{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:30:53Z","timestamp":1767713453506,"version":"3.41.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1023\/a:1010623119469","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T03:31:49Z","timestamp":1040614309000},"page":"241-247","source":"Crossref","is-referenced-by-count":25,"title":["Characteristic Chromosomal Aberrations in Sporadic Cerebellar Hemangioblastomas Revealed by Comparative Genomic Hybridization"],"prefix":"10.1007","volume":"52","author":[{"given":"Sandra H.E.","family":"Sprenger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna M.M.","family":"Gijtenbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Wesseling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raf","family":"Sciot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Van Calenbergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lammens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith W. M.","family":"Jeuken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"339439_CR1","volume-title":"Atlas of tumor pathology","author":"PC Burger","year":"1994","unstructured":"Burger PC, Scheithauer BW: Tumors of the central nervous system. In: Atlas of tumor pathology. Armed forces intitute of pathology, Washington, D.C., 1994"},{"key":"339439_CR2","unstructured":"Kleiheus P, Cavenee WK: Pathology and genetics of tumours of the nervous system \u2013 World Health Organization classification of tumours, 1999"},{"key":"339439_CR3","volume-title":"Mendelian inheritance in man: a catalogue of human genes and genetic disorders","author":"VA McKusick","year":"1994","unstructured":"McKusick VA: Mendelian inheritance in man: a catalogue of human genes and genetic disorders. The John Hopkins University Press, Baltimore & London 11th issue, 1994"},{"key":"339439_CR4","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","volume":"260","author":"F Latif","year":"1993","unstructured":"Latif F, Tory K, Gnarra JR, Yoa M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Schmidt MA, Le Paslier D, Chumakov I, Cohen D, Chinault AC, Maher ER, Linehan WM, Zbar B, Lerman MI: Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260: 1317\u20131320, 1993","journal-title":"Science"},{"key":"339439_CR5","first-page":"4845","volume":"54","author":"H Kanno","year":"1994","unstructured":"Kanno H, Kondo K, Ito S, Yamamoto I, Fujii S, Torigoe S, Sakai N, Hosaka M, Yao M: Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res 54: 4845\u20134847, 1994","journal-title":"Cancer Res"},{"key":"339439_CR6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1096-9896(199606)179:2<151::AID-PATH556>3.0.CO;2-0","volume":"179","author":"J Oberstrass","year":"1996","unstructured":"Oberstrass J, Reifenberger G, Reifenberger J, Wechsler W, Collins VP: Mutations of the von Hippel-Lindau tumor suppressor gene in capillary haemangioblastomas of the central nervous system. J Pathol 179: 151\u2013156, 1996","journal-title":"J Pathol"},{"key":"339439_CR7","first-page":"504","volume":"58","author":"J Lee","year":"1998","unstructured":"Lee J, Dong S, Park W, Yoo N, Kim C, Jang J, Chi J, Zbar BLIA, Linehan WM, Vortmeyer AO, Zhuang Z: Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas. Cancer Res 58: 504\u2013508, 1998","journal-title":"Cancer Res"},{"key":"339439_CR8","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1136\/jnnp.67.6.758","volume":"67","author":"S Glaskar","year":"1999","unstructured":"Glaskar S, Bender BU, Apel TW, Natt E, van Velthoven V, Scheremet R, Zentner J, Neumann HPH: The impact of molecular genetic analysis of the VHL gene in patients with haemangioblastomas of the central nervous system. J Neurol Neurosurg Psychiatry 67: 758\u2013762, 1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5229","key":"339439_CR9","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.7660122","volume":"269","author":"DR Duan","year":"1995","unstructured":"Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garret KP, et al.: Inhibition of transcription elongation by the VHL tumor suppresor protein. Science 269(5229): 1402\u20131406, 