{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:28:46Z","timestamp":1762144126916,"version":"3.41.2"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,9]]},"DOI":"10.1023\/a:1018830408397","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"1957-1963","source":"Crossref","is-referenced-by-count":35,"title":["Nonsteroidal Antiinflammatory Drugs Could Reverse Helicobacter pylori-Induced Apoptosis and Proliferation in Gastric Epithelial Cells"],"prefix":"10.1007","volume":"43","author":[{"given":"G. H.","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. L.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. C.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. K.","family":"Ching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. C. Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"294948_CR1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0889-8553(21)00463-5","volume":"19","author":"DY Graham","year":"1990","unstructured":"Graham DY: The relationship between nonsteroidal anti-inflammatory drug use and peptic ulcer disease. Gastroenterol Clin North Am 19: 171\u2013182, 1990","journal-title":"Gastroenterol Clin North Am"},{"key":"294948_CR2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1136\/gut.34.12.1677","volume":"34","author":"PM Goggin","year":"1993","unstructured":"Goggin PM, Collins DA, Jazrawi RP, Jackson PA, Corbishley CM, Bourke BE, Northfield TC: Prevalence of Helicobacter pyloriinfection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis. Gut 34: 1677\u20131680, 1993","journal-title":"Gut"},{"issue":"suppl1","key":"294948_CR3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2036.1995.tb00781.x","volume":"9","author":"JH Walsh","year":"1995","unstructured":"Walsh JH: Unanswered question about Helicobacter pylori. Aliment Pharmacol Ther 9(suppl 1): 31\u201337, 1995","journal-title":"Aliment Pharmacol Ther"},{"key":"294948_CR4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/gut.36.3.334","volume":"36","author":"AS Taha","year":"1995","unstructured":"Taha AS, Sturrock TD, Russell RI: Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: Predisposition to ulceration and relation to Helicobacter pylori. Gut 36: 334\u2013336, 1995","journal-title":"Gut"},{"key":"294948_CR5","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1242\/jcs.107.12.3569","volume":"107","author":"PA Hall","year":"1994","unstructured":"Hall PA, Coates PJ, Ansari B, Hopwood D: Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. J Cell Sci 107: 3569\u20133577, 1994","journal-title":"J Cell Sci"},{"key":"294948_CR6","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1053\/gast.1996.v110.pm8613014","volume":"110","author":"FG Que","year":"1996","unstructured":"Que FG, Gores GJ: Cell death by apoptosis: basic concepts and disease relevance for the gastroenterologist. Gastroenterology 110: 1238\u20131243, 1996","journal-title":"Gastroenterology"},{"key":"294948_CR7","first-page":"345","volume":"75","author":"L Spyridon","year":"1994","unstructured":"Spyridon L, Akira N, Hiromasa K, Katsutoshi G, Takao M, Yoshiki O, Hideo S, Hisayuki F: The development of the endothelin-1-induced gastric ulcer: time sequence analysis of morphologic changes. Int J Exp Pathol 75: 345\u2013355, 1994","journal-title":"Int J Exp Pathol"},{"key":"294948_CR8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1440-1746.1990.tb01411.x","volume":"5","author":"A Benedetti","year":"1990","unstructured":"Benedetti A, Mancini R, Marucci L, Paolucci F, Jezequel AM, Orlandi F: Quantitative study of apoptosis in normal rat gastroduodenal mucosa. J Gastroenterol Hepatol 5: 369\u2013374, 1990","journal-title":"J Gastroenterol Hepatol"},{"key":"294948_CR9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.38.4.498","volume":"34","author":"SF Moss","year":"1996","unstructured":"Moss SF, Calam J, Agarwal B, Wang S, Holt PR: Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 34: 498\u2013501, 1996","journal-title":"Gut"},{"issue":"suppl1","key":"294948_CR10","first-page":"s17","volume":"7","author":"DAF Lynch","year":"1995","unstructured":"Lynch DAF, Axon ATR: Helicobacter pylori, gastric cancer and gastric epithelial kinetics: A review. Eur J Gastroenterol Hepatol 7(suppl 1): s17\u2013s23, 1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"294948_CR11","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/BF02088228","volume":"41","author":"C Panella","year":"1996","unstructured":"Panella C, Ierardi E, Polimeno L, Balzano T, Ingrosso M, Amoruso A, Traversa A, Francavilla A: Proliferative activity of gastric epithelium in progressive stage s of Helicobacter pyloriinfection. Dig Dis Sci 41: 1132\u20131138, 1996","journal-title":"Dig Dis Sci"},{"key":"294948_CR12","first-page":"1870","volume":"88","author":"F Brenes","year":"1993","unstructured":"Brenes F, Ruiz B, Correa P, Hunter F, Rhamakrisham T, Fontham E, Shi TY: Helicobacter pyloricauses hyperproliferation of the gastric epithelium: Pre-and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 88: 1870\u20131875, 1993","journal-title":"Am J Gastroenterol"},{"key":"294948_CR13","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/0016-5085(92)91720-O","volume":"102","author":"S