{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:28:49Z","timestamp":1773624529435,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1023\/a:1011987423502","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T06:29:09Z","timestamp":1040624949000},"page":"783-786","source":"Crossref","is-referenced-by-count":13,"title":["Glow Discharge Plasma Deposition (GDPD) Technique for the Local Controlled Delivery of Hirudin from Biomaterials"],"prefix":"10.1007","volume":"15","author":[{"given":"Dae-Duk","family":"Kirn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc M.","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddy D.","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Horbett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"suppl1","key":"303889_CR1","first-page":"11","volume":"21","author":"F. Markwardt","year":"1991","unstructured":"F. Markwardt. Past, present and future of hirudin. Haemost.\n21(suppl 1): 11\u201326 (1991).","journal-title":"Haemost."},{"key":"303889_CR2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0168-3659(95)00045-A","volume":"36","author":"R. J. Levy","year":"1995","unstructured":"R. J. Levy, V. Labhasetwar, C. Song, E. Lerner, W. Chen, N. Vyavahare, and X. Qu. Polymeric drug delivery systems for treatment of cardiovascular calcification, arrhythmias and restenosis. J. Control. Rel.\n36:137\u2013147 (1995).","journal-title":"J. Control. Rel."},{"key":"303889_CR3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1054-8807(96)00045-2","volume":"5","author":"D. D. Kim","year":"1996","unstructured":"D. D. Kim, T. A. Horbett, M. M. Takeno, and B. D. Ranter. Pharmacology and controlled release of hirudin for cardiovascular disorders. Cardiovas. Pathol.\n5:337\u2013349 (1996).","journal-title":"Cardiovas. Pathol."},{"key":"303889_CR4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jbm.820260402","volume":"26","author":"G. P. Lopez","year":"1992","unstructured":"G. P. Lopez, B. D. Ratner, C. D. Tidwell, C. L. Haycox, R. J. Rapoza, and T. A. Horbett. Glow discharge plasma deposition of tetraethylene glycol dimethyl ether for fouling-resistant biomaterial surfaces. J. Biomed. Mater. Res.\n26: 415\u2013439 (1992).","journal-title":"J. Biomed. Mater. Res."},{"key":"303889_CR5","first-page":"147","volume":"22","author":"M. M. Takeno","year":"1995","unstructured":"M. M. Takeno, T. A. Horbett, and B. D. Ratner. A novel matrix for the controlled release of the anti-thrombotic peptide, echistatin, Proc. Intern. Symp. Control. Rel. Bioact. Mater.\n22:147 (1995).","journal-title":"Proc. Intern. Symp. Control. Rel. Bioact. Mater."},{"key":"303889_CR6","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1002\/app.1986.070320407","volume":"32","author":"Y. Haque","year":"1986","unstructured":"Y. Haque and B. D. Ratner. Preparation and properties of plasma deposited films with surface energies varying over a wide range. J. Appl. Polym. Sci.\n32: 4369\u20134381 (1986).","journal-title":"J. Appl. Polym. Sci."},{"issue":"supple1","key":"303889_CR7","first-page":"36","volume":"21","author":"M. Spannagl","year":"1991","unstructured":"M. Spannagl, H. Bichler, H. Lill, and W. Shramm. A fast photometric assay for the determination of hirudin. Haemost.\n21(supple 1):36\u201340 (1991).","journal-title":"Haemost."},{"key":"303889_CR8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/B978-0-12-200430-8.50013-0","volume-title":"Plasma deposition, treatment and etching of polymers","author":"B. D. Ratner","year":"1990","unstructured":"B. D. Ratner, A. Chilkoti, and G. P. Lopez. Plasma deposition and treatment for biomedical application. In: Plasma deposition, treatment and etching of polymers. R. D'Agostino (ed.), Academic Press, San Diego, 1990, pp. 463\u2013516."},{"key":"303889_CR9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jps.2600690305","volume":"69","author":"W. D. Rhine","year":"1980","unstructured":"W. D. Rhine, D. S. T. Hsieh, and R. Langer. Polymers for sustained macromolecule release: Procedures to fabricate reproducible delivery systems and control release kinetics. J. Pharm. Sci.\n69:265\u2013270 (1980).","journal-title":"J. Pharm. Sci."},{"key":"303889_CR10","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1378\/chest.108.5.1409","volume":"108","author":"M. N. Ali","year":"1995","unstructured":"M. N. Ali, V. Levy, and A. I. Schafer. The role of thrombin and thrombin inhibitors in coronary angioplasty. Chest\n108:1409\u20131419 (1995).","journal-title":"Chest"},{"key":"303889_CR11","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/0735-1097(94)90616-5","volume":"23","author":"R. Riessen","year":"1994","unstructured":"R. Riessen and J. M. Isner. Prospects for site-specific delivery of pharmacologic and molecular therapies. J. Am. Coll. Cardiol.\n23:1234\u20131244 (1994).","journal-title":"J. Am. Coll. Cardiol."},{"key":"303889_CR12","first-page":"776","volume-title":"Textbook of Interventional Cardiology","author":"R. J. Levy","year":"1992","unstructured":"R. J. Levy. Pharmaceutic stents and regional therapy for restenosis. In E. J. Topol (2nd eds.), Textbook of Interventional Cardiology, Saunders, Philadelphia, 1992, pp. 776\u2013786.","edition":"2nd eds."},{"key":"303889_CR13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2007-1002602","volume":"17","author":"J. Fareed","year":"1991","unstructured":"J. Fareed, J. M. Walenga, D. Hoppensteadt, L. Lyer, and R. Pifarre. Neutralization of recombinant hirudin: Some practical considerations. Semin. Thromb. Hemost.\n17: 137\u2013144 (1991).","journal-title":"Semin. Thromb. Hemost."},{"issue":"suppl1","key":"303889_CR14","first-page":"11","volume":"21","author":"F. Markwardt","year":"1991","unstructured":"F. Markwardt. Past, present and future of hirudin. Haemost.\n21(suppl 1): 11\u201326 (1991).","journal-title":"Haemost."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011987423502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1011987423502\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011987423502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:35:20Z","timestamp":1754033720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1011987423502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["303889"],"URL":"https:\/\/doi.org\/10.1023\/a:1011987423502","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}