{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:31:58Z","timestamp":1784097118285,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1993,6]]},"DOI":"10.1023\/a:1018901009062","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T17:07:13Z","timestamp":1045674433000},"page":"834-838","source":"Crossref","is-referenced-by-count":54,"title":["The Pharmacokinetics of Recombinant Human Relaxin in Nonpregnant Women After Intravenous, Intravaginal, and Intracervical Administration"],"prefix":"10.1007","volume":"10","author":[{"given":"Sharon A.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Spanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Matthew","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Cefalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy C.","family":"Chescheir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Menard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Mordenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"304867_CR1","first-page":"585","volume-title":"The Physiology of Reproduction","author":"O. D. Sherwood","year":"1988","unstructured":"O. D. Sherwood. Relaxin. In E. Knobil and J. Neill (eds.), The Physiology of Reproduction, Raven Press, New York, 1988, pp. 585\u2013673."},{"key":"304867_CR2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1210\/jcem-68-3-627","volume":"68","author":"F. S. Khan-Dawood","year":"1989","unstructured":"F. S. Khan-Dawood, L. T. Goldsmith, G. Weiss, and M. Y. Dawood. Human corpus luteum secretion of relaxin, oxytocin, and progesterone. J. Clin. Endocrinol. Metab.\n68:627\u2013631 (1989).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"304867_CR3","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/j.1460-2075.1984.tb02135.x","volume":"4","author":"P. Hudson","year":"1984","unstructured":"P. Hudson, M. John, R. Crawford, J. Haralambidis, D. Scanlon, J. Gorman, G. Tregear, J. Shine, and H. Niall. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. EMBO J.\n4:2333\u20132339 (1984).","journal-title":"EMBO J."},{"key":"304867_CR4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1210\/jcem-70-2-508","volume":"70","author":"V. Sakbun","year":"1990","unstructured":"V. Sakbun, S. M. Ali, F. C. Greenwood, and G. D. Bryant-Greenwood. Human relaxin in the amnion, chorion, decidua parietalis, basal plate, and placental trophoblast by immunohistochemistry and northern analysis. J. Clin. Endocrinol. Metab.\n70:508\u2013514 (1990).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"304867_CR5","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1210\/jcem-70-6-1771","volume":"70","author":"D. R. Stewart","year":"1990","unstructured":"D. R. Stewart, A. C. Celniker, C. A. Taylor, J. R. Cragnun, J. W. Overstreet, and B. L. Lasley. Relaxin in the peri-implantation period. J. Clin. Endocrinol. Metab.\n70:1771\u20131773 (1990).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"304867_CR6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0015-0282(16)54416-1","volume":"56","author":"M. R. Johnson","year":"1991","unstructured":"M. R. Johnson, M. E. Wren, H. Abdalla, A. Kirkland, A. C. J. Allman, and S. L. Lightman. Relaxin levels in ovum donation pregnancies. Fertil. Steril.\n56:59\u201361 (1991).","journal-title":"Fertil. Steril."},{"key":"304867_CR7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0140-6736(90)91765-3","volume":"336","author":"L. W. Eddie","year":"1990","unstructured":"L. W. Eddie, I. T. Cameron, J. F. Leeton, D. L. Healy, and P. Renou. Ovarian relaxin is not essential for dilation of cervix. Lancet\n336:243 (1990).","journal-title":"Lancet"},{"key":"304867_CR8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(80)90714-X","volume":"1","author":"A. H. MacLennan","year":"1980","unstructured":"A. H. MacLennan, R. C. Green, G. D. Bryant-Greenwood, F. C. Greenwood, and R. F. Seamark. Ripening of the human cervix and induction of labour with purified porcine relaxin. Lancet\n1:220\u2013223 (1980).","journal-title":"Lancet"},{"key":"304867_CR9","first-page":"601","volume":"58","author":"A. H. MacLennan","year":"1981","unstructured":"A. H. MacLennan, R. C. Green, G. D. Bryant-Greenwood, F. C. Greenwood, and R. F. Seamark. Cervical ripening with combinations of vaginal prostaglandin F2a, estradiol, and relaxin. Obstet. Gynecol.\n58:601\u2013604 (1981).","journal-title":"Obstet. Gynecol."},{"key":"304867_CR10","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1021\/bi00245a006","volume":"30","author":"S. J. Shire","year":"1991","unstructured":"S. J. Shire, L. A. Holladay, and E. Rinderknecht. Self-association of human and porcine relaxin as assessed by analytical ultracentrifugation and circular dichroism. Biochemistry\n30:7703\u20137711 (1991).","journal-title":"Biochemistry"},{"key":"304867_CR11","first-page":"598","volume":"68","author":"A. H. MacLennan","year":"1986","unstructured":"A. H. MacLennan, R. C. Green, P. Grant, and R. Nicolson. Ripening of the human cervix and induction of labor with intracervical purified porcine relaxin. Obstet. Gynecol.\n68:598\u2013601 (1986).","journal-title":"Obstet. Gynecol."