{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:24:13Z","timestamp":1778081053577,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,6]]},"DOI":"10.1023\/a:1018859824926","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"1258-1263","source":"Crossref","is-referenced-by-count":22,"title":["Adenosine Protects Against Indomethacin-Induced Gastric Damage in Rats"],"prefix":"10.1007","volume":"43","author":[{"given":"Ayhan","family":"Bozkurt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral","family":"Yuksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goncagul","family":"Haklar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hizir","family":"Kurtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrak C.","family":"Yegen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inci","family":"Alican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"294768_CR1","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.4049\/jimmunol.135.2.1366","volume":"135","author":"BN Cronstein","year":"1985","unstructured":"Cronstein BN, Rosenstein ED, Kramer SB, Weissmann G, Hirschhorn R: Adenosine: A physiologic modulator of superoxide anion and gene ration by human neutrophils (adenosine acts via an A2 receptor on human neutrophils). J Immunol 135:1366 - 1371, 1985","journal-title":"J Immunol"},{"key":"294768_CR2","first-page":"300","volume-title":"Topics and Perspectives in Adenosine Research","author":"BN Cronstein","year":"1987","unstructured":"Cronstein BN, Levin RI, Belanoff J, Weissmann G, Hirschhorn R: A new function for adenosine: Protection of vascular endothelial cells from neutrophil-mediated injury. InTopics and Perspectives in Adenosine Research. E Gerlach, BF Becker (eds). New York, Springer-Verlag, 1987, pp 300 - 308"},{"key":"294768_CR3","first-page":"2407","volume":"46","author":"R Engler","year":"1987","unstructured":"Engler R: Consequence s of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia. Fed Proc 46:2407- 2412, 1987","journal-title":"Fed Proc"},{"key":"294768_CR4","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1007\/BF01536737","volume":"35","author":"CH Cho","year":"1990","unstructured":"Cho CH, Ogle CW: Modulatory action of adenosine on gastric function and ethanol-induced mucosal damage in rats. Dig Dis Sci 35:1334 - 1339, 1990","journal-title":"Dig Dis Sci"},{"key":"294768_CR5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0014-2999(88)90633-4","volume":"147","author":"J Puurunen","year":"1988","unstructured":"Puurunen J, Huttunen P: Central gastric antisecretory action of adenosine in the rat. Eur J Pharmacol 147:59 - 66, 1988","journal-title":"Eur J Pharmacol"},{"key":"294768_CR6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000138278","volume":"34","author":"C Scarpignato","year":"1987","unstructured":"Scarpignato C, Tramacere R, Zappia L, Soldato PC: Inhibition of gastric acid secretion by adenosine receptor stimulation in the rat. Pharmacology 34:264 - 268, 1987","journal-title":"Pharmacology"},{"key":"294768_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-2999(85)90690-9","volume":"115","author":"JD Geiger","year":"1985","unstructured":"Geiger JD, Glavin GB: Adenosine receptor activation in brain reduces stress-induced ulcer formation. Eur J Pharmacol 115:185- 190, 1985","journal-title":"Eur J Pharmacol"},{"key":"294768_CR8","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/0024-3205(87)90516-9","volume":"41","author":"VS Westerberg","year":"1987","unstructured":"Westerberg VS, Geiger JD: Central e ffects of adenosine analogs on stress-induced gastric ulcer formation. Life Sci 41:2201- 2205, 1987","journal-title":"Life Sci"},{"key":"294768_CR9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(91)90339-R","volume":"201","author":"CH Cho","year":"1991","unstructured":"Cho CH, Liao NX, Liu XG, Hui WM, Luk CT, Lam SK: Effects of adenosine on gastric and cardiovascular systems, and ethanol ulceration in male and female rats. Eur J Pharmacol 201:157- 162, 1991","journal-title":"Eur J Pharmacol"},{"key":"294768_CR10","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpcell.1990.259.3.C462","volume":"259","author":"JL