{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:38:05Z","timestamp":1773146285366,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[1998,8]]},"DOI":"10.1023\/a:1006871309864","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T07:57:47Z","timestamp":1040543867000},"page":"177-182","source":"Crossref","is-referenced-by-count":17,"title":["In vivo tissue specific modulation of rat insulin receptor gene expression in an experimental model of mineralocorticoid excess"],"prefix":"10.1007","volume":"185","author":[{"given":"Javier","family":"Campi\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Lahera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Cachofeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Maestro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"del Carmen Carranza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Calle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"162489_CR1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.ph.55.030193.000555","volume":"55","author":"JW Funder","year":"1993","unstructured":"Funder JW: Aldosterone action. Annu Rev Physiol 55: 115-130, 1993","journal-title":"Annu Rev Physiol"},{"key":"162489_CR2","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1210\/endo.132.6.8504747","volume":"132","author":"C Rondinone","year":"1993","unstructured":"Rondinone C, Rodbard MD, Baker ME: Aldosterone stimulates differentiation of mouse 3T3-L1 cells into adipocytes. Endocrinology 132: 2421\u20132426, 1993","journal-title":"Endocrinology"},{"key":"162489_CR3","first-page":"73","volume":"81","author":"J Sauer","year":"1996","unstructured":"Sauer J, Castren M, Hopfner U, Holsboer F, Stalla GK, Arzt E: Inhibition of lipopolysaccharide-induced monocyte interleukin-1 receptor antagonist synthesis by cortisol: Involvement of the mineralocorticoid receptor. J Clin Endocrinol Metab 81: 73\u201379, 1996","journal-title":"J Clin Endocrinol Metab"},{"key":"162489_CR4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0002-9610(64)90252-1","volume":"107","author":"JW Conn","year":"1964","unstructured":"Conn JW, Knope RF, Nesbit RM: Clinical characteristics of primary aldosteronism from an analysis of 145 cases. Am J Surg 107: 159\u2013172, 1964","journal-title":"Am J Surg"},{"key":"162489_CR5","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM196511182732106","volume":"273","author":"JW Conn","year":"1965","unstructured":"Conn JW: Hypertension, the potassium ion and impaired carbohydrate tolerance. New Engl J Med 273: 1135\u20131143, 1965","journal-title":"New Engl J Med"},{"key":"162489_CR6","first-page":"914","volume-title":"Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice","author":"OP Gauda","year":"1990","unstructured":"Gauda OP: Diabetes Secondary to endocrinopathies. In: H Rifkin, D Porte (eds). Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice. Elsevier, New York, 1990, pp 914\u2013916"},{"key":"162489_CR7","first-page":"414","volume":"188","author":"MC Carranza","year":"1991","unstructured":"Carranza MC, Torres A, Calle C: Disminuci\u00f3n en el numero y en la afinidad de los receptores de insulina en el tejido adiposo subcut\u00e1neo de un paciente con hiperaldosteronismo primario. Rev Clin Esp 188: 414\u2013417, 1991","journal-title":"Rev Clin Esp"},{"key":"162489_CR8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","volume":"83","author":"DJ Mangelsdorf","year":"1995","unstructured":"Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Sch\u00fctz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM: The nuclear receptor superfamily: The second decade. Cell 83: 835\u2013839, 1995","journal-title":"Cell"},{"key":"162489_CR9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.med.48.1.231","volume":"48","author":"JW Funder","year":"1997","unstructured":"Funder JW: Glucocorticoid and mineralocorticoid receptors: Biology and clinical relevance. Annu Rev Med 48: 231\u2013240, 1997","journal-title":"Annu Rev Med"},{"key":"162489_CR10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0300-9084(92)90152-5","volume":"74","author":"MA Leal","year":"1992","unstructured":"Leal MA, Caba\u00f1as C, Rius C, Aller P, Calle C: Modulation by dexamethasone of insulin binding and insulin receptor mRNA levels in U937 human promonocytic cells. Biochimie 74: 545\u2013549, 1992","journal-title":"Biochimie"},{"key":"162489_CR11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1507\/endocrj.41.737","volume":"41","author":"MA Leal","year":"1994","unstructured":"Leal MA, Aller P, M\u00e1s A, Carranza MC, Calle C: Tissue-specific changes in insulin receptor mRNA concentrations in dexamethasonetreated and adrenalectomized rats. Endocr J 41: 737\u2013741, 1994","journal-title":"Endocr J"},{"key":"162489_CR12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-2007-1001702","volume":"26","author":"MA Leal","year":"1994","unstructured":"Leal MA, Aller P, Torres A, Picardo A, Davila N, Calle C: Insulin receptor mRNA levels are modulated in a tissue-specific manner in Cushing's syndrome patients. Horm Metab Res 26: 349\u2013350, 1994","journal-title":"Horm Metab