{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:22:30Z","timestamp":1694622150940},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:p>Cell-swelling, induced by a hyposmotic challenge, stimulated the efflux of L-carnitine from a human mammary cancer cell line, MDA-MB-231. The response was dependent upon the extent of the osmotic shock. Hyposmotically-activated L-carnitine efflux was inhibited by the anion transport blocker diiodosalicylate. The efflux of taurine from MDA-MB-231 cells was also stimulated by a hyposmotic shock via a pathway sensitive to diiodosalicylate. L-carnitine efflux from MDA-MB-231 cells was stimulated by isosmotic swelling in a manner which was inhibited by diiodosalicylate. The results suggest that L-carnitine may exit cells via a volume-sensitive pathway: it is possible that L-carnitine efflux may utilize the same pathway as amino acids. The efflux of L-carnitine via this route could have a major effect on the intracellular concentration of L-carnitine and could facilitate transepithelial L-carnitine transport.<\/jats:p>","DOI":"10.1023\/a:1015584724234","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T23:59:19Z","timestamp":1041119959000},"page":"779-787","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyposmotically-Activated Efflux of L-Carnitine from a Human Mammary Cancer Cell Line"],"prefix":"10.1042","volume":"21","author":[{"given":"D.B.","family":"Shennan","sequence":"first","affiliation":[{"name":"Hannah Research Institute, Ayr, KA6 5HL, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/21\/6\/779\/517956\/bsr0210779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/21\/6\/779\/517956\/bsr0210779.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T17:55:04Z","timestamp":1637085304000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/21\/6\/779\/54952\/Hyposmotically-Activated-Efflux-of-L-Carnitine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1023\/a:1015584724234","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,1]]}}}