{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:06:40Z","timestamp":1754161600921,"version":"3.41.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1023\/a:1012330626600","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T07:43:55Z","timestamp":1040629435000},"page":"2325-2332","source":"Crossref","is-referenced-by-count":17,"title":["Familial Adenomatous Polyposis and Extracolonic Cancer"],"prefix":"10.1007","volume":"46","author":[{"given":"Henry T.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Thorson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney D.","family":"McComb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan T.","family":"Tinley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane F.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"362247_CR1","first-page":"801","volume":"36","author":"HT Lynch","year":"1999","unstructured":"Lynch HT, de la Chapelle A: Genetic susceptibility to nonpolyposis colorectal cancer. J Med Genet 36: 801\u2013818, 1999","journal-title":"J Med Genet"},{"key":"362247_CR2","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.34.10.1394","volume":"34","author":"FM Giardiello","year":"1993","unstructured":"Giardiello FM, Offerhaus GJ, Lee DH, Krush AJ, Tersmette AC, Booker, SV, Kelley NC, Hamilton SR: Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis.Gut 34: 1394\u20131396, 1993","journal-title":"Gut"},{"key":"362247_CR3","first-page":"1","volume":"34","author":"S Bulow","year":"1987","unstructured":"Bulow S: Familial polyposis coli. Dan Med Bull 34: 1\u201315, 1987","journal-title":"Dan Med Bull"},{"key":"362247_CR4","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1056\/NEJM199312303292702","volume":"329","author":"SM Powell","year":"1993","unstructured":"Powell SM, Petersen GM, Krush AJ, Booker S, Jen J, Giardiello FM, Hamilton SR, Vogelstein B, Kinzler KW: Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 329: 1982\u20131987, 1993","journal-title":"N Engl J Med"},{"key":"362247_CR5","volume-title":"Familial Polyposis Coli: Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment","author":"HJR Bussey","year":"1975","unstructured":"Bussey HJR: Familial Polyposis Coli: Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment. Baltimore, Johns Hopkins University Press, 1975"},{"key":"362247_CR6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/jmg.30.8.675","volume":"30","author":"ER Maher","year":"1993","unstructured":"Maher ER, Barton DE, Slatter R, Koch DJ, Jones MH, Nagase H, Payne SJ, Charles SJ, Moore AT, Nakamura Y: Evaluation of molecular genetic diagnosis in the management of familial adenomatous polyposis coli: A population based study.J Med Genet 30: 675\u2013678, 1993","journal-title":"J Med Genet"},{"key":"362247_CR7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/BF02048164","volume":"37","author":"HT Lynch","year":"1994","unstructured":"Lynch HT, Fitzgibbons R Jr, Chong S, Cavalieri J, Lynch J, Wallace F, Patel S: Use of doxorubicin and dacarbazine for the management of unresectable intra-abdominal desmoid tumors in Gardner' syndrome. Dis Colon Rectum 37: 260\u2013267, 1994","journal-title":"Dis Colon Rectum"},{"key":"362247_CR8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02360076","volume":"20","author":"H Luschka","year":"1861","unstructured":"Luschka H: Ueber polypose Vegetationen der gesammten Dickdarmschleimhaut. Arch Pathol Anat Physiol Klin Med 20: 133\u2013142, 1861","journal-title":"Arch Pathol Anat Physiol Klin Med"},{"key":"362247_CR9","first-page":"55","volume":"2","author":"NV Sklifosovski","year":"1881","unstructured":"Sklifosovski NV: Polyadenoma tractus intestinalis. Vrach 2:55\u201357, 1881","journal-title":"Vrach"},{"key":"362247_CR10","first-page":"165","volume":"33","author":"WH Cripps","year":"1882","unstructured":"Cripps WH: Two cases of disseminated polyps of the rectum. Trans Pathol Soc London 33: 165\u2013168, 