{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:55:58Z","timestamp":1760547358710,"version":"3.41.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1991,7]]},"DOI":"10.1023\/a:1015895227196","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T20:08:46Z","timestamp":1041106126000},"page":"859-864","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Palytoxin on Guinea Pig Tracheal Strips"],"prefix":"10.1007","volume":"8","author":[{"given":"Casey P.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Franz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"305520_CR1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1126\/science.172.3982.495","volume":"172","author":"R. E. Moore","year":"1971","unstructured":"R. E. Moore and P. J. Scheur. Palytoxin: A new marine toxin from a coelenterate. Science\n172:495\u2013498 (1971).","journal-title":"Science"},{"unstructured":"Y. Hashimoto. Marine toxins and other bioactive marine metabolites. Jpn. Sci. Soc. Press Tokyo 248\u2013254 (1979).","key":"305520_CR2"},{"key":"305520_CR3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-3565(25)30837-2","volume":"201","author":"J. M. Dubois","year":"1977","unstructured":"J. M. Dubois and J. B. Cohen. Effect of palytoxin on membrane potential and current of frog myelinated fibers. J. Pharmacol. Exp. Ther.\n201:148\u2013155 (1977).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0041-0101(82)90141-6","volume":"20","author":"Y. Pichon.","year":"1982","unstructured":"Y. Pichon. Effects of palytoxin on sodium and potassium permeabilities in unmyelinated axons. Toxicon\n20:41\u201347 (1982).","journal-title":"Toxicon"},{"key":"305520_CR5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0005-2736(81)90439-9","volume":"649","author":"E. Habermann","year":"1981","unstructured":"E. Habermann, G. Anhert-Hilger, G. S. Chhatwal, and L. Beress. Delayed hemolytic action of palytoxin. General characteristics. Biochim. Biophys. Acta\n649:481\u2013486 (1981).","journal-title":"Biochim. Biophys. Acta"},{"key":"305520_CR6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00497672","volume":"323","author":"G. S. Chhatwal","year":"1983","unstructured":"G. S. Chhatwal, H.-J. Hessler, and E. Habermann. The action of palytoxin on erythrocytes and resealed ghosts. Formation of small, nonselective pores linked with Na+,K +-ATPase. Naunyn-Schmiedeberg Arch. Pharmacol.\n323:261\u2013268 (1983).","journal-title":"Naunyn-Schmiedeberg Arch. Pharmacol."},{"key":"305520_CR7","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1016\/S0021-9258(20)81999-1","volume":"258","author":"Y. Ishida","year":"1983","unstructured":"Y. Ishida, K. Takagi, M. Takahashi, N. Satake, and S. Shibata. Palytoxin isolated from marine coelenterates: The inhibitory action on (Na,K)-ATPase. J. Biol. Chem.\n258:7900\u20137902 (1983).","journal-title":"J. Biol. Chem."},{"key":"305520_CR8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00507059","volume":"325","author":"H. Bottinger","year":"1984","unstructured":"H. Bottinger and E. Habermann. Palytoxin binds to and inhibits kidney and erythrocyte Na+,K+-ATPase. Naunyn-Schmiedeberg Arch. Pharmacol.\n325:85\u201387 (1984).","journal-title":"Naunyn-Schmiedeberg Arch. Pharmacol."},{"key":"305520_CR9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0005-2736(85)90137-3","volume":"818","author":"L. Lauffer","year":"1985","unstructured":"L. Lauffer, S. Stengelin, L. Beress, and F. Hucho. Palytoxin-induced permeability changes in excitable membranes. Biochim. Biophys. Acta\n818:55\u201360 (1985).","journal-title":"Biochim. Biophys. Acta"},{"key":"305520_CR10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1254\/jjp.26.683","volume":"26","author":"K. Ito","year":"1976","unstructured":"K. Ito, H. Karaki, Y. Ishida, N. Urakawa, and T. Deguchi. Effects of palytoxin on isolated intestinal and vascular smooth muscles. Jpn. J. Pharmacol.\n26:683\u2013692 (1976).","journal-title":"Jpn. J. Pharmacol."},{"key":"305520_CR11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-2999(77)90137-6","volume":"46","author":"K. Ito","year":"1977","unstructured":"K. Ito, H. Karaki, and N. Urakawa. The mode of contractile action of palytoxin on vascular smooth muscle. Eur. J. Pharmacol.\n46:9\u201314 (1977).","journal-title":"Eur. J. Pharmacol."},{"key":"305520_CR12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0022-3565(25)20592-4","volume":"232","author":"Y. Ishida","year":"1985","unstructured":"Y. Ishida, N. Satake, J. Habon, H. Kitano, and S. Shibata. Inhibitory effect of ouabain on the palytoxin-induced contraction of human umbilica1 artery. J. Pharmacol. Exp. Ther.\n232:557\u2013560 (1985).