{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:40:24Z","timestamp":1791157224183,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":7830,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[1998,8]]},"DOI":"10.1023\/a:1008418727472","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T14:30:06Z","timestamp":1040567406000},"page":"849-855","source":"Crossref","is-referenced-by-count":240,"title":["Peripheral T-cell lymphomas: Initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification"],"prefix":"10.1016","volume":"9","author":[{"given":"A.","family":"L\u00f3pez-Guillermo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Salar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Montalb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Castrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Ribera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Brunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garc\u00eda-Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Fern\u00e1ndez","family":"de Sevilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1023\/A:1008418727472_bb0010","series-title":"Histopathology of non-Hodgkin\u2019s lymphomas (based on the Updated Kiel Classification)","author":"Lennert","year":"1992"},{"key":"10.1023\/A:1008418727472_bb0015","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European\u2013American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0020","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1200\/JCO.1984.2.7.788","article-title":"Peripheral T-cell lymphoma: A clinicopathologic study of 42 cases","volume":"2","author":"Greer","year":"1984","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/oxfordjournals.annonc.a057673","article-title":"Peripheral T-cell lymphomas have a worse prognosis than B-cell lymphomas: A prospective study of 361 immunophenotyped patients treated with LNH84 regimen","volume":"1","author":"Coiffier","year":"1990","journal-title":"Ann Oncol"},{"key":"10.1023\/A:1008418727472_bb0030","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1182\/blood.V89.12.4514","article-title":"Evaluation of the revised European-American lymphoma classification confirms the clinical relevance of immonophenotype in 560 cases of aggressive non-Hodgkin\u2019s lymphoma","volume":"89","author":"Melnyk","year":"1997","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0035","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin\u2019s lymphoma","volume":"89","author":"The Non-Hodgkin\u2019s Lymphoma Classification Project","year":"1997","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0040","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/A:1008200307625","article-title":"Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the R.E.A.L. Classification","volume":"8","author":"Ascani","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1023\/A:1008418727472_bb0045","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/1097-0142(19880515)61:10<2060::AID-CNCR2820611022>3.0.CO;2-D","article-title":"Characterization of the spectrum of postthymic T-cell malignancies in Taiwan. A clinicopathologic study of HTLV1-positive and HTLV1-negative cases","volume":"61","author":"Su","year":"1988","journal-title":"Cancer"},{"key":"10.1023\/A:1008418727472_bb0050","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1002\/1097-0142(19920515)69:10<2571::AID-CNCR2820691030>3.0.CO;2-S","article-title":"A phenotypic and genotypic study of three node-based, low-grade peripheral T-cell lymphomas: Angioimmunoblastic lymphoma, T-zone lymphoma, and lymphoepithelioid lymphoma","volume":"69","author":"Takagi","year":"1992","journal-title":"Cancer"},{"key":"10.1023\/A:1008418727472_bb0055","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/1097-0142(19930901)72:5<1762::AID-CNCR2820720541>3.0.CO;2-D","article-title":"Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese","volume":"72","author":"Nakamura","year":"1993","journal-title":"Cancer"},{"key":"10.1023\/A:1008418727472_bb0060","doi-asserted-by":"crossref","first-page":"364","DOI":"10.7326\/0003-4819-117-5-364","article-title":"Tretament of angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma using prednisone with or without the COPBLAM\/IMVP-16 regimen. A multicentre study","volume":"117","author":"Siegert","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1023\/A:1008418727472_bb0065","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/oxfordjournals.annonc.a059281","article-title":"Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: Prognostic impact of clinical observations and laboratory findings at presentation","volume":"6","author":"Siegert","year":"1995","journal-title":"Ann Oncol"},{"key":"10.1023\/A:1008418727472_bb0070","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1200\/JCO.1995.13.3.666","article-title":"Treatment outcome and prognostic factors for primary nasal lymphoma","volume":"13","author":"Liang","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0075","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1182\/blood.V87.4.1474.bloodjournal8741474","article-title":"Natural killer-like T-cell lymphomas: Aggressive lymphomas of T-large granular lymphocytes","volume":"87","author":"Macon","year":"1996","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0080","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1200\/JCO.1996.14.3.955","article-title":"Anaplastic large-cell lymphoma: Clinical and prognostic evaluation of 90 adult patients","volume":"14","author":"Zinzani","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0085","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood.V90.9.3727","article-title":"Primary anaplastic large-cell lymphoma in adults: clinical presentation, immunophenotype, and outcome","volume":"90","author":"Tilly","year":"1997","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002770050272","article-title":"Gamma\/delta T-cell hepatosplenic lymphoma: Review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia","volume":"74","author":"Sallah","year":"1997","journal-title":"Ann Haematol"},{"key":"10.1023\/A:1008418727472_bb0095","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0140-6736(85)92930-7","article-title":"Malignant histiocytosis of the intestine: A T-cell