{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:46:22Z","timestamp":1791071182385,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1023\/a:1005921513083","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T00:10:48Z","timestamp":1040515848000},"page":"97-106","source":"Crossref","is-referenced-by-count":58,"title":["Tumor oxygenation correlates with molecular growth determinants in breast cancer"],"prefix":"10.1007","volume":"48","author":[{"given":"Peter","family":"Hohenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Felgner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Haensch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Schlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"149441_CR1","first-page":"6449","volume":"49","author":"P Vaupel","year":"1989","unstructured":"Vaupel P, Kallinowski F, Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465, 1989","journal-title":"Cancer Res"},{"key":"149441_CR2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0360-3016(88)90002-8","volume":"14","author":"RA Gatenby","year":"1988","unstructured":"Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ: Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14: 831-838, 1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"149441_CR3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0360-3016(93)90280-9","volume":"26","author":"P Okunieff","year":"1993","unstructured":"Okunieff P, Hoeckel M, Dunphy EP, Schlenger K, Knoop C, Vaupel P: Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 26: 631-636, 1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"149441_CR4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0167-8140(84)80077-8","volume":"2","author":"JL Wike-Hooley","year":"1984","unstructured":"Wike-Hooley JL, Haveman J, Reinhold HS: The relevance of tumor pH to the treatment of malignant disease. Radiother Oncol 2: 343-366, 1984","journal-title":"Radiother Oncol"},{"key":"149441_CR5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/jnci\/82.5.371","volume":"82","author":"SD Young","year":"1990","unstructured":"Young SD, Hill RP: Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential. J Natl Cancer Inst 82: 371-380, 1990","journal-title":"J Natl Cancer Inst"},{"key":"149441_CR6","first-page":"941","volume":"56","author":"DM Brizel","year":"1996","unstructured":"Brizel DM, Scully SP, Harrelson J, Layfield LJ, Bean J, Prosnitz LR, Dewhirst MW: Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996","journal-title":"Cancer Res"},{"key":"149441_CR7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0167-8140(93)90025-4","volume":"26","author":"M Hockel","year":"1993","unstructured":"Hockel M, Knoop C, Schlenger K, Vorndran B, Baussmann E, Mitze M, Knapstein PG, Vaupel P: Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26: 45-50, 1993","journal-title":"Radiother Oncol"},{"key":"149441_CR8","first-page":"3496","volume":"47","author":"P Vaupel","year":"1987","unstructured":"Vaupel P, Fortmeyer HP, Runkel S, Kallinowski F: Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res 47: 3496-3503, 1987","journal-title":"Cancer Res"},{"key":"149441_CR9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF01212813","volume":"120","author":"BA Teicher","year":"1994","unstructured":"Teicher BA, Sotomayor EA, Dupuis NP, Kusumoto T, Menon K: Reduced oxygenation in a rat mammary carcinoma after chemo-or radiation therapy and reoxygenation with perflubron emulsion\/carbogen breathing. J Cancer Res Clin Oncol 120: 593-598, 1994","journal-title":"J Cancer Res Clin Oncol"},{"key":"149441_CR10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/978-1-4615-3404-4_41","volume":"316","author":"P Vaupel","year":"1992","unstructured":"Vaupel P, Schlenger KH, Hoeckel M, Okunieff P: Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients. Adv Exp Med Biol 316: 361-371, 1992","journal-title":"Adv Exp Med Biol"},{"key":"149441_CR11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/978-1-4615-2468-7_60","volume":"345","author":"S Runkel","year":"1994","unstructured":"Runkel S, Wischnik A, Teubner J, Kaven E, Gaa J, Melchert F: Oxygenation of mammary tumors as evaluated by ultrasound-guided computerized-pO2-histography. Adv Exp Med Biol 345: 451-458, 1994","journal-title":"Adv Exp Med Biol"},{"key":"149441_CR12","first-page":"3316","volume":"51","author":"P Vaupel","year":"1991","unstructured":"Vaupel P, Schlenger K, Knoop C, Hockel M: Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51: 3316-3322, 1991","journal-title":"Cancer Res"},{"key":"149441_CR13","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1200\/JCO.1993.11.5.899","volume":"11","author":"JA Foekens","year":"1993","unstructured":"Foekens JA, van Putten WL, Portengen H, de Koning HY, Thirion B, Alexieva Figusch J, Klijn JG: Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis. J Clin Oncol 11: 899-908, 1993","journal-title":"J Clin Oncol"},{"key":"149441_CR14","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/bjc.1994.476","volume":"70","author":"JA Foekens","year":"1994","unstructured":"Foekens JA, Portengen H, Look MP, van Putten WL, Thirion B, Bontenbal M, Klijn JG: Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast cancer. Br J Cancer 70: 1217-1223, 1994","journal-title":"Br J Cancer"},{"key":"149441_CR15","first-page":"3448","volume":"44","author":"SL