Res"},{"key":"162489_CR13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/BF03349012","volume":"19","author":"MA Leal","year":"1996","unstructured":"Leal MA, Aller P, Calle C: Effect of dexamethasone on insulin receptor mRNA levels, RNA stability and isotype RNA pattern in U-937 human promonocytic cells. J Endocrinol Invest 19: 530\u2013534, 1996","journal-title":"J Endocrinol Invest"},{"key":"162489_CR14","first-page":"7858","volume":"50","author":"V Papa","year":"1990","unstructured":"Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID: Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells. Cancer Res 50: 7858\u20137862, 1990","journal-title":"Cancer Res"},{"key":"162489_CR15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0303-7207(92)90181-5","volume":"86","author":"G Sesti","year":"1992","unstructured":"Sesti G, Marini A, Briata P, Tullio AN, Montemurro A, Borboni P, De Pirro R, Gherzi R, Lauro R. Androgens increase insulin receptor mRNA levels, insulin binding, and insulin responsiveness in HEp-2 larynx carcinoma cells. Mol Cell Endocrinol 86: 111\u2013118, 1992","journal-title":"Mol Cell Endocrinol"},{"issue":"SupplI","key":"162489_CR16","first-page":"A713","volume":"39","author":"J Campi\u00f3n","year":"1996","unstructured":"Campi\u00f3n J, Aller P, Mata F, Davila N, Maestro B, Calle C: Regulation by aldosterone of insulin receptor mRNA levels in human promonocytic cells. Diabetologia 39 (Suppl I): A713, 1996","journal-title":"Diabetologia"},{"key":"162489_CR17","first-page":"R1516","volume":"267","author":"J Navarro","year":"1994","unstructured":"Navarro J, Sanchez A, S\u00e1iz J, Ruilope LM, Garc\u00eda-Esta\u00f1 J, Romero JC, Moncada S, Lahera V: Hormonal, renal, and metabolic alterations during hypertension induced by chronic inhibition of NO in rats. Am J Physiol 267: R1516\u2013R1512, 1994","journal-title":"Am J Physiol"},{"key":"162489_CR18","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-25-10-1375","volume":"25","author":"V Herbert","year":"1965","unstructured":"Herbert V, Lau K-S, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25: 1375\u20131384, 1965","journal-title":"J Clin Endocrinol Metab"},{"key":"162489_CR19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principe of protein-dye binding. Anal Biochemistry 72: 248\u2013254, 1976","journal-title":"Anal Biochemistry"},{"key":"162489_CR20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","volume":"102","author":"C Labarca","year":"1980","unstructured":"Labarca C, Paigen K: A simple, rapid and sensitive DNA assay procedure. Anal Biochem 102: 344\u2013352, 1980","journal-title":"Anal Biochem"},{"key":"162489_CR21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156\u2013159, 1987","journal-title":"Anal Biochem"},{"key":"162489_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1006872309179","volume":"169","author":"J Campi\u00f3n","year":"1997","unstructured":"Campi\u00f3n J, Aller P, D\u00e1vila N, Carranza MC, de Miguel R, Calle C: Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats. Mol Cell Biochem 169: 165\u2013169, 1997","journal-title":"Mol Cell Biochem"},{"key":"162489_CR23","first-page":"E649","volume":"258","author":"EP Gomez-Sanchez","year":"1990","unstructured":"Gomez-Sanchez EP, Venkataraman MT, Thwaites D, Fort C: ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. Am J Physiol 258: E649\u2013E653, 1990","journal-title":"Am J Physiol"},{"key":"162489_CR24","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1139\/y92-207","volume":"70","author":"S Dai","year":"1992","unstructured":"Dai S, Fraser H, McNeill JH: Effects of deoxycorticosterone acetate on glucose metabolism in nondiabetic and streptozotocin-diabetic rats. Can J Physiol Pharmacol 70: 1468\u20131472, 1992","journal-title":"Can J Physiol Pharmacol"},{"key":"162489_CR25","first-page":"H1798","volume":"263","author":"S Dai","year":"1992","unstructured":"Dai S, McNeill JH: Myocardial performance of STZ-diabetic DOCA-hypertensive rats. Am J Physiol 263: H1798\u2013H1805, 1992","journal-title":"Am J Physiol"},{"key":"162489_CR26","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2337\/diab.16.5.312","volume":"16","author":"G Spergel","year":"1967","unstructured":"Spergel G, Schmidt P, Stern A, Bleicher SJ: Effects of hypokalemia on carbohydrate and lipid metabolism in the rat. Diabetes 16: 312\u2013318, 1967","journal-title":"Diabetes"},{"key":"162489_CR27","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1093\/carcin\/15.9.1807","volume":"15","author":"P Ren","year":"1994","unstructured":"Ren P, de Feijter AW, Paul DL, Ruch RJ: Enhancement of liver cell gap junction protein expression by glucocorticoids. Carcinogenesis 15: 1807\u20131813, 1994","journal-title":"Carcinogenesis"},{"key":"162489_CR28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1210\/mend-1-11-759","volume":"1","author":"BJ Goldstein","year":"1987","unstructured":"Goldstein BJ, M\u00fcller-Wieland D, Kahn CR: Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues. Mol Endocrinol 1: 759\u2013766, 1987","journal-title":"Mol