{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:06:28Z","timestamp":1754161588582,"version":"3.41.2"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1023\/a:1016400829744","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T22:29:52Z","timestamp":1041114592000},"page":"1800-1809","source":"Crossref","is-referenced-by-count":7,"title":["Cholecystokinin Antagonist L364,718 Induces Alterations in Acinar Cells That Prevent Improvement of Acute Pancreatitis Induced by Obstruction"],"prefix":"10.1007","volume":"47","author":[{"given":"Isabel","family":"de Dios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ar\u00e1nzazu","family":"Uru\u00f1uela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel A.","family":"Manso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"378699_CR1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/00365529109025030","volume":"26","author":"R Bialek","year":"1991","unstructured":"Bialek R, Willemer S, Arnold R, Adler G: Evidence of intracellular activation of serine proteases in acute caerulein-induced pancreatitis in rats. Scand J Gastroenterol 26:190\u2013196, 1991","journal-title":"Scand J Gastroenterol"},{"key":"378699_CR2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1172\/JCI114995","volume":"87","author":"SD Leach","year":"1991","unstructured":"Leach SD, Modlin, IM, Scheele, GA, Gorelick FS: Intracellular activation of digestive enzymes in rat pancreatic acini. Stimulation by high dose of cholecystokinin. J Clin Invest 87:362\u2013366, 1991","journal-title":"J Clin Invest"},{"key":"378699_CR3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0016-5085(97)70108-2","volume":"113","author":"AK Saluja","year":"1991","unstructured":"Saluja AK, Donovan EA, Yamanaka K, Yamaguchi Y, Hofbauer B, Steer ML: Caerulein-induced in vitro activation of trypsinogen and rat pancreatic acini is mediated by cathepsin B. Gastroenterology 113:304\u2013310, 1991","journal-title":"Gastroenterology"},{"key":"378699_CR4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00432156","volume":"373","author":"M Lampel","year":"1997","unstructured":"Lampel M, Kern HF: Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch (A) Pathol Anat Histopathol. 373:97\u2013117, 1997","journal-title":"Virchows Arch (A) Pathol Anat Histopathol"},{"key":"378699_CR5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02788433","volume":"2","author":"S Tani","year":"1987","unstructured":"Tani S, Otsuki M, Itoh H, Fujii M, Takahiko N, Oka T, Baba S: Histological and biochemical alterations in experimental acute pancreatitis. Int J Pancreatol 2:337\u2013348, 1987","journal-title":"Int J Pancreatol"},{"key":"378699_CR6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0016-5085(85)80079-2","volume":"88","author":"C Niedereau","year":"1985","unstructured":"Niedereau C, Ferrell LD, Grendell JH: Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript and secretin. Gastroenterology 88:1192\u20131204, 1985","journal-title":"Gastroenterology"},{"key":"378699_CR7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0196-9781(86)90147-6","volume":"7","author":"F Makovec","year":"1986","unstructured":"Makovec F, Bani M, Cereda R, Chiste R, Revel L, Rovati LC, Setnikar I, Rovati LA: Protective effect of CR1409 (cholecystokinin antagonist) on experimental pancreatitis in rats and mice. Peptides 7:1159\u20131164, 1986","journal-title":"Peptides"},{"key":"378699_CR8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00006676-198904000-00013","volume":"4","author":"Otsuki","year":"1989","unstructured":"Otsuki, Tani S, Okabayashi Y, Nakamura T, Fujii H, Fujisawa T, Baba S, Itoh M: Effect of a new cholecystokinin receptor antagonist CR1392 on caerulein-induced acute pancreatitis in rats. Pancreas 4:237\u2013243, 1989","journal-title":"Pancreas"},{"key":"378699_CR9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00006676-199007000-00011","volume":"5","author":"KM Murayama","year":"1990","unstructured":"Murayama KM, Drew JB, Nahrwold D, Joehl RJ: Cholecystokinin antagonist prevents