{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:10:29Z","timestamp":1777633829526,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1988,12]]},"DOI":"10.1023\/a:1015936701543","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T20:32:18Z","timestamp":1041107538000},"page":"772-775","source":"Crossref","is-referenced-by-count":6,"title":["Limiting Solubilities and lonization Constants of Sparingly Soluble Compounds: Determination from Aqueous Potentiometric Titration Data Only"],"prefix":"10.1007","volume":"5","author":[{"given":"Adriaan P.","family":"IJzerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"306293_CR1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.2042-7158.1967.tb07987.x","volume":"19","author":"A. L. Green.","year":"1967","unstructured":"A. L. Green. J. Pharm. Pharmacol.\n19:10\u201316 (1967).","journal-title":"J. Pharm. Pharmacol."},{"key":"306293_CR2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jps.2600600808","volume":"60","author":"R. H. Levy","year":"1971","unstructured":"R. H. Levy and M. Rowland. J. Pharm. Sci.\n60:1155\u20131159 (1971).","journal-title":"J. Pharm. Sci."},{"key":"306293_CR3","doi-asserted-by":"crossref","unstructured":"H. A. Krebs and J. C. Speakman. J. Chem. Soc. 593\u2013595 (1945).","DOI":"10.1039\/jr9450000593"},{"key":"306293_CR4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-5173(82)90142-9","volume":"13","author":"I. Zimmermann.","year":"1983","unstructured":"I. Zimmermann. Int. J. Pharm.\n13:57\u201365 (1983).","journal-title":"Int. J. Pharm."},{"key":"306293_CR5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0378-5173(86)90214-0","volume":"31","author":"I. Zimmermann.","year":"1986","unstructured":"I. Zimmermann. Int. J. Pharm.\n31:69\u201374 (1986).","journal-title":"Int. J. Pharm."},{"key":"306293_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-5173(84)90121-2","volume":"18","author":"G. A. Lewis.","year":"1984","unstructured":"G. A. Lewis. Int. J. Pharm.\n18:207\u2013212 (1984).","journal-title":"Int. J. Pharm."},{"key":"306293_CR7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(88)90023-3","volume":"46","author":"A. P. IJzerman.","year":"1988","unstructured":"A. P. IJzerman. Int. J. Pharm.\n46:173\u2013175 (1988).","journal-title":"Int. J. Pharm."},{"key":"306293_CR8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.2042-7158.1984.tb02978.x","volume":"36","author":"A. P. IJzerman","year":"1984","unstructured":"A. P. IJzerman, T. Bultsma, H. Timmerman, and J. Zaagsma. J. Pharm. Pharmacol.\n36:11\u201315 (1984).","journal-title":"J. Pharm. Pharmacol."},{"key":"306293_CR9","first-page":"69","volume":"56","author":"K. Thoma","year":"1981","unstructured":"K. Thoma and K. Albert. Pharm. Acta Helv.\n56:69\u201377 (1981).","journal-title":"Pharm. Acta Helv."},{"key":"306293_CR10","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/ac60191a041","volume":"34","author":"L. G. Chatten","year":"1962","unstructured":"L. G. Chatten and L. E. Harris. Anal. Chem.\n34:1495\u20131501 (1962).","journal-title":"Anal. Chem."},{"key":"306293_CR11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0378-5173(79)90006-1","volume":"3","author":"W. R. Vezin","year":"1979","unstructured":"W. R. Vezin and A. T. Florence. Int. J. Pharm.\n3:231\u2013237 (1979).","journal-title":"Int. J. Pharm."},{"key":"306293_CR12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1515\/zpch-1925-11621","volume":"116","author":"M. Mizutani.","year":"1925","unstructured":"M. Mizutani. Z. Phys. Chem.\n116:350\u2013358 (1925).","journal-title":"Z. Phys. Chem."},{"key":"306293_CR13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jps.2600560602","volume":"56","author":"L. Z. Benet","year":"1967","unstructured":"L. Z. Benet and J. E. Goyan. J. Pharm. Sci.\n56:665\u2013680 (1967).","journal-title":"J. Pharm. Sci."},{"key":"306293_CR14","first-page":"39","volume-title":"The Determination of Ionization Constants (a Laboratory Manual)","author":"A. Albert","year":"1971","unstructured":"A. Albert and E. P. Serjeant. The Determination of Ionization Constants (a Laboratory Manual), Chapman and Hall, London, 1971, p. 39."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015936701543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1015936701543\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015936701543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:53:37Z","timestamp":1754027617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1015936701543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["306293"],"URL":"https:\/\/doi.org\/10.1023\/a:1015936701543","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}