{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:18:36Z","timestamp":1759814316460,"version":"3.41.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc Drugs Ther"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1023\/a:1007774505445","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T11:08:11Z","timestamp":1040555291000},"page":"619-627","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the Efficacy and Tolerability of a Low-Dose Combination of Isradipine and Spirapril in the First-Line Treatment of Mild to Moderate Essential Hypertension"],"prefix":"10.1007","volume":"11","author":[{"given":"David Bernhard","family":"Pittrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Antlsperger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Wambach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Weidinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"147621_CR1","first-page":"178","volume":"3","author":"J. Chalmers","year":"1987","unstructured":"Chalmers J. The place of combination therapy in the treatment of hypertension: A critical review. J Clin Hypertens 1987;3:178\u2013193.","journal-title":"J Clin Hypertens"},{"key":"147621_CR2","first-page":"278","volume":"3","author":"JR Oster","year":"1987","unstructured":"Oster JR, Epstein M. Fixed-dose combination medications for the treatment of hypertension: A critical review. J Clin Hypertens 1987;3:278\u2013293.","journal-title":"J Clin Hypertens"},{"key":"147621_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0002-8703(95)90454-9","volume":"130","author":"LM Prisant","year":"1995","unstructured":"Prisant LM, Weir MR, Papademetriou V, et al. Low-dose drug combination therapy: An alternative first-line approach to hypertension treatment. Am Heart J 1995;130:359\u2013366.","journal-title":"Am Heart J"},{"key":"147621_CR4","first-page":"712","volume":"6","author":"DB Pittrow","year":"1996","unstructured":"Pittrow DB, Kr\u00f6nig B, Kirch W, Weidinger G. Evaluation of reserpine and clopamide alone or in combination for first-line treatment of hypertension. Am J Hypertens 1996;6:712.","journal-title":"Am J Hypertens"},{"key":"147621_CR5","first-page":"278","volume":"3","author":"JR Oster","year":"1987","unstructured":"Oster JR, Epstein M. Fixed-dose combination medications for the treatment of hypertension: A critical review. J Clin Hypertens 1987;3:278\u2013293.","journal-title":"J Clin Hypertens"},{"key":"147621_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00004872-199001000-00002","volume":"8","author":"HR Brunner","year":"1990","unstructured":"Brunner HR, M\u00e9nard J, Waeber B, et al. Editorial Review: Treating the individual hypertensive patient: Considerations of dose, sequential monotherapy and drug combinations. J Hypertens 1990;8:3\u201311.","journal-title":"J Hypertens"},{"key":"147621_CR7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0002-9149(99)80162-3","volume":"76","author":"NM. Kaplan","year":"1995","unstructured":"Kaplan NM. Combination therapy for hypertension. Am J Cardiol 1995;76:595\u2013596.","journal-title":"Am J Cardiol"},{"key":"147621_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2165\/00003495-199040010-00004","volume":"40","author":"A Fitton","year":"1990","unstructured":"Fitton A, Benfield P. Isradipine: A review of its pharmakodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease. Drugs 1990;40:31\u201374.","journal-title":"Drugs"},{"key":"147621_CR9","doi-asserted-by":"publisher","first-page":"750","DOI":"10.2165\/00003495-199549050-00008","volume":"19","author":"S Noble","year":"1995","unstructured":"Noble S, Sorkin EM. Spirapril: A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension. Drugs 1995;19:750\u201366.","journal-title":"Drugs"},{"issue":"Suppl.2","key":"147621_CR10","first-page":"14","volume":"3","author":"PA Meredith","year":"1994","unstructured":"Meredith PA, Grass P, Guitard C, Elliott HL. Pharmacokinetics of spirapril in renal impairment. Blood Pressure 1994:3(Suppl. 2):14\u201319.","journal-title":"Blood Pressure"},{"key":"147621_CR11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00002018-199512020-00001","volume":"12","author":"AM MacConnachie","year":"1995","unstructured":"MacConnachie AM, Maclean D. Low dose combination antihypertensive therapy. Additional efficacy without additional adverse effects? Drug Safety 1995;12:85\u201390.","journal-title":"Drug Safety"},{"key":"147621_CR12","first-page":"510A","volume":"3","author":"WM Kirkendall","year":"1981","unstructured":"Kirkendall WM, Feinleib M, Freis ED, Mark AL, et al. AHA Committee report: Recommendations for human blood pressure determination by sphygmomanometers. Hypertension 1981;3:510A\u2013519A.","journal-title":"Hypertension"},{"key":"147621_CR13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2125.1987.tb03199.x","volume":"24","author":"M Bellet","year":"1987","unstructured":"Bellet M, Sassano P, Guyenne T, Corvol P, M\u00e9nard J. Converting-enzyme buffers the counter-regulatory response to acute administration of nicardipine. Br J Clin Pharmacol 1987;24:465\u2013472.","journal-title":"Br J Clin Pharmacol"},{"key":"147621_CR14","first-page":"779","volume":"A10","author":"T Morgan","year":"1988","unstructured":"Morgan T, Anderson A, Hopper J. Enalapril and nifedipine in essential hypertension: Synergism of the hypotensive effects in combination. Clin Exp Hypertens 1988;A10:779\u2013789.","journal-title":"Clin Exp Hypertens"},{"key":"147621_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/BF00148477","volume":"3","author":"C Gennari","year":"1989","unstructured":"Gennari C, Nami R, Pavese G, Gragnani S, Bianchini C, Buracchi P. Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension. Cardiovasc Drug Ther 1989;3:319\u2013325.","journal-title":"Cardiovasc Drug Ther"},{"issue":"Suppl.6A","key":"147621_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0002-9343(86)90791-6","volume":"81","author":"FB M\u00fcller","year":"1986","unstructured":"M\u00fcller FB, Bolli P, Linder L, Kiowski W, Erne P, B\u00fchler FR. Calcium antagonists and the second drug for hypertensive therapy. Am J Med 1986;81(Suppl. 6A):25\u201329.","journal-title":"Am J Med"},{"key":"147621_CR17","first-page":"103","volume":"42","author":"S Di Somma","year":"1992","unstructured":"Di Somma S, Petitto M, Liguori V, Carotenuto A, Paulucci A, De Devitiis O. Antihypertensive effects of verapamil, captopril and their combination at rest and during dynamic exercise. Drug Res 1992;42:103\u2013107.","journal-title":"Drug Res"},{"key":"147621_CR18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2125.1993.tb00371.x","volume":"36","author":"AD Bainbridge","year":"1993","unstructured":"Bainbridge AD, MacFadyen RJ, Stark S, Lees KR, Reid JL. The antihypertensive efficacy and tolerability of a low dose combination of ramipril and felodipine ER in mild to moderate essential hypertension. Br J Clin Pharmacol 1993;36:323\u2013330.","journal-title":"Br J Clin Pharmacol"},{"issue":"Suppl.4","key":"147621_CR19","first-page":"S43","volume":"8","author":"M Bellet","year":"1990","unstructured":"Bellet M, Whalen JJ, Bodin F, Serrurier, Tanner K, M\u00e9nard J. Use of cross-over trials to obtain antihypertensive dose-response curves and to study combination therapy during the development of benazepril. J Hypertens 1990;8(Suppl. 4):S43\u2013S48.","journal-title":"J Hypertens"},{"issue":"Suppl.4A","key":"147621_CR20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/0002-9343(89)90206-4","volume":"86","author":"R Eggertsen","year":"1989","unstructured":"Eggertsen R, Svensson A, Dahl\u00f6f B, Hansson L. Additive effect of isradipine in combination with captopril in hypertensive patients. Am J Med 1989;86(Suppl. 4A):124\u2013126.","journal-title":"Am J Med"},{"issue":"Suppl3","key":"147621_CR21","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00005344-199100183-00006","volume":"18","author":"P Fitscha","year":"1991","unstructured":"Fitscha P, Meisner W, Hinzberger G. Evaluation of isradipine and captopril alone or in combination for the treatment of hypertension. J Cardiovasc Pharmacol 1991;18(Suppl 3):S12\u2013S14.","journal-title":"J Cardiovasc Pharmacol"},{"key":"147621_CR22","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1093\/ajh\/6.3.77S","volume":"6","author":"RF Abarquez","year":"1993","unstructured":"Abarquez RF, Sy RG, Castillo RR. Efficacy of slow-release oral isradipine in moderate-to-severe hypertension with add-on spirapril. Am J Hypertens 1993;6:77S\u201379S.","journal-title":"Am J Hypertens"},{"issue":"Suppl.1","key":"147621_CR23","first-page":"40","volume":"3","author":"M Amir","year":"1994","unstructured":"Amir M, Christal N, Bar-On D, Loidl A. Does the combination of ACE-inhibitor and calcium antagonist control hypertension and improve quality of life? The LOMIR-MCT-IL study experience. Blood Pressure 1994;3(Suppl. 1):40\u201342.","journal-title":"Blood Pressure"},{"key":"147621_CR24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/j.1552-4604.1974.tb02309.x","volume":"14","author":"JR. Crout","year":"1974","unstructured":"Crout JR. Fixed combination prescription drugs: FDA policy. J Clin Pharmacol 1974;14:249\u2013254.","journal-title":"J Clin Pharmacol"},{"key":"147621_CR25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/bmj.299.6704.881","volume":"299","author":"H Holzgreve","year":"1989","unstructured":"Holzgreve H, Distler A, Michaelis J, Philipp T, Wellek S, on behalf of the Verapamil versus Diuretic (VERDI) Trial Research Group. Verapamil versus hydrochlorothiazide in the treatment of hypertension: Results of a long-term double blind comparative trial. Br Med J 1989;299:881\u2013886.","journal-title":"Br Med J"},{"issue":"Suppl.8","key":"147621_CR26","first-page":"3","volume":"12","author":"HL Elliot","year":"1994","unstructured":"Elliot HL, Meredith PA. Methodological considerations in calculation of the trough: peak ratio. J Hypertens 1994;12(Suppl. 8):3\u20137.","journal-title":"J Hypertens"},{"key":"147621_CR27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/00004872-199503000-00001","volume":"13","author":"HL Elliott","year":"1995","unstructured":"Elliott HL, Merdith PA. Trough: peak ratio: Clinically useful or practically irrelevant? J Hypert 1995;13:279\u2013283.","journal-title":"J Hypert"},{"unstructured":"Food and Drug Administration. Proposed Guidelines for the Clinical Evaluation of Antihypertensive Drugs. Rockville, MD: Division of Cardio-Renal Drug Products, U.S. Department of Health and Human Services, 1988.","key":"147621_CR28"},{"key":"147621_CR29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ajh\/3.2.151","volume":"3","author":"M Rose","year":"1990","unstructured":"Rose M, McMahon FG. Some problems with antihypertensive drug studies in the context of the new guidelines. Am J Hypertens 1990;3:151\u2013155.","journal-title":"Am J Hypertens"}],"container-title":["Cardiovascular Drugs and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1007774505445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1007774505445\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1007774505445.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T19:01:03Z","timestamp":1751050863000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1007774505445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["147621"],"URL":"https:\/\/doi.org\/10.1023\/a:1007774505445","relation":{},"ISSN":["0920-3206","1573-7241"],"issn-type":[{"type":"print","value":"0920-3206"},{"type":"electronic","value":"1573-7241"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}