{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:25:53Z","timestamp":1771676753501,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1023\/a:1005937502511","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T14:45:40Z","timestamp":1041086740000},"page":"295-310","source":"Crossref","is-referenced-by-count":16,"title":["Preclinical toxicity of a new oral anticancer drug, CI-994 (Acetyldinaline), in rats and dogs"],"prefix":"10.1007","volume":"15","author":[{"given":"Michael J.","family":"Graziano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GaryD.","family":"Pilcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olajide B.","family":"Kasalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Radulovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"153529_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0305-7372(90)90039-I","volume":"17","author":"MR Berger","year":"1990","unstructured":"Berger MR, Richter H, Seelig MH, Eibl H, Schm\u00e4hl D: New cytostatics \u2014 more activity and less toxicity. Cancer Treat Rev 17:143\u2013154, 1990","journal-title":"Cancer Treat Rev"},{"key":"153529_CR2","first-page":"393","volume":"33","author":"CT Howard","year":"1992","unstructured":"Howard CT, Roberts BJ, Vincent PW, Elliott WL: N-acetyl-dinaline. A small molecule with in vivo cytostatic activity. Proc Am Assoc Cancer Res 33:393, 1992","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/13880209509067092","volume":"33","author":"T Corbett","year":"1995","unstructured":"Corbett T, Valeriote F, LoRusso P, Polin L, Panchapor C, Pugh S, White K, Knight J, Demchik L, Jones J, Lowichik N, Biernat L, Foster B, Wozniak A, Lisow L, Valdivieso M, Baker L, Leopold W, Sebolt J, Bissery M-C, Mattes K, Dzubow J, Rake J, Perni R, Wentland M, Coughlin S, Shaw JM, Liversidge G, Liversidge E, Bruno J, Sarpotdar P, Moore R, Patterson G: Tumor models and the discovery and secondary evaluation of solid tumor active agents. Int J Pharmacog 33:102\u2013122, 1995","journal-title":"Int J Pharmacog"},{"key":"153529_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/BF00180810","volume":"14","author":"PM LoRusso","year":"1996","unstructured":"LoRusso PM, Demchik L, Foster B, Knight J, Bissery M-C, Polin LM, Leopold WR, Corbett TH: Preclinical activity of CI-994 (acetyldinaline; PD 123654). Invest. New Drugs 14:349\u2013356, 1996","journal-title":"Invest. New Drugs"},{"key":"153529_CR5","first-page":"3008","volume":"53","author":"HM El-Beltagi","year":"1993","unstructured":"El-Beltagi HM, Martens ACM, Lelieveld P, Haroun EA, Hagenbeek A: Acctyldinaline: a new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells \u2014 preclinical studies in a relevant rat model for human acute myelocytic leukemia. Cancer Res 53:3008\u20133014, 1993","journal-title":"Cancer Res"},{"key":"153529_CR6","first-page":"1795","volume":"7","author":"HM El-Beltagi","year":"1993","unstructured":"El-Beltagi HM, Martens ACM, Dahab GM, Hagenbeek A: Efficacy of acetyldinaline for treatment of minimal residual disease (MRD): Preclinical studies in the BNML rat model for human acute myelocytic leukemia. Leukemia 7:1795\u20131800, 1993","journal-title":"Leukemia"},{"key":"153529_CR7","first-page":"396","volume":"32","author":"AJ Kraker","year":"1991","unstructured":"Kraker AJ, Wolven A, Fry DW, Klohs WD: Cell cycle and nucleotide metabolism effects of 4-(acetylamino)-N-(2-aminophenyl)benzamide (PD 123654, Goe 5549) in HCT-8 cells. Proc Am Assoc Cancer Res 32:396, 1991","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/B978-0-12-380060-2.50021-0","volume-title":"Metabolic Basis of Detoxification","author":"J Caldwell","year":"1982","unstructured":"Caldwell J: Conjugation reactions of nitrogen centers. In: Jakoby WB, Bend JR, Caldwell J (eds) Metabolic Basis of Detoxification. Academic Press, New York, 1982, pp 291\u2013306"},{"key":"153529_CR9","first-page":"503","volume":"29","author":"MR Berger","year":"1988","unstructured":"Berger MR, Klenner T, Schm\u00e4hl D, Weiershausen U: Influence of 