{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T04:01:56Z","timestamp":1750564916296,"version":"3.41.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1023\/a:1005909808529","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T00:10:48Z","timestamp":1040515848000},"page":"61-68","source":"Crossref","is-referenced-by-count":14,"title":["The intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine.HCl, may potentiate doxorubicin in the treatment of metastatic breast cancer: Results of a pilot study"],"prefix":"10.1007","volume":"49","author":[{"given":"Lorne J.","family":"Brandes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Bracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"160755_CR1","first-page":"428","volume-title":"Breast Diseases","author":"IC Henderson","year":"1987","unstructured":"Henderson IC: In: Harris JR, Hellman S, Henderson IC, Kinne DW (eds): Breast Diseases, Philadelphia, PA, Lippincott, pp 428\u2013479, 1987"},{"issue":"Suppl2","key":"160755_CR2","first-page":"123","volume":"22","author":"GW Sledge","year":"1995","unstructured":"Sledge GW: Doxorubicin\/paclitaxel combination chemotherapy for metastatic breast cancer: the Eastern Cooperative Oncology Group experience. Semin Oncol 22:Suppl 2, 123\u2013125, 1995","journal-title":"Semin Oncol"},{"key":"160755_CR3","first-page":"139","volume-title":"Medical Management of Breast Cancer","author":"G Falkson","year":"1991","unstructured":"Falkson G, Falkson CI, Falkson H: In: Powles TJ, Smith IE (eds) Medical Management of Breast Cancer, London, Martin Dunitz, pp 139\u2013152, 1991"},{"key":"160755_CR4","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1200\/JCO.1995.13.10.2483","volume":"13","author":"WR Bezwoda","year":"1995","unstructured":"Bezwoda WR, Seymour L, Dansey RD: High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial. J Clin Oncol 13: 2483\u20132489, 1995","journal-title":"J Clin Oncol"},{"key":"160755_CR5","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0959-8049(94)90076-0","volume":"30A","author":"H de Graaf","year":"1994","unstructured":"de Graaf H, Willemse PHB, de Vries EGE et al.: Intensive chemotherapy with autologous bone marrow transfusion as primary treatment in women with breast cancer and more than five involved axillary lymph nodes. Eur J Cancer 30A: 150\u2013153, 1994","journal-title":"Eur J Cancer"},{"key":"160755_CR6","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1200\/JCO.1997.15.6.2312","volume":"15","author":"AM Gianni","year":"1997","unstructured":"Gianni AM, Siena S, Bregni M et al.: Efficacy, toxicity, and applicability of high-dose sequential chemotherapy as adjuvant treatment in operable breast cancer with 10 or more involved axillary nodes: Five-year results. J Clin Oncol 15: 2312\u20132321, 1997","journal-title":"J Clin Oncol"},{"key":"160755_CR7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/0006-291X(84)90289-4","volume":"123","author":"LJ Brandes","year":"1984","unstructured":"Brandes LJ, Hermonat MW: A diphenylmethane derivative specific for the antiestrogen binding site in rat liver microsomes. Biochem Biophys Res Commun 123: 724\u2013728, 1984","journal-title":"Biochem Biophys Res Commun"},{"key":"160755_CR8","first-page":"31","volume":"89","author":"LJ Brandes","year":"1993","unstructured":"Brandes LJ, LaBella FS: Identification of intracellular histamine receptors (HIC) that regulate cell proliferation. Adv Biosci 89: 31\u201341, 1993","journal-title":"Adv Biosci"},{"key":"160755_CR9","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/(SICI)1098-2744(199606)16:2<68::AID-MC2>3.0.CO;2-J","volume":"16","author":"FS LaBella","year":"1996","unstructured":"LaBella FS, Brandes LJ: Enhancement of tumour growth by drugs with some common molecular actions. Mol Carcinogenesis 16: 68\u201376, 1996","journal-title":"Mol Carcinogenesis"},{"key":"160755_CR10","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/jnci\/83.18.1329","volume":"83","author":"LJ Brandes","year":"1991","unstructured":"Brandes LJ, LaBella FS, Warrington RC: Increased therapeutic index of antineoplastic drugs in combination with intracellular histamine antagonists. J Natl Cancer Inst 83: 1329\u20131336, 1991","journal-title":"J Natl Cancer Inst"},{"key":"160755_CR11","doi-asserted-by":"publisher","first-page":"C113","DOI":"10.1007\/BF02007791","volume":"41","author":"S Corbel","year":"1994","unstructured":"Corbel S, Dy M: Evidence for histamine uptake by murine hematopoietic progenitors. Agents Actions 41: C113\u2013114, 1994","journal-title":"Agents Actions"},{"key":"160755_CR12","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1139\/y88-187","volume":"66","author":"GB Glavin","year":"1988","unstructured":"Glavin GB, Brandes LJ: Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand. Can J Physiol Pharmacol 66: 1139\u20131143, 1988.","journal-title":"Can J Physiol Pharmacol"},{"key":"160755_CR13","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1200\/JCO.1994.12.6.1281","volume":"12","author":"LJ Brandes","year":"1994","unstructured":"Brandes LJ, Simons KJ, Bracken SP, Warrington RC: Results of a clinical trial in humans with refractory cancer