{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:17:46Z","timestamp":1791415066967,"version":"4.3.3"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart Fail Rev"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1023\/a:1015372407647","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T23:08:17Z","timestamp":1041116897000},"page":"131-139","source":"Crossref","is-referenced-by-count":96,"title":["Electron Transport Chain Defects in Heart Failure"],"prefix":"10.1007","volume":"7","author":[{"given":"Jordi","family":"Casademont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"403895_CR1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","volume":"331","author":"GW Dec","year":"1994","unstructured":"Dec GW, Fuster V. Idiopathic dilated cardiomyopathy. N Engl J Med 1994;331:1564\u20131575.","journal-title":"N Engl J Med"},{"key":"403895_CR2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2796.1999.00514.x","volume":"246","author":"C Graff","year":"1999","unstructured":"Graff C, Clayton DA, Larsson NG. Mitochondrial medicine-recent advances. J Intern Med 1999;246: 11\u201323.","journal-title":"J Intern Med"},{"key":"403895_CR3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/387493a0","volume":"387","author":"BF Lang","year":"1997","unstructured":"Lang BF, Burger G, O'Kelly CJ, Cedergren R, Golding GB, Lemieux C, et al. An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature 1997;387:493\u2013497.","journal-title":"Nature"},{"key":"403895_CR4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.cb.07.110191.002321","volume":"7","author":"DA Clayton","year":"1991","unstructured":"Clayton DA. Replication and transcription of vertebrate mitochondrial DNA. Ann Rev Cell Biol 1991; 7:453\u2013478.","journal-title":"Ann Rev Cell Biol"},{"key":"403895_CR5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng0398-199","volume":"18","author":"DM Turnbull","year":"1998","unstructured":"Turnbull DM, Lightowlers RN. An essential guide to mtDNA maintenance. Nature Genet 1998;18:199\u2013200.","journal-title":"Nature Genet"},{"key":"403895_CR6","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","volume":"283","author":"DC Wallace","year":"1999","unstructured":"Wallace DC. Mitochondrial diseases in man and mouse. Science 1999;283:1482\u20131488.","journal-title":"Science"},{"key":"403895_CR7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/jmg.36.7.505","volume":"36","author":"PF Chinnery","year":"1999","unstructured":"Chinnery PF, Howell N, Andrews RM, Turnbull DM. Mitochondrial DNA analysis: polymorphisms and pathogenicity. J Med Genet 1999;36:505\u2013510.","journal-title":"J Med Genet"},{"key":"403895_CR8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0168-9525(97)01266-3","volume":"13","author":"RN Lightowlers","year":"1997","unstructured":"Lightowlers RN, Chinnery PF, Turnbull DM, Howell N. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends Genet 1997;13: 450\u2013455.","journal-title":"Trends Genet"},{"key":"403895_CR9","first-page":"59","volume":"77","author":"M Zeviani","year":"1998","unstructured":"Zeviani M, Tiranti V, Piantadosi C. Mitochondrial Disorders. Rev Mol Med 1998;77:59\u201372.","journal-title":"Rev Mol Med"},{"key":"403895_CR10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/301716","volume":"62","author":"L van den Heuvel","year":"1998","unstructured":"van den Heuvel L, Ruitenbeek W, Smeets R, Gelman-Kohan Z, Elpeleg O, Loeffen J, et al. Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit. Am J Hum Genet 1998;62:262\u2013268.","journal-title":"Am J Hum Genet"},{"key":"403895_CR11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ng1095-144","volume":"11","author":"T Bourgeron","year":"1995","unstructured":"Bourgeron T, Rustin P, Chretien D, Birch-Machin M, Bourgeois M, Viegas-Pequignot E, et al. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Nature Genet 1995;11:144\u2013149.","journal-title":"Nature Genet"},{"key":"403895_CR12","doi-asserted-by":"crossref","unstructured":"Tiranti V, Hoertnagel K, Carrozzo R, Galimberti C, Munaro M, Granatiero M, et al. Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiency. Am J Human Genet 1998;631609\u2013631621.","DOI":"10.1086\/302150"},{"key":"403895_CR13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajmg.1320570224","volume":"57","author":"WA Fenton","year":"1995","unstructured":"Fenton WA. Mitochondrial protein transport-a sysem in search of mutations. Am J Human Genet 1995; 57:235\u2013238.","journal-title":"Am J Human Genet"},{"key":"403895_CR14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1023\/A:1005303008439","volume":"20","author":"P Briones","year":"1997","unstructured":"Briones P, Vilaseca MA, Ribes A, Vernet A, Lluch M, Cusi V, et al. A new case of multiple mitochondrial enzyme deficiencies with decreased amount of heat shock protein 60. J Inherit Metab Dis 1997;20:569\u2013577.","journal-title":"J Inherit Metab Dis"},{"key":"403895_CR15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/bmmb.1993.1053","volume":"50","author":"P Rustin","year":"1993","unstructured":"Rustin P, Chretien D, Bourgeron T, LeBidois J, Sidi D, Rotig A, et al. Investigation of respiratory chain activity in human heart. Biochem Med Metabol Biol 1993;50:120\u2013126.","journal-title":"Biochem Med Metabol Biol"},{"key":"403895_CR16","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI104637","volume":"41","author":"R Luft","year":"1962","unstructured":"Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B. A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical and morphological study. J Clin Invest 1962;41:1776\u20131804.","journal-title":"J Clin Invest"},{"key":"403895_CR17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0008-6363(97)00141-7","volume":"35","author":"C Antozzi","year":"1997","unstructured":"Antozzi C, Zeviani M. Cardiomyopathies in disorders of oxidative metabolism. Cardiovasc Research 1997; 35:184\u2013199.","journal-title":"Cardiovasc Research"},{"key":"403895_CR18","first-page":"190","volume":"13","author":"S DiMauro","year":"1998","unstructured":"DiMauro S, Hirano M. Mitochondria and heart disease. Curr Op Cardiol 1998;13:190\u2013197.","journal-title":"Curr Op Cardiol"},{"key":"403895_CR19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1097-4598(199702)20:2<221::AID-MUS13>3.0.CO;2-5","volume":"20","author":"G Silvestri","year":"1997","unstructured":"Silvestri G, Bertini E, Servidei S, Rana M, Zachara E, Ricci E, et al. Maternally inherited cardiomyopathy: a new phenotype associated with the A to G AT nt.3243 of mitochondrial DNA (MELAS mutation). Muscle Nerve 1997;20:221\u2013225.","journal-title":"Muscle Nerve"},{"key":"403895_CR20","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.91.4.955","volume":"91","author":"R Anan","year":"1995","unstructured":"Anan R, Nakagawa M, Miyata M, Higuchi I, Nakao S, Suehara M, et al. Cardiac involvement in mitochondrial diseases: a study of 17 patients with mitochondrial DNA defects. Circulation 1995;91:955\u2013961.","journal-title":"Circulation"},{"key":"403895_CR21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/clc.4960200310","volume":"20","author":"M Akaike","year":"1997","unstructured":"Akaike M, Kawai H, Yokoi K, Kunishige M, Mine H, Nishida Y, et al. Cardiac dysfunction in patients with chronic progressive external ophthalmoplegia. Clin Cardiol 1997;20:239\u2013243.","journal-title":"Clin Cardiol"},{"key":"403895_CR22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1203\/00006450-199603000-00021","volume":"39","author":"S Pitkanen","year":"1996","unstructured":"Pitkanen S, Merante F, McLeod DR, Applegarth D, Tong T, Robinson BH. Family cardiomyopathy with cataracts and lactic acidosis: a defect in complex I (NADH-dehydrogenase) on the mitochondria respiratory chain. J Pediatr Res 1996;39:513\u2013521.","journal-title":"J Pediatr Res"},{"key":"403895_CR23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0022-510X(97)05379-3","volume":"149","author":"J