{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:46:54Z","timestamp":1781200014901,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[1999,3]]},"DOI":"10.1023\/a:1006128228761","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T00:53:09Z","timestamp":1040518389000},"page":"59-64","source":"Crossref","is-referenced-by-count":59,"title":["Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma"],"prefix":"10.1007","volume":"54","author":[{"given":"Jeffrey K.","family":"Griffith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen A.","family":"Fordyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D.","family":"Gilliland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Joste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Moyzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"200650_CR1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000163771","volume":"61","author":"BA Usmani","year":"1993","unstructured":"Usmani BA: Genomic instability and metastatic progression. Pathobiology 61: 109\u2013116, 1993","journal-title":"Pathobiology"},{"key":"200650_CR2","first-page":"541","volume-title":"Flow Cytometry and Clinical Diagnosis","author":"JW Furlong","year":"1994","unstructured":"Furlong JW: DNA analysis of breast, lung, central nervous system, endocrine, and head and neck tumors. In: Keran DF, Henson CA, Hurtubise PE (eds) Flow Cytometry and Clinical Diagnosis, American Society of Clinical Pathology Press, Chicago, 1994, pp 541\u2013595"},{"key":"200650_CR3","first-page":"5294","volume":"47","author":"LG Dressler","year":"1987","unstructured":"Dressler LG, Seamer LC, Owens MA, Clark GN, McGuire WL: DNA flow cytometry and prognostic factors in frozen breast cancer specimens. Cancer Res 47: 5294\u20135302, 1987","journal-title":"Cancer Res"},{"key":"200650_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1996.5928","volume":"230","author":"F Ishikawa","year":"1997","unstructured":"Ishikawa F: Telomere crisis, the driving force in cancer cell evolution. Biochem Biophys Res Com 230: 1\u20136, 1997","journal-title":"Biochem Biophys Res Com"},{"key":"200650_CR5","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","volume":"85","author":"RK Moyzis","year":"1988","unstructured":"Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD, Meyne J, Ratliff RL, Wu JR: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 85: 6622\u20136626, 1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"200650_CR6","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","volume":"89","author":"RC Allsopp","year":"1992","unstructured":"Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114\u201310118, 1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"200650_CR7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/excr.1995.1306","volume":"220","author":"RC Allsopp","year":"1995","unstructured":"Allsopp RC, Chang E, Kashefiaazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB: Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 220: 194\u2013200, 1995","journal-title":"Exp Cell Res"},{"key":"200650_CR8","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","volume":"345","author":"CB Harley","year":"1990","unstructured":"Harley CB, Futcher AB, Greider CW: Telomeres shorten during aging of human fibroblasts. Nature 345: 458\u2013460, 1990","journal-title":"Nature"},{"key":"200650_CR9","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","volume":"11","author":"CM Counter","year":"1992","unstructured":"Counter CM, Avillon AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11: 1921\u20131929, 1992","journal-title":"EMBO J"},{"key":"200650_CR10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/346866a0","volume":"346","author":"ND Hastie","year":"1990","unstructured":"Hastie ND, Dempster M, Dunlop MG, Thompson EM, Green DK, Allshire RC: Telomere reduction in human colorectal carcinoma and with aging. Nature 346: 866\u2013868, 1990","journal-title":"Nature"},{"key":"200650_CR11","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.91.21.9857","volume":"91","author":"H Vaziri","year":"1994","unstructured":"Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM: Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 91: 9857\u20139860, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"200650_CR12","first-page":"518","volume":"10","author":"T de Lange","year":"1990","unstructured":"de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE: Structure and variability of human chromosome ends. Mol Cell Biol 10: 518\u2013527, 1990","journal-title":"Mol Cell Biol"},{"key":"200650_CR13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/gcc.2870110306","volume":"11","author":"H Schmitt","year":"1994","unstructured":"Schmitt H, Blin N, Zankl H, Scherthan H: Telomere length variation in normal and malignant human tissues. Genes Chrom Cancer 11: 171\u2013177, 1994","journal-title":"Genes Chrom Cancer"},{"key":"200650_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1996.1","volume":"73","author":"EK Parkinson","year":"1996","unstructured":"Parkinson EK: Do telomerase antagonists represent a novel anti-cancer strategy? Br J Cancer 73: 1\u20134, 1996","journal-title":"Br J Cancer"},{"key":"200650_CR15","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","volume":"26","author":"B McClintock","year":"1941","unstructured":"McClintock B: The stability of broken ends of chromosomes in Zea mays. Genetics 26: 234\u2013282, 1941","journal-title":"Genetics"},{"key":"200650_CR16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1073\/pnas.28.11.458","volume":"28","author":"B McClintock","year":"1942","unstructured":"McClintock B: The fusion of broken ends of chromosomes following nuclear fusion. Proc Natl Acad Sci USA 28: 458\u2013463, 1942","journal-title":"Proc Natl Acad Sci USA"},{"key":"200650_CR17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1349-7006.1994.tb02071.x","volume":"85","author":"K