{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:32:36Z","timestamp":1791405156255,"version":"4.3.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1023\/a:1006682413834","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T02:51:24Z","timestamp":1040525484000},"page":"107-116","source":"Crossref","is-referenced-by-count":44,"title":["IL-4 and IFN-\u03b3 mRNA Induction in Human Peripheral Lymphocytes Specific for \u03b2-Lactam Antibiotics in Immediate or Delayed Hypersensitivity Reactions"],"prefix":"10.1007","volume":"20","author":[{"given":"Isabelle","family":"Gaspard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00b4er`ese","family":"Guinnepain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00b4erome","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bachot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Kerdine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bertoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pallardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00b4e","family":"Lebrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"223157_CR1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/archinte.1992.00400170020005","volume":"152","author":"RY Lin","year":"1992","unstructured":"Lin RY: A perspective on penicillin allergy. Arch Intern Med 152:930-937, 1992","journal-title":"Arch Intern Med"},{"key":"223157_CR2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.1994.tb02275.x","volume":"49","author":"JM Vega","year":"1994","unstructured":"Vega JM, Blanca M, Garcia JJ, Carmona MJ, Miranda A, P\u00e9rez-Estrada M, Fernandez S, Acebes JM, Terrados S: Immediate allergic reaction to amoxicillin. Allergy 49:317-322, 1994","journal-title":"Allergy"},{"key":"223157_CR3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ppul.1950120210","volume":"12","author":"M Boguniewicz","year":"1992","unstructured":"Boguniewicz M, Leung DYM: Management of the patient with allergic reactions to antibiotics. Pediatr Pulmonol 12:113-122, 1992","journal-title":"Pediatr Pulmonol"},{"key":"223157_CR4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1398-9995.1995.tb05066.x","volume":"50","author":"A Romano","year":"1995","unstructured":"Romano A, Di Fonso M, Papa G, Pietrantonio F, Federico F, Fabrizi G, Venuti A: Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy 50:113-118, 1995","journal-title":"Allergy"},{"key":"223157_CR5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/0091-6749(93)90088-W","volume":"92","author":"RJ Warington","year":"1993","unstructured":"Warington RJ, Silviu-Dan F, Magro C: Accelerated cell-mediated immune reactions in penicillin allergy. J Allergy Clin Immunol 92:626-628, 1993","journal-title":"J Allergy Clin Immunol"},{"key":"223157_CR6","first-page":"319","volume":"7","author":"A Barbaud","year":"1997","unstructured":"Barbaud A, B\u00e9n\u00e9 M-C, Faure G: Immunological physiopathology of cutaneous adverse drug reactions. Eur J Dermatol 7:319-323, 1997","journal-title":"Eur J Dermatol"},{"key":"223157_CR7","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.4049\/jimmunol.151.7.3440","volume":"151","author":"CA Herrick","year":"1993","unstructured":"Herrick CA, Carucci JA, Kleiner GI, Durkin HG: Regulation of hapten-specific memory IgE responses induced in vitro. J Immunol 151:3440-3449, 1993","journal-title":"J Immunol"},{"key":"223157_CR8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/1523-1747.ep12371697","volume":"101","author":"M Hertl","year":"1993","unstructured":"Hertl M, Bohlen H, Jugert F, Boecker C, Knaup R, Merk HF: Predominance of epidermal CD8+T lymphocytes in bullous cutaneous reactions caused by b-lactam antibiotics. J Invest Dermatol 101:794-799, 1993","journal-title":"J Invest Dermatol"},{"key":"223157_CR9","doi-asserted-by":"crossref","first-page":"95S","DOI":"10.1038\/jid.1995.19","volume":"105","author":"M Hertl","year":"1995","unstructured":"Hertl M, Merk HF: Lymphocyte activation in cutaneous drug reactions. J Invest Dermatol 105:95S-98S, 1995","journal-title":"J Invest Dermatol"},{"key":"223157_CR10","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.4049\/jimmunol.155.5.2670","volume":"155","author":"C Brander","year":"1995","unstructured":"Brander C, Mauri-Hellweg D, Bettens F, Rolli H, Goldman M, Pichler WJ: Heterogeneous T cell responses to b-lactam-modified self-structures are observed in penicillin-allergic individuals. J Immunol 155:2670-2678, 1995","journal-title":"J Immunol"},{"key":"223157_CR11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4049\/jimmunol.155.1.462","volume":"155","author":"D Mauri-Hellweg","year":"1995","unstructured":"Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler