{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:25:38Z","timestamp":1764782738722},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":8133,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1023\/a:1008265304712","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T08:47:34Z","timestamp":1040546854000},"page":"987-994","source":"Crossref","is-referenced-by-count":28,"title":["Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma"],"prefix":"10.1016","volume":"8","author":[{"given":"M.I.","family":"Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cherney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Capello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Magrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1023\/A:1008265304712_bb0005","series-title":"The Non-Hodgkin's Lymphomas","article-title":"Small noncleaved cell lymphomas (Burkitt's and Burkitt-like lymphomas)","author":"Magrath","year":"1997"},{"key":"10.1023\/A:1008265304712_bb0010","first-page":"65","article-title":"Cytogenetics of Burkitt's lymphoma-leukemia: A review","volume":"60","author":"Berger","year":"1985","journal-title":"IARC Sci Publ"},{"key":"10.1023\/A:1008265304712_bb0015","first-page":"319","article-title":"Burkitt's lymphoma cells frequently carry monoallelic DJ rearrangements","volume":"182","author":"Bhatia","year":"1993","journal-title":"Curr Topics Microbiol Immunol"},{"key":"10.1023\/A:1008265304712_bb0020","series-title":"Pathogenesis of small noncleaved cell lymphomas (Burkitt's lymphoma)","author":"Magrath","year":"1997"},{"key":"10.1023\/A:1008265304712_bb0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"10.1023\/A:1008265304712_bb0030","first-page":"887","article-title":"Cell populations during tumorigenesis in Eu-myc transgenic mice","volume":"7","author":"Sidman","year":"1993","journal-title":"Leukemia"},{"key":"10.1023\/A:1008265304712_bb0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng0993-56","article-title":"Point mutations in the c-myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytoma","volume":"5","author":"Bhatia","year":"1993","journal-title":"Nature Genet"},{"key":"10.1023\/A:1008265304712_bb0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.8146655","article-title":"Binding and suppression of the c-myc transcriptional activation domain by p107","volume":"264","author":"Gu W, Bhatia","year":"1994","journal-title":"Science"},{"key":"10.1023\/A:1008265304712_bb0045","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1073\/pnas.92.26.12520","article-title":"Frequent somatic hypermutation of the 5' noncoding region of the bcl-6 gene in B-cell lymphoma","volume":"92","author":"Migliazza","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1023\/A:1008265304712_bb0050","first-page":"3755","article-title":"Frequent mutation of the 5' noncoding region of the bcl-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas","volume":"89","author":"Gaidano","year":"1997","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0055","first-page":"4273","article-title":"The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors","volume":"52","author":"Bhatia","year":"1992","journal-title":"Cancer Res"},{"key":"10.1023\/A:1008265304712_bb0060","first-page":"567","article-title":"Prognostic significance of p53 mutations in small non-cleaved cell lymphomas","volume":"4","author":"Gutierrez","year":"1994","journal-title":"Int J Oncol"},{"key":"10.1023\/A:1008265304712_bb0065","first-page":"5824","article-title":"p53 mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents","volume":"54","author":"Fan","year":"1994","journal-title":"Cancer Res"},{"key":"10.1023\/A:1008265304712_bb0070","first-page":"2508","article-title":"Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells","volume":"57","author":"Cherney","year":"1997","journal-title":"Cancer Res"},{"key":"10.1023\/A:1008265304712_bb0075","first-page":"285","article-title":"Epstein-Barr virus and Burkitt's lymphoma","volume":"3","author":"Magrath","year":"1992","journal-title":"Semin Cancer Biol"},{"key":"10.1023\/A:1008265304712_bb0080","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1182\/blood.V77.5.1092.1092","article-title":"Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma","volume":"77","author":"Neri","year":"1991","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0085","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood.V77.7.1516.1516","article-title":"What of chromosomal breakpoint locations in Burkitt's lymphoma: Relevance to geography and EBV association","volume":"77","author":"Shiramizu","year":"1991","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0090","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1182\/blood.V77.7.1527.1527","article-title":"Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma","volume":"77","author":"Shibata","year":"1991","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0095","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1126\/science.6356358","article-title":"Cellular oncogenes and multi-step carcinogenesis","volume":"222","author":"Land","year":"1983","journal-title":"Science"},{"key":"10.1023\/A:1008265304712_bb0100","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood.V82.8.2289.2289","article-title":"p53 mutations are associated with histologic transformation in follicular lymphomas","volume":"82","author":"LoCoco","year":"1993","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0105","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.176.4.1137","article-title":"Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection","volume":"176","author":"Zelenetz","year":"1992","journal-title":"J Exp Med"},{"key":"10.1023\/A:1008265304712_bb0110","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1182\/blood.V87.12.5242.bloodjournal87125242","article-title":"Analysis of clonal rearrangements of the Ig heavy chain locus in acute leukemia","volume":"87","author":"Height","year":"1996","journal-title":"Blood"},{"key":"10.1023\/A:1008265304712_bb0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/10428199309148520","article-title":"Cytogenetic rearrangements of c-myc oncogene occurs prior to infection with Epstein-Barr virus in the monoclonal malignant B cells from an AIDS patient","volume":"9","author":"Roncella","year":"1993","journal-title":"Leuk Lymph"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/8\/10\/987\/19480394\/8-10-987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T21:11:47Z","timestamp":1582233107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419639876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0923753419639876"],"URL":"https:\/\/doi.org\/10.1023\/a:1008265304712","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}