{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T22:24:23Z","timestamp":1764714263651,"version":"3.41.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1023\/a:1010764720524","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T22:43:46Z","timestamp":1040597026000},"page":"836-844","source":"Crossref","is-referenced-by-count":42,"title":["Increased Oxidative and Nitrative Stress in Human Stomach Associated with cagA+ Helicobacter pylori Infection and Inflammation"],"prefix":"10.1007","volume":"46","author":[{"given":"Chun-Qi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"301935_CR1","first-page":"177","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans-Schistosomes, Liver Flukes and Helicobacter pylori","author":"IARC Working Group","year":"1994","unstructured":"IARC Working Group: Infection with Helicobacter pylori. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans-Schistosomes, Liver Flukes and Helicobacter pylori, Vol 61. Lyon, IARC, 1994, pp 177\u2013240"},{"key":"301935_CR2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1746.1991.tb01468.x","volume":"6","author":"AB Price","year":"1991","unstructured":"Price AB: The Sydney system: Histological division. J Gastroenterol Hepatol 6:209\u2013222, 1991","journal-title":"J Gastroenterol Hepatol"},{"key":"301935_CR3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/gut.42.6.768","volume":"42","author":"IM Drake","year":"1998","unstructured":"Drake IM, Mapstone NP, Schorah CJ, White KLM, Chalmers DM, Dixon MF, Axon ATR: Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: Relation to gastric mucosal ascorbic acid concentrations and effect of H. pylori eradication. Gut 42:768\u2013771, 1998","journal-title":"Gut"},{"key":"301935_CR4","first-page":"3238","volume":"56","author":"EE Mannick","year":"1996","unstructured":"Mannick EE, Bravo LE, Zarama G, Realpe JL, Zhang XJ, Ruiz B, Fontham ET, Mera R, Miller MJ, Correa P: Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants. Cancer Res 56:3238\u20133243, 1996","journal-title":"Cancer Res"},{"key":"301935_CR5","first-page":"1279","volume":"56","author":"SC Baik","year":"1996","unstructured":"Baik SC, Youn HS, Chung MH, Lee WK, Cho MJ, Ko GH, Park CK, Kasai H, Rhee KH: Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. Cancer Res 56:1279\u20131282, 1996","journal-title":"Cancer Res"},{"key":"301935_CR6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/gut.42.3.351","volume":"42","author":"F Farinati","year":"1998","unstructured":"Farinati F, Cardin R, Degan P, Rugge M, Mario FD, Bonvicini P, Naccarato R: Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 42:351\u2013356, 1998","journal-title":"Gut"},{"key":"301935_CR7","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0016-5085(99)70496-8","volume":"116","author":"S Fu","year":"1999","unstructured":"Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KT: Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 116:1319\u20131329, 1999","journal-title":"Gastroenterology"},{"key":"301935_CR8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1005453125433","volume":"45","author":"CQ Li","year":"2000","unstructured":"Li CQ, Pignatelli B, Ohshima H: Coexpression of interleukin-8 and inducible nitric oxide synthase in gastric mucosa infected with cagA+\nHelicobacter pylori. Dig Dis Sci 45:55\u201362, 2000","journal-title":"Dig Dis Sci"},{"key":"301935_CR9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00008469-199812000-00003","volume":"7","author":"B Pignatelli","year":"1998","unstructured":"Pignatelli B, Bancel B, Est\u00e8ve J, Malaveille C, Calmels S, Correa P, Patricot LM, Laval M, Lyandrat N, Ohshima H: Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobacter pylori infection in gastritis and gastric precancerous lesions in humans. Eur J Cancer Prev 7:439\u2013447, 1998","journal-title":"Eur J Cancer Prev"},{"key":"301935_CR10","doi-asserted-by":"crossref","unstructured":"Pignatelli B, Bancel B, Plummer M, Toyokuni S, Patricot L-M, Ohshima H: H. pylori eradication attenuates oxidative stress in human gastric mucosa. Am J Gastroenterol, In press, 2001","DOI":"10.1111\/j.1572-0241.2001.03869.x"},{"key":"301935_CR11","doi-asserted-by":"crossref","first-page":"20313","DOI":"10.1074\/jbc.272.33.20313","volume":"272","author":"BS Berlett","year":"1997","unstructured":"Berlett BS, Stadtman ER: Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272:20313\u201320316, 1997","journal-title":"J Biol Chem"},{"key":"301935_CR12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0891-5849(94)90169-4","volume":"17","author":"E Shacter","year":"1994","unstructured":"Shacter E, Williams JA, Lim M, Levine RL: Differential susceptibility of plasma proteins to oxidative modification: Examination by western blot