WJ: Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol 155:462-472, 1995","journal-title":"J Immunol"},{"key":"223157_CR12","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1084\/jem.114.6.875","volume":"114","author":"BB Levine","year":"1961","unstructured":"Levine BB, Ovary Z: Studies on the mechanism of the formation of the penicillin antigen. J Exp Med 114:875-904, 1961","journal-title":"J Exp Med"},{"key":"223157_CR13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(90)81382-X","volume":"263","author":"M Yvon","year":"1990","unstructured":"Yvon M, Anglade P, Wal J-M: Identification of the binding sites of benzyl penicilloyl, the allergenic metabolite of penicillin, on the serum albumin molecule. FEBS Lett 263:237-240, 1990","journal-title":"FEBS Lett"},{"key":"223157_CR14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1172\/JCI119505","volume":"100","author":"B Schnyder","year":"1997","unstructured":"Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ: Direct, MHC-dependent presentation of the drug sulfamethoxazole to human \u03b1\u03b2 T cell clones. J Clin Invest 100:136-141, 1997","journal-title":"J Clin Invest"},{"key":"223157_CR15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/clin.1993.1028","volume":"66","author":"DL Auci","year":"1993","unstructured":"Auci DL, Kleiner GI, Chice SM, Dukor P, Durkin HG: Control of IgE responses. III. IL-6 and IFN-\u03b1 are isotype-specific regulators of peak BPO-specific IgE antibody-forming cell responses in mice. Clin Immunol Immunopathol 66:219-224, 1993","journal-title":"Clin Immunol Immunopathol"},{"key":"223157_CR16","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1002\/eji.1830261213","volume":"26","author":"S Kerdine","year":"1996","unstructured":"Kerdine S, Pallardy M, Laman\u00e8tre S, Bertoglio J, Lebrec H: Interleukin-10 and interleukin-4 have similar effects on haptenspecific primary antibody responses to penicillin in vivo. Eur J Immunol 26:2890-2894, 1996","journal-title":"Eur J Immunol"},{"key":"223157_CR17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0161-5890(95)00119-0","volume":"33","author":"S Kerdine","year":"1996","unstructured":"Kerdine S, Lebrec H, Bertoglio J, Pallardy M: Interleukin-4 plays a dominant role in Th1-or Th2-like responses during the primary immune response to the hapten penicillin. Mol Immunol 33:71-77, 1996","journal-title":"Mol Immunol"},{"key":"223157_CR18","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4049\/jimmunol.163.2.1053","volume":"163","author":"F Brugnolo","year":"1999","unstructured":"Brugnolo F, Annunziato F, Sampagnaro S, Campi P, Manfredi M, Matucci A, Blanca M, Romagnani S, Maggi E, Parronchi P: Highly Th2-skewed cytokine profile of b-lactam-specific T cells from nonatopic subjects with adverse drug reactions. J Immunol 163: 1053-1059, 1999","journal-title":"J Immunol"},{"key":"223157_CR19","first-page":"111","volume":"40","author":"B Begaud","year":"1985","unstructured":"Begaud B, J-C Evreux, J Jouglard, G Lagier: Imputabilit\u00e9des effets inattendus ou toxiques des m\u00e9dicaments. Th\u00e9rapie 40:111-116, 1985","journal-title":"Th\u00e9rapie"},{"key":"223157_CR20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0006-2952(87)90708-8","volume":"36","author":"NR Kitteringham","year":"1987","unstructured":"Kitteringham NR, Christie G, Coleman JW, Yeung JHK, Park BK: Drug-protein conjugates. XII. A study of the disposition, irreversible binding and immunogenicity of penicillin in the rat. Biochem Pharmacol 36:601-608, 1987","journal-title":"Biochem Pharmacol"},{"key":"223157_CR21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-2697(66)90275-2","volume":"14","author":"AFSA Habeeb","year":"1966","unstructured":"Habeeb AFSA: Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 14:328-336, 1966","journal-title":"Anal Biochem"},{"key":"223157_CR22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987","journal-title":"Anal Biochem"},{"key":"223157_CR23","doi-asserted-by":"crossref","first-page":"21830","DOI":"10.1016\/S0021-9258(19)36687-6","volume":"267","author":"M Bouaboula","year":"1992","unstructured":"Bouaboula M, Legoux P, Pess\u00e9gu\u00e9 B, Delpech B, Dumont X, Piechaczyk M, Casellas P, Shire D: Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control. J Biol Chem 267:21830-21838, 1992","journal-title":"J Biol Chem"},{"key":"223157_CR24","first-page":"161","volume":"4","author":"D Shire","year":"1993","unstructured":"Shire D and the Editorial Staff of European Cytokine Network: An invitation to an open exchange of reagents and information useful for the measurement of cytokines mRNA levels by PCR. Eur Cytokine Netw 