{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:04:08Z","timestamp":1761523448133},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":8133,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1023\/a:1008263516099","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T13:47:34Z","timestamp":1040564854000},"page":"995-1001","source":"Crossref","is-referenced-by-count":108,"title":["A prospective randomised trial of protracted venous infusion 5-fluorouracil with or without mitomycin C in advanced colorectal cancer"],"prefix":"10.1016","volume":"8","author":[{"given":"P.","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Iveson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Padhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Prendiville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Massey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Oates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1023\/A:1008263516099_bb0005","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/1097-0142(19920901)70:3+<1414::AID-CNCR2820701533>3.0.CO;2-I","article-title":"Chemotherapy for metastatic colorectal cancer","volume":"70","author":"Mayer","year":"1992","journal-title":"Cancer"},{"key":"10.1023\/A:1008263516099_bb0010","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/bmj.306.6880.752","article-title":"Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer","volume":"306","author":"Scheithauer","year":"1993","journal-title":"BMJ"},{"key":"10.1023\/A:1008263516099_bb0015","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.1992.10.6.904","article-title":"The Nordic Gastrointestinal Tumour Adjuvant Therapy Group: expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer: A randomized trial","volume":"10","year":"1992","journal-title":"Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0020","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(94)90750-1","article-title":"Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases","volume":"344","author":"Allen-Mersh","year":"1994","journal-title":"Lancet"},{"key":"10.1023\/A:1008263516099_bb0025","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1200\/JCO.1992.10.6.896","article-title":"Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate","volume":"10","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0030","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1200\/JCO.1994.12.5.960","article-title":"Advanced Colorectal Cancer Meta-Analysis Project. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer","volume":"12","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1200\/JCO.1989.7.4.425","article-title":"A prospective randomised comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid Atlantic Oncology Program Study","volume":"7","author":"Lokich","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0040","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1200\/JCO.1995.13.6.1303","article-title":"Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group Study","volume":"13","author":"Leichmann","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0045","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1200\/JCO.1995.13.9.2317","article-title":"Impact of protracted venous infusion fluorouracil with or without interferon-alfa-2b on tumour response, survival, and quality of life in advanced colorectal cancer","volume":"1995","author":"Hill","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0050","first-page":"675","article-title":"Effects of mitomycin C (NSC-26980) in 346 patients with advanced cancer","volume":"52","author":"Moore","year":"1968","journal-title":"Cancer Chemother Rep"},{"key":"10.1023\/A:1008263516099_bb0055","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jama.1968.03140250025006","article-title":"Mitomycin C therapy in advanced gastrointestinal cancer","volume":"204","author":"Moertel","year":"1968","journal-title":"JAMA"},{"key":"10.1023\/A:1008263516099_bb0060","first-page":"287","article-title":"Clinical study of mitomycin C (NSC-26980) in colorectal cancer","volume":"53","author":"Ansfield","year":"1969","journal-title":"Cancer Chemother Rep"},{"key":"10.1023\/A:1008263516099_bb0065","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/1097-0142(197206)29:6<1647::AID-CNCR2820290632>3.0.CO;2-6","article-title":"Clinical experience with mitomycin C in large infrequent doses","volume":"29","author":"Godfrey","year":"1972","journal-title":"Cancer"},{"key":"10.1023\/A:1008263516099_bb0070","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00686271","article-title":"Randomized trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer","volume":"33","author":"Poplin","year":"1994","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1023\/A:1008263516099_bb0075","first-page":"1393","article-title":"The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil","volume":"25","author":"Sartorelli","year":"1965","journal-title":"Cancer Res"},{"key":"10.1023\/A:1008263516099_bb0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0277-5379(89)90273-3","article-title":"Time-dependent interactions between 5-fluorouracil and mitomycin C on a human colon cancer cell line, HCT-8, in