{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:33:40Z","timestamp":1761057220135,"version":"3.41.2"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1023\/a:1012371702918","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T07:43:55Z","timestamp":1040629435000},"page":"2445-2450","source":"Crossref","is-referenced-by-count":30,"title":["Clarithromycin Resistance, but Not CYP2C-19 Polymorphism, Has a Major Impact on Treatment Success in 7-Day Treatment Regimen for Cure of H. pylori Infection: A Multiple Logistic Regression Analysis"],"prefix":"10.1007","volume":"46","author":[{"given":"Hiroto","family":"Miwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ohtaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"362267_CR1","first-page":"10","volume":"35","author":"S Hoshiya","year":"2000","unstructured":"Hoshiya S, Watanabe K, Tokunaga K, et al: Relationship between eradication therapy and clarithromycin-resistant Helicobacter pylori in Japan. J Gastroenterol 35:10\u201314, 2000","journal-title":"J Gastroenterol"},{"key":"362267_CR2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1523-5378.1999.99299.x","volume":"4","author":"T Kamada","year":"1999","unstructured":"Kamada T, Haruma K, Komoto K, et al: Effect of smoking and histological gastritis severity on the rate of H. pylori eradication with omeprazole, amoxicillin, and clarithromycin. Helicobacter 4:204\u2013210, 1999","journal-title":"Helicobacter"},{"key":"362267_CR3","first-page":"A1639","volume":"93","author":"JQ Huang","year":"1998","unstructured":"Huang JQ, Hunt RH. Are one-week anti-H. pylori treatments more effective an patients with peptic ulcer disease (PUD) than in those with non-ulcer dyspepsia (NUD)? Am J Gatroenterol 93:A1639, 1998","journal-title":"Am J Gatroenterol"},{"key":"362267_CR4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.36.6.845","volume":"36","author":"M Moshkowitz","year":"1995","unstructured":"Moshkowitz M, Konikoff FM, Peled Y, et al: High Helicobacter pylori numbers are associated with low eradication rate after triple therapy. Gut 36:845\u2013847, 1995","journal-title":"Gut"},{"issue":"suppl1","key":"362267_CR5","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1097\/00004836-199800001-00030","volume":"27","author":"M Suzuki","year":"1998","unstructured":"Suzuki M, Kitahora T, Nagahashi S, et al: Gastric urease activity is inversely associated with the success of treatment for Helicobacter pylori: Effect of sofalcone. J Clin Gastroenterol 27(suppl 1):S183\u2013S186, 1998","journal-title":"J Clin Gastroenterol"},{"key":"362267_CR6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0016-5107(96)70052-4","volume":"44","author":"BS Sheu","year":"1996","unstructured":"Sheu BS, Yang HB, Su IJ, et al: Bacterial density of Helicobacter pylori predicts the success of triple therapy in bleeding duodenal ulcer. Gastrointest Endosc 44:683\u2013688, 1996","journal-title":"Gastrointest Endosc"},{"key":"362267_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF01213292","volume":"32","author":"P Moayyedi","year":"1997","unstructured":"Moayyedi P, Chalmers DM, Axon AT: Patient factors that predict failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. J Gastroenterol 32:24\u201327, 1997","journal-title":"J Gastroenterol"},{"key":"362267_CR8","first-page":"185","volume":"22","author":"CA Fallone","year":"1999","unstructured":"Fallone CA, Loo V, Joseph L, et al: Predictors of failure of Helicobacter pylori eradication and predictors of ulcer recurrence: A randomized controlled trial. Clin Invest Med 22:185\u2013194, 1999","journal-title":"Clin Invest Med"},{"key":"362267_CR9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/PL00009980","volume":"35","author":"T Fujioka","year":"2000","unstructured":"Fujioka T: Clarithromycin resistance in Helicobacter pylori: Implication for therapy. J Gastroenterol 35:69\u201370, 2000","journal-title":"J Gastroenterol"},{"key":"362267_CR10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0016-5085(99)70119-8","volume":"116","author":"T Lind","year":"1999","unstructured":"Lind T, Megraud F, Unge P, et al: The MACH2 study: Role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies. Gastroenterology 116:248\u2013253, 1999","journal-title":"Gastroenterology"},{"key":"362267_CR11","first-page":"A222","volume":"112","author":"H Miyaji","year":"1997","unstructured":"Miyaji