{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:16:45Z","timestamp":1787001405966,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1023\/a:1005819604858","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T18:56:21Z","timestamp":1040496981000},"page":"149-157","source":"Crossref","is-referenced-by-count":40,"title":["Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification"],"prefix":"10.1007","volume":"36","author":[{"given":"Oded","family":"Ben-Yoseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang W.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"138171_CR1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/ana.410140604","volume":"14","author":"CG Rhodes","year":"1983","unstructured":"Rhodes CG, Wise RJS, Gibbs JM, Frackowiak RSJ, Hatazawa J, Palmer AJ, Thomas DGT, Jones T: In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Ann Neurol 14: 614\u2013626, 1983","journal-title":"Ann Neurol"},{"issue":"suppl","key":"138171_CR2","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1002\/ana.410150727","volume":"15","author":"G Di Chiro","year":"1984","unstructured":"Di Chiro G, Brooks RA, Patronas HJ, Bairmain D, Kornblith PL, Smith BH, Mansi L, Barker J: Issues in the in vivo measurement of glucose metabolism of central nervous system tumors. Ann Neurol 15 (suppl): S138\u2013S146, 1984","journal-title":"Ann Neurol"},{"key":"138171_CR3","first-page":"2007","volume":"32","author":"S Weinhouse","year":"1972","unstructured":"Weinhouse S: Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. Cancer Res 32: 2007\u20132016, 1972","journal-title":"Cancer Res"},{"key":"138171_CR4","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1073\/pnas.74.9.3735","volume":"74","author":"E Bustamante","year":"1977","unstructured":"Bustamante E, Pedersen PL: High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA 74: 3735\u20133739, 1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"138171_CR5","doi-asserted-by":"crossref","first-page":"10904","DOI":"10.1016\/S0021-9258(17)44361-4","volume":"258","author":"DM Parry","year":"1983","unstructured":"Parry DM, Pedersen PL: Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location. J Biol Chem 258: 10904\u201310912, 1983","journal-title":"J Biol Chem"},{"key":"138171_CR6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ijc.2910620218","volume":"62","author":"S Oudard","year":"1995","unstructured":"Oudard S, Poirson F, Miccoli L, Bourgeois Y, Vassault A, Poisson M, Magdelenat H, Dutrillaux B, Poupon M-F: Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int J Cancer 62: 216\u2013222, 1995","journal-title":"Int J Cancer"},{"key":"138171_CR7","doi-asserted-by":"crossref","first-page":"17422","DOI":"10.1016\/S0021-9258(19)77853-3","volume":"263","author":"KK Arora","year":"1988","unstructured":"Arora KK, Pedersen PL: Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J Biol Chem 263: 17422\u201317428, 1988","journal-title":"J Biol Chem"},{"key":"138171_CR8","first-page":"497","volume":"66","author":"A Floridi","year":"1981","unstructured":"Floridi A, Paggi MG, Marcante ML, Silvestrini B, Caputo A, De Martino C: Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. J Natl Cancer Inst 66: 497\u2013499, 1981","journal-title":"J Natl Cancer Inst"},{"key":"138171_CR9","first-page":"4661","volume":"41","author":"A Floridi","year":"1981","unstructured":"Floridi A, Paggi MG, D'Altri S, De Martino C, Marcante ML, Silvestrini B, Caputo A: Effect of lonidamine on energy metabolism in Ehrlich ascites tumor cells. Cancer Res 41: 4661\u20134666, 1981","journal-title":"Cancer Res"},{"key":"138171_CR10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/bjc.1984.232","volume":"50","author":"GM Hahn","year":"1984","unstructured":"Hahn GM, Van Kersen I, Silvestrini B: Inhibition of the recovery from potential lethal damage by lonidamine. Br J Cancer 50: 657\u20136601, 1984","journal-title":"Br J Cancer"},{"issue":"Suppl1","key":"138171_CR11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000225883","volume":"41","author":"JH Kim","year":"1984","unstructured":"Kim JH, Alfieri A, Kim SH, Young CW, Silvestrini B: Radiosensitization of Meth-A fibrosarcoma in mice by lonidamine. Oncology 41 (Suppl 1): 36\u201338, 1984","journal-title":"Oncology"},{"key":"138171_CR12","first-page":"1120","volume":"46","author":"JH Kim","year":"1986","unstructured":"Kim JH, Alfieri A, Kim SH, Young CW: Potentiation of radiation effects on two murine tumors by lonidamine. Cancer Res 46: 1120\u20131123, 1986","journal-title":"Cancer Res"},{"key":"138171_CR13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000225882","volume":"41","author":"JH Kim","year":"1984","unstructured":"Kim JH, Kim SH, Alfieri A, Young CW, Silvestrini B: Lonidamine: A hyperthermic sensitizer of HeLa cells in culture and of the Meth-A tumor in vivo. Oncology 41: 30\u201335, 1984","journal-title":"Oncology"},{"key":"138171_CR14","first-page":"217","volume":"2","author":"MK Adwankar","year":"1986","unstructured":"Adwankar MK, Chitinis MP: Modification of tumor cell sensitivity to antineoplastic agents lonidamine and bouvardin (NSC 259968) at elevated temperatures. Neoplasma 2: 217\u2013223, 