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It is shown that collaborative approaches of clinicians, geneticists, pathologists, biochemists and molecular biologists have contributed significantly to the (prenatal) diagnosis, genetic counselling and prevention of simple gene disorders, and in some instances to successful treatment. DNA technology widens the range to predictive risk testing for multifactorial disorders manifesting in adulthood. This offers new perspectives for potential patients and their close relatives, but also poses new psychosocial and ethical problems.<\/jats:p><jats:p>Despite high expectations of new technologies in the development of new medicines for multifactorial disorders, examples of previous studies on the molecular etiology and pathogenesis of monogenic diseases indicate that a long way is ahead of us. Also the treatment of rare disorders and equal access to cure and care in the Third World need great attention.<\/jats:p>","DOI":"10.1023\/a:1015669626590","type":"journal-article","created":{"date-parts":[[2002,12,29]],"date-time":"2002-12-29T00:22:22Z","timestamp":1041121342000},"page":"139-156","source":"Crossref","is-referenced-by-count":2,"title":["<b><i>Komrower Lecture<\/i><\/b>: New names for old disciplines"],"prefix":"10.1002","volume":"25","author":[{"given":"H.","family":"Galjaard","sequence":"first","affiliation":[{"name":"Departments of Cell Biology and Clinical Genetics Erasmus University  Dr. Molewaterplein 50 Rotterdam 3015 GE The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1969"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(01)00022-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10011"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4535"},{"key":"e_1_2_1_6_1","first-page":"3811","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"D'Azzo A","year":"2001"},{"issue":"887","key":"e_1_2_1_7_1","first-page":"17","article-title":"Global risk assessment in the presymptomatic patient","volume":"11","author":"Deedwania P","year":"2000","journal-title":"Am J Cardiol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"DrukerBJ SawyersCL CapdevilleR et al (2001)Chronic myelogenous leukemia.HematologyJan.87\u2013112..","DOI":"10.1182\/asheducation-2001.1.87"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.1.105"},{"key":"e_1_2_1_10_1","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1 mutation carriers","volume":"56","author":"Easton DF","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60241-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-436"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350411"},{"key":"e_1_2_1_15_1","volume-title":"Embryo Experimentation in Europe; Biomedical, Legal and Philosophical Aspects","author":"Friele MB","year":"2001"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.3.319"},{"key":"e_1_2_1_17_1","volume-title":"Genetic Metabolic Diseases; Early Diagnosis and Prenatal Analysis","author":"Galjaard H","year":"1980"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S026646230000814X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/257060a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0295-102"},{"key":"e_1_2_1_21_1","first-page":"2863","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Goldstein IL","year":"2001"},{"key":"e_1_2_1_22_1","volume-title":"HUGO\u2010HGM","author":"Goodfellow P","year":"2002"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3010-7_5"},{"issue":"6","key":"e_1_2_1_24_1","first-page":"538","article-title":"Global profiling of gene expression in cancer using genomics and proteomics","volume":"3","author":"Hanash SM","year":"2001","journal-title":"Curr Opin Mol Ther"},{"key":"e_1_2_1_25_1","volume-title":"Practical Genetic Counseling","author":"Harper P","year":"2002"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198870101400406"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.6.979"},{"key":"e_1_2_1_28_1","first-page":"9","article-title":"Testing for genetic susceptibility to common cancers, clincal and ethical issues","volume":"13","author":"Holtzman NA","year":"1997","journal-title":"Adv. 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