{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:33:07Z","timestamp":1758634387501,"version":"3.43.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1023\/a:1013301620904","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T16:46:14Z","timestamp":1040661974000},"page":"29-37","source":"Crossref","is-referenced-by-count":17,"title":["Chiral Inversion of (R)-Ketoprofen: Influence of Age and Differing Physiological Status in Dairy Cattle"],"prefix":"10.1007","volume":"26","author":[{"given":"L.","family":"Igarza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Soraci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Auza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zeballos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"397036_CR1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/chir.530070513","volume":"7","author":"G. Aberg","year":"1995","unstructured":"Aberg, G., Ciofalo, V.B. and Pendleton, R., 1995. Inversion of R to S ketoprofen in eight animal species. Chirality, 7, 383-387","journal-title":"Chirality"},{"key":"397036_CR2","first-page":"144","volume-title":"The Basics of Veterinary Clinical Pharmacology","author":"D. Baggot","year":"1977","unstructured":"Baggot, D., 1977. Principles of drug disposition in domestic animals. In: The Basics of Veterinary Clinical Pharmacology, (WB Saunders, Philadelphia), 144-189"},{"key":"397036_CR3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1079\/PNS19960010","volume":"55","author":"D. Bauchart","year":"1996","unstructured":"Bauchart, D., Gruffat, D. and Durand, D., 1996. Lipid absorption and hepatic metabolism in ruminants. Proceedings of the Nutrition Society, 55, 39-47","journal-title":"Proceedings of the Nutrition Society"},{"key":"397036_CR4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0006-2952(98)00342-6","volume":"57","author":"G.S. Browne","year":"1999","unstructured":"Browne, G.S., Nelson, C., Nguyen, T., Ellis, B.A., Day, R.O. and Williams, K.M., 1999. Stereoselective and substrate-dependent inhibition of hepatic mitochondrial \u03b2-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and ketorolac. Biochemical Pharmacology, 57, 837-844","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/(SICI)1520-636X(1996)8:2<163::AID-CHIR1>3.0.CO;2-K","volume":"8","author":"A. Carabaza","year":"1996","unstructured":"Carabaza, A., Suesa, N., Tost, D., Pascual, J., Gomez, M., Gutierrez, M., Ortega, E., Montserrat, X., Garcia, A.M., Mis, R., Cabre, F., Mauleon, D. and Carganico, G., 1996. Stereoselective metabolic pathways of ketoprofen in the rat: incorporation into triacylglycerols and enantiomeric inversion. Chirality, 8, 163-172","journal-title":"Chirality"},{"key":"397036_CR6","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/0006-2952(83)90107-7","volume":"32","author":"J. Caldwell","year":"1983","unstructured":"Caldwell, J. and Marsh, M.V., 1983. Interrelationships between xenobiotic metabolism and lipid biosynthesis. Biochemical Pharmacology, 32, 1667-1672","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0006-2952(88)90762-9","volume":"37","author":"J. Caldwell","year":"1988","unstructured":"Caldwell, J., Hutt, A.J. and Fournel-Gigleux, S., 1988. The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences. Biochemical Pharmacology, 37, 105-114","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1051\/rnd:19870301","volume":"27","author":"Y. Chilliard","year":"1987","unstructured":"Chilliard, Y., 1987. Revue Bibliograhique: Variations quantitatives et m\u00e8tabolisme des lipides dans les tissus adipeux et le foie au cours du cycle gestation-lactation. 2e partie: chez la brebis et la vache. Reproduction Nutrition et D\u00e9v\u00e9loppement, 27, 327-398","journal-title":"Reproduction Nutrition et D\u00e9v\u00e9loppement"},{"key":"397036_CR9","first-page":"81","volume":"63","author":"Y. Chilliard","year":"1986","unstructured":"Chilliard, Y., Morand-Fehr, P., Sauvant, D. and Bas, P., 1986. Utilisation m\u00e9tabolique des lipides par le ruminant en lactation. Bulletin de Technologie CRZV Theix InRA, 63, 81-91","journal-title":"Bulletin de Technologie CRZV Theix InRA"},{"key":"397036_CR10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0022-3565(25)20910-7","volume":"232","author":"J.W. Cox","year":"1985","unstructured":"Cox, J.W., Cox, S.R., Vangiessen, G. and Ruwart, M.J., 1985. Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver. Journal of Pharmacology and Experimental Therapeutics, 232, 636-6443","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"397036_CR11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2460\/ajvr.1996.57.07.1031","volume":"57","author":"F.J. DeGraves","year":"1996","unstructured":"DeGraves, F.J., Riddell, M. and Schumacher, J., 1996. Ketoprofen concentrations in plasma and milk after intravenous administration in dairy cattle. American Journal of Veterinary Research, 57, 1031-1033","journal-title":"American Journal of Veterinary Research"},{"key":"397036_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0163-7827(95)00007-M","volume":"34","author":"P.F. Dodds","year":"1995","unstructured":"Dodds, P.F., 1995. Xenobiotic lipids: the inclusion of xenobiotic compounds in pathways of lipid biosynthesis. Progress in Lipid Research, 34, 219-247","journal-title":"Progress in Lipid Research"},{"key":"397036_CR13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-2275(20)41570-6","volume":"19","author":"R Fears","year":"1978","unstructured":"Fears R, Baggaley, K.H., Alexander, R., Morgan, B. and Hindley, R.M., 1978. The participation of ethyl 4-benzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism. Journal of Lipid Research, 19, 3-11","journal-title":"Journal of Lipid Research"},{"key":"397036_CR14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0378-4347(87)80525-X","volume":"416","author":"R.T. Foster","year":"1987","unstructured":"Foster, R.T. and Jamali, F., 1987. High performance chromatographic assay of ketoprofen enantiomers in human plasma and urine. Journal of Chromatography, 416, 338-393","journal-title":"Journal of Chromatography"},{"key":"397036_CR15","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.3168\/jds.S0022-0302(93)77729-2","volume":"76","author":"R.R. Grummer","year":"1992","unstructured":"Grummer, R.R., 1992. Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Dairy Science, 76, 3882-3896","journal-title":"Journal of Dairy Science"},{"key":"397036_CR16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/chir.530040604","volume":"4","author":"S.D. Hall","year":"1992","unstructured":"Hall, S.D., Hassanzadeh-Khayyat, M., Knalder, M.P. and Mayer, P.R., 1992. Pulmonary inversion of 2-arylpropionic acids: influence of protein binding. Chirality, 4, 349-352","journal-title":"Chirality"},{"key":"397036_CR17","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1439-0442.1996.tb00491.x","volume":"43","author":"P. Holstenius","year":"1996","unstructured":"Holstenius, P. and Holstenius, K., 1996. New aspects of ketone bodies in energy metabolism of dairy cows. A review. Journal of the Veterinary Medical Association, 43, 579-587","journal-title":"Journal of the Veterinary Medical Association"},{"key":"397036_CR18","first-page":"273","volume-title":"Conjugation Reactions in Drug Metabolism","author":"A.J. Hutt","year":"1990","unstructured":"Hutt, A.J. and Caldwell, J., 1990. Amino acid conjugation. In: G.J. Mulder (ed.), Conjugation Reactions in Drug Metabolism, (Taylor and Francis, London), 273-305"},{"key":"397036_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03189920","volume":"13","author":"F. Jamali","year":"1988","unstructured":"Jamali, F., 1988. Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs. European Journal of Drug Metabolism, 13, 1-9","journal-title":"European Journal of Drug Metabolism"},{"key":"397036_CR20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.2042-7158.1991.tb03464.x","volume":"43","author":"P. Jeffrey","year":"1991","unstructured":"Jeffrey, P., Tucker, G.T., Bye, A., Crewe, H.K. and Wright, P.A., 1991. The site of inversion of R-(\u2212)-ibuprofen: studies using rat in situ perfused rat liver. Journal of Pharmacy and Pharmacology, 43, 715-720","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"397036_CR21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1440-1681.1998.tb02152.x","volume":"25","author":"K.M. Knights","year":"1998","unstructured":"Knights, K.M., 