immunoassay. Free Radic Biol. Med 17:429\u2013437, 1994","journal-title":"Free Radic Biol. Med"},{"key":"301935_CR13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/oxfordjournals.jbchem.a021306","volume":"119","author":"A Nakamura","year":"1996","unstructured":"Nakamura A, Goto S: Analysis of protein carbonyls with 2,4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis. J Biochem Tokyo 119:768\u2013774, 1996","journal-title":"J Biochem Tokyo"},{"key":"301935_CR14","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1074\/jbc.273.5.3027","volume":"273","author":"J Tamarit","year":"1998","unstructured":"Tamarit J, Cabiscol E, Ros J: Identification of the major oxidatively damaged proteins in Escherichia coli cells exposed to oxidative stress. J Biol Chem 273:3027\u20133032, 1998","journal-title":"J Biol Chem"},{"key":"301935_CR15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(97)00466-3","volume":"409","author":"C Szabo","year":"1997","unstructured":"Szabo C, O'Connor M, Salzman AL: Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages. FEBS Lett 409:147\u2013150, 1997","journal-title":"FEBS Lett"},{"key":"301935_CR16","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/jcp.39.11.1279-a","volume":"39","author":"SF Gray","year":"1986","unstructured":"Gray SF, Wyatt JI, Rathbone BJ: Simplified techniques for identifying Campylobacter pyloridis. J Clin Pathol 39:1279, 1986","journal-title":"J Clin Pathol"},{"key":"301935_CR17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/jnci\/89.12.863","volume":"89","author":"J Peek-RM","year":"1997","unstructured":"Peek-RM J, Moss SF, Tham KT, Perez PG, Wang S, Miller GG, Atherton JC, Holt PR, Blaser MJ: Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst 89:863\u2013868, 1997","journal-title":"J Natl Cancer Inst"},{"key":"301935_CR18","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1128\/jcm.30.9.2295-2301.1992","volume":"30","author":"L Engstrand","year":"1992","unstructured":"Engstrand L, Nguyen AM, Graham DY, el Zaatari FA: Reverse transcription and polymerase chain reaction amplification of rRNA for detection of Helicobacter species. J Clin Microbiol 30:2295\u20132301, 1992","journal-title":"J Clin Microbiol"},{"key":"301935_CR19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0076-6879(94)33026-3","volume":"233","author":"JS Beckman","year":"1994","unstructured":"Beckman JS, Chen J, Ischiropoulos H, Crow JP: Oxidative chemistry of peroxynitrite. Methods Enzymol 233:229\u2013240, 1994","journal-title":"Methods Enzymol"},{"key":"301935_CR20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","volume":"186","author":"RL Levine","year":"1990","unstructured":"Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER: Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464\u2013478, 1990","journal-title":"Methods Enzymol"},{"key":"301935_CR21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/niox.1999.0216","volume":"3","author":"H Ohshima","year":"1999","unstructured":"Ohshima H, Celan I, Chazotte L, Pignatelli B, Mower HF: Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a post-separation, on-line reduction column and electrochemical detection: Results with various nitrating agents. Nitric Oxide Biol Chem 3:132\u2013141, 1999","journal-title":"Nitric Oxide Biol Chem"},{"key":"301935_CR22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/abio.1998.2799","volume":"263","author":"LJ Yan","year":"1998","unstructured":"Yan LJ, Orr WC, Sohal RS: Identification of oxidized proteins based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing. Anal Biochem 263:67\u201371, 1998","journal-title":"Anal Biochem"},{"key":"301935_CR23","doi-asserted-by":"crossref","first-page":"13136","DOI":"10.1073\/pnas.96.23.13136","volume":"96","author":"B Balabanli","year":"1999","unstructured":"Balabanli B, Kamisaki Y, Martin E, Murad F: Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine. Proc Natl Acad Sci USA 96:13136\u201313141, 1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"301935_CR24","first-page":"9","volume":"7","author":"HE Poulsen","year":"1998","unstructured":"Poulsen HE, Prieme H, Loft S: Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev 7:9\u201316, 1998","journal-title":"Eur J Cancer Prev"},{"key":"301935_CR25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0027-5107(94)90245-3","volume":"305","author":"H Ohshima","year":"1994","unstructured":"Ohshima H, Bartsch H: Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis. Mutat Res 305:253\u2013264, 1994","journal-title":"Mutat Res"},{"key":"301935_CR26","first-page":"72S","volume":"43","author":"KB Hahm","year":"1998","unstructured":"Hahm KB, Lee KJ, Kim JH, Cho SW, Chung MH: Helicobacter pylori infection, oxidative DNA damage, gastric carcinogenesis, and