{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:08:20Z","timestamp":1772888900735,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1023\/a:1011058411804","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T10:14:19Z","timestamp":1040638459000},"page":"494-499","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Topical Anandamide-Transport Inhibitors, AM404 and Olvanil, on Intraocular Pressure in Normotensive Rabbits"],"prefix":"10.1007","volume":"18","author":[{"given":"Krista","family":"Laine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Savinainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarmo T.","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Pate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"300329_CR1","first-page":"249","volume":"2","author":"B. K. Colasanti","year":"1986","unstructured":"B. K. Colasanti. Ocular hypotensive effect of marihuana cannabinoids: Correlate of central action or separate phenomenon? J. Ocul. Pharmacol.\n2:249-304 (1986).","journal-title":"J. Ocul. Pharmacol."},{"key":"300329_CR2","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/jama.1971.03190100074024","volume":"217","author":"R. S. Hepler","year":"1971","unstructured":"R. S. Hepler and I. M. Frank. Marijuana smoking and intraocular pressure. J. Am. Med. Assoc.\n217:1392 (1971).","journal-title":"J. Am. Med. Assoc."},{"key":"300329_CR3","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"W. A. Devane","year":"1992","unstructured":"W. A. Devane, L. Hanu\u0161, A. Breuer, R. G. Pertwee, L. A. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, and R. Mechoulam. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science\n258:1946-1949 (1992).","journal-title":"Science"},{"key":"300329_CR4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","volume":"50","author":"R. Mechoulam","year":"1995","unstructured":"R. Mechoulam, S. Ben-Shabat, L. Hanu\u0161, M. Ligumsky, N. E. Kaminski, A. R. Schatz, A. Gopher, S. Almog, B. R. Martin, D. R. Compton, R. G. Pertwee, G. Griffin, M. Bayewitch, J. Barg, and Z. Vogel. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol.\n50:83-90 (1995).","journal-title":"Biochem. Pharmacol."},{"key":"300329_CR5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3109\/02713689508995801","volume":"14","author":"D. W. Pate","year":"1995","unstructured":"D. W. Pate, K. J\u00e4rvinen, A. Urtti, P. Jarho, and T. J\u00e4rvinen. Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits. Curr. Eye Res.\n14:791-797 (1995).","journal-title":"Curr. Eye Res."},{"key":"300329_CR6","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/0024-3205(96)00169-5","volume":"58","author":"D. W. Pate","year":"1996","unstructured":"D. W. Pate, K. J\u00e4rvinen, A. Urtti, P. Jarho, M. Fich, V. Mahadevan, and T. J\u00e4rvinen. Effects of topical anandamides on intraocular pressure in normotensive rabbits. Life Sci.\n58:1849-1860 (1996).","journal-title":"Life Sci."},{"key":"300329_CR7","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1023\/A:1012131929940","volume":"14","author":"D. W. Pate","year":"1997","unstructured":"D. W. Pate, K. J\u00e4rvinen, A. Urtti, P. Jarho, V. Mahadevan, and T. J\u00e4rvinen. Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbits. Pharm. Res.\n14:1738-1743 (1997).","journal-title":"Pharm. Res."},{"key":"300329_CR8","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0024-3205(98)00499-8","volume":"63","author":"D. W. Pate","year":"1998","unstructured":"D. W. Pate, K. J\u00e4rvinen, A. Urtti, V. Mahadevan, and T. J\u00e4rvinen. Effect of the CB1 receptor antagonist, SR 141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits. Life Sci.\n63:2181-2188 (1998).","journal-title":"Life Sci."},{"key":"300329_CR9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0169-328X(98)00105-3","volume":"58","author":"A. Porcella","year":"1998","unstructured":"A. Porcella, P. Casellas, G. L. Gessa, and L. Pani. Cannabinoid receptor CB1 mRNA is highly impressed in rat ciliary body: Implications for the antiglaucoma properties of marihuana. Mol. Brain Res.\n58:240-245 (1998).","journal-title":"Mol. Brain Res."},{"key":"300329_CR10","doi-asserted-by":"crossref","first-page":"14565","DOI":"10.1073\/pnas.96.25.14565","volume":"96","author":"A. Straiker","year":"1999","unstructured":"A. Straiker, N. Stella, D. Piomelli, K. Mackie, H. J. Karten, and G. Maguire. Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signalling system. Proc. Natl. Acad. Sci. USA\n96:14565-14570 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"300329_CR11","first-page":"2442","volume":"40","author":"A. J. Straiker","year":"1999","unstructured":"A. J. Straiker, G. Maguire, K. Mackie, and J. Lindsey. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. Invest. Ophthalmol. Vis. Sci.\n40:2442-2448 (1999).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"300329_CR12","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","volume":"372","author":"V. Di Marzo","year":"1994","unstructured":"V. Di Marzo, A. Fontana, H. Cadas, S. Schinelli, G. Cimino, J.