{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:43:56Z","timestamp":1770471836192,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1997,12]]},"DOI":"10.1023\/a:1005958123893","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T19:10:48Z","timestamp":1040497848000},"page":"279-287","source":"Crossref","is-referenced-by-count":13,"title":["Il-4r expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4)"],"prefix":"10.1007","volume":"15","author":[{"given":"Jie","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory A.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parkash S.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"153540_CR1","first-page":"S4","volume":"3","author":"GW Rutherford","year":"1990","unstructured":"Rutherford GW, Payne SF, Lemp GF: The epidemiology of AIDS-related Kaposi's sarcoma in San Francisco. J Acq Immun Defic Synd 3:S4\u2013S7, 1990","journal-title":"J Acq Immun Defic Synd"},{"key":"153540_CR2","first-page":"1","volume":"7","author":"PS Gill","year":"1994","unstructured":"Gill PS, Hamilton A, Naidu YM: Epidemic (AIDS-related) Kaposi's sarcoma: Epidemiology, pathogenesis and treatment. AIDS Updates 7:1\u201311, 1994","journal-title":"AIDS Updates"},{"key":"153540_CR3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0002-9343(89)80483-8","volume":"87","author":"PS Gill","year":"1989","unstructured":"Gill PS, Akil B, Rarick M, Colletti P, Rarick MU, Loureiro C, Bernstein-Singer M, Krailo M, Levine AM: Pulmonary Kaposi's sarcoma: Clinical findings and results of therapy. Am J Med 87:57\u201361, 1989","journal-title":"Am J Med"},{"key":"153540_CR4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jcp.39.7.742","volume":"39","author":"RR Jones","year":"1986","unstructured":"Jones RR, Spaull J, Spry C, Jones EW: Histogenesis of Kaposi's sarcoma in patients with and without acquired immunodeficiency syndrome. J Clin Pathol 39:742\u2013749, 1986","journal-title":"J Clin Pathol"},{"key":"153540_CR5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00042560-199504120-00004","volume":"4","author":"S Louie","year":"1995","unstructured":"Louie S, Cai J, Law R, Lin G, Lunardi-Iskandar Y, Jung B, Masood R, Gill PS: The effect of interleukin-1 and IL-1 ra in AIDS-KS. J Acq Immune Defic Synd and Human Retrovir 4:455\u2013460, 1995","journal-title":"J Acq Immune Defic Synd and Human Retrovir"},{"key":"153540_CR6","first-page":"74","volume":"145","author":"J Cai","year":"1994","unstructured":"Cai J, Gill PS, Masood R, Chandrasoma P, Jung B, Law RE, Radka S: Oncostatin-M is an autocrine growth factor in AIDS-KS. Am J Pathol 145:74\u201379, 1994","journal-title":"Am J Pathol"},{"key":"153540_CR7","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1073\/pnas.87.11.4068","volume":"87","author":"SA Miles","year":"1990","unstructured":"Miles SA, Rezai AR, Salazar-Gonzales JF, van der Meyden M, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O: AIDS Kaposi's sarcoma-derived cells produce and respond to IL-6. Proc Natl Acad Sci USA 87:4068\u20134072, 1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"153540_CR8","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1126\/science.1542792","volume":"25","author":"BG Nair","year":"1992","unstructured":"Nair BG, Devico AL, Nakamura S, Copeland TD, Chen Y, Patel A, O'Neil T, Oroszlan S, Gallo RC: Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. Science 25:1430\u20131432, 1992","journal-title":"Science"},{"key":"153540_CR9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1084\/jem.155.3.914","volume":"155","author":"M Howard","year":"1992","unstructured":"Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, Hamaoka T, Paul WE: Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J Exp Med 155:914\u2013923, 1992","journal-title":"J Exp Med"},{"key":"153540_CR10","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1084\/jem.168.6.2183","volume":"168","author":"Y Kawakami","year":"1988","unstructured":"Kawakami Y, Rosenberg SA, Lotze MT: Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma. J Exp Med 168:2183\u20132189, 1988","journal-title":"J Exp