1882","journal-title":"Trans Pathol Soc London"},{"key":"362247_CR11","first-page":"225","volume":"23","author":"T Smith","year":"1887","unstructured":"Smith T: Three cases of multiple polypi of the lower bowel occurring in one family. St Bartholomew' Hosp Rep 23: 225\u2013229, 1887","journal-title":"St Bartholomew' Hosp Rep"},{"key":"362247_CR12","first-page":"133","volume":"41","author":"H Handford","year":"1890","unstructured":"Handford H: Disseminated polypi of the large intestine becoming malignant: Strictures (malignant adenoma) of the rectum and of the splenic flexure of the colon; secondary growths in the liver. Trans Pathol Soc London 41: 133\u2013137, 1890","journal-title":"Trans Pathol Soc London"},{"key":"362247_CR13","doi-asserted-by":"crossref","unstructured":"Lockhart-Mummery P: Cancer and heredity. Lancet i: 427\u2013429, 1925","DOI":"10.1016\/S0140-6736(00)95996-8"},{"key":"362247_CR14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.1320250309","volume":"25","author":"L Herrera","year":"1986","unstructured":"Herrera L, Kakati S, Gibas L, Pietrzak E, Sandberg AA. Gardner syndrome in a man with an interstitial deletion of 5q. Am J Med Genet 25: 473\u2013476, 1986","journal-title":"Am J Med Genet"},{"key":"362247_CR15","first-page":"614","volume":"328","author":"WF Bodmer","year":"1987","unstructured":"Bodmer WF, Bailey CJ, Bodmer J, Bussey HJR, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, Sheer D, Solomon E, Spurr NK: Localization of the gene for familial adenomatous polyposis on chromosome 5. 328: 614\u2013616, 1987","journal-title":"Localization of the gene for familial adenomatous polyposis on chromosome 5"},{"key":"362247_CR16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1126\/science.3479843","volume":"238","author":"M Leppert","year":"1987","unstructured":"Leppert M, Dobbs M, Scambler P, O'Connell P, Nakamura Y, Stauffer D, Woodward S, Burt R, Hughes J, Gardner E, Lathrop M, Wasmuth J, Lalonel J-M, White R: The gene for familial polyposis coli maps to the long arm of chromosome 5. Science 238: 1411\u20131413, 1987","journal-title":"Science"},{"key":"362247_CR17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/BF02150736","volume":"33","author":"ML Arvanitis","year":"1990","unstructured":"Arvanitis ML, Jagelman DG, Fazio VN, Lavery IC, McGannon E: Mortality in patients with familial adenomatous polyposis. Dis Colon Rectum 33: 639\u2013642, 1990","journal-title":"Dis Colon Rectum"},{"key":"362247_CR18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng0997-79","volume":"17","author":"SJ Laken","year":"1997","unstructured":"Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, Vogelstein B: Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 17: 79\u201383, 1997","journal-title":"Nat Genet"},{"key":"362247_CR19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1086\/302262","volume":"64","author":"R Gryfe","year":"1999","unstructured":"Gryfe R, Di Nicola N, Lal G, Gallinger S, Redston M: Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. Am J Hum Genet 64: 378\u2013384, 1999","journal-title":"Am J Hum Genet"},{"key":"362247_CR20","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1002\/1097-0142(19951215)76:12<2427::AID-CNCR2820761205>3.0.CO;2-B","volume":"76","author":"HT Lynch","year":"1995","unstructured":"Lynch HT, Smyrk T, McGinn T, Lanspa S, Cavalieri J, Lynch J, Slominski-Caster S, Cayouette MC, Priluck I, Luce MC: Attenuated familial adenomatous polyposis (AFAP): A phenotypically and genotypically distinctive variant of FAP. Cancer 76: 2427\u20132433, 1995","journal-title":"Cancer"},{"key":"362247_CR21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/gut.43.4.451a","volume":"43","author":"HT Lynch","year":"1998","unstructured":"Lynch HT, Watson P: AFAP: variety is the spice of life. Gut 43:451\u2013452, 1998","journal-title":"Gut"},{"key":"362247_CR22","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199503303321302","volume":"332","author":"SR