{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:59:15Z","timestamp":1753883955887,"version":"3.41.2"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1023\/a:1018897307835","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T16:23:59Z","timestamp":1045671839000},"page":"119-128","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Fludrocortisone and Spironolactone on Sodium and Potassium Losses in Secretory Diarrhea"],"prefix":"10.1007","volume":"42","author":[{"given":"Heimo H.","family":"Wenzl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A. Santa","family":"Ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack L.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Fordtran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"292819_CR1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.1968.tb07282.x","volume":"57","author":"EW Reimold","year":"1968","unstructured":"Reimold EW: The role of aldosterone in hypernatremic dehydration in infants. Acta Paediatr Scand 57:33\u201335, 1968","journal-title":"Acta Paediatr Scand"},{"key":"292819_CR2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/gut.13.11.915","volume":"13","author":"RD Rubens","year":"1972","unstructured":"Rubens RD, Lambert HP: The homeostatic function of the colon in acute gastroenteritis. Gut 13:915\u2013919, 1972","journal-title":"Gut"},{"key":"292819_CR3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1203\/00006450-197802000-00002","volume":"12","author":"C Holmberg","year":"1978","unstructured":"Holmberg C: Electrolyte economy and its hormonal regulation in congenital chloride diarrhea. Pediatr Res 12:82\u201386, 1978","journal-title":"Pediatr Res"},{"key":"292819_CR4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/00365527909181945","volume":"14","author":"K Ladefoged","year":"1979","unstructured":"Ladefoged K, Olgaard K: Fluid and electrolyte absorption and renin-angiotensin-aldosterone axis in patients with severe short-bowel syndrome. Scand J Gastroenterol 14:729\u2013735, 1979","journal-title":"Scand J Gastroenterol"},{"key":"292819_CR5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0022-3476(83)80175-9","volume":"102","author":"KB Schwarz","year":"1983","unstructured":"Schwarz KB, Ternberg JL, Bell MJ, Keating JP: Sodium needs of infants and children with ileostomy. J Pediatr 102:509\u2013513, 1983","journal-title":"J Pediatr"},{"key":"292819_CR6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.1967.sp008380","volume":"193","author":"CJ Edmonds","year":"1967","unstructured":"Edmonds CJ: Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium depleted rats. J Physiol (London) 193:589\u2013602, 1967","journal-title":"J Physiol (London)"},{"key":"292819_CR7","first-page":"F261","volume":"238","author":"PC Will","year":"1980","unstructured":"Will PC, Lebowitz JL, Hopfer U: Induction of amiloride-sensitive sodium transport in the rat colon by mineralocorticoids. Am J Physiol 238:F261\u2013F268, 1980","journal-title":"Am J Physiol"},{"key":"292819_CR8","first-page":"G124","volume":"248","author":"PC Will","year":"1985","unstructured":"Will PC, Cortright RN, DeLisle RC, Douglas JG, Hopfer U: Regulation of amiloride-sensitive-electrogenic sodium transport in the rat colon by steroid hormones. Am J Physiol 248:G124\u2013G132, 1985","journal-title":"Am J Physiol"},{"key":"292819_CR9","first-page":"954","volume-title":"Gastrointestinal Disease: Pathophysiology\/Diagnosis\/Management","author":"JH Sellin","year":"1993","unstructured":"Sellin JH: Intestinal electrolyte absorption and secretion. In Gastrointestinal Disease: Pathophysiology\/Diagnosis\/Management, Volume 1, 5th ed. MH Sleisenger, JS Fordtran (eds). Philadelphia, WB Saunders, 1993, pp 954\u2013976","edition":"5th ed."