{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:40:01Z","timestamp":1752464401641,"version":"3.41.2"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1997,7]]},"DOI":"10.1023\/a:1018818811199","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"1480-1485","source":"Crossref","is-referenced-by-count":9,"title":["Growth Hormone-Releasing Hormone (GRH)-Producing Pancreatic Tumor with No Evidence of Multiple Endocrine Neoplasia Type 1"],"prefix":"10.1007","volume":"42","author":[{"given":"S.","family":"Kawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Midorikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tokoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Oguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kiyosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.Y.","family":"Osamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Katakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"293728_CR1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0889-8529(18)30203-2","volume":"21","author":"G Faglia","year":"1992","unstructured":"Faglia G, Arosia M, Bazzoni N: Ectopic acromegaly. Endocrinol Metab Clin North Am 21:575\u2013595, 1992","journal-title":"Endocrinol Metab Clin North Am"},{"key":"293728_CR2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1677\/joe.0.0590325","volume":"59","author":"C Beck","year":"1973","unstructured":"Beck C, Larkins RG, Martin TJ: Stimulation of growth hormone release from superfused rat pituitary by extracts of hypothalamus and of human lung tumors. J Endocrinol 59:325\u2013333, 1973","journal-title":"J Endocrinol"},{"key":"293728_CR3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI109658","volume":"65","author":"LA Frohman","year":"1980","unstructured":"Frohman LA, Szabo M, Berelowitz M, Stachura ME: Partial purification and characterization of a peptide with growth hormone releasing activity from extrapituitary tumors in patients with acromegaly. J Clin Invest 65:43\u201354, 1980","journal-title":"J Clin Invest"},{"key":"293728_CR4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.6812220","volume":"218","author":"R Guillemin","year":"1982","unstructured":"Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB: Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218:585\u2013587, 1982","journal-title":"Science"},{"key":"293728_CR5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/300276a0","volume":"300","author":"J Rivier","year":"1982","unstructured":"Rivier J, Spiess J, Thorner M, Vale W: Characterization of a growth hormone-releasing factor from a human pancreatic islet tumor. Nature 300:276\u2013278, 1982","journal-title":"Nature"},{"key":"293728_CR6","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/0002-9343(78)90531-4","volume":"64","author":"RH Caplan","year":"1978","unstructured":"Caplan RH, Koob L, Abellera RM, Pagliara AS, Kovacs K, Randall RV: Cure of acromegaly by operative removal of an islet cell tumor of the pancreas. Am J Med. 64:874\u2013822, 1978","journal-title":"Am J Med."},{"key":"293728_CR7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1172\/JCI110708","volume":"70","author":"MO Thorner","year":"1982","unstructured":"Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin RM, Johansen A, Vale W, Horvath E, Kovacs K: Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965\u2013977, 1982","journal-title":"J Clin Invest"},{"key":"293728_CR8","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/1097-0142(19841115)54:10<2097::AID-CNCR2820541009>3.0.CO;2-X","volume":"54","author":"G Berger","year":"1984","unstructured":"Berger G, Trouillas J, Bloch B, Sassolas G, Berger F, Partensky C, Chayvialle JA, Brazeau P, Claustrat B, Lesbros F, Giros C: Multihormonal carcinoid tumor of the pancreas. Secreting growth hormone-releasing factor as a cause of acromegaly. Cancer 54:2097\u20132108, 1984","journal-title":"Cancer"},{"key":"293728_CR9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1210\/jcem-59-5-1002","volume":"59","author":"DM Wilson","year":"1984","unstructured":"Wilson DM, Ceda GP, Bostwick DG, Webber RJ, Minkoff JR, Pont A, Hintz RL, Bensch JG, Kraemer FB, Rosenfeld RG, Hoffman AR: Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor. J Clin Endocrinol Metab 59:1002\u20131005, 1984","journal-title":"J Clin Endocrinol Metab"},{"key":"293728_CR10","first-page":"909","volume":"135","author":"A Sasaki","year":"1985","unstructured":"Sasaki A, Sato S, Hnuyu K, Go M, Shimizu Y, Murakami O, Mouri T, Yoshinaga K, Sasano N: Acromegaly associated with an ectopic GRF producing pancreatic carcinoid tumor: characterization of immunoreactive GRF in pancreatic tumor. J Clin Exp Med 135:909\u2013910, 1985 (in