Levi","year":"1992","unstructured":"Levi S, Goodlad RA, Lee CY, Walport MJ, Wright NA, Hodgeson HJF: Effects of nonsteroidal anti-inflammatory drugs and misoprostal on gastroduodenal epithelial proliferation in arthritis. Gastroenterology 102: 1605\u20131611, 1992","journal-title":"Gastroenterology"},{"key":"294948_CR14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0016-5085(88)90487-8","volume":"95","author":"DY Graham","year":"1988","unstructured":"Graham DY, Smith JL, Spjut HJ, Torres E: Gastric adaptation: studies in humans during continuous aspirin administration. Gastroenterology 95: 327\u2013333, 1988","journal-title":"Gastroenterology"},{"key":"294948_CR15","first-page":"5575","volume":"52","author":"LJ Marnett","year":"1992","unstructured":"Marnett LJ: Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52: 5575\u20135589, 1992","journal-title":"Cancer Res"},{"key":"294948_CR16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-121-4-199408150-00001","volume":"121","author":"E Giovannucci","year":"1994","unstructured":"Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC: Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 121: 241\u2013246, 1994","journal-title":"Ann Intern Med"},{"key":"294948_CR17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI118060","volume":"96","author":"SJ Shiff","year":"1995","unstructured":"Shiff SJ, Qiao L, Tsai LL, Rigas B: Sulindac sulfide, an aspirinlike compound, inhibits proliferation, cause s cell cycle quiescence, and induce apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest 96: 491\u2013503, 1995","journal-title":"J Clin Invest"},{"key":"294948_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/excr.1996.0023","volume":"222","author":"SJ Shiff","year":"1996","unstructured":"Shiff SJ, Koutsos MI, Qiao L, Rigas B: Nonsteroidal anti-inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis. Exp Cell Res 222: 179\u2013188, 1996","journal-title":"Exp Cell Res"},{"issue":"suppl214","key":"294948_CR19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/00365529609094512","volume":"31","author":"C O'Morain","year":"1996","unstructured":"O'Morain C, Buckley M: Helicobacter pyloriand dyspepsia. Scand J Gastroenterol 31( suppl)214: 28\u201330, 1996","journal-title":"Scand J Gastroenterol"},{"key":"294948_CR20","first-page":"949","volume":"91","author":"CK Ching","year":"1996","unstructured":"Ching CK, Wong BCY, Kwok E, Ong L, Covacci A, Lam SK: Prevalence of CagA-bearing Helicobacter pyloristrains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls. Am J Gastroenterol 91: 949\u2013953, 1996","journal-title":"Am J Gastroenterol"},{"key":"294948_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.119.3.493","volume":"119","author":"Y Gavrieli","year":"1992","unstructured":"Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493\u2013501, 1992","journal-title":"J Cell Biol"},{"key":"294948_CR22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0016-5085(92)91109-H","volume":"103","author":"K Yamada","year":"1992","unstructured":"Yamada K, Yoshitake K, Sato M, Ahnen DJ: Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colon epithelium of the rat. Gastroenterology 103: 160\u2013167, 1992","journal-title":"Gastroenterology"},{"key":"294948_CR23","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/0016-5085(92)90311-L","volume":"102","author":"DS Loeb","year":"1992","unstructured":"Loeb DS, Talley NJ, Ahlquist DA, Carpenter HA, Zinsmeister AR: Long-term nonsteroidal anti-inflammatory drug use and gastroduodenal injury: The role of Helicobacter pylori. Gastroenterology 102: 1899\u20131905, 1992","journal-title":"Gastroenterology"},{"key":"294948_CR24","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/BF01536802","volume":"35","author":"JE Ormand","year":"1990","unstructured":"Ormand JE, Talley NJ, Carpenter HA, Shorter RG, Conley CR, Wilson WR, DiMagno EP, Zinsmeister AR, Phillips SF: [14C]Urea breath test for diagnosis of Helicobacter pylori. Dig Dis Sci 35: 879\u2013884, 1990","journal-title":"Dig Dis Sci"},{"key":"294948_CR25","first-page":"3238","volume":"56","author":"EE Mannick","year":"1996","unstructured":"Mannick EE, Bravo LE, Zarama G, Realpe JL, Zhang XJ, Ruiz B, Fontham ETH, Mera R, Miller MJS, Correa P: Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylorigastritis: Effect of antibiotics and antioxidants. Cancer Res 56: 3238\u20133243, 1996","journal-title":"Cancer Res"},{"key":"294948_CR26","first-page":"A307","volume":"110","author":"GH Zhu","year":"1996","unstructured":"Zhu GH, Ching CK, Lam SK, Sheng JZ, Wong TM, Ding SZ: Sialic acid dependent H. pylorilectin as activator of calcium signal in cultured epithelial cells. Gastroenterology 110: A307, 1996","journal-title":"Gastroenterology"},{"key":"294948_CR27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/jlb.59.6.775","volume":"59","author":"DJ McConkey","year":"1996","unstructured":"McConkey DJ, Orrenius S: The role of calcium in the regulation of apoptosis. J Leukoc Biol 59: 775\u2013783, 1996","journal-title":"J Leukoc Biol"},{"key":"294948_CR28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/00365529709000195","volume":"32","author":"J