1998. Role of hepatic fatty acid:coenzyme a ligases in the metabolism of xenobiotic carboxylic acids. Clinical and Experimental Pharmacology and Physiology, 25, 776-782","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"397036_CR22","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/0006-2952(92)90689-G","volume":"44","author":"K.M. Knights","year":"1992","unstructured":"Knights, K.M., Talbot, U.M. and Baillie, T.A., 1992. Evidence of multiple forms of rat liver microsomal coenzyme A ligase catalysing the formation of 2-arylpropionyl-coenzyme A thioesters. Biochemical Pharmacology, 44, 2415-2417","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2885.1995.tb00597.x","volume":"18","author":"M.F. Landoni","year":"1995","unstructured":"Landoni, M.F., Cunningham, F.M. and Lees, P., 1995. Pharmacokinetics and pharmacodynamics of ketoprofen in calves applying PK\/PD modelling. Journal of Veterinary Pharmacology and Therapeutics, 18, 315-324","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"issue":"supplement5","key":"397036_CR24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2165\/00003495-199600525-00005","volume":"52","author":"D. Maule\u00f3n","year":"1996","unstructured":"Maule\u00f3n, D., Artigas, R., Garcia, M.L. and Carganico, G., 1996. Preclinical and clinical development of dexketoprofen. Drugs, 52(supplement 5), 24-46","journal-title":"Drugs"},{"key":"397036_CR25","first-page":"197","volume":"2","author":"J.M. Mayer","year":"1990","unstructured":"Mayer, J.M., 1990. Stereoselective metabolism of anti-inflammatory 2-arylpropionates. Acta Pharmacologica Nordica, 2, 197-216","journal-title":"Acta Pharmacologica Nordica"},{"key":"397036_CR26","first-page":"59","volume":"16","author":"J.M. Mayer","year":"1994","unstructured":"Mayer, J.M., Roy-De Vos, M., Audergon, C., Testa, B. and Etter, J.C., 1994. Interactions of anti-inflammatory 2-arylpropionates (profens) with the metabolism of fatty acids: in vitro studies. International Journal of Tissue Reactions \u2014 Experimental and Clinical Aspects, 16, 59-72","journal-title":"International Journal of Tissue Reactions \u2014 Experimental and Clinical Aspects"},{"key":"397036_CR27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1023\/A:1015979915771","volume":"5","author":"R. Mehvar","year":"1988","unstructured":"Mehvar, R. and Jamali, F., 1988. Pharmacokinetic analysis of enantiomeric inversion of chiral nonsteroidal anti-inflammatory drugs. Pharmaceutical Research, 5, 76-79","journal-title":"Pharmaceutical Research"},{"key":"397036_CR28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/0006-2952(94)90380-8","volume":"48","author":"S. Menzel","year":"1994","unstructured":"Menzel, S., Waibel, R., Brune, K. and Geisslinger, G., 1994. Is the formation of R-ibuprophenyl-adenylate the first stereoselective step in chiral inversion? Biochemical Pharmacology, 48, 1056-1058","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR29","doi-asserted-by":"crossref","first-page":"S-1","DOI":"10.1248\/bpb1978.4.1","volume":"4","author":"Y. Nakamura","year":"1981","unstructured":"Nakamura, Y., Yamaguchi, T. and Takahashi, S., 1981. Optical isomerisation mechanism of R (\u2212) hydratropic acid derivatives. Journal of Pharmacobio Dynamics, 4, S-1","journal-title":"Journal of Pharmacobio Dynamics"},{"key":"397036_CR30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0090-9556(25)07996-6","volume":"11","author":"K.S. Pang","year":"1983","unstructured":"Pang, K.S. and Kwan, K.C., 1983. A commentary: methods and assumptions in the kinetic estimation of metabolite formation. Drug Metabolism and Disposition, 11, 79-84","journal-title":"Drug Metabolism and Disposition"},{"key":"397036_CR31","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/0006-2952(88)90537-0","volume":"37","author":"B.C. Sallustio","year":"1988","unstructured":"Sallustio, B.C., Meffin, P.J. and Knights, M., 1988. The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglicerols. Biochemical Pharmacology, 37, 