{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:17:43Z","timestamp":1778728663830,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1992,2]]},"DOI":"10.1023\/a:1018945608888","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T17:07:13Z","timestamp":1045674433000},"page":"236-243","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Chronic Hypertension on the Blood\u2013Brain Barrier Permeability of Libenzapril"],"prefix":"10.1007","volume":"9","author":[{"given":"Jian-ping","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Rakhit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikumaran","family":"Melethil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"305083_CR1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00687666","volume":"16","author":"B. B. Johansson","year":"1970","unstructured":"B. B. Johansson, C. L. Li, Y. Olsson, and I. Klatzo. The effect of acute arterial hypertension on the blood-brain barrier to protein tracers. Acta Neuropathol. (Berl.)\n16:117\u2013124 (1970).","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"305083_CR2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/01.STR.9.6.588","volume":"9","author":"B. B. Johansson","year":"1978","unstructured":"B. B. Johansson. Effect of an acute increase in intravascular pressure on the blood-brain barrier. A comparison between conscious and anesthetized rats. Stroke\n9:588\u2013590 (1978).","journal-title":"Stroke"},{"key":"305083_CR3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/01.HYP.9.6_Pt_2.III101","volume":"9","author":"W. G. Mayhan","year":"1987","unstructured":"W. G. Mayhan, F. M. Faraci, and D. D. Heistad. Mechanisms of protection of the blood-brain barrier during acute hypertension in chronically hypertensive rats. Hypertension\n9 (Suppl. III):101\u2013105 (1987).","journal-title":"Hypertension"},{"key":"305083_CR4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.HYP.12.6.549","volume":"12","author":"A. H. Werber","year":"1988","unstructured":"A. H. Werber and M. C. Fitch-Burke. Effect of chronic hypertension on acute hypertensive disruption of the blood-brain barrier in rats. Hypertension\n12:549\u2013555 (1988).","journal-title":"Hypertension"},{"key":"305083_CR5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/01.HYP.2.6.809","volume":"2","author":"S. M. Mueller","year":"1980","unstructured":"S. M. Mueller and D. D. Heistad. Effect of chronic hypertension on the blood-brain barrier. Hypertension\n2:809\u2013812 (1980).","journal-title":"Hypertension"},{"key":"305083_CR6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/01.HYP.3.5.586","volume":"3","author":"R. A. Majack","year":"1981","unstructured":"R. A. Majack and R. C. Bhalla. Ultrastructural characteristics of endothelial permeability pathways in chronic hypertension. Hypertension\n3:586\u2013595 (1981).","journal-title":"Hypertension"},{"key":"305083_CR7","volume-title":"Principles of Internal Medicine","author":"K. J. Isselbacher","year":"1980","unstructured":"K. J. Isselbacher, R. D. Adams, E. Braunwald, R. G. Petersdorf, and J. D. Wilson. Principles of Internal Medicine, McGraw-Hill, New York, 1980."},{"key":"305083_CR8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1253\/jcj.27.282","volume":"27","author":"K. Okamoto","year":"1963","unstructured":"K. Okamoto and K. Aoki. Development of a strain of spontaneously hypertensive rats. Jap. Circ. J.\n27:282\u2013294 (1963).","journal-title":"Jap. Circ. J."},{"key":"305083_CR9","first-page":"H690","volume":"234","author":"C. C. Chiueh","year":"1978","unstructured":"C. C. Chiueh and J. J. Kopin. Hyperresponsivity of spontaneously hypertensive rats to indirect measurement of blood pressure. Am. J. Physiol.\n234:H690\u2013H695 (1978).","journal-title":"Am. J. Physiol."},{"key":"305083_CR10","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1152\/ajplegacy.1971.221.6.1629","volume":"221","author":"W. H. Oldendorf","year":"1971","unstructured":"W. H. Oldendorf. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol.\n221:1629\u20131639 (1971).","journal-title":"Am. J. Physiol."},{"key":"305083_CR11","first-page":"46","volume":"96","author":"W. H. Oldendorf","year":"1971","unstructured":"W. H. Oldendorf. Brain uptake of metabolites and drugs following carotid arterial injections. Trans. Am. Neurol. Assoc.\n96:46\u201350 (1971).","journal-title":"Trans. Am. Neurol. Assoc."},{"key":"305083_CR12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"M. Gibaldi","year":"1982","unstructured":"M. Gibaldi and D. Perrier. Pharmacokinetics, Marcel Dekker, New York, 1982, pp. 2\u201384."},{"key":"305083_CR13","volume-title":"PCNONLIN (V3.0) User's Guide","author":"C. M. Metzler","year":"1989","unstructured":"C. M. Metzler and D. L. Weiner. PCNONLIN (V3.0) User's Guide, Statistical Consultants, Inc., Lexington, KY, 1989."},{"key":"305083_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01117450","volume":"6","author":"K. Yamaoka","year":"1978","unstructured":"K. Yamaoka, T. Nakagawa and T. Uno. Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J. Pharmacokin. Biopharm.\n6:165\u2013175 (1978).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"305083_CR15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01061504","volume":"2","author":"H. G. Boxenbaum","year":"1974","unstructured":"H. G. Boxenbaum, S. Riegelman, and R. M. Elashofft. Statistical estimations in pharmacokinetics. J. Pharmacokin. Biopharm.\n2:123\u2013147 (1974).