hyperamylasemia and improves pancreatic exocrine function in caerulein-induced acute pancreatitis. Pancreas 5:439\u2013444, 1990","journal-title":"Pancreas"},{"key":"378699_CR10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00006676-199405000-00005","volume":"9","author":"AC Garcia-Montero","year":"1994","unstructured":"Garcia-Montero AC, Manso MA, Rodriguez AI, de Dios I: Therapeutic and protective effect of subcutaneous injections of L364,718 on caerulein-induced acute pancreatitis. Pancreas 9:309\u2013315, 1994","journal-title":"Pancreas"},{"key":"378699_CR11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI112661","volume":"78","author":"C Niedereau","year":"1986","unstructured":"Niedereau, C, Liddle RA, Ferrell LD, Grendell JH: Beneficial effects of cholecystokinin receptor blockade and inhibition of proteolytic enzyme activity in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. J Clin Invest 78:1056\u20131063, 1986","journal-title":"J Clin Invest"},{"key":"378699_CR12","first-page":"1442","volume":"43","author":"C Niedereau","year":"1996","unstructured":"Niedereau C, Borchard F, L\u00fcthen R, Niedereau M: Early development of experimental biliary pancreatitis and its amelioration by CCK-receptor blockade. Hepato-Gastroenterol 43:1442\u20131453, 1996","journal-title":"Hepato-Gastroenterol"},{"key":"378699_CR13","first-page":"521","volume":"8","author":"I Tachibana","year":"1993","unstructured":"Tachibana I, Kataoka K, Imoto M, Umehara K, Sasaki T, Yorizumi H, Kato M, Yamame Y, Kashima K: Effect of a new cholecystokinin antagonist KSG-504 on cerulein-induced acute pancreatitis in rats. Pancreas 8:521, 1993","journal-title":"Pancreas"},{"key":"378699_CR14","first-page":"43","volume":"94","author":"L Cazak\u00f3","year":"2000","unstructured":"Cazak\u00f3 L, Tak\u00e1kcs T, Varga I, Hai DQ, Tiszlavicz L, Hegyi P, Mandi Y, Matkovics B, Lanovics J: The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: Inflammatory mediators and endogenous cholecystokinin. J Physiol 94:43\u201350, 2000","journal-title":"J Physiol"},{"key":"378699_CR15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00006676-198912000-00013","volume":"4","author":"G Ohshio","year":"1989","unstructured":"Ohshio G, Saluja A, Leli U, Sengupta A, Steer ML: Failure of a potent cholecystokinin antagonist to protect against dietinduced pancreatitis in mice. Pancreas 4:739\u2013743, 1989","journal-title":"Pancreas"},{"key":"378699_CR16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00006676-199508000-00009","volume":"11","author":"R Pescador","year":"1995","unstructured":"Pescador R, Manso MA, Rebollo A, de Dios I: Effect of chronic administration of hydrocortisone on the induction and evolution of acute pancreatitis induced by cerulein. Pancreas 11:165\u2013172, 1995","journal-title":"Pancreas"},{"key":"378699_CR17","first-page":"257","volume":"111","author":"MA Manso","year":"1995","unstructured":"Manso MA, Rebollo A, Pescador R, de Dios I: Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone. Comp Biochem Physiol 111:257\u2013263, 1995","journal-title":"Comp Biochem Physiol"},{"key":"378699_CR18","doi-asserted-by":"crossref","first-page":"G261","DOI":"10.1152\/ajpcell.1988.255.3.C261","volume":"255","author":"DS Louie","year":"1988","unstructured":"Louie DS, Liang JP, Owyang C: Characterization of a new CCK antagonist, L364,718: in vitro and in vivo studies. Am J Physiol 255:G261\u2013G266, 1988","journal-title":"Am J Physiol"},{"key":"378699_CR19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0196-9781(96)00249-5","volume":"18","author":"I De Dios","year":"1997","unstructured":"De Dios I, Rodriguez A, Garcia-Montero AC, Manso MA: Enzyme changes in zymogen CCK and in pancreatic secretion throughout long-term CCK treatment. Peptides 18:101\u2013110, 1997","journal-title":"Peptides"},{"key":"378699_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1113\/jphysiol.1970.sp009013","volume":"206","author":"JCD Hickson","year":"1970","unstructured":"Hickson JCD: The secretion of pancreatic juice