{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:16:42Z","timestamp":1791875802527,"version":"4.3.4"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1023\/a:1020592802989","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T15:12:43Z","timestamp":1048000363000},"page":"299-310","source":"Crossref","is-referenced-by-count":125,"title":["Mixture Toxicity of Priority Pollutants at No Observed Effect Concentrations (NOECs)"],"prefix":"10.1007","volume":"11","author":[{"given":"Helge","family":"Walter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Consolaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gramatica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Scholze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Altenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5096178_CR1","first-page":"61","volume-title":"Biotests in der Praxis","author":"R. Altenburger","year":"2000","unstructured":"Altenburger, R. and Backhaus, T. (2000). Der Faktor Zeit bei der Beurteilung von biologischen Wirkungen. In W. M\u00fccke and M. Limk (eds.) Biotests in der Praxis . M\u00fcnchen: Institut f\u00fcr Toxikologie und Umwelthygiene, Technische Universit\u00e4t M\u00fcnchen. pp. 61\u201334."},{"key":"5096178_CR2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0147-6513(90)90049-B","volume":"20","author":"R. Altenburger","year":"1990","unstructured":"Altenburger, R., B\u00f6deker, W., Faust, M. and Grimme, L.H. (1990). Evaluation of the isobologram method for the assessment of mixtures of chemicals. Combination effect studies with pesticides in algal biotests. Ecotoxicol. Environ. Safety\n20 , 98\u2013114.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-0-12-189410-8.50006-7","volume-title":"Handbook of Hazardous Materials","author":"R. Altenburger","year":"1993","unstructured":"Altenburger, R., B\u00f6deker, W., Faust, M. and Grimme, L.H. (1993). Aquatic Toxicology, Analysis of combination effects. In M. Corn (ed.). Handbook of Hazardous Materials . New York: Academic Press. pp. 15\u201323."},{"key":"5096178_CR4","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0278-6915(97)00088-4","volume":"34","author":"R. Altenburger","year":"1996","unstructured":"Altenburger, R., B\u00f6deker, W., Faust, M. and Grimme, L.H. (1996). Regulations for combined effects of pollutants: Consequences from risk assessment in aquatic toxicology. Food Chem. Toxicol.\n34 , 1155\u20137.","journal-title":"Food Chem. Toxicol."},{"key":"5096178_CR5","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/etc.5620190926","volume":"19","author":"R. Altenburger","year":"2000","unstructured":"Altenburger, R., Backhaus, T., Boedeker, W., Faust, M., Scholze, M. and Grimme, L.H. (2000). Predictability of the toxicity of multiple chemical mixtures to Vibrio fisheri : Mixtures composed of similarly acting chemicals. Environ. Toxicol. Chem.\n19 , 2341\u20137.","journal-title":"Environ. Toxicol. Chem."},{"key":"5096178_CR6","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1002\/etc.5620190927","volume":"19","author":"T. Backhaus","year":"2000","unstructured":"Backhaus, T., Altenburger, R., Boedeker, W., Faust, M., Scholze, M. and Grimme, L.H. (2000). Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri . Environ. Toxicol. Chem.\n19 , 2348\u201356.","journal-title":"Environ. Toxicol. Chem."},{"key":"5096178_CR7","volume-title":"From Chemical Topology to Three-dimensional Geometry","author":"A.T. Balaban","year":"1997","unstructured":"Balaban, A.T. (1997). From Chemical Topology to Three-dimensional Geometry . New York: Plenum Press."},{"key":"5096178_CR8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-5193(85)80176-4","volume":"114","author":"M.C. Berenbaum","year":"1985","unstructured":"Berenbaum, M.C. (1985). The expected effect of a combination of agents: the general solution. J. Theoret. Biol.\n114 , 413\u201331.","journal-title":"J. Theoret. Biol."},{"key":"5096178_CR9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/etc.5620140920","volume":"14","author":"S.J. Broderius","year":"1995","unstructured":"Broderius, S.J., Kahl, M.D. and Hoglund, M.D. (1995). Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals. Environ. Toxicol. Chem.\n14 , 1591\u2013605.","journal-title":"Environ. Toxicol. Chem."