski J: Identification of a mitochondrial Na+\/H+ exchanger. J Biol Chem 273(12):6951-6959, 1998","journal-title":"J Biol Chem"},{"key":"298149_CR37","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1749-6632.1999.tb09250.x","volume":"874","author":"J Orlowski","year":"1999","unstructured":"Orlowski J: Na1\/H1 exchangers. Molecular diversity and relevance to heart. Ann NY Acad Sci 874:346-353, 1999","journal-title":"Ann NY Acad Sci"},{"key":"298149_CR38","doi-asserted-by":"crossref","first-page":"11917","DOI":"10.1016\/S0021-9258(19)50287-3","volume":"268","author":"CM Tse","year":"1993","unstructured":"Tse CM, Levine SA, Yun CH, Montrose MH, Little PJ, Pouyssegur J, Donowitz M: Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+\/H+ exchanger isoform (NHE-2). J Biol Chem 268:11917-11924, 1993","journal-title":"J Biol Chem"},{"issue":"34","key":"298149_CR39","doi-asserted-by":"crossref","first-page":"G483","DOI":"10.1152\/ajpgi.1996.271.3.G483","volume":"271","author":"PK Dudeja","year":"1996","unstructured":"Dudeja PK, Rao DD, Syed I, Joshi V, Dahdal RY, Gardner C, Risk MC, Schmidt L, Bavishi D, Kim KE, Harig JM, Goldstein JL, Layden TJ, Ramaswamy K: Intestinal distribution of human Na+\/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. Am J Physiol (Gastrointest Liver Physiol) 271 (34):G483-G493, 1996","journal-title":"Am J Physiol (Gastrointest Liver Physiol)"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005670404456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005670404456\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005670404456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:04:57Z","timestamp":1752462297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005670404456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["298149"],"URL":"https:\/\/doi.org\/10.1023\/a:1005670404456","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}