4-amino-N-(2\u2032-aminophenyl)benzamide (GOE 1734) on cAMP levels in mammary carcinoma, plasma, heart, and liver of methylnitrosourea-(MNU)induced SD rats, Proc Am Assoc Cancer Res 29:503, 1988","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR10","first-page":"560","volume":"30","author":"MR Berger","year":"1989","unstructured":"Berger MR, Schm\u00e4hl D: Influence of 4-amino-N(2\u2032-aminophenyl)benzamide on sex steroid receptor levels in methylnitrosourea-induced rat mammary carcinoma. Proc Am Assoc Cancer Res 30:560, 1989","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR11","first-page":"400","volume":"32","author":"MR Berger","year":"1991","unstructured":"Berger MR, Gebelein M: Influence of dinaline on nucleotides in rat mammary carcinoma cells. Proc Am Assoc Cancer Res 32:400, 1991","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR12","first-page":"396","volume":"32","author":"W Klohs","year":"1991","unstructured":"Klohs W, Kraker A, Steinkampf R, Moore C, Dominick M: Mitochondrial involvement in the mechanism of action of the novel antiturnor compound 4-(acetylamino)-N-(2-aminophenyl)benzamide (PD 123654, Goe 5549). Proc Am Assoc Caucer Res 32:396, 1991","journal-title":"Proc Am Assoc Caucer Res"},{"key":"153529_CR13","first-page":"302","volume":"28","author":"WR Leopold","year":"1987","unstructured":"Leopold WR, Hook KE, Fry DW: Activity and biochemical properties of Goe 1734 (PD 104208), an anticancer agent with a novel mechanism of activity. Proc Am Assoc Cancer Res 28:302, 1987","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR14","first-page":"584","volume":"30","author":"AJ Kraker","year":"1989","unstructured":"Kraker AJ, Moore CW: Activity and effects of 4-amino-N-(2-aminophenyl)benzamide (Goe 1734, PD 104208), a compound with novel mechanisms of action. Proc Am Assoc Cancer Res 30:584, 1989","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR15","first-page":"S42","volume":"115","author":"G Wulf","year":"1989","unstructured":"Wulf G, Falk H, Weiershausen U, Valet G: Antimetabolic and cytostatic potential of 4-amino-N-(2\u2032-aminophenyl)-benzamide (dinaline) on adriamycin-sensitive and resistent Friend leukemia cells. J Cancer Res Clin Oncol 115:S42, 1989","journal-title":"J Cancer Res Clin Oncol"},{"key":"153529_CR16","first-page":"33","volume":"Suppl4","author":"G Valet","year":"1990","unstructured":"Valet G, Wulf G, Weiershausen U: Cytostatic action of dinaline (4-amino-N-(2-aminophenyl)-benzamide) as determined by flow cytometry. Cytometry Suppl 4:33, 1990","journal-title":"Cytometry"},{"key":"153529_CR17","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ijc.2910620524","volume":"62","author":"SA Rummel","year":"1995","unstructured":"Rummel SA, Kraker AJ, Steinkampf RW, Hook KE, Klohs WD: Role of a small molecular weight phosphoprotein in the mechanism of action of Cl-994 (N-acetyldinaline). Int J Cancer 62:636\u2013642, 1995","journal-title":"Int J Cancer"},{"key":"153529_CR18","first-page":"284","volume":"27","author":"MR Berger","year":"1986","unstructured":"Berger MR, Garzon F, Zeller WJ, Schm\u00e4hl D: Anticancer activity of 4-amino-N-(2\u2032-aminophenyl)benzamide (GOE 1834) in autochthonous rat colonic tumors and in transplanted MXT mouse mammary carcinoma. Proc Am Assoc Cancer Res 27:284, 1986","journal-title":"Proc Am Assoc Cancer Res"},{"key":"153529_CR19","first-page":"1415","volume":"69","author":"MR Berger","year":"1985","unstructured":"Berger MR, Bischoff H, Fritschi E, Henne T, Herrmann M, Pool B-L, Satzinger G, Schm\u00e4hl D, Weiershausen U: Synthesis, toxicity, and therapeutic efficacy of 4-amino-N-(2\u2032-aminophenyl)benzamide: a new compound preferentially active in slowly growing tumors. Cancer Treat Rep 69:1415\u20131424, 1985","journal-title":"Cancer Treat Rep"},{"key":"153529_CR20","unstructured":"Department of Health and Human Services: Guide for the care and use of laboratory animals. NIH Publication No. 86-23, revised 1985"},{"key":"153529_CR21","unstructured":"Animal Welfare Act. Code