{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:50:14Z","timestamp":1791046214648,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1992,4]]},"DOI":"10.1023\/a:1015808917491","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T20:08:46Z","timestamp":1041106126000},"page":"559-564","source":"Crossref","is-referenced-by-count":115,"title":["Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery"],"prefix":"10.1007","volume":"9","author":[{"given":"D.","family":"Bommannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stauffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"305138_CR1","first-page":"112","volume":"6","author":"R. H. Guy","year":"1985","unstructured":"R. H. Guy and J. Hadgraft. Transdermal drug delivery: The ground rules are emerging. Pharm. Int.\n6:112\u2013116 (1985).","journal-title":"Pharm. Int."},{"key":"305138_CR2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jps.2600780503","volume":"78","author":"C. R. Behl","year":"1989","unstructured":"C. R. Behl, S. Kumar, A. W. Malick, S. DelTerezo, W. I. Higuchi, and R. A. Nash. Iontophoretic drug delivery: Effects of physicochemical factors on the skin uptake of nonpeptide drugs. J. Pharm. Sci.\n78:355\u2013360 (1989).","journal-title":"J. Pharm. Sci."},{"key":"305138_CR3","first-page":"247","volume-title":"Transdermal Drug Delivery: Developmental Issues and Research Initiatives","author":"R. R. Burnette","year":"1989","unstructured":"R. R. Burnette, Iontophoresis. In J. Hadgraft and R. H. Guy (eds.), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker, New York, 1989, pp. 247\u2013291."},{"key":"305138_CR4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/jps.2600780507","volume":"78","author":"Y. W. Chien","year":"1989","unstructured":"Y. W. Chien, O. Siddiqui, W. Shi, P. Lelawongs, and J. Liu. Direct current iontophoretic transdermal delivery of peptide and protein drugs. J. Pharm. Sci.\n78:376\u2013383 (1989).","journal-title":"J. Pharm. Sci."},{"key":"305138_CR5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1023\/A:1016327822325","volume":"3","author":"P. Tyle","year":"1986","unstructured":"P. Tyle. Iontophoretic devices for drug delivery. Pharm. Res.\n3:318\u2013326 (1986).","journal-title":"Pharm. Res."},{"key":"305138_CR6","first-page":"197","volume-title":"Transdermal Drug Delivery: Developmental Issues and Research Initiatives","author":"K. A. Walters","year":"1989","unstructured":"K. A. Walters. Penetration enhancers and their use. In J. Hadgraft and R. H. Guy (eds.), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker, New York, 1989, pp. 197\u2013246."},{"key":"305138_CR7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.pa.29.040189.000415","volume":"29","author":"R. B. Stoughton","year":"1989","unstructured":"R. B. Stoughton. Percutaneous absorption of drugs. Ann. Rev. Pharmacol. Toxicol.\n29:55\u201369 (1989).","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"305138_CR8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jps.2600770208","volume":"77","author":"R. R. Burnette","year":"1988","unstructured":"R. R. Burnette and B. Ongpipattanakul. Characterization of the pore transport properties of excised human skin during iontophoresis. J. Pharm. Sci.\n77:132\u2013138 (1988).","journal-title":"J. Pharm. Sci."},{"key":"305138_CR9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1023\/A:1015809725688","volume":"7","author":"M. J. Pikal","year":"1990","unstructured":"M. J. Pikal and S. Shah. Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes. Pharm. Res.\n7:222\u2013229 (1990).","journal-title":"Pharm. Res."},{"key":"305138_CR10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1023\/A:1015846100305","volume":"8","author":"P. G. Green","year":"1991","unstructured":"P. G. Green, R. S. Hinz, A. Kim, F. C. Szoka, Jr., and R. H. Guy. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm. Res.\n8:1121\u20131127 (1991).","journal-title":"Pharm. Res."},{"key":"305138_CR11","unstructured":"NCRP. Biological Effects of Ultrasound: Mechanisms and Clinical Implications, National Council of Radiation Protection and Measurements Report No. 74, Bethesda, MD, 1983."},{"key":"305138_CR12","first-page":"549","volume-title":"Klinik und Therapie des Chronishen, Gelenkreumatismus","author":"K. Fellinger","year":"1956","unstructured":"K. Fellinger and J. Schmid. Klinik und Therapie des Chronishen, Gelenkreumatismus, Maudrich, Vienna, 1956, pp. 549\u2013554."},{"key":"305138_CR13","doi-asserted-by":"crossref","unstructured":"D. M. Skauen and G. M. Zentner. Phonophoresis. Int. J. Pharm.\n20:235\u2013245.","DOI":"10.1016\/0378-5173(84)90171-6"},{"key":"305138_CR14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1023\/A:1015967012253","volume":"6","author":"P. Tyle","year":"1989","unstructured":"P. Tyle and P. Agrawala. Drug delivery by phonophoresis. Pharm. Res.\n6:355\u2013361 (1989).","journal-title":"Pharm. Res."},{"key":"305138_CR15","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/ptj\/68.11.1672","volume":"68","author":"J. P. Davick","year":"1988","unstructured":"J. P. Davick, R. K. Martin, and J. P. Albright. Distribution and deposition of tritiated cortisol using phonophoresis. Phys. Ther.\n68:1672\u20131675 (1988).","journal-title":"Phys. Ther."},{"key":"305138_CR16","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/ptj\/47.7.594","volume":"47","author":"J. E. Griffin","year":"1967","unstructured":"J. E. Griffin, J. L. Echternach, R. E. Price, and J. C. Touchstone. Patients treated with ultrasonic driven hydrocortisone and with ultrasound alone. Phys. Ther.