{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:40:10Z","timestamp":1752464410038,"version":"3.41.2"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,8]]},"DOI":"10.1023\/a:1018823417541","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"1719-1724","source":"Crossref","is-referenced-by-count":0,"title":["Tolerance and Antiviral Effects of High-Dose Interferon-\u03b1 B\/D in Patients with Chronic Hepatitis B"],"prefix":"10.1007","volume":"43","author":[{"given":"M. C.","family":"Rasch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schellekens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M. M.","family":"Van Dijck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Haagsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P.","family":"Michielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.J.A.M.","family":"Van Buuren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Stotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Van Hattum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"294896_CR1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7326\/0003-4819-122-9-199505010-00004","volume":"122","author":"JB Wong","year":"1995","unstructured":"Wong JB, Koff RS, Tine F, Pauker SG: Cost-effectiveness of interferon-alpha 2b for hepatitis B e antigen positive chronic hepatitis B. Ann Intern Med 122:664 - 675, 1995","journal-title":"Ann Intern Med"},{"key":"294896_CR2","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199605303342202","volume":"334","author":"C Niede rau","year":"1996","unstructured":"Niede rau C, Heintges T, Lange S, Goldmann G, Niederau CM, Mohr L, H\u00e4ussinger D: Long-term follow-up of HBeAg positive patients treated with interferon alpha for chronic hepatitis B. N Engl J Med 334:1422- 1427, 1996","journal-title":"N Engl J Med"},{"key":"294896_CR3","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/0016-5085(87)90613-5","volume":"92","author":"ASF Lok","year":"1987","unstructured":"Lok ASF, Lai CL, Wu PC, Leung EKY, Lam TS: Spontaneous hepatitis B e-antigen to antibody seroconversion and reve rsion in Chinese patients with chronic hepatitis B virus infection. Gastroente rology 92:1839 - 1843, 1987","journal-title":"Gastroente rology"},{"key":"294896_CR4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0168-8278(92)90019-L","volume":"15","author":"V Carreno","year":"1992","unstructured":"Carreno V, Castello I, Molina J, Porre s JC, Bartolom\u00e9 J: Long-term follow-up of hepatitis B chronic carrie rs who re sponded to interferon therapy. J Hepatol 15:102- 106, 1992","journal-title":"J Hepatol"},{"key":"294896_CR5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0168-8278(96)80184-X","volume":"24","author":"G Fattovich","year":"1996","unstructured":"Fattovich G, Giustina G, Favarato S, Ruol A, Investigators of the Italian Association for Study of the Liver: A surve y of adverse eve nts in 11241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol 24:38 - 47, 1996","journal-title":"J Hepatol"},{"key":"294896_CR6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1099\/0022-1317-67-8-1633","volume":"67","author":"A Meister","year":"1986","unstructured":"Meister A, Uz\u00e9 G, Mogensen KE, Gre sse r I, Tove y MG, Gr\u00fctter M, Meyer F: Biological activities and receptor binding of two human recombinant interferons and their hybrids. J Gen Virol 67:1633- 1643, 1986","journal-title":"J Gen Virol"},{"unstructured":"Hochkeppel HK: CGP 35 269 recombinant human interferon alpha B\/D hybrid. Antitumor and anti-viral agent. Investigator's brochure. Ciba Ge igy Ltd., Research and De velopment Department, 1991","key":"294896_CR7"},{"key":"294896_CR8","first-page":"258","volume":"32","author":"P Von Wussow","year":"1991","unstructured":"Von Wussow P, Hochkeppel HK, Jakschies D, Rapp U, Franke M, De icher H: Phase I study of a new recombinant hybrid IFN(\u03b11\/\u03b18). Proc Am Assoc Cancer Res 32:258, 1991","journal-title":"Proc Am Assoc Cancer Res"},{"key":"294896_CR9","first-page":"1","volume-title":"The Liver and Portal