Med"},{"key":"153540_CR11","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.1073\/pnas.81.19.6149","volume":"81","author":"R Noelle","year":"1984","unstructured":"Noelle R, Krammer PH, Ohara J, Uhr JW, Vitetta ES: Increased expression of Ia antigens on resting B cells: An additional role for B-cell growth factor. Proc Natl Acad Sci USA 81:6149\u20136155, 1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"153540_CR12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(89)90925-2","volume":"57","author":"RI Tepper","year":"1989","unstructured":"Tepper RI, Pattengale PK, Leder P: Murine IL-4 displays a potent anti-tumor activity in vivo. Cell 57:503\u2013512, 1989","journal-title":"Cell"},{"key":"153540_CR13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1126\/science.1948050","volume":"254","author":"PT Golumbek","year":"1991","unstructured":"Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM: Treatment of established renal cancer by tumor cells engineered to secrete IL-4. Science 254:713\u2013716, 1991","journal-title":"Science"},{"key":"153540_CR14","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1182\/blood.V78.8.2070.2070","volume":"78","author":"F Herrmann","year":"1991","unstructured":"Herrmann F, Andreef M, Gruss M, Brach MA, Lubbert M, Mertelsmann R: IL-4 inhibits growth of multiple myeloma by suppressing IL-6 expression. Blood 78:2070\u20132074, 1991","journal-title":"Blood"},{"key":"153540_CR15","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1073\/pnas.86.10.3803","volume":"86","author":"PH Hart","year":"1989","unstructured":"Hart PH, Vitti GF, Burgess DR, Whatty GA, Piccoli DS, Hamilton JA: Potential anti-inflammatory effects of IL-4: Suppression of human monocyte tumor necrosis factor alpha, IL-1, and prostaglandin E2. Proc Natl Acad Sci USA 86:3803\u20133807, 1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"153540_CR16","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jlb.47.5.475","volume":"47","author":"JD Lee","year":"1990","unstructured":"Lee JD, Swisher SG, Minehart EH, McBride WH, Economou JS: IL-4 down-regulates IL-6 production in human peripheral blood mononuclear cells. J Leukocyte Biol 47:475\u2013479, 1990","journal-title":"J Leukocyte Biol"},{"key":"153540_CR17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1084\/jem.171.3.861","volume":"171","author":"RL Idzerda","year":"1990","unstructured":"Idzerda RL, March CJ, Mosley B, Kyman SD, Bos VT, Gimpet SD, Din WS, Grabstein KH, Widmer MB: Human IL-4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 171:861\u2013873, 1990","journal-title":"J Exp Med"},{"key":"153540_CR18","doi-asserted-by":"crossref","first-page":"14065","DOI":"10.1016\/S0021-9258(19)85209-2","volume":"268","author":"W Debinski","year":"1993","unstructured":"Debinski W, Puri RK, Kreitman J, Pastan I: A wide range of human cancers express interleukin 4 (IL-4) receptors that can be targeted with chimeric toxin composed of IL-4 and Pseudomonas exotoxin. J Biol Chem 268:14065\u201314070, 1993","journal-title":"J Biol Chem"},{"key":"153540_CR19","doi-asserted-by":"crossref","first-page":"21118","DOI":"10.1016\/S0021-9258(18)54828-6","volume":"266","author":"JP Shaw","year":"1991","unstructured":"Shaw JP, Akoyoshi DE, Arrigo DA, Rhoad AE, Sullivan B, Thomas J, Genbauffe PG, Bacha P, Nichols JC: Cytotoxic properties of DAB486EGF and DAB389EGF, epidermal growth factor (EGF) receptor-targeted fusion toxins. J Biol Chem 266:21118\u201321124, 1991","journal-title":"J Biol Chem"},{"key":"153540_CR20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/ijc.2910580520","volume":"58","author":"W Debinski","year":"1994","unstructured":"Debinski W, Puri RK, Pastan I: Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin. Int J Cancer 58:744\u2013748, 1994","journal-title":"Int J Cancer"},{"key":"153540_CR21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.3262925","volume":"242","author":"S Nakamura","year":"1988","unstructured":"Nakamura S, Salahuddin SZ, Biberfeld P, Ensoli B, Markham PD, Wong-Staal F, Gallo RC: Kaposi's sarcoma cells: Long-term culture with growth factor from retrovirus-infected CD4+ T cells. Science 242:426\u2013429, 