of Federal Regulations (CFR), Title opportunity to study human toxicology. In: Powis G, Hacker MP (eds) The Toxicity of Anticancer Drugs. Pergamon, New York, 1991, pp 1\u20139"},{"key":"153529_CR22","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/0165-6147(91)90582-D","volume":"12","author":"M-H Moser","year":"1991","unstructured":"Moser M-H, Paukovits WR: Haemoprotection against cytostatic drugs by stem cell inhibition. Trends Pharmacol Sci 12:304\u2013310, 1991","journal-title":"Trends Pharmacol Sci"},{"key":"153529_CR23","first-page":"235","volume-title":"Clinical Biochemistry of Domestic Animals","author":"JJ Kaneko","year":"1989","unstructured":"Kaneko JJ: Porphyrins and porphyrias. In: Kaneko JJ (ed) Clinical Biochemistry of Domestic Animals. Academic Press, San Diego, 1989, pp 235\u2013255"},{"key":"153529_CR24","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1152\/ajplegacy.1970.218.5.1376","volume":"218","author":"LA Harker","year":"1970","unstructured":"Harker LA: Regulation of thrombopoiesis. Am J Physiol 218:1376\u20131380, 1970","journal-title":"Am J Physiol"},{"key":"153529_CR25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/blood.V75.1.74.74","volume":"75","author":"DJ Kuter","year":"1990","unstructured":"Kuter DJ, Rosenburg RD: Regulation of megakaryoeyte ploidy in vivo in the rat. Blood 75:74\u201381, 1990","journal-title":"Blood"},{"key":"153529_CR26","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0272-0590(92)90053-K","volume":"18","author":"JT Yarrington","year":"1992","unstructured":"Yarrington JT, Wallace CD, Loudy DE, Gibson JP: Three-month effects of MDL 19,660 on the cai\u00fcne platelet and erythrocyte. Fund Appl Toxicol 18:247\u2013254, 1992","journal-title":"Fund Appl Toxicol"},{"key":"153529_CR27","first-page":"75","volume":"8","author":"NG Testa","year":"1988","unstructured":"Testa NG, Hendry JH, Molineux G: Long-term bone marrow damage after cytotoxic treatment. Hematology 8:75\u201391, 1988","journal-title":"Hematology"},{"key":"153529_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0940-2993(11)80260-5","volume":"47","author":"T Nolte","year":"1995","unstructured":"Nolte T, Harleman JH, Jahn W: Histopathology of chemically induced testicular atrophy in rats. Exptl Toxic Pathol 47:267\u2013286, 1995","journal-title":"Exptl Toxic Pathol"},{"key":"153529_CR29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0272-0590(92)90203-T","volume":"18","author":"MJ Graziano","year":"1992","unstructured":"Graziano MJ, Kim S-N, MacDonald JR, Watkins JR: Toxicity of the anticancer folate antagonist trimetrexate in rats. Fund Appl Toxicol 18:115\u2013125, 1992","journal-title":"Fund Appl Toxicol"},{"key":"153529_CR30","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/00001813-199410000-00010","volume":"5","author":"PM Kanter","year":"1994","unstructured":"Kanter PM, Klaich GM, Bullard GA, King JM, Bally MB, Mayer LD: Liposome encapsulated vincristine: preclinical toxicologic and pharmacologic comparison with free vincristine and empty liposomes in mice, rats, and dogs. Anti-Cancer Drugs 5:579\u2013590, 1994","journal-title":"Anti-Cancer Drugs"},{"key":"153529_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1006\/faat.1996.0105","volume":"32","author":"DG Pegg","year":"1996","unstructured":"Pegg DG, Watkins JR, Graziano MJ, McKenna MJ: Subchronic intravenous toxicity of the antineoplastic drug, amsacrine, in male Wistar rats. Fund Appl Toxicol 32:45\u201352, 1996","journal-title":"Fund Appl Toxicol"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005937502511.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005937502511\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005937502511.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T20:02:11Z","timestamp":1753819331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005937502511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["153529"],"URL":"https:\/\/doi.org\/10.1023\/a:1005937502511","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}