{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:40:49Z","timestamp":1788381649872,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,2]]},"DOI":"10.1023\/a:1018862507469","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"349-353","source":"Crossref","is-referenced-by-count":28,"title":["Dissolution of Gallstones with Simvastatin, an HMG CoA Reductase Inhibitor"],"prefix":"10.1007","volume":"43","author":[{"given":"B. A.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Burt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Chisholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H. J.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"294405_CR1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/hep.1840080531","volume":"8","author":"W Duane","year":"1988","unstructured":"Duane W, Hunninghake D, Freeman M, Pooler P, Schlasner L, Gebhard R: Simvastatin, a competitive inhibitor of HMG CoA reductase, lowers cholesterol saturation index of gallbladder bile. Hepatology 8:1147- 1150, 1988","journal-title":"Hepatology"},{"key":"294405_CR2","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/0016-5085(90)91092-K","volume":"98","author":"G Logan","year":"1990","unstructured":"Logan G, Duane W: Lovastatin added to ursodeoxycholic acid further reduces biliary cholesterol saturation. Gastroenterology 98:1572- 1576, 1990","journal-title":"Gastroenterology"},{"key":"294405_CR3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/gut.31.3.348","volume":"31","author":"-. L. Hoogerbrugge","year":"1990","unstructured":"Hoogerbrugge-VD LN, De Rooy F, Jansen H, Van Blankenstein M: Effect of pravastatin on biliary lipid composition and bile acid synthesis in familial hypercholesterolaemia. Gut 31:348 - 350, 1990","journal-title":"Gut"},{"key":"294405_CR4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1746.1994.tb01272.x","volume":"9","author":"IR Wilson","year":"1994","unstructured":"Wilson IR, Hurrell MA, Pattinson NR, Chapman BA: The effect of Simvastatin and bezafibrate on bile composition and gall-bladder emptying in female non-insulin-dependent diabetics. J Gastroenterol Hepatol 9:447- 451, 1994","journal-title":"J Gastroenterol Hepatol"},{"key":"294405_CR5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01229073","volume":"29","author":"S Okamoto","year":"1994","unstructured":"Okamoto S, Nakano K, Kosahara K, Kishinaka M, Oda H, Ichimiya H, Chijiiwa K, Kuroki S: Effect of pravastatin and ursodeoxycholic acid on cholesterol and bile acid me tabolism in patients with cholesterol gallstones. J Gastroenterol 29:47- 55, 1994","journal-title":"J Gastroenterol"},{"key":"294405_CR6","first-page":"1523","volume":"21","author":"JWA Smit","year":"1995","unstructured":"Smit JWA, Van Erpecum KJ, Renooij W, Stolk MFJ, Edgar P, Doornewaard H, Vanbe rge-He negouwen GP: The effect of 3-hydroxy-3-methyl coenzyme A reductase inhibitor pravastatin on bile composition and nucleation of cholesterol crystals in cholesterol gallstone disease. Hepatology 21:1523- 1529, 1995","journal-title":"Hepatology"},{"key":"294405_CR7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/hep.1840060630","volume":"6","author":"R Holzbach","year":"1986","unstructured":"Holzbach R: Re cent progress in understanding cholesterol crystal nucleation as a precursor to human gallstone formation. Hepatology 6:1403- 1406, 1986","journal-title":"Hepatology"},{"key":"294405_CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7326\/0003-4819-95-3-257","volume":"95","author":"LJ Schoenfield","year":"1981","unstructured":"Schoenfield LJ, Lachin JM, Steering Committee (Baum RA, Habig RL, Hanson RF, Hersh Tr, Hightower NC Jr, Hofmann AF, Lasser EC, Marks JW, Mekhjian H, Okun R, Schaefer RA, Shaw L, Soloway RD, Thistle JL, Thomas FB, Tyor MP), National Cooperative Gallstone Study Group, Los Angeles, California and Bethesda, Maryland: Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The National Cooperative Gallstone Study. A controlled trial of efficacy and safety. Ann Intern Med 95:257- 282, 1981","journal-title":"Ann Intern Med"},{"key":"294405_CR9","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/0016-5085(86)90216-7","volume":"91","author":"H Fromm","year":"1986","unstructured":"Fromm H: Gallstone dissolution therapy: Current status and future prospects. Gastroenterology 91:1560 - 1567, 1986","journal-title":"Gastroenterology"},{"key":"294405_CR10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hep.1840040222","volume":"4","author":"S Erlinger","year":"1984","unstructured":"Erlinger S, Co AL, Husson JM, Fevery J: Franco-Belgian cooperative study of ursodeoxycholic acid in the medical dissolution of gallstones: A double-blind, randomized, dose- response study, and comparison with chenodeoxycholic acid. Hepatology 4:308 - 314, 1984","journal-title":"Hepatology"},{"key":"294405_CR11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/BF01393771","volume":"27","author":"WH Bachrach","year":"1982","unstructured":"Bachrach WH, Hofmann AF: Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig Dis Sci 27:737- 856, 1982","journal-title":"Dig Dis Sci"},{"key":"294405_CR12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0016-5085(92)90045-Z","volume":"103","author":"JWA Smit","year":"1992","unstructured":"Smit JWA, Van Erpecum KJ, Stolk MFJ, Geerdink RA, Cluysenger OJJ, Erkelens DW, Van Berge-Henegouwen GP: Successful