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"305083_CR16","first-page":"237","volume-title":"SAS User's Guide","author":"SAS Institute.","year":"1979","unstructured":"SAS Institute. SAS User's Guide, SAS Institute, Raleigh, NC, 1979, pp. 237\u2013241."},{"key":"305083_CR17","first-page":"669","volume":"17","author":"G. M. Kochak","year":"1989","unstructured":"G. M. Kochak, R. L. Choi, J. K. De-Silva, and P. Reydel-Bax. Physiological disposition of CGS 16617 in rat, dog, and man. Drug Metab. Disposit.\n17:669\u2013672 (1989).","journal-title":"Drug Metab. Disposit."},{"key":"305083_CR18","first-page":"461","volume":"9","author":"J. A. Norman","year":"1987","unstructured":"J. A. Norman, M. Lehman, F. R. Goodman, B. W. Barclay, and M. B. Zimmerman. Central and peripheral inhibition of angiotensin converting enzyme (ACE) in the SHR: Correlation with the antihypertensive activity of ACE inhibitors. Clin. Exp. Hypertens. [A]\n9:461\u2013468 (1987).","journal-title":"Clin. Exp. Hypertens. [A]"},{"key":"305083_CR19","unstructured":"Tocanic Farms laboratory animal and services. Research report (1990)."},{"key":"305083_CR20","first-page":"35","volume-title":"Research Techniques in the Rat","author":"C. Petty","year":"1982","unstructured":"C. Petty. Research Techniques in the Rat, C. C. Thomas, Springfield, IL, 1982, p. 35."},{"key":"305083_CR21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/01.RES.15.6.511","volume":"15","author":"E. R. Krieger","year":"1964","unstructured":"E. R. Krieger. Neurogenic hypertension in the rat. Circ. Res.\n15:511\u2013521 (1964).","journal-title":"Circ. Res."},{"key":"305083_CR22","first-page":"736","volume":"37","author":"S. K. Wixson","year":"1987","unstructured":"S. K. Wixson, W. J. White, H. C. Hughes, Jr., C. M. Lang, and W. K. Marshall. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, MAP and heart rate in adult male rats. Lab. Anim. Sci.\n37:736\u2013742 (1987).","journal-title":"Lab. Anim. Sci."},{"key":"305083_CR23","first-page":"374","volume-title":"Textbook of Medical Physiology","author":"A. C. Guyton","year":"1986","unstructured":"A. C. Guyton. The special fluid system of the body. In Textbook of Medical Physiology, Saunders, Philadelphia, PA. 1986, pp. 374\u2013375."},{"key":"305083_CR24","first-page":"R303","volume":"245","author":"J. M. Collins","year":"1983","unstructured":"J. M. Collins, and R. L. Dedrick. Distributed model for drug delivery to CSF and brain tissue. Am. J. Physiol.\n245:R303\u2013R310 (1983).","journal-title":"Am. J. Physiol."},{"key":"305083_CR25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/ajplegacy.1975.228.2.352","volume":"228","author":"L. A. Wade","year":"1975","unstructured":"L. A. Wade and R. Katzman. Rat brain regional uptake and decarboxylation of 1-DOPA following carotid injection. Am. J. Physiol.\n228:352\u2013359 (1975).","journal-title":"Am. J. Physiol."},{"key":"305083_CR26","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/0024-3205(81)90067-9","volume":"29","author":"P. Hatzinikolaou","year":"1981","unstructured":"P. Hatzinikolaou, P. Brecher, and H. Gavras. Chronic hypertension increases tyrosine transport across the BBB in the rat. Life Sci.\n29:1657\u20131660 (1981).","journal-title":"Life Sci."},{"key":"305083_CR27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/bmj.1.5852.507","volume":"1","author":"S. Strandgaard","year":"1973","unstructured":"S. Strandgaard, J. Olsen, E. Skinhoj, and N. A. Lassen. Autoregulation of brain circulation in severe arterial hypertension. Br. Med. J.\n1:507\u2013510 (1973).","journal-title":"Br. Med. J."},{"key":"305083_CR28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/01.STR.13.2.225","volume":"13","author":"W. E. Hoffman","year":"1982","unstructured":"W. E. Hoffman, R. F. Alberecht, and D. J. Miletich. Nitroglycerin induced hypotension will maintain CSF in hypertensive rats. Stroke\n13:225\u2013228 (1982).","journal-title":"Stroke"},{"key":"305083_CR29","first-page":"H406","volume":"224","author":"S. Sadoshima","year":"1983","unstructured":"S. Sadoshima, D. W. Busija, and D. D. Heistad. Mechanisms of protection against stroke in stroke-prone spontaneously hypertensive rats. Am. J. Physiol.\n224:H406\u2013H412 (1983).","journal-title":"Am. J. Physiol."},{"key":"305083_CR30","first-page":"81","volume":"6","author":"B. B. Johanson","year":"1984","unstructured":"B. B. Johanson. Cerebral vascular bed in hypertension and consequences for the brain. Hypertension\n6 (Suppl. III):81\u201386 (1984).","journal-title":"Hypertension"},{"key":"305083_CR31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/ajplegacy.1975.229.4.1110","volume":"229","author":"M. W. B. Bradbury","year":"1975","unstructured":"M. W. B. Bradbury, C. S. Patlak, and W. H. Oldendorf. Analysis of brain uptake and loss of radiotracers after intracarotid injection. Am. J. Physiol.\n229:1110\u20131115 (1975).","journal-title":"Am. J. Physiol."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018945608888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018945608888\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018945608888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:12:21Z","timestamp":1754028741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018945608888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["305083"],"URL":"https:\/\/doi.org\/10.1023\/a:1018945608888","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}