1995","journal-title":"Science"},{"issue":"17","key":"339439_CR10","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1073\/pnas.96.17.9533","volume":"96","author":"A Pause","year":"1999","unstructured":"Pause A, Peterson B, Schaffar G, Stearma R, Klausner RD: Studying interactions of four proteins in the yeast twohybrid system: structural resemblance of the pVHL\/elongin BC\/hCUL-2 complex with the ubiquitin ligase complex SKP1\/cullin\/F-box protein. Proc Natl Acad SciUSA 96(17): 9533\u20139538, 1999","journal-title":"Proc Natl Acad SciUSA"},{"key":"339439_CR11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1359641","volume":"258","author":"A Kallioniemi","year":"1992","unstructured":"Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman FM, Pinkel D: Comparitive Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors. Science 258: 818\u2013821, 1992","journal-title":"Science"},{"key":"339439_CR12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/BF00202476","volume":"90","author":"S du Manoir","year":"1993","unstructured":"du Manoir S, Speicher MR, Joos S, Schrock E, Popp S, Dohner H, Kovacs G, Robert-Nicoud M, Lichter P, Cremer T: Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet 90: 590\u2013610, 1993","journal-title":"Hum Genet"},{"key":"339439_CR13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-5347(01)66017-8","volume":"156","author":"JC Presti","year":"1996","unstructured":"Presti JC, Moch H, Reuter VE, Cordon-Cardo C, Waldman F: Renal cell carcinoma genetic analysis by comparative genomic hybridization and restriction fragment length polymorphism analysis. J Urology 156: 281\u2013285, 1996","journal-title":"J Urology"},{"key":"339439_CR14","first-page":"481","volume":"57","author":"J Gronwald","year":"1997","unstructured":"Gronwald J, Strokel S, Holtgreve-Grez H, Hadaczek P, Brinkschmidt C, Jauch A, Lubinski J, Cremer T: Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: Importance of 1q and 3p copy number changes in metastatic events. Cancer Res 57: 481\u2013487, 1997","journal-title":"Cancer Res"},{"key":"339439_CR15","first-page":"27","volume":"56","author":"H Moch","year":"1996","unstructured":"Moch H, Presti JC, Sauter G, Buchholz N, Jordan P, Mihatsch MJ, Waldman FM: Genetic aberration detected by comparative genomic hybridization are associated with clinical outcome in renal cell carcinoma. Cancer Res 56: 27\u201330, 1996","journal-title":"Cancer Res"},{"key":"339439_CR16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)64769-4","volume":"156","author":"E Edstrom","year":"2000","unstructured":"Edstrom E, Mahlamaki E, Nord B, Kjellman M, Karhu R, Hoog A, Goncharov N, Tean Teh B, Backdahl M, Larsson C: Comparative genomic hybridization reveals frequent losses of chromosome 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology. Am J Pathol 156: 651\u2013659, 2000","journal-title":"Am J Pathol"},{"key":"339439_CR17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/00005072-199906000-00005","volume":"58","author":"JWM Jeuken","year":"1999","unstructured":"Jeuken JWM, Sprenger SHE, Wesseling P, Macville MVE, von Deimling A, Teepen HLJM, van Overbeeke JJ, Boerman RH: Identification of subgroups of high-grade oligodendroglial tumors by comparative genomic hybridization. J Neuropathol Exp Neurol 58: 606\u2013612, 1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"339439_CR18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polsky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16: 1215, 1988","journal-title":"Nucleic Acid Res"},{"key":"339439_CR19","first-page":"218","volume":"83","author":"P Schraml","year":"1999","unstructured":"Schraml P, Zhaou M, Richter J, Brunning Th, Pommer M, Sauter G, Mihatsch MJ, Moch H: Analysis of Renal Tumors in Trichloroethylene-exposed Workers by Comparative Genomic Hybridisation and DNA Sequencing analysis. Verhandlungen der Deutschen Gesellschaft fur Pathologie 83: 218\u2013224, 1999","journal-title":"Verhandlungen der Deutschen Gesellschaft fur Pathologie"},{"key":"339439_CR20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)65166-8","volume":"155","author":"S Knuutila","year":"1999","unstructured":"Knuutila S, Aalto Y, Autio K, Bjorkqvist AM, El-Rafai W, Hemmer S, Huhta T, Kettunen E, Kiuru-Kuhlefelt