{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:12:38Z","timestamp":1777417958712,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1023\/a:1010748316889","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T22:43:46Z","timestamp":1040597026000},"page":"779-784","source":"Crossref","is-referenced-by-count":41,"title":["Gastrointestinal Damage Induced by Celecoxib and Rofecoxib in Rats"],"prefix":"10.1007","volume":"46","author":[{"given":"O.M.","family":"Laudanno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Cesolari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Esnarriaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Piombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Maglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Aramberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sambrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rocaspana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"301927_CR1","doi-asserted-by":"crossref","first-page":"16737","DOI":"10.1016\/S0021-9258(17)44821-6","volume":"265","author":"JV Fu","year":"1990","unstructured":"Fu JV, Masferrer JL, Seiberk K, Needleman P: The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 265:16737\u201316740, 1990","journal-title":"J Biol Chem"},{"key":"301927_CR2","first-page":"1692","volume":"88","author":"W Xie","year":"1991","unstructured":"Xie W, Chipman JG, Roberstson DL, Erikson RL, Simmons DL: Expression of a mitogen-responsive gene encording prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA. 88:1692\u20131696, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"301927_CR3","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.91.25.12013","volume":"91","author":"K Seibert","year":"1994","unstructured":"Seibert K, Zhang Y, Leahy K, Hanser S, Masferrer JL, Perkins W, Lee L, Isakson P: Pharmacologial and biochemical demonstration of the role of cyclooxigenase 2 in inflammation and pain. Proc Natl Acad Sci USA 91:12013\u201312017, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"301927_CR4","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1073\/pnas.89.16.7384","volume":"266","author":"T Hla","year":"1992","unstructured":"Hla T, Neilson K: Human cyclooxygenase 2 cDNA. Proc. Natl Acad Sci USA 266:7384\u20137388, 1992","journal-title":"Proc. Natl Acad Sci USA"},{"key":"301927_CR5","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.91.8.3228","volume":"91","author":"JL Masferrer","year":"1994","unstructured":"Masferrer JL, Zweifel BS, Manning PT, Hanser SD, Leahy KM, Simith WS, Isakson PC, Serberk K: Selective inhibition of inducible cyclooxygenase 2 in vitro is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci USA 91:3228\u20133232, 1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"suppl2A","key":"301927_CR6","first-page":"40","volume":"95","author":"EA Meade","year":"1993","unstructured":"Meade EA, Smith WLL, Dewoitt DL: Differential inhibition of prostaglandin endoperoxidase syntehase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs. J Biol Chem 95(suppl 2A):40\u201345, 1993","journal-title":"J Biol Chem"},{"key":"301927_CR7","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1073\/pnas.90.24.11693","volume":"90","author":"JA Michell","year":"1993","unstructured":"Michell JA, Akaraserremont P, Thiemerman C, Flower RJ, Vane JR: Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 90:11693\u201311697, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"301927_CR8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(98)12154-2","volume":"353","author":"CJ Hawkey","year":"1999","unstructured":"Hawkey CJ: COX-2 inhibitors. Lancet 353:307\u2013314, 1999","journal-title":"Lancet"},{"issue":"suppl51","key":"301927_CR9","first-page":"8","volume":"25","author":"G Singh","year":"1997","unstructured":"Singh G: NSAID-induced G1 complications: The ARAMIS perspective-1997. J Rheumatol 25(suppl 51):8\u201316, 1997","journal-title":"J Rheumatol"},{"issue":"suppl3","key":"301927_CR10","first-page":"183A","volume":"27","author":"O Bedini","year":"1997","unstructured":"Bedini O, Laudanno OM, Naves P, San Miguel P, Cesolari J: Alteraci\u00f3n de la angiog\u00e9nesis y retardo en la reparaci\u00f3n de la \u00falcera g\u00e1strica por \u00facido ac\u00e9tico, en ratas tratadas con Meloxicam. Acta Gastroenteral Latino-Am 27(suppl 3):183A, 1997","journal-title":"Acta Gastroenteral Latino-Am"},{"issue":"1","key":"301927_CR11","first-page":"32A","volume":"22","author":"OM Laudanno","year":"1998","unstructured":"Laudanno OM, Cesolari J, Esnarriaga JM, San Miguel P, Bedini O: Meloxicam (COX-2) vs indomethacin (COX-1) and gastroduodenal ulcer, in rats. Biocell 