of the intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine.HCl in combination with various single anticoplastic agents. J Clin Oncol 12: 1281\u20131290, 1994","journal-title":"J Clin Oncol"},{"key":"160755_CR14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1200\/JCO.1995.13.6.1398","volume":"13","author":"LJ Brandes","year":"1995","unstructured":"Brandes LJ, Bracen SP, Ramsey EW: N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine.HCl in combination with cyclophosphamide: an active, low-toxicity regimen for metastatic hormonally unresponsive prostate cancer. J Clin Oncol 13: 1398\u20131403, 1995","journal-title":"J Clin Oncol"},{"key":"160755_CR15","first-page":"213","volume":"11","author":"EJ Smith","year":"1992","unstructured":"Smith EJ, Vogelzang NJ, Goldberg HL et al.: High-dose cyclophosphamide (CTX) with granulocyte-macrophage colony stimulating factor (GM-CSF) in hormone-refractory prostatic cancer. Proc Am Soc Clin Oncol 11: 213 (Abstract), 1992","journal-title":"Proc Am Soc Clin Oncol"},{"key":"160755_CR16","first-page":"375","volume":"89","author":"LJ Brandes","year":"1993","unstructured":"Brandes LJ, MacDonald KA, Bracken SP et al.: Results of human pilot study testing the hypothesis that the intracellular histamine antagonist DPPE increases the therapeutic index of doxorubicin. Adv Biosci 89: 375\u2013401, 1993","journal-title":"Adv Biosci"},{"key":"160755_CR17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000200489","volume":"47","author":"GB Glavin","year":"1990","unstructured":"Glavin GB, Gerrard JM: Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanaminc.HCl, a non-II1, non-II2 histamine antagonist. Digestion 47: 143\u2013148, 1990","journal-title":"Digestion"},{"key":"160755_CR18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1200\/JCO.1990.8.3.390","volume":"8","author":"WK Evans","year":"1990","unstructured":"Evans WK, Eisenhauer EA, Cormier Y, et al.: Phase II study of amonafide: Results of treatment and lessons learned from the study of an investigational agent in previously untreated patients with extensive small-cell lung cancer. J Clin Oncol 8: 390\u2013395, 1990","journal-title":"J Clin Oncol"},{"key":"160755_CR19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2214\/ajr.132.6.927","volume":"132","author":"JJ Pollen","year":"1979","unstructured":"Pollen JJ, Shlaer WJ: Osteoblastic response to successful treatment of metastatic cancer of the prostate. Am J Roentgenol 132: 927\u2013931, 1979","journal-title":"Am J Roentgenol"},{"key":"160755_CR20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1056\/NEJM198001103020203","volume":"302","author":"JC Henderson","year":"1980","unstructured":"Henderson JC, Canellos GP: Cancer of the breast: the past decade. N Eng J Med 302: 78\u201380, 1980","journal-title":"N Eng J Med"},{"key":"160755_CR21","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1200\/JCO.1987.5.12.1928","volume":"5","author":"DL Ahmann","year":"1987","unstructured":"Ahmann DL, Schaia DJ, Bisel HF, Hahn RG, Edmonson JH, Ingle JN: The effect on survival of initial chemotherapy in advanced breast cancer: polychemotherapy versus single drug. J Clin Oncol 5: 1928\u20131932, 1987","journal-title":"J Clin Oncol"},{"key":"160755_CR22","first-page":"98","volume":"15","author":"B Norris","year":"1996","unstructured":"Norris B, Pritchard K, James K, et al.: A phase III comparative study of vinorelbine (VNB) combined with doxorubicin (DOX) versus doxorubicin alone in recurrent\/metastatic breast cancer (MBC): A National Cancer Institute of Canada (NCIC CTG) study. Proc Amer Soc Clin Oncol 15:98, 1996","journal-title":"Proc Amer Soc Clin Oncol"},{"key":"160755_CR23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/0002-9343(85)90395-X","volume":"78","author":"JL Speyer","year":"1985","unstructured":"Speyer JL, Green MD, Dubin N, et al.: Prospective evaluation of cardiotoxicity during a six-hour doxorubicin infusion regimen in women with adenocarcinoma of the breast. Am J Med 78: 555\u2013563, 1985","journal-title":"Am J Med"},{"key":"160755_CR24","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/1097-0142(19900215)65:4<870::AID-CNCR2820650407>3.0.CO;2-D","volume":"65","author":"J Shapira","year":"1990","unstructured":"Shapira J, Gottfried M, Lishner M, Ravid M: Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen: A prospective randomized evaluation. Cancer 65: 870\u2013873, 1990","journal-title":"Cancer"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005909808529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005909808529\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1023\/A:1005909808529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005909808529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:23:38Z","timestamp":1750479818000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005909808529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["160755"],"URL":"https:\/\/doi.org\/10.1023\/a:1005909808529","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"type":"print","value":"0167-6806"},{"type":"electronic","value":"1573-7217"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}