Wallace","year":"1990","unstructured":"Wallace JL, Keenan CM, Granger DN: Gastric ulceration induced by nonsteroid antiinflammatory drugs is a neutrophildependent process. Am J Physiol 259:G462- G467, 1990","journal-title":"Am J Physiol"},{"key":"294768_CR11","first-page":"1","volume":"22","author":"G Pihan","year":"1994","unstructured":"Pihan G, Regillo C, Szabo S: Free radicals and lipid peroxidation in ethanol or aspirin-induced mucosal injury. Dig Dis Sci 22:1- 8, 1994","journal-title":"Dig Dis Sci"},{"key":"294768_CR12","first-page":"G470","volume":"261","author":"PM Vaananen","year":"1991","unstructured":"Vaananen PM, Meddings JB, Wallace JL: Role of oxygenderived free radicals in indomethacin-induced gastric injury. Am J Physiol 261:G470 - G475, 1991","journal-title":"Am J Physiol"},{"key":"294768_CR13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0022-3565(25)31091-8","volume":"203","author":"JF Gerkens","year":"1977","unstructured":"Gerkens JF, Shand DG, Flexner C, Nies AS, Oates JA, Data JL: The effect of indomethacin and aspirin on gastric blood flow and acid secretion. J Pharmacol Exp Ther 203:246 - 252, 1977","journal-title":"J Pharmacol Exp Ther"},{"key":"294768_CR14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/BF02091537","volume":"41","author":"T Co\u015fkun","year":"1996","unstructured":"Co\u015fkun T, Ye\u011fen B\u00c7, Alican \u0130, Peker \u00d6, Kurtel H: Coldrestraint stress-induced gastric mucosal dysfunction: role of nitric oxide. Dig Dis Sci 41:956 - 963, 1996","journal-title":"Dig Dis Sci"},{"key":"294768_CR15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265- 275, 1951","journal-title":"J Biol Chem"},{"key":"294768_CR16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","volume":"186","author":"RL Levine","year":"1990","unstructured":"Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A, Ahn B, Shaltiel S, Stadtman ER: Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464 - 478, 1990","journal-title":"Methods Enzymol"},{"key":"294768_CR17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/gut.35.2.179","volume":"35","author":"GR Davies","year":"1994","unstructured":"Davies GR, Simmonds NJ, Stevens TRJ, Sheaff MT, Banatvala N, Lavienson IF, Blake DR, Rampton DS: Helicobacter pyloristimulates antral mucosal reactive oxygen metabolite production in vivo.Gut 35:179 - 185, 1994","journal-title":"Gut"},{"key":"294768_CR18","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1172\/JCI116491","volume":"91","author":"Y Ohara","year":"1993","unstructured":"Ohara Y, Peterson TE, Harrison DG: Hype rcholesterolemia increase s endothelial superoxide anion production. J Clin Invest 91:2546 - 2551, 1993","journal-title":"J Clin Invest"},{"key":"294768_CR19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2796.1990.tb01487.x","volume":"228","author":"KD Crissinger","year":"1990","unstructured":"Crissinger KD, Kvietys PR, Granger DN: Pathophysiology of gastrointestinal mucosal permeability. J Int Med 228:145- 154, 1990","journal-title":"J Int Med"},{"key":"294768_CR20","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(54)80008-4","volume":"26","author":"H Shay","year":"1954","unstructured":"Shay H, Sun DCY, Gruenstein R: A quantitative method for me asuring spontaneous gastric se cretion in the rat. Gastroenterology 26:906 - 913, 1954","journal-title":"Gastroenterology"},{"issue":"10","key":"294768_CR21","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1016\/S0021-9258(19)50445-8","volume":"267","author":"GL Stielst","year":"1992","unstructured":"Stielst GL: Adenosine receptors. J Biol Chem 267(10):6451- 6454, 1992","journal-title":"J Biol Chem"},{"key":"294768_CR22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1021\/jm00345a001","volume":"25","author":"JW Daly","year":"1982","unstructured":"Daly JW: Adenosine receptors: Targets for future drugs. J Med Chem 25:197- 207, 1982","journal-title":"J Med Chem"},{"key":"294768_CR23","first-page":"331","volume":"158","author":"BB Fredholm","year":"1984","unstructured":"Fredholm BB: Gastrointestinal and metabolic effects of methylxanthines. Prog Clin