lymphoma","volume":"2","author":"Isaacson","year":"1985","journal-title":"Lancet"},{"key":"10.1023\/A:1008418727472_bb0100","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1046\/j.1365-2141.1997.1462962.x","article-title":"CD56+ NK lymphomas: Clinicopathological features and prognosis","volume":"97","author":"Kwong","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1023\/A:1008418727472_bb0105","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1200\/JCO.1991.9.8.1426","article-title":"Similar outcome of treatment of B-cell and T-cell diffuse large-cell lymphomas: The Stanford experience","volume":"9","author":"Kwak","year":"1991","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/1097-0142(19890101)63:1<158::AID-CNCR2820630125>3.0.CO;2-B","article-title":"Peripheral T-cell lymphoma","volume":"63","author":"Armitage","year":"1989","journal-title":"Cancer"},{"key":"10.1023\/A:1008418727472_bb0115","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1182\/blood.V72.2.436.436","article-title":"The prognostic significance of the immunotype in diffuse large-cell lymphoma: A comparative study of the T-cell and B-cell phenotype","volume":"72","author":"Lippman","year":"1988","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1200\/JCO.1989.7.6.725","article-title":"Direct comparisons of peripheral T-cell lymphoma with diffuse B-cell lymphoma of comparable histological grades should peripheral T-cell lymphoma be considered separately?","volume":"7","author":"Cheng","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0125","article-title":"Prognostic significance of T-cell phenotype in aggressive non-Hodgkin\u2019s lymphoma","author":"Gisselbrecht","year":"1998","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/10428199609045720","article-title":"Peripheral T-cell lymphomas respond well to vincristine, adriamycin, cyclophosphamide, prednisone and etoposide (VACPE) and have similar outcome as high-grade B-cell lymphomas","volume":"24","author":"Karakas","year":"1996","journal-title":"Leuk Lymph"},{"issue":"Suppl2","key":"10.1023\/A:1008418727472_bb0135","first-page":"213","article-title":"Report of the first workshop on prognostic factors in large-cell lymphomas","volume":"2","author":"Coiffier","year":"1991","journal-title":"Ann Oncol"},{"key":"10.1023\/A:1008418727472_bb0140","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/00001622-199210000-00007","article-title":"Prognostic factors in non-Hodgkin\u2019s lymphoma","volume":"4","author":"Shipp","year":"1992","journal-title":"Curr Opin Oncol"},{"key":"10.1023\/A:1008418727472_bb0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10428199309147362","article-title":"Large-cell lymphoma: A study of prognostic factors and assessment of five recently proposed predictive systems","volume":"10","author":"L\u00f3pez-Guillermo","year":"1993","journal-title":"Leuk Lymph"},{"key":"10.1023\/A:1008418727472_bb0150","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"Development of a predictive model for aggressive lymphoma: The international NHL prognostic factors project","volume":"329","author":"The non-Hodgkin\u2019s lymphoma prognostic factors project","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1023\/A:1008418727472_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2559.1993.tb00128.x","article-title":"Peripheral T-cell lymphoma: A clinicopathological study of 41 cases and evaluation of the prognostic significance of the Updated Kiel Classification","volume":"22","author":"Montalb\u00e1n","year":"1993","journal-title":"Histopathology"},{"key":"10.1023\/A:1008418727472_bb0160","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non-parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1023\/A:1008418727472_bb0165","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2307\/2529177","article-title":"Conservatism of the approximation \u03a3(O-E)2\/E in the log-rank test for survival data or tumour incidence data","volume":"29","author":"Peto","year":"1973","journal-title":"Biometrics"},{"key":"10.1023\/A:1008418727472_bb0170","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J Royal Stat Soc"},{"key":"10.1023\/A:1008418727472_bb0175","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1182\/blood.V87.1.284.284","article-title":"High incidence of the t(2;5)(p23;q35) translocation in anaplastic large-cell lymphoma and its lack of detection in Hodgkin\u2019s disease. Comparison of cytogenetic analysis reverse transcriptase-polymerase chain reaction, and P-80 immunostaining","volume":"87","author":"Lamant","year":"1996","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0180","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1182\/blood.V87.3.1081.bloodjournal8731081","article-title":"Molecular characterization of the t(2;5)(p23;q35) translocation in anaplastic large-cell lymphoma (Ki-1) and Hodgkin\u2019s disease","volume":"87","author":"Yee","year":"1996","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0185","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1182\/blood.V87.10.4358.bloodjournal87104358","volume":"87","author":"Pittaluga","year":"1996","journal-title":"Blood"},{"key":"10.1023\/A:1008418727472_bb0190","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1200\/JCO.1997.15.6.2296","article-title":"Predictive capacity of the International Prognostic Factor Index in patients with peripheral T-cell lymphoma","volume":"15","author":"Ansell","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1023\/A:1008418727472_bb0195","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/oxfordjournals.annonc.a058324","article-title":"A proposal for a simple staging system for intermediate grade lymphoma and immunoblastic lymphoma based on the \u2018tumor score\u2019","volume":"3","author":"Rodriguez","year":"1992","journal-title":"Ann Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419559580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419559580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/9\/8\/849\/19481938\/9-8-849.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T09:22:50Z","timestamp":1733563370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419559580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["S0923753419559580"],"URL":"https:\/\/doi.org\/10.1023\/a:1008418727472","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}