-C. Schwarzt, and D. Piomelli. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature\n372:686-691 (1994).","journal-title":"Nature"},{"key":"300329_CR13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0006-2952(93)90486-G","volume":"46","author":"D. G. Deutsch","year":"1993","unstructured":"D. G. Deutsch and S. A. Chin. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol.\n46:791-796 (1993).","journal-title":"Biochem. Pharmacol."},{"key":"300329_CR14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1471-4159.1997.69020631.x","volume":"69","author":"C. J. Hillard","year":"1997","unstructured":"C. J. Hillard, W. S. Edgemond, A. Jarrahian, and W. B. Campbell. Accumulation of N-arachidonoylethanolamide (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem.\n69:631-638 (1997).","journal-title":"J. Neurochem."},{"key":"300329_CR15","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.277.5329.1094","volume":"277","author":"M. Beltramo","year":"1997","unstructured":"M. Beltramo, N. Stella, A. Calignano, S. Y. Lin, A. Makriyannis, and D. Piomelli. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science\n277:1094-1097 (1997).","journal-title":"Science"},{"key":"300329_CR16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(98)00821-8","volume":"364","author":"M. Beltramo","year":"1999","unstructured":"M. Beltramo and D. Piomelli. Anandamide transport inhibition by the vanilloid agonist olvanil. Eur. J. Pharmacol.\n364:75-78 (1999).","journal-title":"Eur. J. Pharmacol."},{"key":"300329_CR17","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(97)01297-1","volume":"337","author":"A. Calignano","year":"1997","unstructured":"A. Calignano, G. La Rana, M. Beltramo, A. Makriyannis, and D. Piomelli. Potentiation of anandamide hypotension by the transport inhibitor AM404. Eur. J. Pharmacol.\n337:R1-R2 (1997).","journal-title":"Eur. J. Pharmacol."},{"key":"300329_CR18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0014-5793(94)00773-X","volume":"350","author":"M. Rinaldi-Carmona","year":"1994","unstructured":"M. Rinaldi-Carmona, F. Barth, M. H\u00e9aulme, D. Shire, B. Calandra, C. Congy, S. Martinez, J. Maruani, G. N\u00e9liat, D. Caput, P. Ferrara, P. Soubri\u00e9, J. C. Breli\u00e9re, and G. Le Fur. SR 141716A, a potent and selective antagonist on the brain cannabinoid receptor. FEBS Lett.\n350:240-244 (1994).","journal-title":"FEBS Lett."},{"key":"300329_CR19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0306-4522(98)00571-5","volume":"90","author":"J. T. Laitinen","year":"1999","unstructured":"J. T. Laitinen. Selective detection of adenosine A1 receptor-dependent G protein activity in basal and stimulated conditions of rat brain [35S]guanosine 5\u2032-(thio)triphosphate autoradiography. Neuroscience\n90:1265-1279 (1999).","journal-title":"Neuroscience"},{"key":"300329_CR20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1046\/j.1471-4159.1998.71020808.x","volume":"71","author":"J. T. Laitinen","year":"1998","unstructured":"J. T. Laitinen and M. Jokinen. Guanosine 5\u2032-(\u2212[35S]thio) triphosphate autoradiography allows selective detection of histamine H3 receptor-dependent activation of G proteins in rat brain tissue sections. J. Neurochem.\n71:808-816 (1998).","journal-title":"J. Neurochem."},{"key":"300329_CR21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0026-895X(25)10492-6","volume":"48","author":"C. C. Felder","year":"1995","unstructured":"C. C. Felder, K. E. Joyce, E. M. Briley, J. Mansouri, K. Mackie, O. Blond, Y. Lai, A. L. Ma, and R. L. Mitchell. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors Mol. Pharmacol.\n48:443-450 (1995).","journal-title":"Mol. Pharmacol."},{"key":"300329_CR22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-2999(97)01255-7","volume":"336","author":"T. H. Burkey","year":"1997","unstructured":"T. H. Burkey, R. M. Quock, P. Consroe, F. J. Ehlert, Y. Hosohata, W. R. Roeske, and H. I. Yamamura. Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain. Eur. J. Pharmacol.\n336:295-298 (1997).","journal-title":"Eur. J. Pharmacol."},{"key":"300329_CR23","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-3565(24)35376-5","volume":"292","author":"F. Rakhshan","year":"2000","unstructured":"F. Rakhshan, T. A. Day, R. D. Blakeley, and E. L. Barker. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. J. Pharmacol. Exp. Ther.\n292:960-967 (2000).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"300329_CR24","doi-asserted-by":"crossref","first-page":"32332","DOI":"10.1074\/jbc.273.48.32332","volume":"273","author":"M. Maccarone","year":"1998","unstructured":"M. Maccarone, M. van der Stelt, A. Rossi, G. A. Veldink, J. F. G. Vliegenthart, and A. F. Agr\u00f2. Anandamide hydrolysis by human cells in culture and brain. J. Biol. Chem.\n273:32332-32339 (1998).","journal-title":"J. Biol. Chem."