22(no 1):32A. 1998","journal-title":"Biocell"},{"key":"301927_CR12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0016-5085(81)90497-2","volume":"81","author":"H Satoh","year":"1981","unstructured":"Satoh H, Inada I, Hirata T, Maki Y: Indomethacin produces gastric antral ulcers in the refed rat. Gastroenterology 81:719\u2013725, 1981","journal-title":"Gastroenterology"},{"key":"301927_CR13","first-page":"249","volume":"28","author":"OM Laudanno","year":"1998","unstructured":"Laudanno OM, Cesolari JA, Esnarriaga J, Flaherty P, Vada J, Guastalli G, San Miguel P, Bedini O: Selectividad in vitro de DAINEs COX-1, COX-2 y \u00falceras gastrointestinales en ratas. Acta Gastroenterol Latino-Am 28:249\u2013255, 1998","journal-title":"Acta Gastroenterol Latino-Am"},{"key":"301927_CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","volume":"16","author":"S Okabe","year":"1971","unstructured":"Okabe S, Roth, Pfeiffer CJ: A method for experimental, pen-etrating gastric and duodenal ulcers in rats. Am J Dig Dis. 16:277\u2013284, 1971","journal-title":"Am J Dig Dis."},{"key":"301927_CR15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1254\/jjp.18.9","volume":"18","author":"K Takagi","year":"1968","unstructured":"Takagi K, Okabe S: The effect of drug on the production and recovery processes of stress ulcer. Jpn J Pharmacol 18:9\u201318, 1968","journal-title":"Jpn J Pharmacol"},{"key":"301927_CR16","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"JE Krawisz","year":"1984","unstructured":"Krawisz JE, Sharon P, Stenson WF: Quantitative assay for acute inflammation based on myeloperoxidase activity: Assessment of inflammation in rats and hamster. Gastroenterology 87:1344\u20131350, 1984","journal-title":"Gastroenterology"},{"key":"301927_CR17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0016-5085(98)70370-1","volume":"115","author":"JL Wallace","year":"1998","unstructured":"Wallace JL, Bak A, Mcknight W, Asfaha S, Sharkey KA, MACNaughton WK: Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity. Gastroenterology 115:101\u2013109, 1998","journal-title":"Gastroenterology"},{"key":"301927_CR18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0022-3565(24)34934-1","volume":"290","author":"CC Chan","year":"1999","unstructured":"Chan CC, Boyce S, Brideau C, et al: Rofecoxib: A potent and orally active cyclooxygenase-2inhibitor: Pharmacological and biochemical profiles. Pharmacol Exp Ther 290:551\u2013560, 1999","journal-title":"Pharmacol Exp Ther"},{"key":"301927_CR19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1073\/pnas.96.1.272","volume":"96","author":"BF Mc Adams","year":"1999","unstructured":"Mc Adams BF: Systemic biosynthesis of prostaglandin by cyclooxygenase 2 (COX-2). The human pharmacology of a selective inhibition of COX-2. Proc Natl Acad Sci USA 96:272\u2013277, 1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"301927_CR20","first-page":"63A","volume":"23","author":"JM Esnarriaga","year":"1999","unstructured":"Esnarriaga JM, Laudanno OM, Maglione C, Cesolari J, Guastalli G, Piombo G: Neutrophils in indomethacin gastric injury, in rats. Biocell 23(1):63A, 1999","journal-title":"Biocell"},{"key":"301927_CR21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/gut.34.2.156","volume":"34","author":"MA Trevethick","year":"1993","unstructured":"Trevethick MA, Clayton NM, Strong P, Harman IW: Do infiltrating neutrophils to pathogenesis of indomethacin induce ulceration of the rat gastric antrum?. Gut 34:156\u2013160, 1993","journal-title":"Gut"},{"key":"301927_CR22","first-page":"1272A","volume":"80","author":"OM Laudanno","year":"1998","unstructured":"Laudanno OM, Cesolari JA, Esnarriaga J, San Miguel P, Bedini O: Gastric antrum and indomethacin ulcers, in rats. Digestion 80:1272A, 1998","journal-title":"Digestion"},{"key":"301927_CR23","first-page":"1272A","volume":"80","author":"H Satoh","year":"1981","unstructured":"Satoh H, Guth PH: Gastric antral ulcers produced by indomethacin in the rat. III. Role of acid and prostaglandin. Gastroenterology 80:1272A, 1981","journal-title":"Gastroenterology"},{"key":"301927_CR24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0140-6736(95)91378-5","volume":"346","author":"J Hayllar","year":"1995","unstructured":"Hayllar J, Byarmason I: NSAIDs, COX-2 inhibitors, and the gut. Lancet 346:521\u2013522, 1995","journal-title":"Lancet"},{"key":"301927_CR25","first-page":"1277","volume":"29","author":"HT Schreider","year":"1990","unstructured":"Schreider HT, Nuernberg B, Dietzel K, Brune K: Biliary elimination of nonsteroidal anti-inflammatory drugs in patients. Br J Clin Pharmacol 29:1277\u20131281. 