in response to stimulation of the vagus nerves in the pig. J Physiol 206:275\u2013297, 1970.","journal-title":"J Physiol"},{"key":"378699_CR21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0022-1759(90)90069-8","volume":"127","author":"PA Vanderberghe","year":"1990","unstructured":"Vanderberghe PA, Ceuppens JL: Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a fluorescent calcium indicator. J Immunol Methods 127:197\u2013205, 1990","journal-title":"J Immunol Methods"},{"key":"378699_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00006676-199301000-00019","volume":"8","author":"S Tani","year":"1993","unstructured":"Tani S, Itoh H, Koide M, Okabayashi Y, Otsuki M: Involvement of endogenous cholecystokinin in the development of acute pancreatitis induced by closed duodenal loop. Pancreas 8:109\u2013115, 1993","journal-title":"Pancreas"},{"key":"378699_CR23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0016-5085(91)90601-G","volume":"100","author":"G Ohshio","year":"1991","unstructured":"Ohshio G, Saluja A, Steer ML: Effects of short-term pancreatic duct obstruction in rats. Gastroenterology 100:196\u2013202, 1991","journal-title":"Gastroenterology"},{"key":"378699_CR24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/cs0980143","volume":"98","author":"A Uru\u00f1uela","year":"2000","unstructured":"Uru\u00f1uela A, Manso MA, Pinto RM, Orfao A, de Dios I: Enzyme load in pancreatic acinar cells is increased in the early stages of acute pancreatitis induced by duct obstruction in rats. Clin Sci 98:143\u2013150, 2000","journal-title":"Clin Sci"},{"issue":"Suppl","key":"378699_CR25","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1046\/j.1440-1746.2000.02178.x","volume":"15","author":"M Otsuki","year":"2000","unstructured":"Otsuki M: Pathophysiological role of cholecystokinin in humans. J Gastroenterol Hepatol 15(Suppl):D71\u2013D83, 2000","journal-title":"J Gastroenterol Hepatol"},{"key":"378699_CR26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/jsre.1993.1019","volume":"54","author":"KM Murayama","year":"1993","unstructured":"Murayama KM, Samuel I, Toriumi Y, Solomon TE, Turkelson CM, Joehl RJ: Increased circulating cholecystokinin in obstruction-induced acute pancreatitis. J Surg Res 54:126\u2013131, 1993","journal-title":"J Surg Res"},{"key":"378699_CR27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00006676-199704000-00005","volume":"14","author":"H Shirohara","year":"1997","unstructured":"Shirohara H, Otsuki M: Plasma cholecystokinin levels in acute pancreatitis. Pancreas 14:249\u2013254, 1997","journal-title":"Pancreas"},{"key":"378699_CR28","first-page":"G100","volume":"249","author":"C Niedereau","year":"1985","unstructured":"Niedereau C, Grendell JH, Rothman SS: Effect of proglumide on ductal and basolateral secretion of pancreatic digestive enzymes. Am J Physiol 249:G100\u2013G107, 1985","journal-title":"Am J Physiol"},{"key":"378699_CR29","first-page":"100","volume":"249","author":"G Adler","year":"1985","unstructured":"Adler G, Hahn C, Kern HF, Rao KN: Caerulein-induced pancreatitis in rat: Increased lysosomal enzyme activity and autophagocytosis. Digestion 249:100\u2013107, 1985","journal-title":"Digestion"},{"key":"378699_CR30","first-page":"G835","volume":"276","author":"AK Saluja","year":"1999","unstructured":"Saluja AK, Baghat L, Lee HS, Bathia M, Frossard JL, Steer ML: Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 276:G835\u2013G842, 1999","journal-title":"Am J Physiol"},{"key":"378699_CR31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-9440(10)64515-4","volume":"157","author":"B Kr\u00fcger","year":"2000","unstructured":"Kr\u00fcger B, Albrecht E, Lerch MM: The role of intracellular calcium signalling in premature protease activation and the onset of pancreatitis. Am J Pathol 157:43\u201350, 2000","journal-title":"Am J Pathol"},{"key":"378699_CR32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1006920217206","volume":"200","author":"MA Manso","year":"1999","unstructured":"Manso MA, Garcia-Montero AC, Tabernero