Endocrinol"},{"key":"162489_CR29","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1042\/bst0181263","volume":"18","author":"RM Knott","year":"1990","unstructured":"Knott RM, Hesketh JE, Trayhurn P. Insulin receptor gene expression in skeletal muscle and brown adipose tissue. Biochem Soc T 18: 1263, 1990","journal-title":"Biochem Soc T"},{"key":"162489_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-2007-979931","volume":"27","author":"E Tozzo","year":"1995","unstructured":"Tozzo E, Tessier F, Desbuquois B: Expression of the hepatic insulin receptor gene in the rat during postnatal development. Horm Metab Res 27: 163\u2013168, 1995","journal-title":"Horm Metab Res"},{"key":"162489_CR31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1210\/mend-5-5-653","volume":"5","author":"M Tewari","year":"1991","unstructured":"Tewari M, Tewari DS, Taub R: Posttranscriptional mechanism account for differences in steady state levels of insulin receptor messenger RNA in different cells. Mol Endocrinol 5: 653\u2013660, 1991","journal-title":"Mol Endocrinol"},{"key":"162489_CR32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1210\/endo.137.2.8593833","volume":"137","author":"RW Brown","year":"1996","unstructured":"Brown RW, Diaz R, Robson AC, Kotelevtsev YV, Mullins JJ, Kaufman JH, Seckl JR: The ontogeny of 11 b-hydroxisteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology 137: 794\u2013797, 1996","journal-title":"Endocrinology"},{"key":"162489_CR33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","volume":"237","author":"JL Arriza","year":"1987","unstructured":"Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM: Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor. Science 237: 268\u2013275, 1987","journal-title":"Science"},{"key":"162489_CR34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1210\/endo-100-2-398","volume":"100","author":"D Feldman","year":"1977","unstructured":"Feldman D, Loose D: Glucocorticoid receptors in adipose tissue. Endocrinology 100: 398\u2013405, 1977","journal-title":"Endocrinology"},{"key":"162489_CR35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0960-0760(95)00162-S","volume":"55","author":"LJ Bloem","year":"1995","unstructured":"Bloem LJ, Guo C, Pratt JH: Identification of a splice variant of the rat and human mineralocorticoid receptor genes. J Steroid Biochem Molec Biol 55: 159\u2013162, 1995","journal-title":"J Steroid Biochem Molec Biol"},{"key":"162489_CR36","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1210\/mend-3-10-1674","volume":"3","author":"JM Reul","year":"1989","unstructured":"Reul JM, Pearce PT, Funder JW, Krozowski ZS: Type I and type II corticosteroid receptor gene expression in the rat: Effect of adrenalectomy and dexamethasone administration. Mol Endocrinol 3: 1674\u20131680, 1989","journal-title":"Mol Endocrinol"},{"key":"162489_CR37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0960-0760(96)00167-7","volume":"60","author":"CM Bamberger","year":"1997","unstructured":"Bamberger CM, Bamberger A-M, Wald M, Chrousos GP, Schulte HM: Inhibition of mineralocorticoid activity by the \u03b2-isoform of the human glucocorticoid receptor. J Steroid Biochem Biol 60: 43\u201350, 1997","journal-title":"J Steroid Biochem Biol"},{"key":"162489_CR38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-6147(96)81590-2","volume":"17","author":"T Trapp","year":"1996","unstructured":"Trapp T, Holsboer F: Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action. Trends Pharmacol Sci 17: 145\u2013149, 1996","journal-title":"Trends Pharmacol Sci"},{"key":"162489_CR39","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2265.1994.tb02573.x","volume":"41","author":"M Ishimori","year":"1994","unstructured":"Ishimori M, Takeda N, Okumura S, Murai T, Inouye H, Yasuda K: Increased insulin sensitivity in patients with aldosterone producing adenoma. Clin Endocrinol 41: 433\u2013438, 1994","journal-title":"Clin Endocrinol"},{"key":"162489_CR40","first-page":"755","volume":"8","author":"K Shimamoto","year":"1994","unstructured":"Shimamoto K, Shiiki M, Ise T, Miyazaki Y, Higashiura K, Fukuoka M, Hirata A, Masuda A, Nakagawa M, Limura O: Does insulin resistance participate in an impaired glucose tolerance in primary aldosteronism? J Human Hypertens 8: 755\u2013759, 1994","journal-title":"J Human Hypertens"},{"key":"162489_CR41","first-page":"625","volume":"8","author":"J-K Lee","year":"1994","unstructured":"Lee J-K, Tsai SY: Multiple hormone response elements can confer glucocorticoid regulation on the human insulin receptor gene. Mol Endocrinol 8: 625\u2013634, 1994","journal-title":"Mol Endocrinol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006871309864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1006871309864\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006871309864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:12:34Z","timestamp":1747746754000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1006871309864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["162489"],"URL":"https:\/\/doi.org\/10.1023\/a:1006871309864","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}