{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:40:01Z","timestamp":1752464401665,"version":"3.41.2"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1023\/a:1018850412148","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"1482-1487","source":"Crossref","is-referenced-by-count":30,"title":["Search for Putative Virulence Factors of Helicobacter pylori (The Low-Molecular-Weight (33-35 K) Antigen)"],"prefix":"10.1007","volume":"43","author":[{"given":"Yoshio","family":"Yamaoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"294812_CR1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0016-5085(93)90038-E","volume":"105","author":"DY Graham","year":"1993","unstructured":"Graham DY, Go MF: Helicobacter pylori:Current status. Gastroenterology 105:279 - 282, 1993","journal-title":"Gastroenterology"},{"key":"294812_CR2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1440-1746.1991.tb01448.x","volume":"6","author":"DY Graham","year":"1991","unstructured":"Graham DY: Helicobacter pylori:Its epidemiology and its role in duodenal ulcer disease. J Gastroenterol Hepatol 6:105- 113, 1991","journal-title":"J Gastroenterol Hepatol"},{"key":"294812_CR3","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM199110173251604","volume":"325","author":"A Nomura","year":"1991","unstructured":"Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez PG, Blaser MJ: Helicobacter pyloriinfection and gastric carcinoma among Japane se Ame ricans in Hawaii. N Engl J Med 325:1132- 1136, 1991","journal-title":"N Engl J Med"},{"key":"294812_CR4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","volume":"325","author":"J Parsonnet","year":"1991","unstructured":"Parsonnet J, Friedman GD, Vanderstee n DP, Chang Y, Vogelman JH, Orentre ich N, Sibley RK: Helicobacter pyloriinfection and the risk of gastric carcinoma. N Engl J Med 325:1127- 1131, 1991","journal-title":"N Engl J Med"},{"key":"294812_CR5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0046-8177(93)90233-7","volume":"24","author":"PG Issacson","year":"1993","unstructured":"Issacson PG, Spencer J: Is gastric lymphoma an infectious disease? Hum Pathol 24:569 - 570, 1993","journal-title":"Hum Pathol"},{"key":"294812_CR6","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1056\/NEJM198912073212302","volume":"321","author":"CP Dooley","year":"1989","unstructured":"Dooley CP, Cohen H, Fitzgibbons PL, Baue r M, Appleman MD, Pe re z-Perez GI, Blaser MJ: Prevalence of Helicobacter pyloriinfection and histologic gastritis in asymptomatic persons. N Engl J Med 321:1562- 1566, 1989","journal-title":"N Engl J Med"},{"key":"294812_CR7","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1128\/jcm.33.6.1496-1500.1995","volume":"33","author":"TL Cover","year":"1995","unstructured":"Cover TL, Glupczynski Y, Lage AP, Burette A, Tummuru MKR, Pere z-Pe rez GI, Blase r MJ: Serologic detection of infection with cagA1 Helicobacter pyloristrains. J Clin Microbiol 33:1496 - 1500, 1995","journal-title":"J Clin Microbiol"},{"key":"294812_CR8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/(SICI)1097-0215(1997)10+<34::AID-IJC9>3.0.CO;2-A","volume":"10","author":"T Hirohata","year":"1997","unstructured":"Hirohata T, Kono S: Diet\/nutrition and stomach cance r in Japan. Int J Cancer Suppl 10:34 - 36, 1997","journal-title":"Int J Cancer Suppl"},{"key":"294812_CR9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/iai.63.1.94-98.1995","volume":"63","author":"Z Xiang","year":"1995","unstructured":"Xiang Z, Censini S, Bayeli PF, Te lford JL, Figura N, Rappuoli R, Covacci A: Analysis of expre ssion of CagA and VacA virulence factors in 43 strains of Helicobacter pylorireveals that clinical isolates can be divided into two major type s and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 63:94 - 98, 1995","journal-title":"Infect Immun"},{"key":"294812_CR10","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","volume":"93","author":"S Censini","year":"1996","unstructured":"Censini S, Lange C, Xiang Z, Crabtre e JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A: cag,a pathogenicity island of Helicobacter pylori,encodes type I-specifi c and disease-associated virulence factors. Proc Natl Acad Sci USA 93:14648 - 14653, 1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"294812_CR11","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","volume":"90","author":"A Covacci","year":"1993","unstructured":"Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N, Rappuoli R: Molecular characte rization of the 128-k immunodominant antigen of Helicobacter pyloriassociated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 90:5791- 5795, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"294812_CR12","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1128\/iai.61.5.1799-1809.1993","volume":"61","author":"MK Tummuru","year":"1993","unstructured":"Tummuru MK, Cover TL, Blaser MJ: Cloning and expre ssion of a high-molecular-mass major antigen of Helicobacter pylori:Evidence of linkage to cytotoxin production. Infect Immun 61:1799 - 1809, 1993","journal-title":"Infect Immun"},{"key":"294812_CR13","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/iai.58.3.603-610.1990","volume":"58","author":"TL Cover","year":"1990","unstructured":"Cover TL, Dooley CP, Blase r MJ: Characterization of and human serologic response to proteins in Helicobacter pyloribroth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 58:603- 610, 1990","journal-title":"Infect Immun"},{"key":"294812_CR14","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/0140-6736(91)90477-7","volume":"338","author":"JE