Biol Res 158:331- 354, 1984","journal-title":"Prog Clin Biol Res"},{"key":"294768_CR24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/bj2270669","volume":"227","author":"PA Roberts","year":"1985","unstructured":"Roberts PA, Newby AC, Hallett MB, Campbell AK: Inhibition by adenosine of reactive oxygen me tabolite production by human polymorphonuclear leucocytes. Biochem J 227:669 - 674, 1985","journal-title":"Biochem J"},{"key":"294768_CR25","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/gut.25.7.718","volume":"25","author":"RA Levine","year":"1984","unstructured":"Levine RA, Schwartzel EH Jr: Effect of indomethacin on basal and histamine-stimulated human gastric acid secretion. Gut 25:718 - 722, 1984","journal-title":"Gut"},{"key":"294768_CR26","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0016-5085(84)90201-4","volume":"87","author":"M Feldman","year":"1984","unstructured":"Feldman M, Colturi TJ: Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 87:1339 - 1343, 1984","journal-title":"Gastroenterology"},{"key":"294768_CR27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/BF02063956","volume":"40","author":"KA Wagner","year":"1995","unstructured":"Wagner KA, Nandi J, King RL, Levine RA: The e ffects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat. Dig Dis Sci 40:134 - 140, 1995","journal-title":"Dig Dis Sci"},{"key":"294768_CR28","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0016-5085(91)90536-T","volume":"101","author":"RA Levine","year":"1991","unstructured":"Levine RA, Nandi J, King RL: Nonsalicylate nonsteroidal antiinflammatory drugs augment prestimulated acid secretion in rabbit parietal cells: Investigation of the me chanisms of action. Gastroenterology 101:756 - 765, 1991","journal-title":"Gastroenterology"},{"key":"294768_CR29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0016-5085(86)91109-1","volume":"90","author":"PH Rowe","year":"1986","unstructured":"Rowe PH, Starlinger MJ, Kasdon E, Marrone G, Silen W: Effect of systemic administration of aspirin, salicylate and indomethacin on amphibian gastric mucosa. Gastroenterology 90:559 - 569, 1986","journal-title":"Gastroenterology"},{"key":"294768_CR30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/0016-5085(88)90166-7","volume":"95","author":"KP Kolbasa","year":"1988","unstructured":"Kolbasa KP, Lancoster C, Olaffson AS, Gilbertson SK, Robert A: Indomethacin-induced gastric antral ulcers in hamsters. Gastroenterology 95:932- 944, 1988","journal-title":"Gastroenterology"},{"key":"294768_CR31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0022-3565(25)22393-X","volume":"270","author":"K Kuratani","year":"1994","unstructured":"Kuratani K, Kodama H, Yamaguchi I: Enhancement of gastric mucosal blood flow by beta-3 adrenergic agonists prevents indomethacin induced antral ulcer in the rat. J Pharmacol Exp Ther 270:559 - 565, 1994","journal-title":"J Pharmacol Exp Ther"},{"key":"294768_CR32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01782814","volume":"44","author":"\u0130 Alican","year":"1995","unstructured":"Alican \u0130, Co\u015fkun T, \u00c7orak A, Ye\u011fen B\u00c7, Oktay \u015e, Kurtel H: Role of neutrophils in indomethacin-induced gastric mucosal lesions. Inflamm Res 44:164 - 168, 1995","journal-title":"Inflamm Res"},{"key":"294768_CR33","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1006\/bbrc.1993.2291","volume":"196","author":"RE Stafford","year":"1993","unstructured":"Stafford RE, Mak IT, Kramer JH, Weglicki WB: Protein oxidation in magne sium deficient rat brains and kidneys. Biochem Biophys Res Commun 196:596 - 600, 1993","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018859824926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018859824926\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018859824926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:44:22Z","timestamp":1752461062000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018859824926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["294768"],"URL":"https:\/\/doi.org\/10.1023\/a:1018859824926","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]}}}