H, Ito S, Azuma T, et al: The prevalence of the drug resistance in Helicobacter pylori and the effects of the resistance on the eradication therapy in Japan. Gastroenterology 112:A222, 1997","journal-title":"Gastroenterology"},{"key":"362267_CR12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1523-5378.1997.tb00085.x","volume":"2","author":"DS Tompkins","year":"1997","unstructured":"Tompkins DS, Perkin J, Smith C. Failed treatment of Helicobacter pylori infection associated with resistance to clarithromycin. Helicobacter 2:185\u2013187, 1997","journal-title":"Helicobacter"},{"key":"362267_CR13","first-page":"1860","volume":"88","author":"WL Peterson","year":"1993","unstructured":"Peterson WL, Graham DY, Marshall B, et al: Clarithromycin as monotherapy for eradication of Helicobacter pylori: A randomized, double-blind trial. Am J Gastroenterol 88:1860\u20131864, 1993","journal-title":"Am J Gastroenterol"},{"key":"362267_CR14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/gut.35.3.323","volume":"35","author":"RP Logan","year":"1994","unstructured":"Logan RP, Gummett PA, Schaufelberger HD, et al: Eradication of Helicobacter pylori with clarithromycin and omeprazole. Gut 35:323\u2013326, 1994","journal-title":"Gut"},{"key":"362267_CR15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1523-5378.1999.99278.x","volume":"4","author":"P Vincent","year":"1999","unstructured":"Vincent P, Michaud L, Martin de Lasalle E, et al: 13C-urea breath test and gastric mucosal colonization by Helicobacter pylori in children: Quantitative relation and usefulness for diagnosis of infection. Helicobacter 4:233\u2013237, 1999","journal-title":"Helicobacter"},{"key":"362267_CR16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.7326\/0003-4819-129-12-199812150-00006","volume":"129","author":"T Furuta","year":"1998","unstructured":"Furuta T, Ohashi K, Kamata T, et al: Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 129:1027\u20131030, 1998","journal-title":"Ann Intern Med"},{"key":"362267_CR17","first-page":"S43","volume":"suppl223","author":"RE Pounder","year":"1997","unstructured":"Pounder RE: New developments in Helicobacter pylori eradication therapy. Scand J Gastroenterol (suppl 223):S43\u2013S45, 1997","journal-title":"Scand J Gastroenterol"},{"key":"362267_CR18","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/S0016-5085(97)80027-3","volume":"113","author":"P. Unge","year":"1997","unstructured":"Unge P. What other regimens are under investigation to treat Helicobacter pylori infection? Gastroenterology 113:S131\u2013S148, 1997","journal-title":"Gastroenterology"},{"key":"362267_CR19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0009-9236(96)90214-3","volume":"60","author":"T Kubota","year":"1996","unstructured":"Kubota T, Chiba K, Ishizaki T: Genotyping of S-mephenytoin 4_-hydroxylation in an extended Japanese population. Clin Pharmacol Ther 60:661\u2013666, 1996","journal-title":"Clin Pharmacol Ther"},{"key":"362267_CR20","doi-asserted-by":"crossref","first-page":"15419","DOI":"10.1016\/S0021-9258(17)40694-6","volume":"269","author":"SM De Morais","year":"1994","unstructured":"De Morais SM, Wilkinson GR, Blaisdell J, et al: The major genetic defect responsible for the polymorphism of Smephenytoin metabolism in humans. J Biol Chem 269:15419\u201315422, 1994","journal-title":"J Biol Chem"},{"key":"362267_CR21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0026-895X(25)09788-3","volume":"46","author":"SM De Morais","year":"1994","unstructured":"De Morais SM, Wilkinson GR, Blaisdell J, et al: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 46:594\u2013598, 1994","journal-title":"Mol Pharmacol"},{"key":"362267_CR22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1523-5378.1997.tb00063.x","volume":"2","author":"H Miwa","year":"1997","unstructured":"Miwa H, Murai T, Ohkura R, et al: Effect of fasting subjects' posture in 13C urea breath test for detection of Helicobacter pylori infection withy fasting subjects. Helicobacter 2:82\u201385, 1997","journal-title":"Helicobacter"},{"issue":"10","key":"362267_CR23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1440-1746.1998.tb00567.x","volume":"13","author":"H Miwa","year":"1998","unstructured":"Miwa H, Murai T, Ohkura R, et al: Usefulness of 13C urea breath test for detection of H. pylori infection in fasting patients. J Gastroenterol Hepatol 