vitro","volume":"25","author":"Rusello","year":"1989","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0085","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/1097-0142(197905)43:5<1598::AID-CNCR2820430505>3.0.CO;2-Y","article-title":"Treatment of advanced gastrointestinal cancer with 5-fluorouracil and mitomycin C","volume":"43","author":"Krauss","year":"1979","journal-title":"Cancer"},{"key":"10.1023\/A:1008263516099_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/mpo.2950040107","article-title":"Mitomycin C alone and in combination with infused 5-fluorouracil in the treatement of disseminated gastrointestinal carcinomas","volume":"4","author":"Buroker","year":"1978","journal-title":"Med Pediatr Oncol"},{"key":"10.1023\/A:1008263516099_bb0095","first-page":"1228","article-title":"5-FU infusion with mitomycin-C versus 5-FU infusion with methyl-CCNU in the treatment of advanced colon cancer","volume":"42","author":"Buroker","year":"1978","journal-title":"A Southwest Oncology Group Study. Cancer"},{"key":"10.1023\/A:1008263516099_bb0100","first-page":"565","article-title":"Combination chemotherapy (5-fluorouracil, methyl-CCNU, mitomycin C) versus 5-fluorouracil alone for advanced previously untreated colorectal carcinoma","volume":"4","author":"Richards","year":"1986","journal-title":"A phase III study of the Piedmont Oncology Association. J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0105","series-title":"National Cancer Institute: Guidelines for Reporting of Adverse Drug Reactions","year":"1998"},{"key":"10.1023\/A:1008263516099_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","article-title":"Reporting results of cancer treatment","volume":"47","author":"Miller","year":"1981","journal-title":"Cancer"},{"key":"10.1023\/A:1008263516099_bb0115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in the international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1023\/A:1008263516099_bb0120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00435732","article-title":"Testing the EORTC Quality of Life Questionnaire on cancer patients with heterogeneous diagnoses","volume":"2","author":"Ringdal","year":"1993","journal-title":"Quality of Life Res"},{"key":"10.1023\/A:1008263516099_bb0125","first-page":"1249","volume":"43","author":"Hjermsted","year":"1995","journal-title":"study of the European Organisation for Research and Treatment of Cancer Care Quality-of-Life Questionnaire"},{"key":"10.1023\/A:1008263516099_bb0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"Am Stat Assoc"},{"key":"10.1023\/A:1008263516099_bb0135","first-page":"185","article-title":"Asymtotically efficient invariant procedures","volume":"A135","author":"Peto","year":"1972","journal-title":"J R Stat Soc"},{"key":"10.1023\/A:1008263516099_bb0140","series-title":"Analysis of Survival Data","author":"Cox","year":"1984"},{"key":"10.1023\/A:1008263516099_bb0145","first-page":"769","article-title":"Continuous infusion fluorouracil\/leucovorin and bolus mitomycin-C as a salvage regimen for patients with colorectal cancer","volume":"75","author":"Conti","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0150","first-page":"1","article-title":"Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU v","volume":"38","author":"Baker","year":"1976","journal-title":"methyl-CCNU plus bolus weekly 5-FU. Cancer"},{"key":"10.1023\/A:1008263516099_bb0155","first-page":"702","article-title":"Randomised phase II trial comparing 5-FU bolus and low dose leucovorin versus 5-FU bolus plus continuous 5-FU infusion and high dose LV in metastatic colorectal cancer","volume":"31A","author":"Bosset","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1023\/A:1008263516099_bb0160","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/jnci\/88.10.668","article-title":"Phase III study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer","volume":"88","author":"Hansen","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1023\/A:1008263516099_bb0165","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1200\/JCO.1989.7.6.781","article-title":"Cancer-associated hemolytic-uremic syndrome: Analysis of 85 cases from a national registry","volume":"7","author":"Lesesne","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0170","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1200\/JCO.1985.3.5.723","article-title":"Carcinoma-associated hemolytic-uremic syndrome: A complication of mitomycin C chemotherapy","volume":"3","author":"Cantell","year":"1985","journal-title":"Clin Oncol"},{"key":"10.1023\/A:1008263516099_bb0175","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/0959-8049(93)90537-P","article-title":"A toxic interaction between mitomycin C and tamoxifen causing haemolytic uraemic syndrome","volume":"29","author":"Montes","year":"1993","journal-title":"Eur J Cancer"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/8\/10\/995\/19480410\/8-10-995.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T02:11:53Z","timestamp":1582251113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419639888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0923753419639888"],"URL":"https:\/\/doi.org\/10.1023\/a:1008263516099","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}