1988","journal-title":"Science"},{"key":"153540_CR22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/aid.1993.9.741","volume":"9","author":"R Masood","year":"1993","unstructured":"Masood R, Husain SR, Rahman A, Gill PS: Potentiation of cytotoxicity of Kaposi's sarcoma related to immunodeficiency syndrome (AIDS) by liposome encapsulated doxorubicin. AIDS Res Hum Retro 9:741\u2013745, 1993","journal-title":"AIDS Res Hum Retro"},{"key":"153540_CR23","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1182\/blood.V89.5.1491","volume":"89","author":"J Cai","year":"1997","unstructured":"Cai J, Zheng T, Lotz M, Zhang Y, Masood R, Gill P: Glucocorticoids enhance AIDS-related Kaposi's sarcoma growth through inhibition of TGF-\u03b2. Blood 89:1491\u20131500, 1997","journal-title":"Blood"},{"key":"153540_CR24","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","volume":"51","author":"G Scatchard","year":"1949","unstructured":"Scatchard G: The attraction of proteins for small molecules and ions. Annu NY Acad Sci 51:660, 1949","journal-title":"Annu NY Acad Sci"},{"key":"153540_CR25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1008205424763","volume":"8","author":"A Tulpule","year":"1997","unstructured":"Tulpule A, Joshi B, DeGuzman N, Espina BM, Mocharnuk R, Prakash O, Templeton D, Levine AM, Gill PS: Interleukin-4 in the treatment of AIDS-related Kaposi's sarcoma. Ann Oncol 8:79\u201383, 1997","journal-title":"Ann Oncol"},{"key":"153540_CR26","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1016\/S0021-9258(17)35741-1","volume":"26","author":"M Colombatti","year":"1986","unstructured":"Colombatti M, Greenfield L, Youle RJ: Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry. J Biol Chem 26:3030\u20133035, 1986","journal-title":"J Biol Chem"},{"key":"153540_CR27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/357216a0","volume":"357","author":"S Choe","year":"1992","unstructured":"Choe S, Bennett MJ, Fujii G, Curmi PM, Kantardjieff KA, Collier RJ, Eisenberg D: The crystal structure of diphtheria toxin. Nature 357:216\u2013222, 1992","journal-title":"Nature"},{"key":"153540_CR28","doi-asserted-by":"crossref","first-page":"22524","DOI":"10.1016\/S0021-9258(17)31678-2","volume":"269","author":"JA Silverman","year":"1994","unstructured":"Silverman JA, Mindell JA, Finkelstein A, Shen WH, Collier RJ: Mutational analysis of the helical hairpin region of diphtheria toxin transmembrane domain. J Biol Chem 269:22524\u201322532, 1994","journal-title":"J Biol Chem"},{"key":"153540_CR29","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1016\/S0021-9258(17)41825-4","volume":"269","author":"IH Madshus","year":"1994","unstructured":"Madshus IH, Wiedlocha A, Sandvig K: Intermediates in translocation of diphtheria toxin across the plasma membrane. J Biol Chem 269:4648\u20134652, 1994","journal-title":"J Biol Chem"},{"key":"153540_CR30","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0091-6749(95)70134-6","volume":"95","author":"HH Jabara","year":"1995","unstructured":"Jabara HH, Vercelli D, Schneider LC, Williams DP, Genbauffe FS, Poisson LR, Waters CA, Geha RS: Interleukin-4 receptor expression by human B cells: Functional analysis with a human interleukin-4 toxin DAB389IL-4. J Allergy Clin Immunol 95:893\u2013900, 1995","journal-title":"J Allergy Clin Immunol"},{"key":"153540_CR31","first-page":"3011","volume":"51","author":"RK Puri","year":"1991","unstructured":"Puri RK, Ogata M, Leland P, Feldman GM, Fitzgerald D, Pastan I: Expression of high-affinity IL-4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between IL-4 and Pseudomonas exotoxin. Cancer Res 51:3011\u20133017, 1991","journal-title":"Cancer Res"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005958123893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005958123893\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005958123893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T19:56:32Z","timestamp":1753818992000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005958123893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["153540"],"URL":"https:\/\/doi.org\/10.1023\/a:1005958123893","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}