},{"key":"5096178_CR10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10408449891344164","volume":"28","author":"F.R. Cassee","year":"1998","unstructured":"Cassee, F.R., Groten, J.P., van Bladeren, P.J. and Feron, V.J. (1998). Toxicological evaluation and risk assessment of chemical mixtures. Critical Rev. Toxicol.\n28 , 73\u2013101.","journal-title":"Critical Rev. Toxicol."},{"key":"5096178_CR11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/etc.5620150201","volume":"15","author":"P.M. Chapman","year":"1996","unstructured":"Chapman, P.M., Cadwell, R.S. and Chapman, P.F. (1996). A warning: NOECs are inappropriate for regulatory use. Environ. Toxicol. Chem.\n15 , 77\u20139.","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"5096178_CR12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/ee\/3.2.217","volume":"3","author":"D.R. Cole","year":"1974","unstructured":"Cole, D.R., Plapp, Jr. F, W. (1974). Inhibition of growth and photosynthesis in Chlorella pyrenoidosa by a polychlorinated biphenyl and several insecticides. Environ. Entomol.\n3 (2), 217\u201320.","journal-title":"Environ. Entomol."},{"key":"5096178_CR13","unstructured":"CSTE\/EEC, (1994). Scientific Advisory Committee Activity Report published by the Commission of the European Communities, Office for Official Publication of the E.C., Luxembourg: EUR (1992\u20131993)."},{"key":"5096178_CR14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/2528490","volume":"20","author":"C.W. Dunnett","year":"1964","unstructured":"Dunnett, C.W. (1964). New tables for multiple comparisons with a control. Biometrics\n20 , 482\u201391.","journal-title":"Biometrics"},{"key":"5096178_CR15","unstructured":"European Inland Fisheries Advisory Commission (EIFAC). (1987). Water quality criteria for European freshwater fish Revised report on combined effects on freshwater fish and other aquatic life of mixtures of toxicants in water. EIFAC Technical Paper No. 37, Rev 1."},{"key":"5096178_CR16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/eesa.1996.1483","volume":"36","author":"A. Fargasova","year":"1997","unstructured":"Fargasova, A. (1997). Comparative study of ecotoxicological effect of triorganotin compounds on various biological subjects. Ecotoxicol. Environ. Safety\n36 , 38\u201342.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s001289900584","volume":"60","author":"A. Fargasova","year":"1998","unstructured":"Fargasova, A. (1998). Comparison of effects of tibutyl-, triphenyl-, and tribenzyltin compounds on freshwater benthos and algae Scenedesmus quadricauda . Bull. Environ. Contam. Toxicol.\n60 , 9\u201315.","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"5096178_CR18","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2134\/jeq2000.00472425002900040005x","volume":"29","author":"M. Faust","year":"2000","unstructured":"Faust, M., Altenburger, R., Backhaus, T., Boedeker, W., Scholze, M. and Grimme, L.H. (2000). Predictive assessment of the aquatic toxicity of multiple chemical mixtures. J. Environ. Quality\n29 , 1063\u20138.","journal-title":"J. Environ. Quality"},{"key":"5096178_CR19","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1289\/ehp.98106s61281","volume":"106","author":"V.J. Feron","year":"1998","unstructured":"Feron, V.J., Cassee, F.R. and Groten, J.P. (1998). Toxicology of chemical mixtures: international perspective. Environ. Health Persp.\n106 , 1281\u20139.","journal-title":"Environ. Health Persp."},{"key":"5096178_CR20","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/0045-6535(85)90156-0","volume":"14","author":"H. Geyer","year":"1985","unstructured":"Geyer, H., Scheunert, I. and Korte, F. (1985). The effects of organic environmental chemicals on the growth of the alga Scenedesmus subspicatus : a contribution to environmental biology. Chemosphere\n14 , 1355\u201369.","journal-title":"Chemosphere"},{"key":"5096178_CR21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0045-6535(00)00180-6","volume":"42","author":"P. Gramatica","year":"2001","unstructured":"Gramatica, P., Vighi, M., Consolaro, F., Todeschini, R., Finizio, A. and Faust, M. (2001). QSAR approach for the selection of congeneric compounds with a similar toxicological mode of action. Chemosphere\n42 , 873\u201383.","journal-title":"Chemosphere"},{"key":"5096178_CR22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0031-6997(25)06847-4","volume":"47","author":"W.R. Greco","year":"1995","unstructured":"Greco, W.R., Bravo, G. and Parsons, J.C. (1995). The search for synergy: A critical review from a response surface perspective. Pharmacol. Rev.