Hypertension","author":"CG Child 3rd","year":"1964","unstructured":"Child CG 3rd, Turcotte J: Surgery and portal hypertension. InThe Liver and Portal Hypertension. CG Child 3rd, JE Dunphy (eds). Philadelphia, WB Saunders, 1964, pp 1- 85"},{"key":"294896_CR10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L","volume":"1","author":"DA Karnofsky","year":"1948","unstructured":"Karnofsky DA, Abelmann WH, Craver LF, Burchenal JH: The use of nitrogen mustard in the palliative treatme nt of carcinoma with particular refe rence to bronchogenic carcinoma. Cancer 1:634 - 656, 1948","journal-title":"Cancer"},{"key":"294896_CR11","volume-title":"Cance r The rapy Evaluation Program","author":"National Institutes of He alth","year":"1988","unstructured":"National Institutes of He alth: Common Toxicity Criteria. Cance r The rapy Evaluation Program, Division of Cance r Treatment, Bethesda, Maryland, 1988"},{"key":"294896_CR12","first-page":"922","volume":"80","author":"A Imagawa","year":"1995","unstructured":"Imagawa A, Itoh N, Hanafusa T, Oda Y, Waguri M, Miyagawa J, Kono N, Kuwajima M, Matsuzawa Y: Autoimmune endocrine disease induced by interferon-alpha therapy for chronic active type C hepatitis. J Clin Endocrinol Metab 80:922- 926, 1995","journal-title":"J Clin Endocrinol Metab"},{"key":"294896_CR13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/eje.0.1320587","volume":"132","author":"D Preziati","year":"1995","unstructured":"Preziati D, La Rosa L, Covini G, Marcelli R, Re scalli S, Persani L, Del Ninno E, Meroni PL, Colombo M, Beck-Pe ccoz P: Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2b. Eur J Endocrinol 132:587- 593, 1995","journal-title":"Eur J Endocrinol"},{"key":"294896_CR14","first-page":"1613","volume":"297","author":"EJ Kamfe r","year":"1988","unstructured":"Kamfe r EJ, Mc Carthy DM: Immune thrombocytopenia and interferon-alpha. Br Med J 297:1613, 1988","journal-title":"Br Med J"},{"key":"294896_CR15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1600-0609.1986.tb02290.x","volume":"36","author":"EA Abdi","year":"1986","unstructured":"Abdi EA, Brien W, Venner PM: Auto-immune thrombocytopenia re lated to interferon therapy. Scand J Haematol 36:515- 519, 1986","journal-title":"Scand J Haematol"},{"key":"294896_CR16","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1056\/NEJM198911023211806","volume":"321","author":"LR Deyton","year":"1989","unstructured":"Deyton LR, Walker RE, Kovacs JA, Herpin B, Parker M, Masur H, Fauci AS, Lane HC: Reversible cardiac dysfunction associated with interferon alpha therapy in AIDS patients with kaposi's sarcoma. N Engl J Med 321:1246 - 1249, 1989","journal-title":"N Engl J Med"},{"key":"294896_CR17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1378\/chest.99.3.557","volume":"99","author":"M Sonnenblick","year":"1991","unstructured":"Sonnenblick M, Rosin A: Cardiotoxicity of interferon. A re view of 44 case s. Chest 99:557- 561, 1991","journal-title":"Chest"},{"key":"294896_CR18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJM199008023230503","volume":"323","author":"RP Perrillo","year":"1990","unstructured":"Perrillo RP, Schiff ER, Davis GL, Bodenheime r HC Jr, Lindsay K, Payne J, Dienstag JL, O'Brien C, Tamburro C, Jacobson IA, Sampliner R, Feit D, Lefkowitch J, Kuhns M, Meschievitz C, Sanghvi B, Albrecht J, Gibas A, Hepatitis Interventional Therapy Group: A randomized, controlled trial of interferon alpha-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 323:295- 301, 1990","journal-title":"N Engl J Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018823417541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018823417541\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018823417541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:00:42Z","timestamp":1752462042000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018823417541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["294896"],"URL":"https:\/\/doi.org\/10.1023\/a:1018823417541","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}