S, Larramendy ML, Lushnikova T, Monni O, Pere H, Tapper J, Tarkkannen M, Varis A, Wasenius VM, Wolf M, Zhu Y: DNA copy number losses in human neoplasms. Am J Pathol 155: 683\u2013694, 1999","journal-title":"Am J Pathol"},{"key":"339439_CR21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<424::AID-HUMU9>3.0.CO;2-H","volume":"12","author":"S Olschwang","year":"1998","unstructured":"Olschwang S, Richard S, Boisson C, Giraud S, Laurent-Puig P, Resche F, Thomas G: Germline mutation profile of the VHL gene in von Hippel-Lindau disease and in sporadic heamangioblastoma. Human Mutation 12: 424\u2013430, 1998","journal-title":"Human Mutation"},{"key":"339439_CR22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ajcp\/107.4.459","volume":"107","author":"JYM Tse","year":"1997","unstructured":"Tse JYM, Wong JHC, Lo K, Poon W, Huang D, Ng H: Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar haemangioblastomas. Am J Clin Pathol 107: 459\u2013466, 1997","journal-title":"Am J Clin Pathol"},{"key":"339439_CR23","doi-asserted-by":"crossref","first-page":"9700","DOI":"10.1073\/pnas.91.21.9700","volume":"91","author":"JG Herman","year":"1995","unstructured":"Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DR, Gnarra JR, Linehan WM, Baylin SB: Silencing of the VHL tumor suppressor gene by DNA methylation in renal cell carcinoma. Proc Natl Acad Sci USA 91: 9700\u20139704, 1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"339439_CR24","first-page":"1","volume":"23","author":"S Richard","year":"2000","unstructured":"Richard S, David P, Marsot-Dupuch K, Giraud S, Beroud C, Resche F: Central nervous system haemangioblastomas, endolympatic sac tumors, and von Hippel-Lindau disease. Springer-Verlag 23: 1\u201322, 2000","journal-title":"Springer-Verlag"},{"key":"339439_CR25","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/00005072-199711000-00009","volume":"56","author":"R Stratmann","year":"2000","unstructured":"Stratmann R, Krieg M, Haas R, Plate KH: Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. J Neuropathol Exp Neurol 56: 1242\u20131252, 2000","journal-title":"J Neuropathol Exp Neurol"},{"key":"339439_CR26","first-page":"1358","volume":"55","author":"S Wizigmann-Voos","year":"1995","unstructured":"Wizigmann-Voos S, Breier G, Risau W, Plate KH: Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and 247 sporadic hemangioblastomas. Cancer Res 55: 1358\u20131364, 1995","journal-title":"Cancer Res"},{"key":"339439_CR27","first-page":"367","volume":"148","author":"T Bohling","year":"1996","unstructured":"Bohling T, Turunen O, Jaaskelainen J, Carpen O, Saino M, Wahlstrom T, Vaheri A, Haltia M: Ezrin expression in stromal cells of capillary hemangioblastoma. Am J Pathol 148: 367\u2013373, 1996","journal-title":"Am J Pathol"},{"key":"339439_CR28","first-page":"1107","volume":"152","author":"S Knuutila","year":"1998","unstructured":"Knuutila S, Bjorkqvist AM, Autio K, Trakkanen M, Wolf M, Monni O, Szymanska J, Larramendy ML, Tapper J, Pere H, El-Rafai W, Hemmer S, Wasenius VM, Vidgren V, Zhu Y: DNA copy number amplifications in human neoplasms. Am J Pathol 152: 1107\u20131123, 1998","journal-title":"Am J Pathol"},{"key":"339439_CR29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0046-8177(97)90075-7","volume":"28","author":"AO Vortmeyer","year":"1997","unstructured":"Vortmeyer AO, Gnarra JR, Emmert-Buck MR, Katz D, Linehan WM, Oldfoeld EH, Zhuang Z: von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum Pathol 28: 541\u2013543, 1997","journal-title":"Hum Pathol"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010623119469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1010623119469\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010623119469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:04:33Z","timestamp":1749632673000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1010623119469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["339439"],"URL":"https:\/\/doi.org\/10.1023\/a:1010623119469","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"type":"print","value":"0167-594X"},{"type":"electronic","value":"1573-7373"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}