Fitzpatrick","year":"1984","unstructured":"Fitzpatrick SL, Brightwell J, Wittliff JL, Barrows GH, Schultz GS: Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels. Cancer Res 44: 3448-3453, 1984","journal-title":"Cancer Res"},{"key":"149441_CR16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00666183","volume":"29","author":"JG Klijn","year":"1994","unstructured":"Klijn JG, Look MP, Portengen H, Alexieva Figusch J, van Putten WL, Foekens JA: The prognostic value of epidermal growth factor receptor (EGF-R) in primary breast cancer: results of a 10 year follow-up study. Breast Cancer Res Treat 29: 73-83, 1994","journal-title":"Breast Cancer Res Treat"},{"key":"149441_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00666181","volume":"29","author":"M Toi","year":"1994","unstructured":"Toi M, Tominaga T, Osaki A, Toge T: Role of epidermal growth factor receptor expression in primary breast cancer: results of a biochemical study and an immunocytochemical study. Breast Cancer Res Treat 29: 51-58, 1994","journal-title":"Breast Cancer Res Treat"},{"issue":"A","key":"149441_CR18","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0959-8049(05)80215-1","volume":"29","author":"RI Nicholson","year":"1993","unstructured":"Nicholson RI, McClelland RA, Finlay P, Eaton CL, Gullick WJ, Dixon AR, Robertson JF, Ellis IO, Blamey RW: Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Eur J Cancer 29A: 1018-1023, 1993","journal-title":"Eur J Cancer"},{"key":"149441_CR19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01611175","volume":"421","author":"P Shrestha","year":"1992","unstructured":"Shrestha P, Yamada K, Wada T, Maeda S, Watatani M, Yasutomi M, Takagi H, Mori M: Proliferating cell nuclear antigen in breast lesions: correlation of c-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer. Virchows Arch Path Anat A 421: 193-202, 1992","journal-title":"Virchows Arch Path Anat A"},{"key":"149441_CR20","first-page":"1147","volume":"13","author":"H Ji","year":"1993","unstructured":"Ji H, Lipponen P, Aaltomaa S, Syrjanen K, Syrjanen S: c-erb-B2 oncogene related to p53 expression, cell proliferation and prognosis in breast cancer. Anticancer Res 13:1147-1152, 1993","journal-title":"Anticancer Res"},{"key":"149441_CR21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","volume":"235","author":"DJ Slamon","year":"1987","unstructured":"Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene. Science 235: 177-182, 1987","journal-title":"Science"},{"key":"149441_CR22","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1200\/JCO.1993.11.10.1936","volume":"11","author":"R Seshadri","year":"1993","unstructured":"Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P: Clinical significance of HER-2\/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group. J Clin Oncol 11: 1936-1942, 1993","journal-title":"J Clin Oncol"},{"key":"149441_CR23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jnci\/85.3.200","volume":"85","author":"DC Allred","year":"1993","unstructured":"Allred DC, Clark GM, Elledge R, Fuqua SA, Brown RW, Chamness GC, Osborne CK, McGuire WL: Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 85: 200-206, 1993","journal-title":"J Natl Cancer Inst"},{"key":"149441_CR24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0959-8049(95)00530-7","volume":"32A","author":"BR Westley","year":"1996","unstructured":"Westley BR, May FE: Cathepsin D and breast cancer. Eur J Cancer 32A: 15-24, 1996","journal-title":"Eur J Cancer"},{"key":"149441_CR25","first-page":"3688","volume":"48","author":"P Briozzo","year":"1988","unstructured":"Briozzo P, Morisset M, Capony F, Rougeot C, Rochefort H: In vitrodegradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res 48: 3688-3692, 1988","journal-title":"Cancer Res"},{"key":"149441_CR26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/jnci\/84.11.845","volume":"84","author":"AD Thor","year":"1992","unstructured":"Thor AD, Moore DH II, Edgerton SM, Kawasaki ES, Reihsaus E, Lynch HT, Marcus JN, Schwartz L, Chen LC, Mayall BH et al.: Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst 84: 845-855, 1992","journal-title":"J Natl Cancer Inst"},{"key":"149441_CR27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00000658-199404000-00002","volume":"219","author":"JR Marks","year":"1994","unstructured":"Marks JR, Humphrey PA, Wu K, Berry D, Bandarenko N, Kerns BJ, Iglehart JD: Overexpression of p53 and HER-2\/ neu proteins as prognostic markers in early stage breast cancer. Ann Surg 219: 332-341, 1994","journal-title":"Ann Surg"},{"key":"149441_CR28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/bjc.1996.317","volume":"74","author":"P Salven","year":"1996","unstructured":"Salven P, Joensuu H, Heikkila P, Matikainen MT, Wasenius VM, Alanko A, Alitalo K: Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis. Br J Cancer74: 69-72, 1996","journal-title":"Br J Cancer"},{"key":"149441_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00666041","volume":"36","author":"P Bevilacqua","year":"1995","unstructured":"Bevilacqua P, Barbareschi M, Verderio P, Boracchi P, Caffo O, Dalla Palma P, Meli S, Weidner N, Gasparini G: Prognostic value of intratumoral microvessel density, a measure of tumor angiogenesis, in node-negative breast carcinoma - results of a multiparametric study. Breast Cancer Res Treat 36: 205-217, 