{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:23:24Z","timestamp":1755217404155,"version":"3.43.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1023\/a:1008096801895","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T07:45:23Z","timestamp":1040543123000},"page":"351-358","source":"Crossref","is-referenced-by-count":5,"title":["Comparative effects of scopoletin and cyanide on rat brain, 1: Histopathology"],"prefix":"10.1007","volume":"53","author":[{"given":"L.U.S.","family":"Ezeanyika","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Obidoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.O.","family":"Shoyinka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"208020_CR1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1079\/BJN19670057","volume":"21","author":"OL Ekpechi","year":"167","unstructured":"Ekpechi OL (167) Pathogenesis of endemic goitre in Eastern Nigeria. Br J Nutr 21: 537-545.","journal-title":"Br J Nutr"},{"key":"208020_CR2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0308-8146(80)90025-4","volume":"6","author":"OL Oke","year":"1980","unstructured":"Oke OL (1980) Toxicity of cyanogenic glycosides. Food Chem 6: 97-109.","journal-title":"Food Chem"},{"key":"208020_CR3","unstructured":"Ermans AM, et al. (1982) Role of cassava in the etiology of endemic goitre and cretinism. In: Delange F, Ahluwalia R (eds), Cassava toxicity and thyroid research and public health issues: Proc IDRC conference, 31 May-2 June. IDRC - 207e. 9-16."},{"issue":"3","key":"208020_CR4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1079\/BJN19910097","volume":"65","author":"BP Kamalu","year":"1993","unstructured":"Kamalu BP (1993) Pathological changes in growing dogs fed on a balanced cassava (Manihot esculentaCrantz) diets. Br J Nutr 65(3): 365-372.","journal-title":"Br J Nutr"},{"key":"208020_CR5","unstructured":"Delange F, et al. (1982) Nutritional factors involved in the goitrogenic action of cassava. In: Delange F, Ahluwalia R (eds), Cassava toxicity and thyroid research and public health issues: Proc IDRC conference, 31 May-2 June. IDRC - 207e. 17-26."},{"key":"208020_CR6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000393156","volume":"36","author":"BO Osuntokun","year":"1981","unstructured":"Osuntokun BO (1981) Cassava diet, chronic cyanide intoxication and neuropathy in Nigerian Africans. Wld Rev Nutr Diet 36: 141-173.","journal-title":"Wld Rev Nutr Diet"},{"key":"208020_CR7","unstructured":"Gaitan E (1982) Role of other naturally occurring goitrogens in the etiology of endemic goitre. In: Delange F, Ahluwalia R (eds), Cassava toxicity and thyroid research and public health issues: Proc IDRC conference, 31 May-2 June. IDRC - 207e. 27-34."},{"key":"208020_CR8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1399-3054.1966.tb07068.x","volume":"19","author":"F Nartey","year":"1966","unstructured":"Nartey F (1966) Aflatoxins of Aspergillus flavusgrown on cassava. Physiol Plant 19: 812-822.","journal-title":"Physiol Plant"},{"key":"208020_CR9","first-page":"249","volume":"16","author":"JE Rickard","year":"1981","unstructured":"Rickard JE (1981) Study of the production of xylem occlusions and scopoletin in cassava roots in response to injury. R Microsc Sc Proc 16: 249.","journal-title":"R Microsc Sc Proc"},{"key":"208020_CR10","unstructured":"Uritani I, Data ES, Tanaka Y (1982) In: Uritani I, Reye ED (eds), Bioresources investigation on production, storage, processing and vegetation of root crops in the tropics, pp 32. Nagoya: Nagoya University Co-op."},{"issue":"3","key":"208020_CR11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3136\/nskkk1962.30.175","volume":"30","author":"DN Flores","year":"1983","unstructured":"Flores DN, Garcia VV, Uritani I (1983) The relationship between methods of making cassava flour and coumarin formation during drying. J Jpn Soc Food Sci Tech 30(3): 175-177.","journal-title":"J Jpn Soc Food Sci Tech"},{"key":"208020_CR12","unstructured":"Obasi SC (1992) Studies on the in vitro effect of scopoletin and aflatoxin B1 on bovine blood and hepatic mitochondria. PhD Thesis in Biochemistry, University of Nigeria."