1986","journal-title":"Neoplasma"},{"key":"138171_CR15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0014-4800(88)90013-5","volume":"49","author":"A Floridi","year":"1988","unstructured":"Floridi A, Gambacurta A, Bgnato A, Bianchi C, Paggi MG, Silvestrini B: Modulation of adriamycin uptake by lonidamine in Ehrlich ascites tumor cells. Exp Mol Pathol 49: 421\u2013431, 1988","journal-title":"Exp Mol Pathol"},{"key":"138171_CR16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF00694335","volume":"1","author":"KW Rosbe","year":"1989","unstructured":"Rosbe KW, Brann TW, Holden SA, Tiecher BA, Frei E: Effect of lonidamine on the erythrotoxicity of four alkalating agents in vitro. Cancer Chemother Pharmacol 1: 32\u201336, 1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"138171_CR17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-4800(88)90044-5","volume":"48","author":"G Arancia","year":"1988","unstructured":"Arancia G, Malorni W, Crateri Trovaluschi P, Isacchi G, Giannela G, De Martino C: Differential effect of lonidamine on the plasma membrane ultrastructure of normal and leukemic human lymphocytes. Exp Mol Pathol 48: 37\u201347, 1988","journal-title":"Exp Mol Pathol"},{"key":"138171_CR18","first-page":"2037","volume":"12","author":"W Malorni","year":"1992","unstructured":"Malorni W, Meschini S, Mararrese P, Arancia G: The cytoskeleton as a subcellular target of antineoplastic drug lonidamine. Anticancer Res 12: 2037\u20132045, 1992","journal-title":"Anticancer Res"},{"key":"138171_CR19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0006-2952(93)90423-T","volume":"46","author":"S Castilgione","year":"1993","unstructured":"Castilgione S, Kennedy KA, Floridi A, Fiskum G: Nonionophoretic elevation of intracellular Ca2+ by lonidamine. Biochem Pharmacol 46: 330\u2013332, 1993","journal-title":"Biochem Pharmacol"},{"key":"138171_CR20","first-page":"2814","volume":"55","author":"H Ben-Horin","year":"1995","unstructured":"Ben-Horin H, Tassini M, Vivi A, Navon G, Kaplan O: Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies. Cancer Res 55: 2814\u20132821, 1995","journal-title":"Cancer Res"},{"key":"138171_CR21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2307\/3577906","volume":"129","author":"JC Lyons","year":"1992","unstructured":"Lyons JC, Kim GE, Song CW: Modification of intracellular pH and thermosensitivity. Radiation Res 129: 79\u201387, 1992","journal-title":"Radiation Res"},{"key":"138171_CR22","first-page":"060","volume":"94","author":"O Ben-Yoseph","year":"1994","unstructured":"Ben-Yoseph O, Kingsley PB, Camp DM, Robinson TE, Ross BD: Measurement of pentose phosphate pathway activity by microdialysis in vivo and in a single incubation in vitro. Neurosci Protocols 94: 060\u201302\u201301\u201313, 1994","journal-title":"Neurosci Protocols"},{"key":"138171_CR23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1042\/bj3020031","volume":"302","author":"BD Ross","year":"1994","unstructured":"Ross BD, Kingsley PB, Ben-Yoseph O: Measurement of pentose phosphate pathway activity in a single incubation with [1,6-13C2,6,6-2H2]glucose. Biochem J 302: 31\u201338, 1994","journal-title":"Biochem J"},{"key":"138171_CR24","first-page":"13","volume":"19","author":"JE Wilson","year":"1989","unstructured":"Wilson JE: Rapid purification of mitochondrial hexokinase from rat brain by a single affinity chromatography step on Affi-Gel blue. Prep Biochem 19: 13\u201321, 1989","journal-title":"Prep Biochem"},{"key":"138171_CR25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/nbm.1940010109","volume":"1","author":"M Stubbs","year":"1988","unstructured":"Stubbs M, Vanstapel F, Rodrigues LM, Griffiths JR: Phosphate metabolites in rat skin. NMR Biomed 1: 50\u201355, 1988","journal-title":"NMR Biomed"},{"issue":"Suppl1","key":"138171_CR26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000225881","volume":"41","author":"C De Martino","year":"1984","unstructured":"De Martino C, Battelli T, Paggi MG, Nista A, Marcante ML, D'Atri S, Malorni W, Gallo M, Floridi A: Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study. Oncology 41 (Suppl 1): 15\u2013 29, 1984","journal-title":"Oncology"},{"key":"138171_CR27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/bj1540405","volume":"154","author":"TL Spencer","year":"1976","unstructured":"Spencer TL, Lehninger AL: L-lactate transport in Ehrlich ascites tumor cells. Biochem J 154: 405\u2013414, 1976","journal-title":"Biochem J"},{"key":"138171_CR28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0360-3016(94)90528-2","volume":"30","author":"CW Song","year":"1994","unstructured":"Song CW, Lyons JC, Makepeace CM, Griffin RJ, Cragoe EJ: Effects of HMA, an analog of amiloride, on the thermosensitivity of tumors in vivo. Int J Radiat Oncol Biol Phys 30: 133\u2013139, 1994","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005819604858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005819604858\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005819604858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:13:38Z","timestamp":1749618818000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005819604858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["138171"],"URL":"https:\/\/doi.org\/10.1023\/a:1005819604858","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}