},{"key":"300329_CR25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0021-5155(97)00050-6","volume":"41","author":"Y. Mikawa","year":"1997","unstructured":"Y. Mikawa, S. Matsuda, T. Kanagawa, T. Tajika, N. Ueda, and Y. Mimura. Ocular activity of topically administered anandamide in the rabbit. Jpn. J. Ophthalmol.\n41:217-220 (1997).","journal-title":"Jpn. J. Ophthalmol."},{"key":"300329_CR26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0026-895X(25)09876-1","volume":"34","author":"W. A. Devane","year":"1988","unstructured":"W. A. Devane, F. A. Dysarz III, M. R. Johnson, L. S. Melvin, and A. C. Howlett. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol.\n34:605-613 (1988).","journal-title":"Mol. Pharmacol."},{"key":"300329_CR27","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1073\/pnas.96.10.5802","volume":"96","author":"D. Piomelli","year":"1999","unstructured":"D. Piomelli, M. Beltramo, S. Glasnapp, S. Y. Lin, A. Goutopoulos, X.-Q. Xie, and A. Makriyannis. Structural determinants for recognition and translocation by the anandamide transporter. Proc. Natl. Acad. Sci. USA\n96:5802-5807 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"300329_CR28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","volume":"215","author":"T. Sugiura","year":"1995","unstructured":"T. Sugiura, S. Kondo, A. Sukagawa, S. Nakane, A. Shinoda, K. Itoh, A. Yamashita, and K. Waku. 2-Arachidonoylgylcerol: A possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun.\n215:89-97 (1995).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"300329_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0378-5173(97)00111-7","volume":"153","author":"P. Jarho","year":"1997","unstructured":"P. Jarho, K. J\u00e4rvinen, A. Urtti, V. J. Stella, and T. J\u00e4rvinen. The use of cyclodextrins in ophthalmic formulations of dipivefrin. Int. J. Pharm.\n153:225-233 (1997).","journal-title":"Int. J. Pharm."},{"key":"300329_CR30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-5173(90)90269-A","volume":"64","author":"H. W. Frijlink","year":"1990","unstructured":"H. W. Frijlink, A. C. Eissens, A. J. M. Schoonen, and C. F. Lerk. The effect of cyclodextrins on drug absorption. II. In vivo observation. Int. J. Pharm.\n64:195-205 (1990).","journal-title":"Int. J. Pharm."},{"key":"300329_CR31","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/jm980461j","volume":"42","author":"W. Lang","year":"1999","unstructured":"W. Lang, C. Qin, S. Lin, A. D. Khanolkar, A. Goutopoulos, P. Fan, K. Aboudzid, Z. Meng, D. Biegel, and A. Makriyannis. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. J. Med. Chem.\n42:896-902 (1999).","journal-title":"J. Med. Chem."},{"key":"300329_CR32","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1021\/jm960152y","volume":"39","author":"A. D. Khanolkar","year":"1996","unstructured":"A. D. Khanolkar, V. Abadji, S. Lin, A. G. Hill, G. Taha, K. Abouzid, Z. Meng, P. Fan, and A. Makriyannis. Head group analogs of arachidonyl-ethanolamide, the endogenous cannabinoid ligand. J. Med. Chem\n39:4515-4519 (1996).","journal-title":"J. Med. Chem"},{"key":"300329_CR33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0014-5793(98)01175-2","volume":"436","author":"V. Di Marzo","year":"1998","unstructured":"V. Di Marzo, T. Bisogno, D. Melck, R. Ross, H. Brockie, L. Stevenson, R. Pertwee, and L. De Petrocellis. Interactions between synthetic vanilloids and the endogenous cannabinoid system, FEBS Lett.\n436:449-454 (1998).","journal-title":"FEBS Lett."},{"key":"300329_CR34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(00)00207-7","volume":"396","author":"P. M. Zygmunt","year":"2000","unstructured":"P. M. Zygmunt, H. Chuang, P. Movahed, D. Julius, and E. D. H\u00f6gest\u00e4tt. The anandamide transport inhibitor AM404 activates vanilloid receptors, Eur. J. Pharmacol.\n396:39-42 (2000).","journal-title":"Eur. J. Pharmacol."},{"key":"300329_CR35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0165-6147(00)01459-0","volume":"21","author":"D. Smart","year":"2000","unstructured":"D. Smart and J. C. Jerman. Anandamide: an endogenous activator of the vanilloid receptor. Trends Pharmacol. Sci.\n21:134 (2000).","journal-title":"Trends Pharmacol. Sci."},{"key":"300329_CR36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1523\/JNEUROSCI.11-02-00563.1991","volume":"11","author":"M. Herkenham","year":"1991","unstructured":"M. Herkenham, A. B. Lynn, M. R. Johnson, L. S. Melvin, B. R. de Costa, and K. C. Rice. Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study. J. Neurosci.\n11:563-583 (1991).","journal-title":"J. Neurosci."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011058411804.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1011058411804\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011058411804.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:42:57Z","timestamp":1754034177000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1011058411804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["300329"],"URL":"https:\/\/doi.org\/10.1023\/a:1011058411804","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}