},{"key":"292819_CR10","first-page":"337","volume-title":"Textbook of Gastroenterology","author":"JD Kaunitz","year":"1994","unstructured":"Kaunitz JD, Barrett KE: Electrolyte secretion and absorption: Small intestine and colon. In Textbook of Gastroenterology. Yamada T (ed). Philadelphia, JB Lippincott, 1994, pp 337\u2013338"},{"key":"292819_CR11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0016-5085(94)90184-8","volume":"107","author":"R Agarwal","year":"1994","unstructured":"Agarwal R, Afzalpurkar R, Fordtran JS: Pathophysiology of potassium absorption and secretion by the human intestine. Gastroenterology 107:548\u2013571, 1994","journal-title":"Gastroenterology"},{"key":"292819_CR12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/gut.31.2.194","volume":"31","author":"HR Jenkins","year":"1990","unstructured":"Jenkins HR, Fenton TR, McIntosh N, Dillon MJ, Milla PJ: Development of colonic sodium transport in early childhood and it regulation by aldosterone. Gut 31:194\u2013197, 1990","journal-title":"Gut"},{"key":"292819_CR13","first-page":"336","volume-title":"Endocrine Physiology","author":"CR Martin","year":"1985","unstructured":"Martin CR: Endocrine Physiology, New York, Oxford University Press, 1985, pp 336\u2013339"},{"key":"292819_CR14","volume-title":"Martindale: The Extra Pharmacopoeia","author":"JEF Reynolds","year":"1993","unstructured":"Reynolds JEF: Martindale: The Extra Pharmacopoeia. London, The Pharmaceutical Press, 1993"},{"key":"292819_CR15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0002-8703(78)90052-2","volume":"96","author":"HR Ochs","year":"1978","unstructured":"Ochs HR, Greenblatt DJ, Bodem G, Smith TW: Spironolactone. Am Heart J 96:389\u2013400, 1978","journal-title":"Am Heart J"},{"key":"292819_CR16","first-page":"2245","volume-title":"Medical Economist Data","author":"Aldactone","year":"1993","unstructured":"Aldactone. Physicians' Desk Reference 1993. Medical Economist Data, Montvale, New Jersey, 1993, p 2245"},{"key":"292819_CR17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0016-5085(93)90267-G","volume":"104","author":"AJ Eherer","year":"1993","unstructured":"Eherer AJ, Santa Ana CA, Porter J, Fordtran JS: Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. Gastroenterology 104:1007\u20131012, 1993","journal-title":"Gastroenterology"},{"key":"292819_CR18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/BF01072465","volume":"23","author":"DR Saunders","year":"1978","unstructured":"Saunders DR, Siller J, Surawica C, Tygat GN: Effect of phenolphthalein on the function and structure of rodent and human intestine. Dig Dis Sci 23:909\u2013913, 1978","journal-title":"Dig Dis Sci"},{"key":"292819_CR19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0016-5085(80)90856-2","volume":"78","author":"DW Powell","year":"1980","unstructured":"Powell DW, Lawrence BA, Morris SM, Etheridge DR: Effect of phenolphthalein on in vitro rabbit ileal electrolyte transport. Gastroenterology 78:454\u2013463, 1980","journal-title":"Gastroenterology"},{"key":"292819_CR20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1172\/JCI103747","volume":"37","author":"JT August","year":"1958","unstructured":"August JT, Nelson DH, Thorn GW: Response of normal subjects to large amounts of aldosterone. J Clin Invest 37:1549\u20131555, 1958","journal-title":"J Clin Invest"},{"key":"292819_CR21","first-page":"1405","volume":"26","author":"JS Fordtran","year":"1967","unstructured":"Fordtran JS: Speculations on the pathogenesis of diarrhea. Fed Proc 26:1405\u20131414, 1967","journal-title":"Fed Proc"},{"key":"292819_CR22","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/clinchem\/20.9.1173","volume":"20","author":"DP Collin","year":"1974","unstructured":"Collin DP, McCormick PG: Determination of short chain fatty acids in stool ultrafiltrate and urine. Clin Chem 20:1173\u20131180, 1974","journal-title":"Clin Chem"},{"key":"292819_CR23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI115317","volume":"88","author":"KD Fine","year":"1991","unstructured":"Fine KD, Santa Ana CA, Porter JL, Fordtran JS: Intestinal absorption of magnesium from food and supplements. J Clin Invest 88:396\u2013402, 1991","journal-title":"J