Mourmans","year":"1997","unstructured":"Mourmans J, Wendel U, Bentlage HACM, Trijbels JM, Smeitink JA, de Coo IF, et al. Clinical heterogenicity in respiratory chain complex III deficiency in childhood. J Neurol Sci 1997;149:111\u2013117.","journal-title":"J Neurol Sci"},{"key":"403895_CR24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/ana.410410219","volume":"41","author":"PL Adams","year":"1997","unstructured":"Adams PL, Lightowlers RN, Turnbull DN. Molecular analysis of cytochrome c oxidase deficiency in Leigh's syndrome. Ann Neurol 1997;41:268\u2013270.","journal-title":"Ann Neurol"},{"key":"403895_CR25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF01799256","volume":"19","author":"A Lombes","year":"1996","unstructured":"Lombes A, Romero MB, Touati G, Frachon P, Cheval MA, Giraud M, et al. Clinical and molecular heterogeneity of cytochrome c oxidase deficiency in the newborn. J Inherit Metab Dis 1996;19:286\u2013295.","journal-title":"J Inherit Metab Dis"},{"key":"403895_CR26","first-page":"1244","volume":"48","author":"S Bohlega","year":"1996","unstructured":"Bohlega S, Tanji K, Santorelli M, Hirano M, al-Jishi A, DiMauro S. Multiple mitochondrial DNA deletions associated with autosomal recesive ophthalmoplegia and severe cardiomyopathy. Neurology 1996;48:1244\u20131253.","journal-title":"Neurology"},{"key":"403895_CR27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/0140-6736(92)92496-3","volume":"340","author":"A Suomalainen","year":"1992","unstructured":"Suomalainen A, Paetau A, Leinonen H, Majander A, Peltonen L, Somer H. Inherited idiopathic dilated cardiomyopathy with multiple deletions of mitochondrial DNA. Lancet 1992;340:1319\u20131320.","journal-title":"Lancet"},{"key":"403895_CR28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0887-8994(96)00018-5","volume":"14","author":"CJ Macmillan","year":"1996","unstructured":"Macmillan CJ, Shoulbridge EA. Mitochondrial DNA depletion: prevalence in a pediatric population referred for neurologic evaluation. Pediatr Neurol 1996;14:203\u2013210.","journal-title":"Pediatr Neurol"},{"key":"403895_CR29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1023\/A:1005322409330","volume":"20","author":"J Marin-Garcia","year":"1997","unstructured":"Marin-Garcia J, Anathakrishnan R, Goldenthal MJ, Filiano JJ, Perez-Atayade A. Cardiac mitochondrial dysfunction and DNA depletion in children with hypertrophic cardiomyopathy. J Inherit Metab Dis 1997;20:674\u2013680.","journal-title":"J Inherit Metab Dis"},{"key":"403895_CR30","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.1002\/mus.880181433","volume":"3","author":"M Zeviani","year":"1995","unstructured":"Zeviani M, Mariotti C, Antozzi C, Fratta GM, Rustin P, Prelle A. OXPHOS defects and mitochondrial DNA Electron Transport Chain Defects in Heart Failure 137 mutations in cardiomyopathy. Muscle Nerve 1995; 3:S170\u2013S174.","journal-title":"Muscle Nerve"},{"key":"403895_CR31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/bbrc.1995.1648","volume":"210","author":"YY Li","year":"1995","unstructured":"Li YY, Hengstenberg C, Maisch B. Whole mitochondrial genome amplification reveals basal level multiple deletions in mtDNA of patients with dilated cardiomyopathy. Biochem Biophys Research Commun 1995;210:211\u2013218.","journal-title":"Biochem Biophys Research Commun"},{"key":"403895_CR32","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1006\/jmcc.1997.0501","volume":"29","author":"YY Li","year":"1997","unstructured":"Li YY, Maisch B, Rose ML, Hengstenberg C. Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy. J Mol Cell Cardiol 1997; 29:2699\u20132709.","journal-title":"J Mol Cell Cardiol"},{"key":"403895_CR33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0009-8981(95)06166-5","volume":"243","author":"A Bobba","year":"1995","unstructured":"Bobba A, Giannattasio S, Pucci A, Lippolis R, Camaschella C, Marra E. Characterization of mitochondrial DNA in primary cardiomyopathies. Clin Chim Acta 1995;243:181\u2013189.","journal-title":"Clin Chim Acta"},{"key":"403895_CR34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/0002-8703(91)90020-I","volume":"121","author":"K Hattori","year":"1991","unstructured":"Hattori K, Tanaka M, Sugiyama S, Obayashi T, Ito T, Satake T, et al. Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. Am Heart J 1991; 121:1735\u20131742.","journal-title":"Am Heart J"},{"key":"403895_CR35","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1093\/nar\/23.20.4122","volume":"23","author":"S Melov","year":"1995","unstructured":"Melov S, Shoffner JM, Kaufman A, Wallace DC. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle Nucleic Acids Res 1995;23:4122\u20134126.","journal-title":"Nucleic Acids Res"},{"key":"403895_CR36","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/bbrc.1995.1232","volume":"207","author":"T Ozawa","year":"1995","unstructured":"Ozawa T, Katsumata K, Hayakawa M, Tanaka M, Sugiyama S, Tanaka T, et al. Genotype and phenotype of severe mitochondrial cardiomyopathy: a recipient of heart transplantation and the genetic control. Biochem Biophys Research Commun 1995;207:613\u2013620.","journal-title":"Biochem Biophys Research Commun"},{"key":"403895_CR37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/1071-9164(95)90003-9","volume":"1","author":"J Marin-Garcia","year":"1995","unstructured":"Marin-Garcia J, Goldenthal MJ, Pierpont ME, Ananthakrishnan R. Impaired mitochondrial function in idiopathic dilated cardiomyopathy: biochemical and molecular analysis. J Cardiac Failure 1995;1:285\u2013291.","journal-title":"J Cardiac Failure"},{"key":"403895_CR38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-8807(97)00101-4","volume":"7","author":"J Marin-Garcia","year":"1998","unstructured":"Marin-Garcia J, Goldenthal MJ. Mitochondrial DNA defects in cardiomyopathies. Cardiovasc Pathol 1998; 7:205\u2013213.","journal-title":"Cardiovasc Pathol"},{"key":"403895_CR39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.RES.85.4.357","volume":"85","author":"T Ide","year":"1999","unstructured":"Ide T, Tsutsui H, Kinugawa S, Utsumi H, Kang D, Hattori N, et al. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circulation Res 1999; 85:357\u2013363.","journal-title":"Circulation Res"},{"key":"403895_CR40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1203\/00006450-199603000-00021","volume":"39","author":"S Pitkanen","year":"1996","unstructured":"Pitkanen S, Merante F, McLeod DR, Applegarth D, Tong T, Robinson BH. Familial cardiomyopathy with cataracts and lactic acidosis: a defect in complex I (NADH-dehydrogenase) of the mitochondria respiratory chain. Pediatr Res 1996;39:513\u2013521.","journal-title":"Pediatr Res"},{"key":"403895_CR41","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0008-6363(99)00388-0","volume":"45","author":"D Jarreta","year":"2000","unstructured":"Jarreta D, Or\u00fas J, Barrientos A, Mir\u00f3 O, Roig E, Heras, et al. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc Res 2000;45:860\u2013865.","journal-title":"Cardiovasc Res"},{"key":"403895_CR42","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0002-9440(10)65738-0","volume":"153","author":"E Arbustini","year":"1998","unstructured":"Arbustini E, Diegoli M, Fasani R, Grasso M, Morbini P, Banchieri, et al. Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy. Am J Pathol 1998;153:1501\u20131510.","journal-title":"Am J Pathol"},{"key":"403895_CR43","first-page":"1167","volume":"134","author":"J Muller-Hocker","year":"1989","unstructured":"Muller-Hocker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol 1989;134:1167\u20131173.","journal-title":"Am J Pathol"},{"key":"403895_CR44","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.CIR.95.4.766","volume":"95","author":"JN Cohn","year":"1997","unstructured":"Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA, et al. Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on heart failure research. Circulation 1997;95:766\u2013770.","journal-title":"Circulation"},{"key":"403895_CR45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0925-4439(97)00076-8","volume":"1406","author":"B Bornstein","year":"1998","unstructured":"Bornstein B, Huertas R, Ochoa P, Campos Y, Guillen F, Garesse R, et al. Mitochondrial gene expression and respiratory enzyme activities in cardiac diseases. Biochim Biophys Acta 1998;1406:85\u201390.","journal-title":"Biochim Biophys Acta"},{"key":"403895_CR46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0002-9149(93)91135-5","volume":"72","author":"I Maurer","year":"1993","unstructured":"Maurer I, Zierz S. Myocardial respiratory chain enzyme activities in idiopathic dilated cardiomyopathy, and comparison with those in atherosclerotic coronary artery disease and valvular aortic stenosis. Am J Cardiol 1993;72:428\u2013433.","journal-title":"Am J Cardiol"},{"key":"403895_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s003950050055","volume":"93","author":"AM Vogt","year":"1998","unstructured":"Vogt AM, Kubler W. Heart failure: is there an energy deficit contributing to contractile dysfunction? Basic Res Cardiol 1998;93:1\u201310.","journal-title":"Basic Res Cardiol"},{"key":"403895_CR48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF02258357","volume":"4","author":"HC Lee","year":"1997","unstructured":"Lee HC, Wei YH. Role in mitochondrial in human aging. J Biomed Sci 1997;4:319\u2013326.","journal-title":"J Biomed Sci"},{"key":"403895_CR49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/448","volume":"19","author":"DC Wallace","year":"1998","unstructured":"Wallace DC, Melov S. Radicals r'aging. Nature Genet 1998;19:105\u2013106.","journal-title":"Nature Genet"},{"key":"403895_CR50","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ana.410340416","volume":"34","author":"P Mecocci","year":"1993","unstructured":"Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993;34: 609\u2013616.","journal-title":"Ann Neurol"},{"key":"403895_CR51","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0140-6736(89)92143-0","volume":"1","author":"I Trounce","year":"1989","unstructured":"Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989;1:637\u2013639.","journal-title":"Lancet"},{"key":"403895_CR52","doi-asserted-by":"crossref","unstructured":"Mir\u00f3 O, Casademont J, Casals E, Perea M, Urbano-M\u00e1rquez A, Rustin P, et al. Aging is associated with an increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc Res 2000; (in press).","DOI":"10.1016\/S0008-6363(00)00122-X"},{"key":"403895_CR53","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1006\/bbrc.1996.1839","volume":"229","author":"A Barrientos","year":"1996","unstructured":"Barrientos A, Casademont J, R\u00f6tig A, Mir\u00f3 O, Urbano-M\u00e1rquez A, Rustin P, et al. Absence of relationship between the level of electron transport chain activities and ageing in skeletal muscle. Biochem Biophys Res Commun 1996;229:536\u2013539.","journal-title":"Biochem Biophys Res Commun"},{"key":"403895_CR54","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj3290249","volume":"329","author":"D Chretien","year":"1998","unstructured":"Chretien D, Gallego J, Barrientos A, Casademont J, Cardellach F, Munnich A, et al. Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of agerelated changes. Biochem J 1998;329:249\u2013254.","journal-title":"Biochem J"},{"key":"403895_CR55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1054-8807(99)00010-1","volume":"8","author":"J Marin-Garcia","year":"1999","unstructured":"Marin-Garcia J, Goldenthal MJ, Pierpont MEM, Ananthakrishnan R, Perez-Atayde A. Is age a contributory factor of mitochondrial bioenergetic decline and DNA defects in idiopathic dilated cardiomyopathy? Cardiovasc Pathol 1999;8:217\u2013222.","journal-title":"Cardiovasc Pathol"},{"key":"403895_CR56","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0092-8674(00)81728-6","volume":"94","author":"DR Green","year":"1998","unstructured":"Green DR. Apoptotic pathways: the roads to ruin. Cell 1998;94:695\u2013698.","journal-title":"Cell"},{"key":"403895_CR57","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1006\/jmcc.1998.0739","volume":"30","author":"VG Sharov","year":"1998","unstructured":"Sharov VG, Goussev A, Lesch M, Goldstein S, Sabbah HN. Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol 1998;30:1757\u20131762.","journal-title":"J Mol Cell Cardiol"},{"key":"403895_CR58","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0022-5223(98)70136-9","volume":"116","author":"SH Lee","year":"1998","unstructured":"Lee SH, Doliba N, Osbakken M, Oz M, Mancini D. Improvement of myocardial mitochondrial function after hemodynamic support with left ventricular assist devices in patients with heart failure. J Thorac Cardiovasc Surg 1998;116:344-349.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"403895_CR59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0008-6363(96)00245-3","volume":"33","author":"WC Stanley","year":"1997","unstructured":"Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res 1997; 33:243\u2013257.","journal-title":"Cardiovasc Res"},{"key":"403895_CR60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/biof.5520090225","volume":"9","author":"H Munkholm","year":"1999","unstructured":"Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10 treatment in serious heart failure. BioFactors 1999;9:285\u2013289.","journal-title":"BioFactors"},{"key":"403895_CR61","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/S0022-2828(95)91551-6","volume":"27","author":"A Sanbe","year":"1995","unstructured":"Sanbe A, Tanonaka K, Kobayasi R, Takeo S. Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction. J Mol Cel Cardiol 1995;27: 2209\u20132222.","journal-title":"J Mol Cel Cardiol"},{"key":"403895_CR62","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0733-8651(05)70043-6","volume":"16","author":"AM Ball","year":"1998","unstructured":"Ball AM, Sole MJ. Oxidative stress and the pathogenesis of heart failure. Cardiol Clin 1998;16:665\u2013675.","journal-title":"Cardiol Clin"},{"key":"403895_CR63","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.CIR.100.7.690","volume":"100","author":"T Ide","year":"1999","unstructured":"Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A. Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action. Circulation 1999;100:690\u2013692.","journal-title":"Circulation"},{"key":"403895_CR64","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0735-1097(96)00574-8","volume":"29","author":"N Khaper","year":"1997","unstructured":"Khaper N, Singal PK. Effects of afterload-reducing drugs on pathogenesis of antioxidant changes and congestive heart failure in rats. J Am Coll Cardiol 1997;29:856\u2013861.","journal-title":"J Am Coll Cardiol"},{"key":"403895_CR65","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0891-5849(97)00014-2","volume":"23","author":"M Bartosz","year":"1997","unstructured":"Bartosz M, Kedziora J, Bartosz G. Antioxidant and prooxidant properties of captopril and enalapril. Free Radic Biol Med 1997;23:729\u2013735.","journal-title":"Free Radic Biol Med"},{"key":"403895_CR66","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1161\/01.CIR.89.6.2829","volume":"89","author":"N Siveski-Iliskovic","year":"1994","unstructured":"Siveski-Iliskovic N, Kaul N, Singal PK. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 1994;89:2829\u20132835.","journal-title":"Circulation"},{"issue":"Suppl1","key":"403895_CR67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0033-0620(98)80027-3","volume":"41","author":"G Feuerstein","year":"1998","unstructured":"Feuerstein G, Yue TL, Ma X, Ruffolo RR. Novel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilol. Progr Cardiovasc Dis 1998;41(Suppl 1):17\u201324.","journal-title":"Progr Cardiovasc Dis"},{"key":"403895_CR68","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0002-8703(92)90410-W","volume":"124","author":"T Obayashi","year":"1992","unstructured":"Obayashi T, Hattori K, Sugiyama S, Tanaka M, Tanaka T, Itoyama S, et al. Point