Piotrowski","year":"1997","unstructured":"Piotrowski J, Piotrowski E, Skrodzka D, Slomiany A, Slomiany BL: Induction of acute gastritis and epithelial apoptosis by Helicobacter pylorilipopolysaccharide. Scand J Gastroenterol 32: 203\u2013211, 1997","journal-title":"Scand J Gastroenterol"},{"key":"294948_CR29","doi-asserted-by":"crossref","first-page":"A683","DOI":"10.1053\/gast.1997.v112.pm9041228","volume":"112","author":"BCY Wong","year":"1997","unstructured":"Wong BCY, Zhu GH, Eggo MC, Yuen ST, Chan EYT, Lam SK: Nonsteroidal antiinflammatory drugs (NSAIDs) induces apoptosis in human gastric carcinoma cells. Gastroenterology 112: A683, 1997","journal-title":"Gastroenterology"},{"key":"294948_CR30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jcb.240580205","volume":"58","author":"W Meikrantz","year":"1995","unstructured":"Meikrantz W, Schlegel R: Apoptosis and the cell cycle. J Cell Biochem 58: 160\u2013174, 1995","journal-title":"J Cell Biochem"},{"key":"294948_CR31","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","volume":"325","author":"J Parsonnet","year":"1991","unstructured":"Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK: Helicobacter pyloriinfection and the risk of gastric carcinoma. N Engl J Med 325: 1127\u20131131, 1991","journal-title":"N Engl J Med"},{"key":"294948_CR32","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/0140-6736(93)90938-D","volume":"314","author":"The Eurogast Study Group","year":"1993","unstructured":"The Eurogast Study Group: An international association between Helicobacter pyloriinfection and gastric cancer. Lancet 314: 1359\u20131362, 1993","journal-title":"Lancet"},{"key":"294948_CR33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2036.1994.tb00274.x","volume":"8","author":"AG Fraser","year":"1994","unstructured":"Fraser AG, Sim R, Sankey EA, Dhillon AP, Pounder RE: Effect of eradication of Helicobacter pylorion gastric epithelial cell proliferation. Aliment Pharmacol Ther 8: 167\u2013173, 1994","journal-title":"Aliment Pharmacol Ther"},{"key":"294948_CR34","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.2136249","volume":"249","author":"BN Ames","year":"1990","unstructured":"Ames BN, Gold LS: Too many rodent carcinogens: Mitogenesis increase s mutagenesis. Science 249: 970\u2013971, 1990","journal-title":"Science"},{"key":"294948_CR35","first-page":"235","volume":"48","author":"M Lipkin","year":"1988","unstructured":"Lipkin M: Biomarkers of increase d susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Cancer Res 48: 235\u2013245, 1988","journal-title":"Cancer Res"},{"key":"294948_CR36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2036.1995.tb00424.x","volume":"9","author":"SM Sant","year":"1995","unstructured":"Sant SM, Cahill RJ, Gilvarry J, O'Morain CA: Do nonsteroidal anti-inflammatory drugs have an e ffect on gastric cell turnover? Aliment Pharmacol Ther 9: 575\u2013579, 1995","journal-title":"Aliment Pharmacol Ther"},{"key":"294948_CR37","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/0140-6736(90)92341-E","volume":"336","author":"S Levi","year":"1990","unstructured":"Levi S, Goodlad RA, Lee CY, Stamp G, Walport MJ, Wright NA, Hodgson HJF: Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 336: 840\u2013843, 1990","journal-title":"Lancet"},{"key":"294948_CR38","first-page":"164","volume":"45","author":"P Emery","year":"1991","unstructured":"Emery P, Samon M: Systemic mediators of inflammation. Br J Hosp Med 45: 164\u2013168, 1991","journal-title":"Br J Hosp Med"},{"key":"294948_CR39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/000456329002700301","volume":"27","author":"J Lunec","year":"1990","unstructured":"Lunec J: Fre e radicals: Their involvement in disease processes. Ann Clin Biochem 27: 173\u2013182, 1990","journal-title":"Ann Clin Biochem"},{"key":"294948_CR40","first-page":"2111","volume":"55","author":"MJ Blaser","year":"1995","unstructured":"Blaser MJ, Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomurn A: Infection with Helicobacter pyloristrains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55: 2111\u20132115, 1995","journal-title":"Cancer Res"},{"key":"294948_CR41","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/jnci\/89.12.863","volume":"89","author":"RM Peek Jr","year":"1997","unstructured":"Peek RM Jr, Moss SF, Tham KT, Perez-Pe rez GI, Wang SB, Miller GG, Atherton JC, Holt PR, Blaser MJ: Helicobacter pyloricagA+ strains and dissociation of gastric epithelial cells proliferation from apoptosis. J Natl Cancer Inst 89: 863\u2013868, 1997","journal-title":"J Natl Cancer Inst"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018830408397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018830408397\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018830408397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:07:55Z","timestamp":1752462475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018830408397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["294948"],"URL":"https:\/\/doi.org\/10.1023\/a:1018830408397","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}