Takauchi","year":"1994","unstructured":"Takauchi K, Tashiro S, Ohtaki M, Kamada N: Telomere reduction of specific chromosome translocation in acute myelocytic leukemia. Jap J Cancer Res 85: 127\u2013130, 1994","journal-title":"Jap J Cancer Res"},{"key":"200650_CR18","first-page":"937","volume":"10","author":"K Hiyama","year":"1995","unstructured":"Hiyama K, Ishioka S, Shirotani Y, Inai K, Hiyama E, Murakami I, Isobe T, Inamizu T, Yamakido M: Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb. Oncogene 10: 937\u2013944, 1995","journal-title":"Oncogene"},{"key":"200650_CR19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1349-7006.1992.tb00081.x","volume":"83","author":"E Hiyama","year":"1992","unstructured":"Hiyama E, Hiyama K, Yokoyama T, Ichikawa T, Matsuura Y: Length of telomere repeats in neuroblastoma: correlation with prognosis and biological characteristics. Jpn J Cancer Res 83: 159\u2013164, 1992","journal-title":"Jpn J Cancer Res"},{"key":"200650_CR20","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/1097-0142(19940615)73:12<2978::AID-CNCR2820731215>3.0.CO;2-5","volume":"73","author":"E Odagiri","year":"1993","unstructured":"Odagiri E, Kanda N, Jibiki K, Demura R, Aikawa E, Demura H: Reduction of telomeric length and c-erb2 gene amplification in human breast cancer, fibroadenoma and gynecomastia. Cancer 73: 2978\u20132984, 1993","journal-title":"Cancer"},{"key":"200650_CR21","first-page":"3557","volume":"54","author":"J Ohyashiki","year":"1994","unstructured":"Ohyashiki J, Ohyashiki K, Fujimura K, Kawakubo K, Shimamoto T, Iwabuchi A, Toyama K: Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes. Cancer Res 54: 3557\u20133560, 1994","journal-title":"Cancer Res"},{"key":"200650_CR22","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/0002-9378(92)91791-8","volume":"167","author":"J Smith","year":"1992","unstructured":"Smith J, Yeh G: Telomere reduction in endometrial carcinoma. Am J Obstet Gynecol 167: 1883\u20131887, 1992","journal-title":"Am J Obstet Gynecol"},{"key":"200650_CR23","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/clinchem\/43.5.708","volume":"43","author":"R Dahse","year":"1997","unstructured":"Dahse R, Fiedler W, Ernst G: Telomeres and telomerase: Biological and clinical importance. Clin Chem 43: 708\u2013714, 1997","journal-title":"Clin Chem"},{"key":"200650_CR24","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2144\/97233st05","volume":"23","author":"J Bryant","year":"1997","unstructured":"Bryant J, Hutchings K, Moyzis R, Griffith JK: A sensitive measure of telomere DNA content in human tissues. Biotechniques 23: 476\u2013484, 1997","journal-title":"Biotechniques"},{"key":"200650_CR25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0091-679X(08)61722-7","volume":"41","author":"LG Dressler","year":"1994","unstructured":"Dressler LG, Seamer LC: Controls, standards and histogram interpretation in DNA flow cytometry. Meth Cell Biol 41: 241\u2013262, 1994","journal-title":"Meth Cell Biol"},{"key":"200650_CR26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0165-4608(94)90047-7","volume":"78","author":"K Ohyashiki","year":"1994","unstructured":"Ohyashiki K, Ohyashiki JH, Fujimura T, Kawakubo K, Shimamoto T, Saito M, Nakazawa S, Toyama K: Telomere shortening in leukemic cells is related to their genetic alterations but not replicative capability. Cancer Genet Cytogen 78: 64\u201367, 1994","journal-title":"Cancer Genet Cytogen"},{"key":"200650_CR27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jnci\/88.2.116","volume":"88","author":"E Hiyama","year":"1996","unstructured":"Hiyama E, Gollahon L, Kataoka T, Kuroi K, Yokoyama T, Gazdar A, Hiyama K, Mieczyslaw A, Piatyszek A, Shay J: Telomerase activity in human breast cancer. J Natl Cancer Inst 88: 116\u2013122, 1996","journal-title":"J Natl Cancer Inst"},{"key":"200650_CR28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3835(96)04304-2","volume":"106","author":"P Rogalla","year":"1996","unstructured":"Rogalla P, Rohen C, Bonk U, Bullerdieck J: Telomere repeat fragment lengths are not correlated with histological grade in 85 breast cancers. Cancer Letters 106: 155\u2013161, 1996","journal-title":"Cancer Letters"},{"key":"200650_CR29","first-page":"620","volume":"146","author":"Z Zhuang","year":"1995","unstructured":"Zhuang Z, Bertheau P, Emmert-Buck M, Liotta L, Gnarra J, Linehan M, Lubensky I: A microdissection technique for archivalDNAanalysis of specific cell populations in lesions 1mm in size. Am J Path 146: 620\u2013625, 1995","journal-title":"Am J Path"},{"key":"200650_CR30","first-page":"467","volume":"55","author":"Z Zhuang","year":"1995","unstructured":"Zhuang Z, Merino M, Chuaqui R, Liotta L, Emmert-Buck M: Identical allelic loss on chromosome 11q13 in microdissected in situ invasive human breast cancer. Cancer Res 55: 467\u2013471, 1995","journal-title":"Cancer Res"},{"key":"200650_CR31","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","volume":"19","author":"CW Elston","year":"1991","unstructured":"Elston CW, Ellis IO: Pathological prognostic factors in breast cancer: 1. The value of histological grade in breast cancer; experience from a large study with long term follow-up. Histopath 19: 403\u2013410, 1991","journal-title":"Histopath"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006128228761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1006128228761\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1023\/A:1006128228761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006128228761.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:33:59Z","timestamp":1750480439000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1006128228761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["200650"],"URL":"https:\/\/doi.org\/10.1023\/a:1006128228761","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}