{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:48:05Z","timestamp":1767887285024,"version":"3.49.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1023\/a:1006268018519","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T20:20:41Z","timestamp":1040502041000},"page":"97-101","source":"Crossref","is-referenced-by-count":29,"title":["Phase II trial of uracil\/tegafur (UFT) plus leucovorin in patients with advanced biliary carcinoma"],"prefix":"10.1007","volume":"17","author":[{"given":"Sridhar","family":"Mani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sciortino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Arrietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Schilsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everett E.","family":"Vokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Benner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"232039_CR1","first-page":"319","volume-title":"Cancer Treatment","author":"CM Haskell","year":"1980","unstructured":"Haskell CM: Cancer of the liver. In: Haskell CM (ed), Cancer Treatment. Philadelphia: WB Saunders, 1980, pp 319\u2013357"},{"key":"232039_CR2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/1097-0142(19840915)54:6<965::AID-CNCR2820540603>3.0.CO;2-X","volume":"54","author":"G Falkson","year":"1984","unstructured":"Falkson G, MacIntyre JM, Moertel CG: Eastern Cooperative Oncology Group experience with chemotherapy for inoperable gallbladder and bile duct cancer. Cancer 54: 965, 1984","journal-title":"Cancer"},{"issue":"9","key":"232039_CR3","first-page":"14","volume":"11","author":"Y Maehara","year":"1997","unstructured":"Maehara Y, Kakeji Y, Ohno S et al.: Scientific basis for the combination of tegafur with uracil. Oncol 11(9) (Suppl 10): 14\u201316, 1997","journal-title":"Oncol"},{"issue":"9","key":"232039_CR4","first-page":"35","volume":"11","author":"R Pazdur","year":"1997","unstructured":"Pazdur R: Phase I and pharmacokinetic evaluations of UFT plus oral leucovorin. Oncol 11(9) (Suppl 10): 35\u201338, 1997","journal-title":"Oncol"},{"key":"232039_CR5","first-page":"1161","volume":"5","author":"T Taguchi","year":"1978","unstructured":"Taguchi T, Nakano H, Jikuya H et al.: Effect of uracil on the antitumor activity of florafur. Jpn J Cancer Chemother 5: 1161\u20131165, 1978","journal-title":"Jpn J Cancer Chemother"},{"key":"232039_CR6","first-page":"966","volume":"7","author":"T Taguchi","year":"1980","unstructured":"Taguchi T, Furue H, Koyanna Y et al.: Phase I study of UFT. Jpn J Cancer Chemother 7: 966\u2013972, 1980","journal-title":"Jpn J Cancer Chemother"},{"key":"232039_CR7","first-page":"1558","volume":"7","author":"O Nakajima","year":"1980","unstructured":"Nakajima O, Ihara K, Isoda T et al.: Phase I and II studies on mixture of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil. Jpn J Cancer Chemother 7: 1558\u20131568, 1980","journal-title":"Jpn J Cancer Chemother"},{"issue":"9","key":"232039_CR8","first-page":"30","volume":"11","author":"T Taguchi","year":"1997","unstructured":"Taguchi T: Experience with UFT in Japan. Oncol 11(9) (Suppl 10): 30\u201335, 1997","journal-title":"Oncol"},{"key":"232039_CR9","first-page":"333","volume":"22","author":"K Ota","year":"1988","unstructured":"Ota K, Taguchi T, Kimura K: Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chemother Pharmacol 22: 333\u2013338, 1988","journal-title":"Cancer Chemother Pharmacol"},{"issue":"9","key":"232039_CR10","first-page":"124","volume":"11","author":"S Mani","year":"1997","unstructured":"Mani S: An ongoing phase II study of UFT plus leucovorin in advanced hepatobiliary tumors and pancreatic adenocarcinomas. Oncol 11(9) (Suppl 10): 124\u2013128, 1997","journal-title":"Oncol"},{"key":"232039_CR11","first-page":"141","volume":"8","author":"JA Ajani","year":"1990","unstructured":"Ajani JA, Welch SR, Raber MN et al.: Comprehensive criteria for survival and therapy-induced toxicity. Cancer Invest 8: 141\u2013153, 1990","journal-title":"Cancer Invest"},{"key":"232039_CR12","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1200\/JCO.1994.12.11.2296","volume":"12","author":"R Pazdur","year":"1994","unstructured":"Pazdur R, Lassere Y, Rhodes V et al.: Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 12: 2296\u20132300, 1994","journal-title":"J Clin Oncol"},{"key":"232039_CR13","first-page":"205","volume":"15","author":"Y Sakata","year":"1988","unstructured":"Sakata Y, Munakata A, Baba T et al.: Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki cooperative study group of cancer chemotherapy. Gan To Kagaku Ryoho 15: 205\u2013271, 1988","journal-title":"Gan To Kagaku Ryoho"},{"key":"232039_CR14","first-page":"1893","volume":"17","author":"K Koda","year":"1990","unstructured":"Koda K, Nakazawa O, Morita K et al.: Combination chemotherapy of UFT and adriamycin and cisplatin for advanced gastrointestinal cancer. Gan To Kagaku Ryoho 17: 1893\u20131900, 1990","journal-title":"Gan To Kagaku Ryoho"},{"key":"232039_CR15","first-page":"1329","volume":"33","author":"K Koda","year":"1987","unstructured":"Koda K, Kure T, Terada S et al.: Combination chemotherapy of UFT with adriamycin in advanced gastrointestinal cancer. Gan No Rinsho 33: 1329\u20131335, 1987","journal-title":"Gan No Rinsho"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006268018519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1006268018519\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006268018519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T20:02:51Z","timestamp":1753819371000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1006268018519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["232039"],"URL":"https:\/\/doi.org\/10.1023\/a:1006268018519","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}