Clin Invest"},{"key":"292819_CR24","unstructured":"Sigma Stat Statistical Software. Jandel Corporation, San Rafael, California, 1995, pp 28\u201339"},{"key":"292819_CR25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.7326\/0003-4819-43-4-658","volume":"43","author":"JA Luetscher Jr","year":"1955","unstructured":"Luetscher JA Jr, Curtis RH: Aldosterone: Observations on the regulation of sodium and potassium balance. Ann Intern Med 43:658, 1955","journal-title":"Ann Intern Med"},{"key":"292819_CR26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI103434","volume":"36","author":"JH Laragh","year":"1957","unstructured":"Laragh JH, Stoerk HC: A study of the mechanism of secretion of the sodium-retaining hormone aldosterone. J Clin Invest 36:383\u2013392, 1957","journal-title":"J Clin Invest"},{"key":"292819_CR27","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/0026-0495(79)90201-4","volume":"28","author":"MG Nicholls","year":"1979","unstructured":"Nicholls MG, Ramsay LE, Boddy K, Fraser R, Morton JJ, Robertson JIS: Mineralocorticoid-induced blood pressure, electrolyte, and hormone changes, and reversal with spironolactone, in healthy men. Metabolism 28:584\u2013593, 1979","journal-title":"Metabolism"},{"key":"292819_CR28","first-page":"540","volume":"24","author":"AS Relman","year":"1952","unstructured":"Relman AS, Schwartz WB: The effect of DOCA on electrolyte balance in normal man and its relation to sodium chloride intake. Yale J Biol Med 24:540\u2013558, 1952","journal-title":"Yale J Biol Med"},{"key":"292819_CR29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jn\/79.4.407","volume":"79","author":"C Consolazio","year":"1963","unstructured":"Consolazio C, Matoush LO, Nelson RA, Harding RS, Canham JE: Excretion of sodium, potassium, magnesium and iron in human sweat and the relation of each to balance and requirements. J Nutr 79:407\u2013415, 1963","journal-title":"J Nutr"},{"key":"292819_CR30","first-page":"290","volume-title":"Gastrointestinal Disease. Pathophysiology Diagnosis and Management","author":"KD Fine","year":"1989","unstructured":"Fine KD, Krejs GJ, Fordtran JS: Diarrhea. In Gastrointestinal Disease. Pathophysiology Diagnosis and Management. MH Sleisenger, JS Fordtran (eds). Philadelphia, WB Saunders, 1989, pp 290\u2013316"},{"key":"292819_CR31","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/0016-5085(95)90134-5","volume":"108","author":"HH Wenzl","year":"1995","unstructured":"Wenzl HH, Fine KD, Schiller LR, Fordtran JS: Determinants of decreased fecal consistency in patients with diarrhea. Gastroenterology 108:1729\u20131738, 1995","journal-title":"Gastroenterology"},{"key":"292819_CR32","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1172\/JCI103891","volume":"38","author":"EJ Huth","year":"1959","unstructured":"Huth EJ, Squires RD, Elkinton JR: Experimental potassium depletion in normal human subjects. II. Renal and hormonal factors in the development of extracellular alkalosis during depletion. J Clin Invest 38:1149\u20131165, 1959","journal-title":"J Clin Invest"},{"key":"292819_CR33","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/gut.7.6.697","volume":"7","author":"RG Elmslie","year":"1966","unstructured":"Elmslie RG, Mulholland AT, Shields R: Blocking by spironolactone (SC 9420) of the action of aldosterone upon the intestinal transport of potassium, sodium, and water. Gut 7:697\u2013699, 1966","journal-title":"Gut"},{"key":"292819_CR34","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0016-5085(19)34211-8","volume":"53","author":"AM Clarke","year":"1967","unstructured":"Clarke AM, Hill GL, Macbeth WG: Intestinal adaptation to salt depletion in a patient with ileostomy. Gastroenterology 53:444\u2013449, 1967","journal-title":"Gastroenterology"},{"key":"292819_CR35","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0140-6736(70)91397-8","volume":"2","author":"CJ Edmonds","year":"1970","unstructured":"Edmonds CJ: Measurement of electrical