1990","journal-title":"Br J Clin Pharmacol"},{"key":"301927_CR26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/gast.1997.v112.pm9024292","volume":"112","author":"H Mizuno","year":"1997","unstructured":"Mizuno H, Sakamoto C, Matsuda K, Wada K, Hahida T, Noguahi H, Akamatsu T, Kasuga M: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by specific antagonist delays healing in mice. Gastroenterology 112:387\u2013397, 1997","journal-title":"Gastroenterology"},{"key":"301927_CR27","first-page":"881A","volume":"110","author":"AD Chang","year":"1996","unstructured":"Chang AD, Ramanujam KS, Wilson KT: Co-expression of inducible nitric oxide synthase (INOS), cyclooxygenase (COX-2), and TGF-B in rat models of colitis. Gastroenterology 110:881A, 1996 (abstract)","journal-title":"Gastroenterology"},{"key":"301927_CR28","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1172\/JCI119013","volume":"98","author":"BK Reuter","year":"1996","unstructured":"Reuter BK, Asfaha S, Buret A, Sharkey KA, Wallace JL: Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclo-oxygenase-2. J Clin Invest 98:2076\u20132085, 1996","journal-title":"J Clin Invest"},{"key":"301927_CR29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1074\/jbc.272.1.601","volume":"272","author":"JF Schmedtje Jr","year":"1997","unstructured":"Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS: Hypoxia induces cyclooxygenase-2 via the NF-\u03baB p65 transcriptor factor in human vascular endothelial cells. J Biol Chem 272:601\u2013608, 1997","journal-title":"J Biol Chem"},{"key":"301927_CR30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0016-5085(99)70496-8","volume":"116","author":"S Fu","year":"1999","unstructured":"Fu S, Ramanujam KS, Wong A, et al: Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 116:1319\u20131329, 1999","journal-title":"Gastroenterology"},{"key":"301927_CR31","doi-asserted-by":"crossref","first-page":"666A","DOI":"10.1016\/S0016-5085(98)82727-3","volume":"114","author":"KS Ramanujam","year":"1998","unstructured":"Ramanujam KS, Wilson KT: Helicobacter pylori induces cyclooxygenase-2 expression in human gastric epithelial cells by a tyrosine phosphorylation-dependent mechanism. Gastroenterology 114:666A, 1998 (abstract)","journal-title":"Gastroenterology"},{"key":"301927_CR32","doi-asserted-by":"crossref","first-page":"160A","DOI":"10.1016\/S0016-5085(98)80647-1","volume":"114","author":"LM Jackson","year":"1998","unstructured":"Jackson LM, Wu K, Mahida YR, et al: COX-1 expression in human gastric mucosa infected with Helicobacter pylori: Constitutive or induced? Gastroenterology 114:160A, 1998","journal-title":"Gastroenterology"},{"key":"301927_CR33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/carcin\/16.5.1023","volume":"16","author":"SM Plummer","year":"1995","unstructured":"Plummer SM, Hall H, Faux SP: Oxidation and genotoxicity of fecapentaene-12 are potentiated by prostaglandin H synthase. Carcinogenesis 16:1023\u20131028, 1995","journal-title":"Carcinogenesis"},{"key":"301927_CR34","first-page":"2556","volume":"56","author":"SK Boolbol","year":"1996","unstructured":"Boolbol SK, Dannenberg AJ, Chadburn A, et al: Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 56:2556\u20132560, 1996","journal-title":"Cancer Res"},{"key":"301927_CR35","first-page":"1276","volume":"57","author":"A Ristimaki","year":"1997","unstructured":"Ristimaki A, Honkanen H, Jaukala H, Sepponen P, Harkonen M: Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res 57:1276\u20131280, 1997","journal-title":"Cancer Res"},{"key":"301927_CR36","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0016-5085(94)90246-1","volume":"107","author":"CE Eberhart","year":"1994","unstructured":"Eberhart CE, Coffey RY, Radhica A, Giardello FM, Ferrenbach S, DuBois R N: Up regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183\u20131188. 1994","journal-title":"Gastroenterology"},{"key":"301927_CR37","first-page":"2929","volume":"58","author":"KT Wilson","year":"1998","unstructured":"Wilson KT, Fu S, Ramanujam KS, Meltzer SJ: Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 58:2929\u20132934, 1998","journal-title":"Cancer Res."}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010748316889.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1010748316889\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010748316889.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:10:53Z","timestamp":1752462653000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1010748316889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["301927"],"URL":"https:\/\/doi.org\/10.1023\/a:1010748316889","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}