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR13","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0021-5198(19)52415-5","volume":"33","author":"H. Ozaki","year":"1983","unstructured":"H. Ozaki, J. Tomono, H. Nagase, and N. Urakawa. The mechanism of contractile action of palytoxin on vascular smooth muscle of guinea-pig aorta. Jpn. J. Pharmacol.\n33:1155\u20131162 (1983).","journal-title":"Jpn. J. Pharmacol."},{"key":"305520_CR14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0021-5198(19)52372-1","volume":"34","author":"H. Ozaki","year":"1984","unstructured":"H. Ozaki, H. Nagase, K. Ito, and N. Urakawa. Effects of palytoxin on Na, K and ATP contents of vascular smooth muscle of rabbit aorta. Jpn. J. Pharmacol.\n34:57\u201366 (1984a).","journal-title":"Jpn. J. Pharmacol."},{"key":"305520_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-3565(25)21523-3","volume":"231","author":"H. Ozaki","year":"1984","unstructured":"H. Ozaki, H. Nagase, and N. Urakawa. Involvement of the sugar moiety in the inhibitory action of the cardiac glycosides on the palytoxin-induced responses in vascular smooth muscles. J. Pharmacol. Exp. Ther.\n231:153\u2013158 (1984b).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/BF00169127","volume":"335","author":"H. Nagase","year":"1987","unstructured":"H. Nagase, H. Karaki, and N. Urakawa. Palytoxin-induced endothelium-dependent relaxation in the isolated rat aorta. Naunyn-Schmiedeberg Arch. Pharmacol.\n335:575\u2013579 (1987).","journal-title":"Naunyn-Schmiedeberg Arch. Pharmacol."},{"key":"305520_CR17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0022-3565(25)39164-0","volume":"242","author":"H. Nagase","year":"1987","unstructured":"H. Nagase and H. Karaki. Palytoxin-induced contraction and release of prostaglandins and norepinephrine in the aorta. J. Pharmacol. Exp. Ther.\n242:1120\u20131125 (1987).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0022-3565(25)11006-9","volume":"243","author":"R. M. Muccitelli","year":"1987","unstructured":"R. M. Muccitelli, S. S. Tucker, D. W. P. Hay, T. J. Torphy, and M. A. Wasserman. Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine-, and antigen-induced contractions. J. Pharmacol. Exp. Ther.\n243:467\u2013473 (1987).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2460\/javma.1986.188.03.252","volume":"188","author":"A. W. Smith.","year":"1986","unstructured":"A. W. Smith. Report of the AVMA panel on euthanasia. J. Am. Vet. Med. Assoc.\n188:252\u2013268 (1986).","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"305520_CR20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0022-3565(25)39237-2","volume":"243","author":"E. Tschirhart","year":"1987","unstructured":"E. Tschirhart, N. Frossard, C. Bertrand, and Y. Landry. Arachidonic acid metabolites and airway epithelium-dependent relaxant factor. J. Pharmacol. Exp. Ther.\n243:310\u2013316 (1987).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1476-5381.1986.tb10150.x","volume":"87","author":"R. B. Goldie","year":"1986","unstructured":"R. B. Goldie, J. M. Papadimitriou, J. W. Paterson, P. J.Rigby, H. M. Self, and D. Spina. Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists. Br. J. Pharmacol.\n87:5\u201314 (1986).","journal-title":"Br. J. Pharmacol."},{"key":"305520_CR22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(86)90330-4","volume":"129","author":"D. W. P. Hay","year":"1986","unstructured":"D. W. P. Hay, S. G. Farmer, D. Raeburn, V. A. Robinson, W. W. Fleming, and J. F. Fedan. Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle. Eur. J. Pharmacol.\n129:11\u201318 (1986).","journal-title":"Eur. J. Pharmacol."},{"key":"305520_CR23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/cs0700571","volume":"70","author":"C. Murlas.","year":"1986","unstructured":"C. Murlas. Effects of mucosal removal on guinea-pig airway smooth muscle responsiveness. Clin. Sci.\n70:571\u2013575 (1986).","journal-title":"Clin. Sci."},{"key":"305520_CR24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(86)90020-8","volume":"132","author":"E. Tschirhart","year":"1986","unstructured":"E. Tschirhart and Y. Landry. Airway epithelium releases a relaxant factor: Demonstration with substance P. Eur. J. Pharmacol.\n132:103\u2013104 (1986).","journal-title":"Eur. J. Pharmacol."},{"key":"305520_CR25","first-page":"387","volume":"86C","author":"H. Ozaki","year":"1987","unstructured":"H. Ozaki, H. Nagase, H. Karaki, and N. Urakawa. Effects of palytoxin on contractile response and calcium movement in guinea-pig taenia coli. Comp. Biochem. Physiol.\n86C:387\u2013393 (1987).","journal-title":"Comp. Biochem. Physiol."