1919-1923","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1432-1033.1993.tb18181.x","volume":"216","author":"K. Schoonjans","year":"1993","unstructured":"Schoonjans, K., Staels, B., Grimaldi, P. and Auwerx, J., 1993. Acyl-CoA synthetase nRNA expression is controlled by fibric, feeding and liver proliferation. European Journal of Biochemistry, 216, 615-622","journal-title":"European Journal of Biochemistry"},{"key":"397036_CR33","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0022-3565(25)38854-3","volume":"269","author":"M. Shirley","year":"1994","unstructured":"Shirley, M., Guan, X., Kaise, D., Halsted, G.W. and Baillie, T.A., 1994. Taurine conjugation of ibuprofen in human and rat liver in vitro. Relationship to metabolic chiral inversion. Journal of Pharmacology and Experimental Therapeutics, 269, 1166-1175","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"397036_CR34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/chir.530070707","volume":"7","author":"A. Soraci","year":"1995","unstructured":"Soraci, A. and Benoit, E., 1995. In vitro fenoprophenyl-coenzyme A thioester formation: interspecies variations. Chirality, 7, 534-540","journal-title":"Chirality"},{"key":"397036_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2885.1995.tb00574.x","volume":"18","author":"A. Soraci","year":"1995","unstructured":"Soraci, A., Benoit, E. and Delatour, P., 1995. Comparative metabolism of R(\u2212)-fenoprofen in rats and sheep. Journal of Veterinary Pharmacology and Therapeutics, 18, 1-5","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"397036_CR36","first-page":"13","volume":"27","author":"A. Soraci","year":"1996","unstructured":"Soraci, A., Jaussaud, P., Benoit, E. and Delatour, P., 1996. Chiral inversion of fenoprofen in horses and dogs: an in vivo-in vitro study. Veterinary Research, 27, 13-22","journal-title":"Veterinary Research"},{"key":"397036_CR37","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1016\/S0021-9258(19)38942-2","volume":"265","author":"W. Sukuzi","year":"1990","unstructured":"Sukuzi, W., Kawarabyasi, Y.U., Kondo, T., Abe, K., Nishikawa, K., Kimura, S., Hashimoto, T. and Yamamoto, T., 1990. Structure and regulation of rat long-chain acid-CoA synthetase. Journal of Biological Chemistry, 265, 8681-8685","journal-title":"Journal of Biological Chemistry"},{"key":"397036_CR38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/chir.530040603","volume":"4","author":"Y. Tanaka","year":"1992","unstructured":"Tanaka, Y., Shimomura, Y., Hirota, T., Nozaki, A., Ebata, M., Takasaky, W., Sigehara, E., Hayashi, R. and Caldwell, J., 1992. Formation of glycine conjugate and (\u2212) and (+) enantiomers from (+)-(S)-2-phenylpropionic acid suggesting the formation of the CoA thioester intermediate in dogs. Chirality, 4, 342-348","journal-title":"Chirality"},{"key":"397036_CR39","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1016\/0006-2952(86)90443-0","volume":"35","author":"K.M. Williams","year":"1986","unstructured":"Williams, K.M., Day, R.O., Knihinicki, R.D. and Duffield, A., 1986. The stereoselective uptake of ibuprofen enantiomers into adipose tissue. Biochemical Pharmacology, 35, 3403-3405","journal-title":"Biochemical Pharmacology"},{"key":"397036_CR40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/chir.530040302","volume":"4","author":"B. Zhao","year":"1992","unstructured":"Zhao, B., Geisslinger, G., Hall, I., Day, R.O. and Williams, K.M., 1992. The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat. Chirality, 4, 137-141","journal-title":"Chirality"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1013301620904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1013301620904\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1013301620904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:14:05Z","timestamp":1754903645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1013301620904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["397036"],"URL":"https:\/\/doi.org\/10.1023\/a:1013301620904","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"type":"print","value":"0165-7380"},{"type":"electronic","value":"1573-7446"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}