},{"issue":"2","key":"208020_CR13","first-page":"89","volume":"38","author":"SC Obasi","year":"1994","unstructured":"Obasi SC, Njoku OU, Obidoa O (1994) Effects of single oral doses of scopoletin and aflatoxin B1 on the clotting time, serum cholesterol and phospholipid levels of chicks. Indian J Physiol and Pharmacol 38(2): 89-94.","journal-title":"Indian J Physiol and Pharmacol"},{"key":"208020_CR14","first-page":"811","volume-title":"Official methods of analysis","author":"AOAC","year":"1975","unstructured":"AOAC (1975) Official methods of analysis, 12th edn, pp 811\u2013812. Washington, DC: Association of Official Analytical Chemists.","edition":"12th edn"},{"key":"208020_CR15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi H, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.","journal-title":"Anal Biochem"},{"key":"208020_CR16","volume-title":"Statistical methods of detecting differences between treatment means","author":"IU Obi","year":"1986","unstructured":"Obi IU (1986) Statistical methods of detecting differences between treatment means. Enugu, Nigeria: SNAAP Press."},{"key":"208020_CR17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0308-8146(82)90097-8","volume":"9","author":"OO Tewe","year":"1982","unstructured":"Tewe OO, Maner JH (1982) Cyanide, protein and iodine interaction in the physiology and metabolism of rats. Food Chem 9: 195-204.","journal-title":"Food Chem"},{"issue":"2","key":"208020_CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01092132","volume":"32","author":"FC Chilaka","year":"1985","unstructured":"Chilaka FC, Anosike EO, Obidoa O (1985) Effects of prolonged gari diet on some microsomal enzyme activities of rats liver. Plant Foods Hum Nutr 32(2): 159-164.","journal-title":"Plant Foods Hum Nutr"},{"key":"208020_CR19","first-page":"143","volume-title":"Toxic constituents of plant foodstuffs","author":"RD Montgomery","year":"1980","unstructured":"Montgomery RD (1980) Cyanogens. In: Liener IE (ed), Toxic constituents of plant foodstuffs, 2nd edn, pp 143-160. New York: Academic Press.","edition":"2nd edn"},{"issue":"1","key":"208020_CR20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0015-6264(73)90064-3","volume":"11","author":"VJ Feron","year":"1973","unstructured":"Feron VJ, De Groot AP, Spangers MT, Til HP (1973) An evaluation of the criteria 'organ weight' under conditions of growth retardation. Food Cosmet Toxicol 11(1): 85-94.","journal-title":"Food Cosmet Toxicol"},{"key":"208020_CR21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0300-483X(77)90037-3","volume":"7","author":"K Sh\u00e4rer","year":"1977","unstructured":"Sh\u00e4rer K (1977) The effect of chronic underfeeding on organ weights of rats. How to interpret organ weight changes in cases of marked growth retardation in toxicity tests. Toxicology 7: 45-56.","journal-title":"Toxicology"},{"key":"208020_CR22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0041-008X(79)90066-8","volume":"47","author":"S Oishi","year":"1979","unstructured":"Oishi S, Oishi H, Hiraga K (1979) The effect of food restriction for 4 weeks on common toxicity parameters in male rats. Toxicol Appl Pharmacol 47: 15-22.","journal-title":"Toxicol Appl Pharmacol"},{"key":"208020_CR23","unstructured":"Osuntokun BO (1973) Ataxic neuropathy associated with high cassava diets in West Africa. In: Nestel B, MacIntyre R (eds), Chronic cassava toxicity. Proceedings of an interdisciplinary workshop, London, UK, 29-30 January. IDRC Monogr IDRC-010e."},{"key":"208020_CR24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF02196398","volume":"41","author":"O Obidoa","year":"1991","unstructured":"Obidoa O, Obasi SC (1991) Coumarin compounds in cassava diets, 2: Health implications of Scopoletin in gari. Plant Foods Hum Nutr 41: 283-289.","journal-title":"Plant Foods Hum Nutr"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1008096801895.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1008096801895\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1008096801895.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:00:57Z","timestamp":1754398857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1008096801895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["208020"],"URL":"https:\/\/doi.org\/10.1023\/a:1008096801895","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"type":"print","value":"0921-9668"},{"type":"electronic","value":"1573-9104"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}