potential difference as an instant screening-test for hyperaldosteronism. Lancet 2:624\u2013627, 1970","journal-title":"Lancet"},{"key":"292819_CR36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/gut.13.3.197","volume":"13","author":"RL Guerrant","year":"1972","unstructured":"Guerrant RL, Chen LC, Rohde JE: Effect of spironolactone on stool electrolyte losses during human cholera. Gut 13:197\u2013200, 1972","journal-title":"Gut"},{"key":"292819_CR37","first-page":"G300","volume":"241","author":"AN Charney","year":"1981","unstructured":"Charney AN, Wallach J, Ceccarelli S, Donowitz M, Costenbader CL. Effects of spironolactone and amiloride on corticosteroid-induced changes in colonic function. Am J Physiol 241:G300\u2013G305, 1981","journal-title":"Am J Physiol"},{"key":"292819_CR38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1113\/jphysiol.1989.sp017542","volume":"410","author":"HJ Binder","year":"1989","unstructured":"Binder HJ, McGlone F, Sandle GI: Effects of corticosteroid-hormones on the electrophysiology of the rat distal colon: Implications for Na and K transport. J Physiol 410:425\u2013441, 1989","journal-title":"J Physiol"},{"key":"292819_CR39","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1136\/gut.32.6.640","volume":"32","author":"B Duclos","year":"1991","unstructured":"Duclos B, Bories P, Mathieu-Daude JC, Michel H: Jejunal permeability to water and electrolytes in patients with chronic intrahepatic hypertension: Evidence for a role of aldosterone. Gut 32:640\u2013644, 1991","journal-title":"Gut"},{"key":"292819_CR40","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/gut.27.8.913","volume":"27","author":"H Sj\u00f6vall","year":"1986","unstructured":"Sj\u00f6vall H, Abrahamsson H, Westlander G, Gillberg R, Redfors S, Jodal M, Lundgren O: Intestinal fluid and electrolyte transport in man during reduced circulating blood volume. Gut 27:913\u2013918, 1986","journal-title":"Gut"},{"key":"292819_CR41","unstructured":"Sj\u00f6vall H: Sympathetic control of jejunal fluid and electrolyte transport: An experimental study in cats and rats. Acta Physiol Scand Suppl 535, 1984"},{"key":"292819_CR42","first-page":"527","volume-title":"Handbook of Physiology, The Gastrointestinal System","author":"DR Brown","year":"1991","unstructured":"Brown DR, Miller RJ: Neurohormonal control of fluid and electrolyte transport in intestinal mucosa. In Handbook of Physiology, The Gastrointestinal System. SG Schultz, M Field, RA Frizzell, BB Rauner (eds). Bethesda, Maryland, American Physiology Society, 1991, pp 527\u2013589"},{"key":"292819_CR43","first-page":"G17","volume":"240","author":"NR Levens","year":"1981","unstructured":"Levens NR, Peach MJ, Carey RM, Poat JA, Munday KA: Response of rat jejunum to angiotensin II: Role of norepinephrine and prostaglandins. Am J Physiol 240 (Gastrointest Liver Physiol 3):G17\u2013G24, 1981","journal-title":"Am J Physiol"},{"key":"292819_CR44","first-page":"R526","volume":"243","author":"DB Young","year":"1982","unstructured":"Young DB, Jackson TE: Effects of aldosterone on potassium distribution. Am J Physiol 243:R526\u2013R530, 1982","journal-title":"Am J Physiol"},{"key":"292819_CR45","first-page":"558","volume":"69","author":"R Levitan","year":"1972","unstructured":"Levitan R: Salt and water absorption from the normal human colon: effect of 9-alpha-fluorohydrocortisone administration. J Lab Clin Med 69:558\u2013564, 1972","journal-title":"J Lab Clin Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018897307835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018897307835\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018897307835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:54:27Z","timestamp":1752461667000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018897307835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["292819"],"URL":"https:\/\/doi.org\/10.1023\/a:1018897307835","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}