{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:15:16Z","timestamp":1754162116996,"version":"3.41.2"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1023\/a:1005899720463","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T18:56:21Z","timestamp":1040496981000},"page":"261-264","source":"Crossref","is-referenced-by-count":12,"title":["Phase II trial of topotecan in advanced gastric cancer: A Southwest Oncology Group study"],"prefix":"10.1007","volume":"15","author":[{"given":"Jacqueline K.","family":"Benedetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A.","family":"Burris III","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley P.","family":"Balcerzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"142533_CR1","unstructured":"American Cancer Society. Cancer facts and figures, 1992."},{"key":"142533_CR2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/0003-4819-93-4-533","volume":"93","author":"JS MacDonald","year":"1980","unstructured":"MacDonald JS, Schein PS, Woolley PV, Smythe T, Ueno W, Hoth D, Smith F, Boiron M, Gisselbrecht C, Brunet R, Lagarde C: 5-fluorouracil, doxorubicin, mitomycin-C (FAM) combination chemotherapy for advanced gastric cancer. Ann Int Med 93: 533\u2013536, 1980.","journal-title":"Ann Int Med"},{"key":"142533_CR3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1200\/JCO.1984.2.12.1372","volume":"2","author":"HO Douglass Jr.","year":"1984","unstructured":"Douglass HO Jr., Lavin PT, Goudsmit A, Klaassen DJ, Paul AR: An Eastern cooperative group evaluation of combinations of methyl-CCNU, mitomycin-C, adriamycin and 5-fluorouracil in advanced measurable gastric cancer (EST 2277). J Clin Oncol 2: 1372\u20131381, 1984.","journal-title":"J Clin Oncol"},{"key":"142533_CR4","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1001\/jama.1985.03350380077025","volume":"253","author":"SA Cullinan","year":"1985","unstructured":"Cullinan SA, Moertel CG, Fleming TR, Rubin JR, Krook JE, Everson LK, Windschitl HE, Twito DI, Marschke RF, Foley JF, Pfeifle DM, Barlow JF: A comparison of three chemotherapeutic regiments in the treatment of advanced pancreatic and gastric carcinoma. JAMA 253: 2061\u20132067, 1985.","journal-title":"JAMA"},{"issue":"4","key":"142533_CR5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1200\/JCO.1992.10.4.541","volume":"10","author":"D Kelsen","year":"1992","unstructured":"Kelsen D, Atiq OT, Saltz L, Niedzwiecki D, Ginn D, Chapman D, Heelan R, Lightdale C, Vinciguerra V, Brennan M: FAMTX versus etoposide, doxorubicin and cisplatin: A random assignment trial in gastric cancer. J Clin Oncol 10(4): 541\u2013548, 1992.","journal-title":"J Clin Oncol"},{"key":"142533_CR6","first-page":"2475A","volume":"30","author":"WD Kingsbury","year":"1989","unstructured":"Kingsbury WD, Herzburg RP, Boehm JC, Holden KG, Jakas DR, Caranfa MJ, McCabe FL, Faucette LF, Johnson RK: Chemical synthesis and structure-activity relationships related to SKF 104864, a novel water-soluble analog of camptothecin. (Abstract) Proc Am Assoc Cancer Res 30: 2475A, 1989.","journal-title":"(Abstract) Proc Am Assoc Cancer Res"},{"key":"142533_CR7","doi-asserted-by":"crossref","first-page":"14873","DOI":"10.1016\/S0021-9258(17)38654-4","volume":"260","author":"Y-H Hsiang","year":"1985","unstructured":"Hsiang Y-H, Hertzbert R, Hecht S, Liu L: Camptothecin induces protein-linked DNA breaks viamammalian DNA topoisomerase I. J Biol Chem 260: 14873\u201314878, 1985.","journal-title":"J Biol Chem"},{"key":"142533_CR8","first-page":"2558A","volume":"31","author":"H Burris","year":"1990","unstructured":"Burris H, Kuhn J, Johnson R, Von Hoff D, SKF 104864: Preclinical studies of a new topoisomerase I inhibitor. (Abstract) Proc Amer Assoc Cancer Res 31: 2558A, 1990.","journal-title":"(Abstract) Proc Amer Assoc Cancer Res"},{"key":"142533_CR9","unstructured":"Rowinsky E, Grochow L, hendricks C, Sartorius S, Ettinger D, McGuire W, Forastiere A, Hurowitz L, Easter V, Donehower R: Phase I and pharmacologic study of topotecan (SK&F 104864): a novel topoisomerase I inhibitor. (Abstract) Proc Amer Soc Clin Oncol: 10240A, 1991."},{"key":"142533_CR10","first-page":"1229A","volume":"32","author":"G Recondo","year":"1991","unstructured":"Recondo G, Abbruzzese J, Newman B, Kuhn J, Von Hoff D, Garteiz D, Raber M: A Phase I trial of topotecan (TOPO) administered by a 24-hour infusion. (Abstract) Proc Amer Assoc Cancer Res 32: 1229A, 1991.","journal-title":"(Abstract) Proc Amer Assoc Cancer Res"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005899720463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005899720463\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005899720463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T19:44:46Z","timestamp":1753818286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005899720463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["142533"],"URL":"https:\/\/doi.org\/10.1023\/a:1005899720463","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"type":"print","value":"0167-6997"},{"type":"electronic","value":"1573-0646"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}