\n47 , 331\u201385.","journal-title":"Pharmacol. Rev."},{"key":"5096178_CR23","unstructured":"Grimme, L.H., Altenburger, R., B\u00f6deker, W. and Faust, M. (1994). Kombinationswirkungen von Schadstoffen\u2014Toxizit\u00e4t bin\u00e4rer Kombinationen von Pestiziden und Tensiden im Algenbiotest. Forschungsbericht 102 07 205. Umweltforschungsplan des Bundesministers f\u00fcr Umwelt, Naturschutz und Reaktorsicherheit."},{"key":"5096178_CR24","volume-title":"Predictability and assessment of the aquatic toxicity of mixtures of substances\u2014multicomponent mixtures of dissimilarly acting chemicals at low effect concentrations","author":"L.H. Grimme","year":"1998","unstructured":"Grimme, L.H., Altenburger, R., Backhaus, T., Boedeker, W., Faust, M. and Scholze, M. (1998). Predictability and assessment of the aquatic toxicity of mixtures of substances\u2014multicomponent mixtures of dissimilarly acting chemicals at low effect concentrations (in German). UFZ-Bericht Nr. 25\/1998, Leipzig, Germany, Umweltforschungszentrum Leipzig-Halle GmbH."},{"key":"5096178_CR25","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0278-6915(97)00097-5","volume":"34","author":"D. Henschler","year":"1996","unstructured":"Henschler, D., Bolt, H.M., Jonker, D., Pieters, M.N. and Groten, J.P. (1996). Experimental designs and risk assessment in combination toxicology: panel discussion. Food Chem. Toxicol.\n34 , 1183\u20135.","journal-title":"Food Chem. Toxicol."},{"key":"5096178_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0166-445X(85)90005-0","volume":"6","author":"J. Hermens","year":"1985","unstructured":"Hermens, J., Broekhuysen, E., Canton, H. and Wegman, R. (1985a). Quantitative structure-activity relationships and mixture toxicity studies of alcohols and chlorohydrocarbons: effects on growth of Daphnia magna . Aquatic Toxicol.\n6 , 209\u201317.","journal-title":"Aquatic Toxicol."},{"key":"5096178_CR27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0147-6513(85)90030-2","volume":"9","author":"J. Hermens","year":"1985","unstructured":"Hermens, J., Busser, F., Leeuwangh, P. and Musch, A. (1985b). Quantitative structure-activity relationships and mixture toxicity of organic chemicals in Photobacterium phosphoreum : the MICROTOX test. Ecotoxicol. Environ. Safety\n9 , 17\u201325.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0166-445X(84)90005-5","volume":"5","author":"J. Hermens","year":"1984","unstructured":"Hermens, J., Canton, H., Janssen, P. and Jong, R. (1984a). Quantitative structure-activity relationships and toxicity studies of mixtures of chemicals with anaesthetic potency: acute lethal and sublethal toxicity to Daphnia magna . Aquatic Toxicol.\n5 , 143\u201354.","journal-title":"Aquatic Toxicol."},{"key":"5096178_CR29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-445X(84)90012-2","volume":"5","author":"J. Hermens","year":"1984","unstructured":"Hermens, J., Canton, H., Steyger, N. and Wegmann, R. (1984b). Joint effects of a mixture of 14 chemicals on mortality and inhibition of reproduction of Daphnia magna . Aquatic Toxicol.\n5 , 315\u201322.","journal-title":"Aquatic Toxicol."},{"key":"5096178_CR30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0147-6513(82)90020-3","volume":"6","author":"J. Hermens","year":"1982","unstructured":"Hermens, J. and Leeuwangh, P. (1982). Joint toxicity of mixtures of 8 and 24 chemicals to the guppy (Poecilia reticulata ). Ecotoxicol. Environ. Safety\n6 , 302\u201310.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR31","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0147-6513(84)90007-1","volume":"8","author":"J. Hermens","year":"1984","unstructured":"Hermens, J., Leeuwangh, P. and Musch, A. (1984c). Quantitative structure-activity relationships and mixture toxicity studies of chloro-and alkylanilines at an acute lethal toxicity level to the guppy (Poecilia reticulata ). Ecotoxicol. Environ. Safety\n8 , 388\u201394.