},{"key":"304867_CR12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/03602538308991387","volume":"14","author":"D. P. Benziger","year":"1983","unstructured":"D. P. Benziger and J. Edelson. Absorption from the vagina. Drug Metab. Rev.\n14:137\u2013168 (1983).","journal-title":"Drug Metab. Rev."},{"key":"304867_CR13","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1021\/bi00238a026","volume":"30","author":"E. Canova-Davis","year":"1991","unstructured":"E. Canova-Davis, T. J. Kessler, P.-J. Lee, D. T. W. Fei, P. Griffin, J. T. Stults, J. D. Wade, and E. Rinderknecht. Use of recombinant DNA derived human relaxin to probe the structure of the native protein. Biochemistry\n30:6006\u20136013 (1991).","journal-title":"Biochemistry"},{"key":"304867_CR14","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1210\/endo.130.5.1572287","volume":"130","author":"J. W. Winslow","year":"1992","unstructured":"J. W. Winslow, A. Shih, J. H. Bourell, G. Weiss, B. Reed, J. T. Stults, and L. T. Goldsmith. Human seminal relaxin is a product of the same gene as human luteal relaxin. Endocrinology\n130:2660\u20132668 (1992).","journal-title":"Endocrinology"},{"key":"304867_CR15","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1023\/A:1015861108966","volume":"8","author":"B. L. Ferraiolo","year":"1991","unstructured":"B. L. Ferraiolo, J. Winslow, G. Laramee, A. Celniker, and P. Johnston. The pharmacokinetics and metabolism of human relaxins in rhesus monkeys. Pharm. Res.\n8:1032\u20131038 (1991).","journal-title":"Pharm. Res."},{"key":"304867_CR16","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/clinchem\/32.12.2160","volume":"32","author":"M. R\u00e5nby","year":"1986","unstructured":"M. R\u00e5nby, N. Bergsdorf, T. Nilsson, G. Mellbring, B. Winblad, and G. Bucht. Age dependence of tissue plasminogen activator concentrations in plasma, as studied by an improved enzyme-linked immunosorbent assay. Clin. Chem.\n32:2160\u20132165 (1986).","journal-title":"Clin. Chem."},{"key":"304867_CR17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF01062831","volume":"4","author":"J. G. Wagner","year":"1976","unstructured":"J. G. Wagner. Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data. J. Pharmacokin. Biopharm.\n4:443\u2013467 (1976).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"304867_CR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1018915307554","volume":"9","author":"J. Mordenti","year":"1992","unstructured":"J. Mordenti and A. Rescigno. Estimation of permanence time, exit time, dilution factor, and steady-state volume of distribution. Pharm. Res.\n9:17\u201325 (1992).","journal-title":"Pharm. Res."},{"key":"304867_CR19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/A:1015863507496","volume":"9","author":"P. A. Cossum","year":"1992","unstructured":"P. A. Cossum, K. A. Dwyer, M. Roth, S. A. Chen, B. Moffat, R. Vandlen, and B. L. Ferraiolo. The disposition of a human relaxin (hRlx-2) in pregnant and nonpregnant rats. Pharm. Res.\n9:419\u2013424 (1992).","journal-title":"Pharm. Res."},{"key":"304867_CR20","first-page":"48","volume-title":"Clinical Pharmacokinetics: Concepts and Applications","author":"M. Rowland","year":"1980","unstructured":"M. Rowland and T. N. Tozer. In Clinical Pharmacokinetics: Concepts and Applications, Lea and Febiger, Philadelphia, 1980, pp. 48\u201378."},{"key":"304867_CR21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0300-9629(80)90255-8","volume":"67A","author":"J. W. Prothero","year":"1980","unstructured":"J. W. Prothero. Scaling of blood parameters in mammals. Comp. Biochem. Physiol.\n67A:649\u2013657 (1980).","journal-title":"Comp. Biochem. Physiol."},{"key":"304867_CR22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/978-3-642-66345-1_4","volume-title":"The Human Female Reproduction Tract","author":"H. Ludwig","year":"1976","unstructured":"H. Ludwig and H. Metzger. The Human Female Reproduction Tract, Springer-Verlag, Berlin, 1976, pp. 8\u201315."},{"key":"304867_CR23","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1023\/A:1015836720294","volume":"8","author":"J. Mordenti","year":"1991","unstructured":"J. Mordenti, S. A. Chen, J. A. Moore, B. L. Ferraiolo, and J. D. Green. Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharm. Res.\n8:1351\u20131359 (1991).","journal-title":"Pharm. Res."},{"key":"304867_CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1018982726441","volume":"10","author":"S. A. Chen","year":"1993","unstructured":"S. A. Chen, B. Reed, T. Nguyen, N. Gaylord, G. B. Fuller, and J. Mordenti. The pharmacokinetics and absorption of recombinant human relaxin in nonpregnant rabbits and rhesus monkeys after intravenous and intravaginal administration. Pharm. Res.\n10:223\u2013227 (1993).","journal-title":"Pharm. Res."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018901009062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018901009062\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018901009062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:08:47Z","timestamp":1754028527000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018901009062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["304867"],"URL":"https:\/\/doi.org\/10.1023\/a:1018901009062","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}