reversibility by rebamipide. Dig Dis Sci 43:72S\u201377S, 1998","journal-title":"Dig Dis Sci"},{"key":"301935_CR27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0278-6915(90)90173-K","volume":"28","author":"H Ohshima","year":"1990","unstructured":"Ohshima H, Friesen M, Brouet I, Bartsch H: Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins. Food Chem Toxicol 28:647\u2013652, 1990","journal-title":"Food Chem Toxicol"},{"key":"301935_CR28","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/tx9501445","volume":"9","author":"JS Beckman","year":"1996","unstructured":"Beckman JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836\u2013844, 1996","journal-title":"Chem Res Toxicol"},{"key":"301935_CR29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/gut.45.2.199","volume":"45","author":"B Zingarelli","year":"1999","unstructured":"Zingarelli B, Szabo C, Salzman AL: Reduced oxidative and nitrosative damage in murine experimental colitis in the asbsence of inducible nitric oxide synthase. Gut 45:199\u2013209, 1999","journal-title":"Gut"},{"key":"301935_CR30","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/jcp.48.10.967","volume":"48","author":"JE Crabtree","year":"1995","unstructured":"Crabtree JE, Xiang Z, Lindley IJ, Tompkins DS, Rappuoli R, Covacci A: Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori. J Clin Pathol 48:967\u2013969, 1995","journal-title":"J Clin Pathol"},{"key":"301935_CR31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1365-2958.1995.18050867.x","volume":"18","author":"MK Tummuru","year":"1995","unstructured":"Tummuru MK, Sharma SA, Blaser MJ: Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 18:867\u2013876, 1995","journal-title":"Mol Microbiol"},{"key":"301935_CR32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1098-2744(199808)22:4<209::AID-MC1>3.0.CO;2-E","volume":"22","author":"DC Liebler","year":"1998","unstructured":"Liebler DC, Aust AE, Wilson GL, Copeland ES: Reactive oxidants from nitric oxide, oxidants and cellular signalling, and repair of oxidative DNA damage: A chemical pathology study section workshop. Mol Carcinog 22:209\u2013220, 1998","journal-title":"Mol Carcinog"},{"key":"301935_CR33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0016-5085(96)70055-0","volume":"111","author":"II Singer","year":"1996","unstructured":"Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, Stenson WF: Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111:871\u2013885, 1996","journal-title":"Gastroenterology"},{"key":"301935_CR34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0891-5849(98)00208-1","volume":"26","author":"P. F. Mecocci","year":"1999","unstructured":"Mecocci P, Fano G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF: Agedependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med 26:303\u2013308, 1999","journal-title":"Free Radic Biol Med"},{"key":"301935_CR35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0891-5849(99)00108-2","volume":"27","author":"O Pansarasa","year":"1999","unstructured":"Pansarasa O, Bertorelli L, Vecchiet J, Felzani G, Marzatico F: Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med 27:617\u2013622, 1999","journal-title":"Free Radic Biol Med"},{"key":"301935_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.1998.0755","volume":"356","author":"H Ischiropoulos","year":"1998","unstructured":"Ischiropoulos H: Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys 356:1\u201311, 1998","journal-title":"Arch Biochem Biophys"},{"key":"301935_CR37","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1097\/00003246-199909000-00007","volume":"27","author":"NJ Lamb","year":"1999","unstructured":"Lamb NJ, Gutteridge JMC, Baker C, Evans TW, Quinlan GJ: Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination. Crit Care Med 27:1738\u20131744, 1999","journal-title":"Crit Care Med"},{"key":"301935_CR38","doi-asserted-by":"crossref","first-page":"386S","DOI":"10.1093\/ajcn\/53.1.386S","volume":"53","author":"VN Singh","year":"1991","unstructured":"Singh VN, Gaby SK: Premalignant lesions: Role of antioxidant vitamins and beta-carotene in risk reduction and prevention of malignant transformation. Am J Clin Nutr 53:386S\u2013390S, 1991","journal-title":"Am J Clin Nutr"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010764720524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1010764720524\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1010764720524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:50:03Z","timestamp":1752461403000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1010764720524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["301935"],"URL":"https:\/\/doi.org\/10.1023\/a:1010764720524","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}