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0147-6513(85)90049-1","volume":"9","author":"J. Hermens","year":"1985","unstructured":"Hermens, J., Leeuwangh, P. and Musch, A. (1985c). Joint toxicity of mixtures of groups of organic aquatic pollutants to the guppy (Poecilia reticulata ). Ecotoxicol. Environ. Safety\n9 , 321\u20136.","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"5096178_CR33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/aoc.590070604","volume":"7","author":"G. Huang","year":"1993","unstructured":"Huang, G., Bai, Z., Dai, S. and Xie, Q. (1993). Accumulation and toxic effect of organometallic compounds on algae. Appl. Organometallic Chem.\n7 , 373\u201380.","journal-title":"Appl. Organometallic Chem."},{"key":"5096178_CR34","unstructured":"HyperChem, Re4 for Windows 95 Autodesk Inc. Sausalito, CA."},{"key":"5096178_CR35","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0278-6915(97)00077-X","volume":"34","author":"D. Jonker","year":"1996","unstructured":"Jonker, D., Wouterson, R.A. and Feron, V.J. (1996). Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action. Food Chem. Toxicol.\n34 , 1075\u201382.","journal-title":"Food Chem. Toxicol."},{"key":"5096178_CR36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0013-9327(75)90033-6","volume":"9","author":"P.B. Kauss","year":"1975","unstructured":"Kauss, P.B. and Hutchinson, T.C. (1975). The effects of water-soluble petroleum components on the growth of Chlorella vulgaris beijerinck . Environ. Pollut.\n9 , 157\u201374.","journal-title":"Environ. Pollut."},{"key":"5096178_CR37","unstructured":"Kier, L.B. and Hall, L.H. (1986). Molecular Connectivity in Structure-Activity Analysis . UK Research Studies Press Letchworth."},{"key":"5096178_CR38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0300-483X(81)90132-3","volume":"19","author":"H. K\u00f6nemann","year":"1981","unstructured":"K\u00f6nemann, H. (1981a). Fish toxicity tests with mixtures of more than two chemicals: a proposal for a quantitative approach and experimental results. Toxicology\n19 , 229\u201338.","journal-title":"Toxicology"},{"key":"5096178_CR39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0300-483X(81)90130-X","volume":"19","author":"H. K\u00f6nemann","year":"1981","unstructured":"K\u00f6nemann, H. (1981b). Quantitative structure-activity relationships in fish toxicity studies 1. Relationships for 50 industrial pollutants. Toxicology\n19 , 209\u201321.","journal-title":"Toxicology"},{"key":"5096178_CR40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0300-483X(81)90131-1","volume":"19","author":"H. K\u00f6nemann","year":"1981","unstructured":"K\u00f6nemann, H. and Musch, A. (1981). Quantitative structure-activity relationships in fish toxicity studies. Part 2: The influence of pH on the QSAR of chlorophenols. Toxicology\n19 , 223\u20138.","journal-title":"Toxicology"},{"key":"5096178_CR41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0048-9697(98)00261-7","volume":"221","author":"A. Kortenkamp","year":"1998","unstructured":"Kortenkamp, A. and Altenburger, R. (1998). Synergisms with mixtures of xenoestrogens\u2014a reevaluation using the method of isoboles. Sci. Total Environ.\n221 , 59\u201373.","journal-title":"Sci. Total Environ."},{"key":"5096178_CR42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2307\/3545738","volume":"73","author":"R. Laskowski","year":"1995","unstructured":"Laskowski, R. (1995). Some good reasons to ban the use of NOEC, LOEC and related concepts in ecotoxicology. Oikos\n73 , 140\u20133.","journal-title":"Oikos"},{"key":"5096178_CR43","first-page":"609","volume-title":"Fundamentals of Aquatic Toxicology","author":"R.L. Lipnick","year":"1995","unstructured":"Lipnick, R.L. (1995). Structure-activity relationships. In G.R. Rand (ed.) Fundamentals of Aquatic Toxicology . 2nd edn. London UK: Taylor & Francis. pp. 609\u201355.","edition":"2nd edn."},{"key":"5096178_CR44","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/BF02394172","volume":"14","author":"K. Leeuwen van","year":"1990","unstructured":"Leeuwen van, K. (1990). Ecotoxicological effect assessment in the netherlands: recent developments. Environ. Manag.\n14 , 779\u201392.","journal-title":"Environ. Manag."},{"key":"5096178_CR45","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1577\/1548-8659(1984)113<74:CATTAO>2.0.CO;2","volume":"113","author":"R.E. Millemann","year":"1984","unstructured":"Millemann, R.E., Birge, W.J., Black, J.A., Cushman, R.M., Daniels, K.L., Franco, P.J. and Giddings, J.M. (1984). Comparative acute toxicity to aquatic organisms of components of coal-derived synthetic fuels. Trans. Am. Fisheries Soc.