{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:45:59Z","timestamp":1768909559969,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1023\/a:1007547622844","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T10:04:10Z","timestamp":1040551450000},"page":"437-441","source":"Crossref","is-referenced-by-count":65,"title":["Hyperammonemia Impairs NMDA Receptor-Dependent Long-Term Potentiation in the CA1 of Rat Hippocampus In Vitro"],"prefix":"10.1007","volume":"25","author":[{"given":"Mar\u00eda-Dolores","family":"Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Monfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Mar\u00eda","family":"Gaztelu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Felipo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"224403_CR1","first-page":"362","volume-title":"The Metabolic Basis of Inherited Disease","author":"V. E. Shih","year":"1978","unstructured":"Shih, V. E. 1978. Urea cycle disorders and other congenital hyperammonemic syndromes. Pages 362\u2013386, The Metabolic Basis of Inherited Disease, McGrawHill, New York."},{"key":"224403_CR2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM198406073102304","volume":"310","author":"M. Msall","year":"1984","unstructured":"Msall, M., Batshaw, M. L., Suss, R., Brusilow, S. W., and Mellitis, E. D. 1984. Neurologic outcome in children with inborn errors of urea synthesis. Outcome of urea cycle enzymopathies. N. Eng. J. Med. 310:1500\u20131505.","journal-title":"N. Eng. J. Med."},{"key":"224403_CR3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4615-5945-0_2","volume":"420","author":"A. Michalak","year":"1997","unstructured":"Michalak, A., Knecht, K., and Butterworth, R. F. 1997. Hepatic encephalopathy in acute liver failure: role of the glutamate system. Adv. Exp. Med. Bio. 420:35\u201344.","journal-title":"Adv. Exp. Med. Bio."},{"key":"224403_CR4","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1046\/j.1460-9568.1998.00329.x","volume":"10","author":"C. Hermenegildo","year":"1998","unstructured":"Hermenegildo, C., Montoliu, C., Llansola, M., Mu\u00f1oz, M. D., Gaztelu, J. M., Mi\u00f1ana, M. D., and Felipo, V. 1998. Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo. Eur. J. Neurosci. 10:3201\u20133209.","journal-title":"Eur. J. Neurosci."},{"key":"224403_CR5","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1111\/j.1460-9568.1995.tb01036.x","volume":"7","author":"G. Marcaida","year":"1995","unstructured":"Marcaida, G., Mi\u00f1ana, M. D., Burgal, M., Grisol\u00eda, S., and Felipo, V. 1995. Ammonia prevents activation of NMDA receptors in rat cerebellar neuronal cultures. Eur. J. Neurosci. 7:2389\u20132396.","journal-title":"Eur. J. Neurosci."},{"key":"224403_CR6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0165-6147(91)90527-Y","volume":"12","author":"I. Izquierdo","year":"1991","unstructured":"Izquierdo, I. 1991. Role of NMDA receptors in memory. Trends Pharmacol. Sci. 12:128\u2013129.","journal-title":"Trends Pharmacol. Sci."},{"key":"224403_CR7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.ne.14.030191.002115","volume":"14","author":"D. V. Madison","year":"1991","unstructured":"Madison, D. V., Malenka, R. C., and Nicoll, R. A. 1991. Mechanisms underlying long-term potentiation of synaptic transmission. Ann. Rev. Neurosci. 14:379\u2013397.","journal-title":"Ann. Rev. Neurosci."},{"key":"224403_CR8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0306-4522(95)00349-N","volume":"69","author":"C. L. Boulton","year":"1995","unstructured":"Boulton, C. L., Southam, E., and Garthwaite, J. 1995. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 69:699\u2013703.","journal-title":"Neuroscience"},{"key":"224403_CR9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1113\/jphysiol.1973.sp010274","volume":"232","author":"T. V. P. Bliss","year":"1973","unstructured":"Bliss, T. V. P., and Gardner-Medwin, A. R. 1973. Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of perforant path. J. Physiol. (Lond) 232:357\u2013374.","journal-title":"J. Physiol. (Lond)"},{"key":"224403_CR10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","volume":"232","author":"T. V. P. Bliss","year":"1973","unstructured":"Bliss, T. V. P., and Lomo, T. 1973. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of perforant path. J. Physiol. (Lond) 232:331\u2013356.","journal-title":"J. Physiol. (Lond)"},{"key":"224403_CR11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"T. V. P. Bliss","year":"1993","unstructured":"Bliss, T. V. P., and Collingridge, G. L. 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31\u201339.","journal-title":"Nature"},{"key":"224403_CR12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hep.1840100310","volume":"10","author":"I. Azor\u00edn","year":"1989","unstructured":"Azor\u00edn, I., Mi\u00f1ana, M. D., Felipo, V., and Grisol\u00eda, S. 1989. A simple animal model of hyperammonemia. Hepatology 10:311\u2013314.","journal-title":"Hepatology"},{"key":"224403_CR13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00005072-199509000-00005","volume":"54","author":"M. D. Mi\u00f1ana","year":"1995","unstructured":"Mi\u00f1ana, M. D., Marcaida, G., Grisol\u00eda, S., and Felipo, V. 1995. Prenatal exposure of rats to ammonia impairs NMDA receptor function and affords delayed protection against ammonia toxicity and glutamate neurotoxicity. Neuropathol. Exp. Neurol. 54:644\u2013650.","journal-title":"Neuropathol. Exp. Neurol."