\n47:594\u2013601 (1967).","journal-title":"Phys. Ther."},{"key":"305138_CR17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00002060-196304000-00001","volume":"42","author":"J. E. Griffin","year":"1963","unstructured":"J. E. Griffin and J. C. Touchstone. Ultrasonic movement of cortisol into pig tissues. I. Movement into skeletal muscle. Am. J. Phys. Med.\n42:77\u201385 (1963).","journal-title":"Am. J. Phys. Med."},{"key":"305138_CR18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00002060-196502000-00003","volume":"44","author":"J. E. Griffin","year":"1965","unstructured":"J. E. Griffin, J. C. Touchstone, and A. C-Y. Liu. Ultrasonic movement of cortisol into pig tissues. I. Movement into paravertebral nerve. Am. J. Phys. Med.\n44:20\u201325 (1965).","journal-title":"Am. J. Phys. Med."},{"key":"305138_CR19","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1172\/JCI114119","volume":"83","author":"D. Levy","year":"1989","unstructured":"D. Levy, J. Kost, Y. Meshulam, and R. Langer. Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. J. Clin. Invest.\n83:2074\u20132078 (1989).","journal-title":"J. Clin. Invest."},{"key":"305138_CR20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/ptj\/69.2.113","volume":"69","author":"H. A. Benson","year":"1989","unstructured":"H. A. Benson, J. C. McElnay, and R. Harland. Use of ultrasound to enhance percutaneous penetration of benzydamine. Phys. Ther.\n69:113\u2013118 (1989).","journal-title":"Phys. Ther."},{"key":"305138_CR21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2125.1985.tb05089.x","volume":"20","author":"J. C. McElnay","year":"1985","unstructured":"J. C. McElnay, M. P. Matthews, R. Harland, and D. F. McCafferty. The effect of ultrasound on the percutaneous absorption of lignocaine. Br. J. Clin. Pharmacol.\n20:421\u2013424 (1985).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"305138_CR22","first-page":"1122","volume":"13","author":"H. Pratzel","year":"1986","unstructured":"H. Pratzel, P. Dittrich, and W. Kukovetz. Spontaneous and forced cutaneous absorption of indomethacin in pigs and humans. J. Rheumatol.\n13:1122\u20131125 (1986).","journal-title":"J. Rheumatol."},{"key":"305138_CR23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000401285","volume":"7","author":"R. J. Scheuplein","year":"1976","unstructured":"R. J. Scheuplein. Permeability of the skin: A review of major concepts. Curr. Prob. Dermatol.\n7:172\u2013186 (1976).","journal-title":"Curr. Prob. Dermatol."},{"key":"305138_CR24","doi-asserted-by":"crossref","first-page":"44s","DOI":"10.1038\/jid.1983.12","volume":"80","author":"P. M. Elias","year":"1983","unstructured":"P. M. Elias. Epidermal lipids, barrier function and desquamation. J. Invest. Dermatol.\n80:44s\u201349s (1983).","journal-title":"J. Invest. Dermatol."},{"key":"305138_CR25","volume-title":"Ultrasound: Biological Effects and Potential Hazards","author":"A. R. Williams","year":"1983","unstructured":"A. R. Williams. Ultrasound: Biological Effects and Potential Hazards, Academic Press, San Francisco, 1983."},{"key":"305138_CR26","first-page":"23","volume-title":"Biological Effects of Ultrasound","author":"W. L. Nyborg","year":"1985","unstructured":"W. L. Nyborg. Mechanisms. In W. L. Nyborg and M. C. Ziskin (eds.), Biological Effects of Ultrasound, Churchill Livingstone, New York, 1985, pp. 23\u201333."},{"key":"305138_CR27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0301-5629(78)90076-5","volume":"3","author":"P. L. Carson","year":"1978","unstructured":"P. L. Carson, P. R. Fischella, and T. V. Oughton. Ultrasonic power and intensities produced by diagnostic ultrasound equipment. Ultrasound Med. Biol.\n3:341\u2013350 (1978).","journal-title":"Ultrasound Med. Biol."},{"key":"305138_CR28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3109\/03091907909161676","volume":"3","author":"M. J. Lunt","year":"1979","unstructured":"M. J. Lunt and B. Ashley. A simple balance for measuring ultrasonic power. J. Med. Eng. Technol.\n3:194\u2013196 (1979).","journal-title":"J. Med. Eng. Technol."},{"key":"305138_CR29","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1073\/pnas.87.10.3871","volume":"87","author":"R. O. Potts","year":"1990","unstructured":"R. O. Potts and M. L. Francoeur. Lipid biophysics of water loss through the skin. Proc. Natl. Acad. Sci.\n87:3871\u20133873 (1990).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"305138_CR30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jps.2600760108","volume":"76","author":"G. M. Golden","year":"1987","unstructured":"G. M. Golden, J. E. McKie, and R. O. Potts. Role of stratum corneum lipid fluidity in transdermal drug flux. J. Pharm. Sci.\n76:25\u201328 (1987).","journal-title":"J. Pharm. Sci."},{"key":"305138_CR31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/jps.2600721019","volume":"72","author":"L. R. Brown","year":"1983","unstructured":"L. R. Brown, C. L. Wei, and R. Langer. In vivo and in vitro release of macromolecules from polymeric drug delivery systems. J. Pharm. Sci.\n72:1181\u20131185 (1983).","journal-title":"J. Pharm. Sci."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015808917491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1015808917491\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015808917491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:14:29Z","timestamp":1754028869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1015808917491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["305138"],"URL":"https:\/\/doi.org\/10.1023\/a:1015808917491","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}