1995","journal-title":"Breast Cancer Res Treat"},{"key":"149441_CR30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/32.2.6198355","volume":"32","author":"JL Cordell","year":"1984","unstructured":"Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KA, Stein H, Mason DY: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes). J Histochem Cytochem 32: 219-229, 1984","journal-title":"J Histochem Cytochem"},{"key":"149441_CR31","first-page":"239","volume":"172","author":"O Thews","year":"1996","unstructured":"Thews O, Vaupel P: Relevant parameters for describing the oxygenation status of solid tumors. Strahlenther Onkol 172: 239-243, 1996","journal-title":"Strahlenther Onkol"},{"key":"149441_CR32","first-page":"4478","volume":"50","author":"Y Boucher","year":"1990","unstructured":"Boucher Y, Baxter LT, Jain RK: Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 50: 4478-4484, 1990","journal-title":"Cancer Res"},{"key":"149441_CR33","first-page":"6695","volume":"51","author":"HD Roh","year":"1991","unstructured":"Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK: Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res 51: 6695-6698, 1991","journal-title":"Cancer Res"},{"key":"149441_CR34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01187501","volume":"118","author":"G Wiedemann","year":"1992","unstructured":"Wiedemann G, Roszinski S, Biersack A, Weiss C, Wagner T: Local hyperthermia enhances cyclophosphamide, ifosfamide and cis-diamminedichloroplatinum cytotoxicity on human-derived breast carcinoma and sarcoma xenografts in nude mice. J Cancer Res Clin Oncol 118: 129-135, 1992","journal-title":"J Cancer Res Clin Oncol"},{"key":"149441_CR35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0748-7983(96)90645-9","volume":"22","author":"P Hohenberger","year":"1996","unstructured":"Hohenberger P, Finke LH, Schlag PM: Intracompartmental pressure during hyperthermic isolated limb perfusion for melanoma and sarcoma. Eur J Surg Oncol 22: 147-151, 1996","journal-title":"Eur J Surg Oncol"},{"issue":"A","key":"149441_CR36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0959-8049(95)00637-0","volume":"32","author":"H Rochefort","year":"1996","unstructured":"Rochefort H: The prognostic value of cathepsin D in breast cancer. A long road to the clinic. Eur J Cancer 32A: 7-8, 1996","journal-title":"Eur J Cancer"},{"key":"149441_CR37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-9120(94)90050-7","volume":"27","author":"J Kalra","year":"1994","unstructured":"Kalra J, Prasad K: Oxygen free radicals and cardiac depression. Clin Biochem 27: 163-168, 1994","journal-title":"Clin Biochem"},{"key":"149441_CR38","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/ijc.2910490603","volume":"48","author":"F Monschke","year":"1991","unstructured":"Monschke F, Muller WU, Winkler U, Streffer C: Cell proliferation and vascularization in human breast carcinomas. Int J Cancer 48: 812-815, 1991","journal-title":"Int J Cancer"},{"key":"149441_CR39","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0360-3016(93)90465-8","volume":"27","author":"EM Zeman","year":"1993","unstructured":"Zeman EM, Calkins DP, Cline JM, Thrall DE, Raleigh JA: The relationship between proliferative and oxygenation status in spontaneous canine tumors. Int J Radiat Oncol Biol Phys 27: 891-898, 1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"149441_CR40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00666204","volume":"32","author":"RM Elledge","year":"1994","unstructured":"Elledge RM, Allred DC: The p53 tumor suppressor gene in breast cancer. Breast Cancer Res Treat 32: 39-47, 1994","journal-title":"Breast Cancer Res Treat"},{"key":"149441_CR41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00203392","volume":"427","author":"J Palacios","year":"1995","unstructured":"Palacios J, Benito N, Pizarro A, Limeres MA, Suarez A, Cano A, Gamallo C: Relationship between ERBB2 and Ecadherin expression in human breast cancer. Virchows Arch 427: 259-263, 1995","journal-title":"Virchows Arch"},{"key":"149441_CR42","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/BF01194273","volume":"120","author":"C Wiltschke","year":"1994","unstructured":"Wiltschke C, Kindas Muegge I, Steininger A, Reiner A, Reiner G, Preis PN: Coexpression of HER-2\/neu and p53 is associated with a shorter disease-free survival in node-positive breast cancer patients. J Cancer Res Clin Oncol 120: 737-742, 1994","journal-title":"J Cancer Res Clin Oncol"},{"key":"149441_CR43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000227527","volume":"53","author":"J Horiguchi","year":"1996","unstructured":"Horiguchi J, Iino Y, Takei H: Expression of pS2 estrogeninducible protein in primary breast cancer. Oncology 53: 12-15, 1996","journal-title":"Oncology"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005921513083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005921513083\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1023\/A:1005921513083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005921513083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:16:10Z","timestamp":1750479370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005921513083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["149441"],"URL":"https:\/\/doi.org\/10.1023\/a:1005921513083","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}