},{"key":"224403_CR14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0165-0270(81)90049-2","volume":"4","author":"R. A. Nicoll","year":"1981","unstructured":"Nicoll, R. A., and Alger, B. E. 1981. A simple chamber for recording from submerged brain slices. J. Neuroci. Methods 4:153\u2013156.","journal-title":"J. Neuroci. Methods"},{"key":"224403_CR15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0006-8993(97)00444-7","volume":"763","author":"S. Matsuyama","year":"1997","unstructured":"Matsuyama, S., Namgung, U., and Routtenberg, A. 1997. Long-term potentiation persistence greater in C57BL\/6 than in DBA\/2 mice: predicted on basis of protein kinase C levels and learning performance. Brain Res. 763:127\u2013130.","journal-title":"Brain Res."},{"key":"224403_CR16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/347477a0","volume":"347","author":"L. M. Grover","year":"1990","unstructured":"Grover, L. M., and Teyler, T. J. 1990. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347:477\u2013479.","journal-title":"Nature"},{"key":"224403_CR17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0896-6273(92)90227-5","volume":"9","author":"R. C. Malenka","year":"1992","unstructured":"Malenka, R. C., Lancaster, B., and Zucker, R. S. 1992. Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation. Neuron 9:121\u2013128.","journal-title":"Neuron"},{"key":"224403_CR18","first-page":"236","volume":"10","author":"R. Anwyl","year":"1989","unstructured":"Anwyl, R. 1989. Protein kinase C and long-term potentiation in the hippocampus. TiPS 10:236\u2013239.","journal-title":"TiPS"},{"key":"224403_CR19","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1523\/JNEUROSCI.10-10-03353.1990","volume":"10","author":"P. A. Colley","year":"1990","unstructured":"Colley, P. A., Sheu, F. S., and Routtenberg, A. 1990. Inhibition of Protein Kinase C Blocks Two Components of LTP Persistence, Leaving Initial Potentiation Intact. J. Neurosci. 10:3353\u20133360.","journal-title":"J. Neurosci."},{"key":"224403_CR20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0896-6273(92)90198-M","volume":"8","author":"C. Gianotti","year":"1992","unstructured":"Gianotti, C., Nunzi, M. G., Gispen, W. H., and Corradetti, R. 1992. Phosphorylation of the presynaptic protein B-50 (GAP-43) is increased during electrically induced long-term potentiation. Neuron 8:843\u2013848.","journal-title":"Neuron"},{"key":"224403_CR21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/syn.890190208","volume":"19","author":"L. M. Grover","year":"1995","unstructured":"Grover, L. M., and Teyler, T. J. 1995. Different mechanisms may be required for maintenance of NMDA receptor-dependent and independent forms of long-term potentiation. Synapse 19:121\u2013133.","journal-title":"Synapse"},{"key":"224403_CR22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0166-4328(94)00124-X","volume":"66","author":"P. Pasinelli","year":"1995","unstructured":"Pasinelli, P., Ramakers, G. M., Urban, I. J., Hens, J. J., Oestreicher, A. B., de-Graan, P. N., and Gispen, W. H. 1995. Longterm potentiation and synaptic protein phosphorylation. Behav. Brain Res. 66:53\u201359.","journal-title":"Behav. Brain Res."},{"key":"224403_CR23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(96)01159-6","volume":"749","author":"S. J. Chen","year":"1997","unstructured":"Chen, S. J., Sweatt, J. D., and Klann, E. 1997. Enhanced phosphorylation of the postsynaptic protein kinase C substrate RC3\/ neurogranin during long-term potentiation. Brain Res. 749:181\u2013187.","journal-title":"Brain Res."},{"key":"224403_CR24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0896-6273(95)90048-9","volume":"15","author":"J. H. Wang","year":"1995","unstructured":"Wang, J. H., and Kelly, P. T. 1995. Postsynaptic injection of Ca2+\/CaM induces synaptic potentiation requiring CaMKII and PKC activity. Neuron 15:443\u2013452.","journal-title":"Neuron"},{"key":"224403_CR25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1432-1033.1993.tb17917.x","volume":"214","author":"V. Felipo","year":"1993","unstructured":"Felipo, V., Grau, E., Mi\u00f1ana, M. D., and Grisolia, S. 1993. Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin. Eur. J. Biochem. 214:243\u2013249.","journal-title":"Eur. J. Biochem."},{"key":"224403_CR26","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1046\/j.1471-4159.1994.63062172.x","volume":"63","author":"E. Kosenko","year":"1994","unstructured":"Kosenko, E., Kaminsky, Y., Grau, E., Mi\u00f1ana, M. D., Marcaida, G., Grisol\u00eda, S., and Felipo, V. 1994. Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and of Na+\/K+-ATPase. J. Neurochem. 63:2172\u20132178.","journal-title":"J. Neurochem."},{"key":"224403_CR27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF02237958","volume":"11","author":"E. Grau","year":"1996","unstructured":"Grau, E., Marcaida, G., Montoliu, C., Mi\u00f1ana, M. D., Grisol\u00eda, S., and Felipo, V. 1996. Effects of Hyperammonemia on Brain Protein Kinase C Substrates. Metab. Brain Dis. 11:205\u2013215.","journal-title":"Metab. Brain Dis."},{"key":"224403_CR28","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/j.1471-4159.1988.tb01165.x","volume":"51","author":"M. D. Mi\u00f1ana","year":"1988","unstructured":"Mi\u00f1ana, M. D., Felipo, V., Wallace, R., and Grisol\u00eda, S. 1988 High ammonia levels in brain induce tubulin in cerebrum but not in cerebellum. J. Neurochem. 51:1839\u20131842.","journal-title":"J. Neurochem."}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1007547622844.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1007547622844\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1007547622844.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T09:16:16Z","timestamp":1749719776000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1007547622844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["224403"],"URL":"https:\/\/doi.org\/10.1023\/a:1007547622844","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}