mutations in mitochondrial DNA in patients with hypertrophic cardiomyopathy. Am Heart J 1992;124:1263\u20131269.","journal-title":"Am Heart J"},{"key":"403895_CR69","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1002\/mus.880181432","volume":"3","author":"M Tanaka","year":"1995","unstructured":"Tanaka M, Obayashi T, Yoneda M, Kovalenko SA, Sugiyama A, Ozawa T. Mitochondrial DNA mutations in cardiomyopathy: combinations of replacements yielding cysteine residues and tRNA mutations. Muscle Nerve 1995;3:S165\u2013S169.","journal-title":"Muscle Nerve"},{"key":"403895_CR70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00711378","volume":"18","author":"J Marin-Garcia","year":"1995","unstructured":"Marin-Garcia J, Ananthakrishnan R, Gonzalvo A, Goldenthal MJ. Novel mutations in mitochondrial cytochrome b in fatal post partum cardiomyopathy. J Inherit Metab Dis 1995;18:77\u201378.","journal-title":"J Inherit Metab Dis"},{"key":"403895_CR71","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ajmg.1320500310","volume":"50","author":"GM Pastores","year":"1994","unstructured":"Pastores GM, Santorelli F, Shanske S, Gelb BD, Fyfe B, Wolfe D, et al. Leigh syndrome and hypertrophic cardiomyopathy in an infant with a mitochondrial point mutation (T8993G). Am J Med Genet 1994; 50:265\u2013271.","journal-title":"Am J Med Genet"},{"key":"403895_CR72","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s002469900084","volume":"17","author":"J Marin-Garcia","year":"1996","unstructured":"Marin-Garcia J, Ananthakrishnan R, Korson M, Goldenthal MJ, Perz-Atayde A. Cardiac mitochondrial dysfunction in Leigh syndrome. Pediatr Cardiol 1996;17:387\u2013389.","journal-title":"Pediatr Cardiol"},{"key":"403895_CR73","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1006\/bbrc.1995.2172","volume":"213","author":"C Casali","year":"1995","unstructured":"Casali C, Santorelli FM, D'Amati G, Bernucci P, DeBiase L, DiMauro S. A novel mtDNA point mutation in maternally inherited cardiomyopathy. Biochem Biophys Res Commun 1995;213:588\u2013593.","journal-title":"Biochem Biophys Res Commun"},{"key":"403895_CR74","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/0140-6736(90)93162-I","volume":"336","author":"M Tanaka","year":"1990","unstructured":"Tanaka M, Ino H, Ohno K, Hattori K, Sato W, Ozawa T, et al. Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet 1990;336:1452.","journal-title":"Lancet"},{"key":"403895_CR75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-291X(05)80773-9","volume":"186","author":"M Taniike","year":"1992","unstructured":"Taniike M, Fukushima H, Yanagihara I, Tsukamoto H, Tanaka J, Fujimura H, et al. Mitochondrial tRNAIle mutation in fatal cardiomyopathy. Biochem Biophys Res Commun 1992;186:47\u201353.","journal-title":"Biochem Biophys Res Commun"},{"key":"403895_CR76","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1006\/bbrc.1995.2697","volume":"216","author":"FM Santorelli","year":"1995","unstructured":"Santorelli FM, Mak SC, Vazquez-Acebedo M, Gonzalez-Astiazaran A, Ridaura-Sanz C, Gonzalez-Halphen D, et al. A novel mitochondrial DNA point mutation associated with encephalocardiomyopathy. Biochem Biophys Res Commun 1995;216:835\u2013840.","journal-title":"Biochem Biophys Res Commun"},{"key":"403895_CR77","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1098-1004(1996)8:3<216::AID-HUMU4>3.0.CO;2-7","volume":"8","author":"F Merante","year":"1996","unstructured":"Merante F, Myint T, Tein I, Benson L, Robinson BH. An additional mitochondrial tRNAIle point mutation (A to G at nucleoside 4295) causing hypertrophic cardiomyopathy. Hum Mutat 1996;8:216\u2013222.","journal-title":"Hum Mutat"},{"key":"403895_CR78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0140-6736(91)90136-D","volume":"338","author":"M Zeviani","year":"1991","unstructured":"Zeviani M, Gellera C, Antozzi C, Rimoldi M, Morandi L, Villani F, et al. Maternally inherited myopathy and cardiomyopathy: association with mutation in mitochondrial DNA