Japanese)","journal-title":"J Clin Exp Med"},{"key":"293728_CR11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0002-9343(85)90559-5","volume":"79","author":"JLC Ch'ng","year":"1985","unstructured":"Ch'ng JLC, Christofides ND, Kraenzlin ME, Keshavarzian A, Burrin JM, Woolf IL, Hodgson HJF, Bloom SR: Growth hormone secretion dynamics in a patient with ectopic growth hormone-releasing factor production. Am J Med 79:135\u2013138, 1985","journal-title":"Am J Med"},{"key":"293728_CR12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00705425","volume":"409","author":"W Saeger","year":"1986","unstructured":"Saeger W, Schulte HM, Kloeppel G: Morphology of a GHRH producing pancreatic islet cell tumour causing acromegaly. Virchows Arch (Pathol Anat) 409:547\u2013554, 1986","journal-title":"Virchows Arch (Pathol Anat)"},{"key":"293728_CR13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00000478-198710000-00008","volume":"11","author":"T Sano","year":"1987","unstructured":"Sano T, Yamasaki R, Saito H, Hirose T, Kudo E, Kameyama K, Hiraishi K, Saito S, Hizawa K: Growth hormone-releasing hormone (GHRH)-secreting pancreatic tumor in patient with multiple endocrine neoplasia type 1. Am J Surg Pathol 11:810\u2013815, 1987","journal-title":"Am J Surg Pathol"},{"key":"293728_CR14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/1097-0142(19880715)62:2<445::AID-CNCR2820620233>3.0.CO;2-5","volume":"62","author":"JA Ramsay","year":"1988","unstructured":"Ramsay JA, Kovacs K, Asa SL, Pike MJ, Thorner MO: Reversible sellar enlargement due to growth hormone-releasing hormone production by pancreatic endocrine tumor in an acromegalic patient with multiple endocrine neoplasia type I syndrome. Cancer 62:445\u2013450, 1988","journal-title":"Cancer"},{"key":"293728_CR15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3171\/jns.1995.83.4.0719","volume":"83","author":"S Genka","year":"1995","unstructured":"Genka S, Soeda H, Takahashi M, Katakami H, Sanno N, Osamura Y, Fuchinoue T, Teramoto A: Acromegaly, diabetes insipidus and visual loss caused by metabolic growth hormone-releasing-hormone (GRH)-producing malignant pancreatic endocrine tumor in the pituitary gland. J Neurosurg 83:719\u2013723, 1995","journal-title":"J Neurosurg"},{"key":"293728_CR16","first-page":"1358","volume":"91","author":"K Ohyama","year":"1987","unstructured":"Ohyama K, Fujimoto M, Nakagomi Y, Kato K: Clinical availability of radioimmunoassay of plasma growth hormone releasing factor. J Jpn Pediatr Soc 91:1358\u20131365, 1987 (in Japanese)","journal-title":"J Jpn Pediatr Soc"},{"key":"293728_CR17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1507\/endocrj.40.133","volume":"40","author":"RY Osamura","year":"1993","unstructured":"Osamura RY, Oda K, Utsunomiya H, Inada K, Katakami H, Voss JW, Mayo K, Rosenfeld MG: Immunohistochemical expression of pit-1 protein in pituitary glands of human GRF transgenic mice: Its relationship with hormonal expressions. Endocrine J 40:133\u2013139, 1993","journal-title":"Endocrine J"},{"key":"293728_CR18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1210\/edrv-9-3-357","volume":"9","author":"T Sano","year":"1988","unstructured":"Sano T, Asa S, Kovacs K: Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocrine Rev 9:357\u2013373, 1988","journal-title":"Endocrine Rev"},{"key":"293728_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.1993.tb00964.x","volume":"38","author":"RV Thakker","year":"1993","unstructured":"Thakker RV: The molecular genetics of the multiple endocrine neoplasia syndromes. Clin Endocrinol 38:1\u201314, 1993","journal-title":"Clin Endocrinol"},{"key":"293728_CR20","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0002-9343(70)90055-0","volume":"48","author":"CJ Pepine","year":"1970","unstructured":"Pepine CJ, Aloia J: Heart muscle disease in acromegaly. Am J Med 48:530\u2013534, 1970","journal-title":"Am J Med"},{"key":"293728_CR21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/hrt.41.6.697","volume":"4","author":"HM Mather","year":"1979","unstructured":"Mather HM, Boyd MJ, Jenkins JS: Heart size and function in acromegaly. Br Heart J 4:697\u2013701, 1979","journal-title":"Br Heart J"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018818811199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018818811199\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018818811199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:15:51Z","timestamp":1752462951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018818811199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["293728"],"URL":"https:\/\/doi.org\/10.1023\/a:1018818811199","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}