13(10):1039\u20131043, 1998","journal-title":"J Gastroenterol Hepatol"},{"key":"362267_CR24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1440-1746.1999.01867.x","volume":"14","author":"H Miwa","year":"1999","unstructured":"Miwa H, Nagahara A, Sato K, et al: Efficacy of 1 week PPI\/AC therapy for H. pylori infection in the Japanese population. J Gastroenterol Hepatol 14:317\u2013321, 1999","journal-title":"J Gastroenterol Hepatol"},{"key":"362267_CR25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1523-5378.1998.08041.x","volume":"3","author":"H Miwa","year":"1998","unstructured":"Miwa H, Ohkura R, Murai T, et al. Effectiveness of OAC therapy for H. pylori infection in Japanese population, Helicobacter 3:132\u2013138, 1998","journal-title":"Helicobacter"},{"key":"362267_CR26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1365-2036.1999.00526.x","volume":"13","author":"H Miwa","year":"1999","unstructured":"Miwa H, Ohkura R, Murai T, et al: Impact of rabeprazole, a new proton pump inhibitor, in PPI\/AC therapy for Helicobacter pylori infection-comparison with omeprazole and lansoprazole. Aliment Pharmacol Ther 13:741\u2013746, 1999","journal-title":"Aliment Pharmacol Ther"},{"key":"362267_CR27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0016-5085(92)90095-G","volume":"102","author":"DY Graham","year":"1992","unstructured":"Graham DY, Lew GM, Malaty HM, et al: Factors influencing the eradication of Helicobacter pylori with triple therapy. Gastroenterology 102:493\u2013496, 1992","journal-title":"Gastroenterology"},{"key":"362267_CR28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0009-9236(96)90004-1","volume":"59","author":"I Ieiri","year":"1996","unstructured":"Ieiri I, Kubota T, Urae A, et al: Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4, in Japanese subjects. Clin Pharmacol Ther 59:647\u2013653, 1996","journal-title":"Clin Pharmacol Ther"},{"key":"362267_CR29","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1046\/j.1365-2036.11.s1.4.x","volume":"11","author":"WL Peterson","year":"1997","unstructured":"Peterson WL: The role of antisecretory drugs in the treatment of Helicobacter infection. Aliment Pharmacol Ther 11 (suppl): S21\u2013S25, 1997","journal-title":"Aliment Pharmacol Ther"},{"key":"362267_CR30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/jcp.51.3.220","volume":"51","author":"F Mirshahi","year":"1998","unstructured":"Mirshahi F, Fowler G, Patel A, et al: Omeprazole may exert both a bacteriostatic and a bacteriocidal effect on the growth of Helicobacter pylori (NCTC 11637) in vitro by inhibiting bacterial urease activity. J Clin Pathol 51:220\u2013224, 1998","journal-title":"J Clin Pathol"},{"key":"362267_CR31","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s005350070077","volume":"35","author":"H Miwa","year":"2000","unstructured":"Miwa H, Murai T, Sato K, et al: Comparison of the efficacy of 400 mg and 800 mg of clarithromycin used with lansoprazole and amoxicillin in eradication regimens for H. pylori infection in Japanese population. J Gastroenterol 35:536\u2013539, 2000","journal-title":"J Gastroenterol"},{"key":"362267_CR32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0021-5198(19)48734-9","volume":"58","author":"K Chiba","year":"1992","unstructured":"Chiba K, Kusaka M, Ishibashi T, et al: Interethnic differences in genetic polymorphism of mephenytoin hydroxylation among four oriental populations. Jpn J Pharmacol 58:78, 1992","journal-title":"Jpn J Pharmacol"},{"key":"362267_CR33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2125.1985.tb02673.x","volume":"19","author":"M Jurima","year":"1985","unstructured":"Jurima M, Inaba T, Kadar D, et al: Genetic polymorphism of mephenyton p(4)-hydroxylation: Difference between orientals and Caucasians. Br J Clin Pharmacol 19:483\u2013487, 1985","journal-title":"Br J Clin Pharmacol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1012371702918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1012371702918\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1012371702918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T04:00:18Z","timestamp":1753761618000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1012371702918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["362267"],"URL":"https:\/\/doi.org\/10.1023\/a:1012371702918","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}