{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:48:29Z","timestamp":1790077709272,"version":"4.0.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1023\/a:1018974501232","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T17:07:13Z","timestamp":1045674433000},"page":"156-159","source":"Crossref","is-referenced-by-count":28,"title":["Comparison of the Pharmacokinetics of an Ondansetron Solution (8 mg) When Administered Intravenously, Orally, to the Colon, and to the Rectum"],"prefix":"10.1007","volume":"11","author":[{"given":"Poe-Hirr","family":"Hsyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Frederick","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haig P.","family":"Bozigian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita H.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Shamburek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"304417_CR1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(87)92208-2","volume":"27","author":"D. Cunningham","year":"1987","unstructured":"D. Cunningham, J. Hawthorn, A. Pople, J. C. Gazet, H. T. Ford, T. Challoner, and R. C. Coombes. Prevention of emesis in patients receiving cytotoxic drugs by GR 38032F, a selective 5-HT3 receptor antagonist. Lancet\n27:1461\u20131463 (1987).","journal-title":"Lancet"},{"key":"304417_CR2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1097-0142(19900915)66:6<1101::AID-CNCR2820660604>3.0.CO;2-F","volume":"66","author":"A. Khojasteh","year":"1990","unstructured":"A. Khojasteh, G. Sartian, E. Tapazoglou, E. Lester, D. Gandara, S. Bernard, and A. Finn. Ondansetron for the prevention of emesis induced by high dose cisplatin. Cancer\n66:1101\u20131105 (1990).","journal-title":"Cancer"},{"key":"304417_CR3","unstructured":"T. L. Lloyd, A. E. Gooding, and J. J. Tomlinson. Determination of ondansetron in human serum or plasma using robotic solid phase extraction and HPLC (submitted to J. Chromatog.)."},{"key":"304417_CR4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"M. Gibaldi","year":"1982","unstructured":"M. Gibaldi and D. Perrier. Pharmacokinetics, Marcel Dekkar, New York, 1982, pp. 63\u201372, 409\u2013417."},{"key":"304417_CR5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/jps.2600570602","volume":"57","author":"J. C. K. Loo","year":"1968","unstructured":"J. C. K. Loo and S. Riegelman. New method for calculating the intrinsic absorption rate of the drugs. J. Pharm. Sci.\n57:918 (1968).","journal-title":"J. Pharm. Sci."},{"key":"304417_CR6","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/jps.2600800913","volume":"80","author":"P. V. Colthup","year":"1991","unstructured":"P. V. Colthup, C. C. Felgate, J. L. Palmer, and N. L. Scully. Determination of ondansetron in plasma and its pharmacokinetics in the young and elderly. J. Pharm. Sci.\n80:868\u2013871 (1991).","journal-title":"J. Pharm. Sci."},{"key":"304417_CR7","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1093\/jnci\/82.22.1776","volume":"82","author":"H. M. Lazarus","year":"1990","unstructured":"H. M. Lazarus, J. C. Bryson, E. Lemon, J. F. Pritchard, and J. Blumer. Antiemetic efficacy and pharmacokinetic analyses of the serotonin antagonist ondansetron during multiple-day chemotherapy with cisplatin prior to autologous bone marrow transplantation. J. Natl. Cancer Inst.\n82:1776\u20131778 (1990).","journal-title":"J. Natl. Cancer Inst."},{"key":"304417_CR8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/clpt.1992.7","volume":"51","author":"J. F. Pritchard","year":"1992","unstructured":"J. F. Pritchard, J. C. Bryson, A. E. Kernodle, T. L. Benedetti, and J. R. Powell. Age and gender effects on ondansetron pharmacokinetics: Evaluation of healthy aged volunteers. Clin. Pharmacol. Ther.\n51:51\u201355 (1992).","journal-title":"Clin. Pharmacol. Ther."},{"key":"304417_CR9","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/0016-5085(80)90925-7","volume":"79","author":"N. W. Read","year":"1980","unstructured":"N. W. Read, C. A. Miles, D. Fisher, A. M. Holgate, N. D. Kime, M. A. Mitchell, A. M. Reeve, T. B. Roche, and M. Walker. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhoea. Gastroenterology\n79:1276\u20131282 (1980).","journal-title":"Gastroenterology"},{"key":"304417_CR10","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.27.8.886","volume":"27","author":"S. S. Davis","year":"1986","unstructured":"S. S. Davis, J. G. Hardy, and J. W. Fara. Transit of pharmaceutical dosage forms through the small intestine. Gut\n27:886\u2013892 (1986).","journal-title":"Gut"},{"key":"304417_CR11","unstructured":"L.-S. Gan, P.-H. Hsyu, J. F. Pritchard, and D. R. Thakker. Mechanism of intestinal absorption of ranitidine and ondansetron: Transport across Caco-2 cell monolayers. Pharm. Res. (in press)."},{"key":"304417_CR12","first-page":"133","volume-title":"Drug Delivery to the Gastrointestinal Tract","author":"D. C. Taylor","year":"1989","unstructured":"D. C. Taylor, L. Lunch, and D. E. Leahy. Models for intestinal permeability to drugs. In J. G. Hardy, S. S. Davis, and C. G. Wilson (eds.), Drug Delivery to the Gastrointestinal Tract, Ellis Horwood, Chichester, England, 1989, pp. 133\u2013146."}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018974501232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1018974501232\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1018974501232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:08:28Z","timestamp":1754028508000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1018974501232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["304417"],"URL":"https:\/\/doi.org\/10.1023\/a:1018974501232","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}