Crabtree","year":"1991","unstructured":"Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, Rathbone BJ: Mucosal Ig A recognition of Helicobacter pylori120 K protein, peptic ulceration, and gastric pathology. Lance t 338:332- 335, 1991","journal-title":"Lance t"},{"key":"294812_CR15","first-page":"2111","volume":"55","author":"MJ Blaser","year":"1995","unstructured":"Blaser MJ, Perez-Pe re z GI, Kleanthous H, Cove r TL, Pe ek RM, Chyou PH, Stemmermann GN, Nomura A: Infection with Helicobacter pyloristrains possessing cagAis associated with an increase d risk of developing adenocarcinoma of the stomach. Cancer Res 55:2111- 2115, 1995","journal-title":"Cancer Res"},{"key":"294812_CR16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.40.3.297","volume":"40","author":"J Parsonnet","year":"1997","unstructured":"Parsonnet J, Friedman GD, Orentreich N, Vogelman H: Risk for gastric cance r in people with CagA positive or CagA negative Helicobacter pyloriinfection. Gut 40:297- 301, 1997","journal-title":"Gut"},{"key":"294812_CR17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gut.41.4.442","volume":"40","author":"Y Yamaoka","year":"1997","unstructured":"Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi J: Induction of various cytokines and development of seve re mucosal infl ammation by cagAgene-positive Helicobacter pyloristrains. Gut 40:442- 451, 1997","journal-title":"Gut"},{"key":"294812_CR18","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/jcm.35.7.1710-1714.1997","volume":"35","author":"Y Ito","year":"1997","unstructured":"Ito Y, Azuma T, Ito S, Miyaji H, Hirai M, Yamazaki Y, Sato F, Kato T, Kohli Y, Kuriyama M: Analysis of typing of the vacA gene from cagA-positive strains of Helicobacter pyloriisolated in Japan. J Clin Microbiol 35:1710 - 1714, 1997","journal-title":"J Clin Microbiol"},{"key":"294812_CR19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/00365529709025082","volume":"32","author":"T Shimoyama","year":"1997","unstructured":"Shimoyama T, Fukuda S, Mikami T, Saito Y, Munakata A: High prevalence of the cagA-positive Helicobacter pyloristrains in Japane se asymptomatic patients and gastric cancer patients. Scand J Gastroenterol 32:465- 468, 1997","journal-title":"Scand J Gastroenterol"},{"key":"294812_CR20","first-page":"1322","volume":"91","author":"S Miehlke","year":"1996","unstructured":"Miehlke S, Kibler K, Kim JG, Figura N, Small SM, Graham DY, Go MF: Allelic variation in the cagAgene of Helicobacter pyloriobtained from Korea compare d to the United States. Am J Gastroente rol 91:1322- 1325, 1996","journal-title":"Am J Gastroente rol"},{"key":"294812_CR21","first-page":"107","volume":"1","author":"MF Go","year":"1996","unstructured":"Go MF, Graham DY: Prese nce of the cagAgene in the majority of Helicobac ter pyloristrains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. He licobacter 1:107- 111, 1996","journal-title":"He licobacter"},{"key":"294812_CR22","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1053\/gast.1996.v110.pm8964399","volume":"110","author":"Y Yamaoka","year":"1996","unstructured":"Yamaoka Y, Kita M, Kodama T, Sawai N, Imanishi J: Helicobacter pylori cagAgene and expre ssion of cytokine messe nge r RNA in gastric mucosa. Gastroenterology 110:1744 - 1752, 1996","journal-title":"Gastroenterology"},{"key":"294812_CR23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0046-8177(96)90135-5","volume":"27","author":"HMT El-Zimaity","year":"1996","unstructured":"El-Zimaity HMT, Graham DY, Al-Assi MT, Malaty H, Karttunen TJ, Graham DP, Huberman RM, Genta RM: Inte robse rver variation in the histopathological asse ssment of Helicobacter pylorigastritis. Hum Pathol 27:35- 41, 1996","journal-title":"Hum Pathol"},{"key":"294812_CR24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","volume":"20","author":"MF Dixon","year":"1996","unstructured":"Dixon MF, Genta RM, Yardley JH, Correa P: Classifi cation and grading of gastritis: the updated Sydney system. Am J Surg Pathol 20:1161- 1181, 1996","journal-title":"Am J Surg Pathol"},{"issue":"suppl2","key":"294812_CR25","first-page":"A83","volume":"39","author":"C Jonas","year":"1996","unstructured":"Jonas C, N'Knize M, Van Loey AM, Laurent I, Dineur M, DeKoster E, De ltenre M: Striking difference in immunoblotting results between Maghrebis and European Hp positive ulcer patients. Gut 39( suppl 2):A83, 1996","journal-title":"Gut"},{"key":"294812_CR26","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/S0016-5085(97)70019-2","volume":"113","author":"DY Graham","year":"1997","unstructured":"Graham DY: Helicobacter pyloriinfection in the pathogenesis of duodenal ulcer and gastric cancer: A mode l. Gastroente rology 113:1983- 1991, 1997","journal-title":"Gastroente rology"},{"key":"294812_CR27","first-page":"1785","volume":"91","author":"HM Mitchell","year":"1996","unstructured":"Mitchell HM, Hazell SL, Li YY, Hu PJ: Serological response to specifi c Helicobacter pyloriantigens: Antibody against CagA antigen is not predictive of gastric cance r in a deve loping country. Am J Gastroente rol 91:1785- 1788, 1996","journal-title":"Am J Gastroente rol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018850412148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018850412148\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018850412148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:09:27Z","timestamp":1752462567000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018850412148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["294812"],"URL":"https:\/\/doi.org\/10.1023\/a:1018850412148","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}