Hamilton","year":"1995","unstructured":"Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM, Krush AJ, Bert T, Cohen Z, Tetu B, Burger PC, Wood PA, Taqi F, Booker SV, Petersen GM, Offerhaus GJA, Tersmette AC, Giardiello FM, Vogelstein B, Kinzler KW: The molecular basis of Turcot' syndrome. N Engl J Med 332:839\u2013847, 1995","journal-title":"N Engl J Med"},{"key":"362247_CR23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/030089169908500106","volume":"85","author":"S Presciuttini","year":"1999","unstructured":"Presciuttini S, Gismondi V, Scarcello E, Sala P, D'Elia F, Rossetti C, Caroti-Ghelli C, Molina F, Groden J, Mosca F, Bertario L, Varesco L: Different expressivity of two adjacent mutations of the APC gene. Tumori 85: 28\u201331, 1999","journal-title":"Tumori"},{"key":"362247_CR24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/hmg\/4.3.337","volume":"4","author":"R Caspari","year":"1995","unstructured":"Caspari R, Olschwang S, Friedl W, Mandl M, Boisson C, B\u00d6ker T, Augustin A, Kadmon M, M\u00d6slein G, Thomas G, Propping P: Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. Hum Mol Genet 4: 337\u2013340, 1995","journal-title":"Hum Mol Genet"},{"key":"362247_CR25","first-page":"4055","volume":"52","author":"H Nagase","year":"1992","unstructured":"Nagase H, Miyoshi Y, Horii A, Ogawa M, Utsunomiya J, Baba S, Sasazuki T, Nakamura Y: Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res 52: 4055\u20134057, 1992","journal-title":"Cancer Res"},{"key":"362247_CR26","first-page":"2598","volume":"91","author":"HT Lynch","year":"1996","unstructured":"Lynch HT, Fitzgibbons R Jr: Surgery, desmoid tumors and familial adenomatous polyposis: Case report and literature review. Am J Gastroenterol 91: 2598\u20132601, 1996","journal-title":"Am J Gastroenterol"},{"key":"362247_CR27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJM199703203361202","volume":"336","author":"FM Giardiello","year":"1997","unstructured":"Giardiello FM, Brensinger JD, Petersen GM, Luce MC, Hylind LM, Bacon JA, Booker SV, Parker RD, Hamilton SR: The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med 336: 823\u2013827, 1997","journal-title":"N Engl J Med"},{"key":"362247_CR28","first-page":"251","volume":"92","author":"SM Powell","year":"1998","unstructured":"Powell SM: Direct analysis for familial adenomatous polyposis mutations. Methods Mol Biol 92: 251\u2013266, 1998","journal-title":"Methods Mol Biol"},{"key":"362247_CR29","first-page":"850","volume":"31","author":"M Ponz de Leon","year":"1999","unstructured":"Ponz de Leon M, Benatti P, Percesepe A, Cacciatore A, Sassatelli R, Bertoni G, Sabadini G, Varesco L, Gismondi V, Mareni C, Montera M, Di Gregorio C, Landi P, Roncucci L: Clinical features and genotype-phenotype correlations in 41 Italian families with adenomatous coli. Ital J Gastroenterol Hepatol 31: 850\u2013860, 1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"362247_CR30","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1086\/301883","volume":"62","author":"C Soravia","year":"1998","unstructured":"Soravia C, Berk T, Madlensky L, Mitri A, Cheng H, Gallinger S, Cohen Z, Bapat B: Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 62: 1290\u20131301, 1998 LYNCH ET AL 2332 Digestive Diseases and Sciences, Vol. 46, No. 11 (November 2001)","journal-title":"Am J Hum Genet"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1012330626600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1012330626600\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1012330626600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T03:27:31Z","timestamp":1753759651000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1012330626600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["362247"],"URL":"https:\/\/doi.org\/10.1023\/a:1012330626600","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}