dissolution of cholesterol gallstone during treatment with pravastatin. Gastroenterology 103:1068 - 1070, 1992","journal-title":"Gastroenterology"},{"key":"294405_CR13","first-page":"A302","volume":"102","author":"F Bazzoli","year":"1992","unstructured":"Bazzoli F, Mazzella G, Zagori RM, Orsini M, Polimeni C, Novelli V, Fossi S, Morelli MC, Festi D, Aldini R, Roda A, Roda E: HMG CoA reductase inhibitors lower biliary cholesterol saturation but are ineffective cholesterol gallstone dissolving agents. Gastroenterology 102:A302, 1992","journal-title":"Gastroenterology"},{"key":"294405_CR14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","volume":"234","author":"GR Bartlett","year":"1959","unstructured":"Bartlett GR: Phosphorus assay in column chromatography. J Biol Chem 234:466 - 468, 1959","journal-title":"J Biol Chem"},{"key":"294405_CR15","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","volume":"19","author":"M Carey","year":"1978","unstructured":"Carey M: Critical tables for calculating the cholesterol saturation index of native bile. J Lipid Re s 19:945- 955, 1978","journal-title":"J Lipid Re s"},{"key":"294405_CR16","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/ajcn\/33.12.2657","volume":"33","author":"HO Bang","year":"1980","unstructured":"Bang HO, Dyerburg J, Sinclair HM: The composition of Eskimo food in northwestern Greenland. Am J Clin Nutri 33:2657- 2661, 1980","journal-title":"Am J Clin Nutri"},{"key":"294405_CR17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0009-8981(85)90287-6","volume":"145","author":"A Hernanz","year":"1985","unstructured":"Hernanz A, Codoceo R: An improved high performance liquid chromatography determination of conjugated bile acids in se-rum using paired-ion chromatography. Clin Chim Acta 145:197- 203, 1985","journal-title":"Clin Chim Acta"},{"key":"294405_CR18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-2275(20)38684-3","volume":"28","author":"SS Rossi","year":"1987","unstructured":"Rossi SS, Converse JL, Hofmann AF: High pressure liquid chromatographic analysis of conjugate bile acids in human bile: Simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids. J Lipid Res 28:589 - 595, 1987","journal-title":"J Lipid Res"},{"key":"294405_CR19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0039-128X(71)90072-9","volume":"18","author":"PDG Dean","year":"1971","unstructured":"Dean PDG, Exley D, Johnson MW: Preparation of 17\u03b2-oestradiol-6-(O-carboxymethyl) oxime-bovineserum albumin. Steroids 18:593- 603, 1971","journal-title":"Steroids"},{"key":"294405_CR20","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/hep.1840150617","volume":"15","author":"G Mazella","year":"1992","unstructured":"Mazella G, Parini P, Festi D, Bazzoli F, Aldini R, Roda A, Tonelli D: Effect of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolaemia. Hepatology 15:1072- 1078, 1992","journal-title":"Hepatology"},{"key":"294405_CR21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/hep.1840190413","volume":"19","author":"P Loria","year":"1994","unstructured":"Loria P, Bertolotti M, Cassinadri MT, Dilengite MA, Bozzoli M, Carubbi F, Concari M: Short term effects of Simvastatin on bile acid synthesis and bile lipid secretion in human subjects. Hepatology 19:882- 888, 1994","journal-title":"Hepatology"},{"key":"294405_CR22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2362.1991.tb01810.x","volume":"21","author":"M Muraca","year":"1991","unstructured":"Muraca M, Baggio G, Miconi L, Vilei MT, Martini S, Gabelli C, Belluco C, Lise M, Crepaldi G: Acute effects of HMG-CoA reductase inhibitors on biliary lipids in patients with interrupted enterohepatic circulation. Eur J Clin Invest 21:204 - 208, 1991","journal-title":"Eur J Clin Invest"},{"key":"294405_CR23","doi-asserted-by":"crossref","first-page":"G701","DOI":"10.1152\/ajpgi.1986.251.5.G701","volume":"251","author":"WW La Morte","year":"1986","unstructured":"La Morte WW, LaMont JT, Hale N, Booker ML, Scott TE, Turner B: Gallbladder prostoglandins and lysophospholipids as mediators of mucin secretion during cholelithiasis. Am J Physiol (Gastrointest Live r Physiol) 251:G701- G709, 1986","journal-title":"Am J Physiol (Gastrointest Live r Physiol)"},{"key":"294405_CR24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/BF02534904","volume":"16","author":"A Cantafora","year":"1981","unstructured":"Cantafora A, Angelico M, DiBiase A: Structure of biliary phosphatidylcholine in cholesterol gallstone patients. Lipids 16:589 - 592, 1981","journal-title":"Lipids"},{"key":"294405_CR25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0016-5085(92)90848-S","volume":"103","author":"JW Marks","year":"1992","unstructured":"Marks JW, Bonorris GG, Albers G, Schoenfield LJ. The se quence of biliary events preceding the formation of gallstones in humans. Gastroenterology 103:566 - 570, 1992","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018862507469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018862507469\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018862507469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:49:10Z","timestamp":1752461350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018862507469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["294405"],"URL":"https:\/\/doi.org\/10.1023\/a:1018862507469","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}