tRNA(Leu)(UUR). Lancet 1991;338:143\u2013147.","journal-title":"Lancet"},{"key":"403895_CR79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/humu.1380030107","volume":"3","author":"G Silvestri","year":"1994","unstructured":"Silvestri G, Santorelli FM, Shanske S, Whitley CB, Schimmenti LA, Smith SA, et al. A new mtDNA mutation in the tRNALeu (UUR) gene associated with maternally inherited cardiomyopathy. Hum Mutat 1994;3:37\u201343.","journal-title":"Hum Mutat"},{"key":"403895_CR80","first-page":"933","volume":"58","author":"FM Santorelli","year":"1996","unstructured":"Santorelli FM, Mak SC, El-Schahawi M, Casali C, Shanske S, Baram TZ, et al. Maternally inherited cardiomyopathy and hearing loss associated with a novel mutation in the mitochondrial tRNA(Lys) gene (G8363A). Am J Hum Genet 1996;58:933\u2013939.","journal-title":"Am J Hum Genet"},{"key":"403895_CR81","first-page":"437","volume":"55","author":"F Merante","year":"1994","unstructured":"Merante F, Tein I, Benson L, Robinson BH. Maternally inherited cardiomyopathy due to a novel T-to-C transition at nucleotide 9997 in the mitochondrial tRNAGly gene. Am J Hum Genet 1994;55:437\u2013446.","journal-title":"Am J Hum Genet"},{"key":"403895_CR82","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0008-6363(95)00209-X","volume":"31","author":"J Marin-Garcia","year":"1996","unstructured":"Marin-Garcia J, Goldenthal MJ, Ananthakrishnan R, Pierpont ME, Fricker FJ, Lipshultz SE, et al. Specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy. Cardiovasc Res 1996;31:306\u2013313.","journal-title":"Cardiovasc Res"},{"key":"403895_CR83","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0006-291X(90)92166-W","volume":"170","author":"T Ozawa","year":"1990","unstructured":"Ozawa T, Tanaka M, Sugiyama S, Hattori K, Ito T, Ohno K, et al. Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy. Biochem Biophys Res Commun 1990;170:830\u2013836.","journal-title":"Biochem Biophys Res Commun"},{"key":"403895_CR84","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1001\/jama.1991.03470130092035","volume":"266","author":"M Corral-Debrinski","year":"1991","unstructured":"Corral-Debrinski M, Stepien G, Shoffner JM, Lott MT, Kanter K, Wallace DC. Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease. JAMA 1991; 266:1812\u20131816.","journal-title":"JAMA"},{"key":"403895_CR85","first-page":"492","volume":"48","author":"CT Moraes","year":"1991","unstructured":"Moraes CT, Shanske S, Tritschler HJ, Aprille JR, Andreetta F, Bonilla E, et al. mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am J Hum Genet 1991;48:492\u2013501.","journal-title":"Am J Hum Genet"},{"key":"403895_CR86","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1212\/WNL.42.1.209","volume":"42","author":"HJ Tristchler","year":"1992","unstructured":"Tristchler HJ, Andreeta F, Moraes CT, Bonilla E, Arnaudo E, Danon MJ, et al. Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA. Neurology 1992;42:209\u2013217.","journal-title":"Neurology"},{"key":"403895_CR87","first-page":"153","volume":"1271","author":"M Zeviani","year":"1995","unstructured":"Zeviani M, Amati P, Comi G, Fratta G, Miriotti C, Tiranti V. Searching for genes affecting the structural integrity of the mitochondrial genome. Biochem Biophys Acta 1995;1271:153\u2013158.","journal-title":"Biochem Biophys Acta"}],"container-title":["Heart Failure Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015372407647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1015372407647\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015372407647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:28:37Z","timestamp":1747996117000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1015372407647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["403895"],"URL":"https:\/\/doi.org\/10.1023\/a:1015372407647","relation":{},"ISSN":["1382-4147","1573-7322"],"issn-type":[{"value":"1382-4147","type":"print"},{"value":"1573-7322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}