},{"key":"305520_CR26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/978-1-4684-0889-8_32","volume-title":"Animal, Plant, and Microbial Toxins","author":"T. Deguchi","year":"1976","unstructured":"T. Deguchi, N. Urakawa, and S. Takamatsu. Some pharmacological properties of palythoatoxin isolated from the zoanthid, Palythoa tuberculosa. In A. Ohsaka, K. Hayashi, and Y. Sawai (eds.), Animal, Plant, and Microbial Toxins, Vol. 2, Plenum Press, New York, 1976, pp. 379\u2013394."},{"key":"305520_CR27","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/BF01918825","volume":"33","author":"S. Weidmann.","year":"1977","unstructured":"S. Weidmann. Effects of palytoxin on electrical activity of dog and rabbit heart. Experientia\n33:1487\u20131489 (1977).","journal-title":"Experientia"},{"key":"305520_CR28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1476-5381.1980.tb10975.x","volume":"71","author":"Y. Kudo","year":"1980","unstructured":"Y. Kudo and S. Shibata. The potent depolarizing action of palytoxin isolated from Palythoa tuberculosa on the isolated spinal cord of the frog. Br. J. Pharmacol.\n71:575\u2013579 (1980).","journal-title":"Br. J. Pharmacol."},{"key":"305520_CR29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-2999(86)90214-1","volume":"127","author":"S. Shibata","year":"1986","unstructured":"S. Shibata, N. Satake, S. Ueda, Y. Ohizumi, F. Flores, and R. Paulino. The contractile action of palytoxin in the isolated rabbit urinary bladder. Eur. J. Pharmacol.\n127:129\u2013133 (1986).","journal-title":"Eur. J. Pharmacol."},{"key":"305520_CR30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0041-008X(75)90026-5","volume":"34","author":"J. A. Vick","year":"1975","unstructured":"J. A. Vick and J. S. Wiles. Mechanism of action and treatment of palytoxin poisoning. Toxicol. Appl. Pharmacol.\n34:214\u2013223 (1975).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"305520_CR31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1440-1681.1981.tb00149.x","volume":"8","author":"B. R. Creese","year":"1981","unstructured":"B. R. Creese and M. A. Denborough. Sources of calcium for contraction of guinea pig isolated tracheal smooth muscle. Clin. Exp. Pharmacol. Physiol.\n8:175\u2013182 (1981).","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"305520_CR32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1476-5381.1983.tb10728.x","volume":"80","author":"R. W. Foster","year":"1983","unstructured":"R. W. Foster, R. C. Small, and A. H. Weston. The spasmogenic action of potassium chloride in guinea pig trachealis. Br. J. Pharmacol.\n80:553\u2013559 (1983).","journal-title":"Br. J. Pharmacol."},{"key":"305520_CR33","first-page":"175P","volume":"72","author":"M. G. Martorana","year":"1980","unstructured":"M. G. Martorana and I. W. Rodger. Effects of calcium withdrawal and verapamil on excitation-contraction coupling in sensitised guinea pig airway smooth muscle. Br. J. Pharmacol.\n72:175P (1980).","journal-title":"Br. J. Pharmacol."},{"key":"305520_CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-3565(25)32153-1","volume":"214","author":"Y. Ohizumi","year":"1980","unstructured":"Y. Ohizumi and S. Shibata. Mechanism of the excitatory action of palytoxin and N-acetylpalytoxin in the isolated guinea-pig vas deferens. J. Pharmac. Exp. Ther.\n214:209\u2013212 (1980).","journal-title":"J. Pharmac. Exp. Ther."},{"key":"305520_CR35","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0022-3565(25)39102-0","volume":"242","author":"D. Raeburn","year":"1987","unstructured":"D. Raeburn, D. W. P. Hay, S. G. Farmer, and J. S. Fedan. Influence of cartilage on reactivity and on the effectiveness of verapamil in guinea pig isolated airway smooth muscle. J. Pharmacol. Exp. Ther.\n242:450\u2013454 (1987).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"305520_CR36","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/0024-3205(86)90563-1","volume":"38","author":"D. Raeburn","year":"1986","unstructured":"D. Raeburn, I. W. Rodger, D. W. P. Hay, and J. S. Fedan. The dependence of airway smooth muscle on extracellular Ca2+ for contraction is influenced by the presence of cartilage. Life Sci.\n38:1499\u20131505 (1986b).","journal-title":"Life Sci."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015895227196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1015895227196\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015895227196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:55:02Z","timestamp":1754027702000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1015895227196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["305520"],"URL":"https:\/\/doi.org\/10.1023\/a:1015895227196","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"type":"print","value":"0724-8741"},{"type":"electronic","value":"1573-904X"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}