4:161-162, 1993","journal-title":"Eur Cytokine Netw"},{"key":"223157_CR25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2133.1993.tb00255.x","volume":"128","author":"M Hertl","year":"1993","unstructured":"Hertl M, Geisel J, Boecker C, Merk HF: Selective generation of CD8+ T-cell clones from the peripheral blood of patients with cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 128:619-626, 1993","journal-title":"Br J Dermatol"},{"key":"223157_CR26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1523-1747.1998.00122.x","volume":"110","author":"HU Weltzien","year":"1998","unstructured":"Weltzien HU, Padovan E: Molecular features of penicillin allergy. J Invest Dermatol 110:203-206, 1998","journal-title":"J Invest Dermatol"},{"key":"223157_CR27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0091-6749(94)90202-X","volume":"94","author":"RS Kalish","year":"1994","unstructured":"Kalish RS, Laporte A, Wood JA, Johnson KL: Sulfonamidereactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. J Allergy Clin Immunol 94:465-472, 1994","journal-title":"J Allergy Clin Immunol"},{"key":"223157_CR28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000233856","volume":"78","author":"JC Roujeau","year":"1985","unstructured":"Roujeau JC, Albengres E, Moritz S: Lymphocyte transformation test in drug-induced toxic epidermal necrolysis. Int Arch Allergy Appl Immunol 78:22-24, 1985","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"223157_CR29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0091-6749(84)90108-8","volume":"74","author":"NK Adkinson","year":"1984","unstructured":"Adkinson NK: Risk factors for drug allergy. J Allergy Clin Immunol 74:567-572, 1984","journal-title":"J Allergy Clin Immunol"},{"key":"223157_CR30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/taap.1996.0129","volume":"138","author":"RJ Dearman","year":"1996","unstructured":"Dearman RJ, Basketter DA, Kimber I: Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Toxicol Appl Pharmacol 138:308-316, 1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"223157_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(97)00094-5","volume":"94","author":"CA Ryan","year":"1998","unstructured":"Ryan CA, Dearman RJ, Kimber I, Gerberick F: Inducible interleukin 4 (IL-4) production and mRNA expression following exposure of mice to chemical allergens. Toxicol Lett 94:1-11, 1998","journal-title":"Toxicol Lett"},{"key":"223157_CR32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0167-5699(91)90137-I","volume":"12","author":"ML Kapsenberg","year":"1991","unstructured":"Kapsenberg ML, Wierenga EA, Bos JD, Jansen HM: Functional subsets of allergen-reactive human CD41 T cells. Immunol Today 12:392-395, 1991","journal-title":"Immunol Today"},{"key":"223157_CR33","first-page":"75","volume":"9","author":"MP Laan","year":"1998","unstructured":"Laan MP, Baert MRM, Vredendaal AECM, Savelkoul HFJ: Differential mRNA expression and production of interleukin-4 and interferon-gamma in stimulated peripheral blood mononuclear cells of house-dust mite-allergic patients. Eur Cytokine Netw 9:75-84, 1998","journal-title":"Eur Cytokine Netw"},{"key":"223157_CR34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1398-9995.1999.0_083.x","volume":"54","author":"J Ring","year":"1999","unstructured":"Ring J, Thewes M: The clinical expression of allergy in the skin. Allergy 54:192-197, 1999","journal-title":"Allergy"},{"key":"223157_CR35","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.4049\/jimmunol.158.6.2567","volume":"158","author":"F Dieli","year":"1997","unstructured":"Dieli F, Asherson GL, Sireci G, Dominici R, Scir\u00e9 E, Salerno A: Development of IFN-\u03b3-producing CD8+ \u03b3\u03b4+ T lymphocytes during contact sensitivity. J Immunol 158:2567-2575, 1997","journal-title":"J Immunol"},{"key":"223157_CR36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.4049\/jimmunol.162.2.1171","volume":"162","author":"E Padovan","year":"1999","unstructured":"Padovan E, von Greyerz S, Pichler WJ, Weltzien U: Antigendependent and-independent IFN-\u03b3 modulation by penicillins. J Immunol 162:1171-1177, 1999.","journal-title":"J Immunol"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006682413834.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1006682413834\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006682413834.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:26:39Z","timestamp":1751030799000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1006682413834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["223157"],"URL":"https:\/\/doi.org\/10.1023\/a:1006682413834","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}