MD, Orfao A, de Dios I: The recovery of acute pancreatitis depends on the enzyme amount stored in zymogen granules at early stages. Mol Cell Biochem 200:35\u201341, 1999","journal-title":"Mol Cell Biochem"},{"key":"378699_CR33","first-page":"459","volume":"21","author":"M Machado","year":"2000","unstructured":"Machado M, Cunha J, Abdo E, Coelho A, Sampetri S, Kubrusli M: Does the pancreatic enzyme content modify the outcome of acute pancreatitis? Pancreas 21:459, 2000","journal-title":"Pancreas"},{"key":"378699_CR34","doi-asserted-by":"crossref","first-page":"13126","DOI":"10.1073\/pnas.97.24.13126","volume":"97","author":"M Raraty","year":"2000","unstructured":"Raraty, M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, Petersen OH: Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci USA 97:13126\u201313131, 2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"378699_CR35","first-page":"297","volume":"56","author":"OH Petersen","year":"1994","unstructured":"Petersen OH, Petersen C, Kasai H: Calcium and hormone action. Am J Physiol 56:297\u2013319, 1994","journal-title":"Am J Physiol"},{"key":"378699_CR36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/gast.1996.v111.pm8690215","volume":"111","author":"JB Ward","year":"1996","unstructured":"Ward JB, Sutton R, Jenkins SA, Petersen OH: Progressive disruption of acinar cell calcium signalling is an early feature of cerulein-induced pancreatitis in mice. Gastroenterology 111:481\u2013491, 1996","journal-title":"Gastroenterology"},{"key":"378699_CR37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0009-2797(91)90026-4","volume":"80","author":"W Malorni","year":"1991","unstructured":"Malorni W, Iosi F, Mirabelli F, Bellomo G: Cytoskeleton as a target of menadione-induced oxidative stress in cultured mammalian cells: Alterations underlying surface bleb formation. Chem Biol Interact 80:217\u2013236, 1991","journal-title":"Chem Biol Interact"},{"key":"378699_CR38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000007486","volume":"59","author":"H Weber","year":"1998","unstructured":"Weber H, Roesner JP, Nebe B, Rychly J, Werner A, Schr\u00f6der H, Jonas L, Leitzmann P, Schneider KP, Dummler W: Increased cytosolic Ca2+ amplifies oxygen radical-induced alterations of the ultrastructure and the energy metabolism of isolated rat pancreatic acinar cells. Digestion 59:175\u2013185, 1998","journal-title":"Digestion"},{"key":"378699_CR39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0005-2744(79)90104-9","volume":"571","author":"E Colomb","year":"1979","unstructured":"Colomb E, Figarella C: Comparative studies on the mechanisms of activation of two human trypsinogens. Biochim Biophys Acta 571:343\u2013351, 1979","journal-title":"Biochim Biophys Acta"},{"key":"378699_CR40","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0016-5085(89)90779-8","volume":"96","author":"M Silverman","year":"1989","unstructured":"Silverman M, Ilardi C, Bank S, Kranz V, Lendvai S: Effects of cholecystokinin antagonist L364,718 on experimental pancreatitis in mice. Gastroenterology 96:186\u2013192, 1989","journal-title":"Gastroenterology"},{"key":"378699_CR41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00006676-199005000-00007","volume":"5","author":"S Tani","year":"1990","unstructured":"Tani S, Okabayashi Y, Nakamura T, Fujii M, Itoh H, Otsuki M: Effect of a new cholecystokinin receptor antagonist loxiglumide on acute pancreatitis in two experimental animal models. Pancreas 5:284\u2013290, 1990","journal-title":"Pancreas"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1016400829744.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1016400829744\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1016400829744.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T03:13:17Z","timestamp":1753758797000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1016400829744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["378699"],"URL":"https:\/\/doi.org\/10.1023\/a:1016400829744","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}