\n113 , 74\u201385.","journal-title":"Trans. Am. Fisheries Soc."},{"key":"5096178_CR46","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/etc.5620160425","volume":"16","author":"D.R.J. Moore","year":"1997","unstructured":"Moore, D.R.J. and Caux, P.-Y. (1997). Estimating low toxic effects. Environ. Toxicol. Chem.\n16 , 794\u2013801.","journal-title":"Environ. Toxicol. Chem."},{"issue":"5\/6","key":"5096178_CR47","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/03601239109372752","volume":"26","author":"I.Y. Mostafa","year":"1991","unstructured":"Mostafa, I.Y., Shabana, E.F., Khalil, Z. and Mostafa, F.I.Y. (1991). The metabolic fate of 14c-parathion by some fresh water phytoplankton and its possible effects on the algal metabolism. J. Environ. Sci. Health\n26 (5\/6), 499\u2013512.","journal-title":"J. Environ. Sci. Health"},{"key":"5096178_CR48","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1002\/etc.5620161130","volume":"11","author":"P.A. Pape-Lyndstrom","year":"1997","unstructured":"Pape-Lyndstrom, P.A. and Lydy, M.J. (1997). Synergistic toxicity of atrazine and organophosphate insecticides contravenes the response addition mixture model. Environ. Toxicol. Chem.\n11 , 2415\u201320.","journal-title":"Environ. Toxicol. Chem."},{"key":"5096178_CR49","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-7091-9276-4","volume-title":"Combined Effects of Drugs and Toxic Agents. Modern Evaluation in Theory and Practice","author":"G. P\u00f6ch","year":"1993","unstructured":"P\u00f6ch, G. (1993). Combined Effects of Drugs and Toxic Agents. Modern Evaluation in Theory and Practice . Wien, New York: Springer Verlag."},{"issue":"1","key":"5096178_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-445X(98)00111-8","volume":"46","author":"E.U. Ramos","year":"1999","unstructured":"Ramos, E.U., Vaes, W.H.J., Mayer, P. and Hermens, J.L.M. (1999). Algal growth inhibition of Chlorella pyrenoidosa by polar narcotic pollutants: toxic cell concentrations and QSAR modelling. Aquatic Toxicol.\n46 (1), 1\u201310.","journal-title":"Aquatic Toxicol."},{"key":"5096178_CR51","unstructured":"SCAN\u2014Software for Chemometric Analysis, (1995) rel 11 for Windows. Minitab USA."},{"issue":"1","key":"5096178_CR52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/eesa.1994.1007","volume":"27","author":"H. Sch\u00e4fer","year":"1994","unstructured":"Sch\u00e4fer, H., Hettler, H., Fritsche, U., Pitzen, G., Roderer, G. and Wenzel, A. (1994). Biotests using unicellular algae and ciliates for prediciting long-term effects of toxicants. Ecotoxicol. Environ. Safety\n27(1) , 64\u201381.","journal-title":"Ecotoxicol. Environ. Safety"},{"issue":"2","key":"5096178_CR53","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/etc.5620200228","volume":"20","author":"M. Scholze","year":"2001","unstructured":"Scholze, M., Boedeker, W., Faust, M., Backhaus, T., Altenburger, R. and Grimme, L.H. (2001). A general best-fit method for concentration-response curves and the estimation of low-effect concentrations. Environ. Toxicol. Chem.\n20 (2), 448\u201357.","journal-title":"Environ. Toxicol. Chem."},{"key":"5096178_CR54","first-page":"665","volume-title":"Ecotoxicology","author":"G. Sch\u00fc\u00fcrmann","year":"1998","unstructured":"Sch\u00fc\u00fcrmann, G. (1998). Ecotoxic modes of action of chemical substances. In G. Sch\u00fc\u00fcrmann and B. Markert (eds). Ecotoxicology . New York: John Wiley and Spektrum Akademischer Verlag. pp. 665\u2013749."},{"key":"5096178_CR55","volume-title":"Bad Neuenahr-Ahrweiler GmbH","author":"C. Streffer","year":"2000","unstructured":"Streffer, C., B\u00fccker, J., Cansier, A., Cansier, D., Gethmann, C.F., Guderian, R., Hanekamp, G., Henschler, D., P\u00f6ch, G., Rehbinder, E., Renn, O., Slesina, M. and Wuttke, K. (2000). Umweltstandards. Kombinierte Expositionen und ihre Auswirkungen auf den Menschen und seine Umwelt. Europ\u00e4ische Akademie zur Erfoschung von Folgen wissenschaftlichtechnischer Entwicklungen. Bad Neuenahr-Ahrweiler GmbH, Bd. 5. Berlin: Springer."},{"key":"5096178_CR56","unstructured":"Todeschini, R. and Consonni, V. (2000a). DRAGON\u2014Software for the calculation of molecular descriptors, version 1.0 for Windows. Free download from http:\/\/www.disat.unimib.it\/chm."},{"key":"5096178_CR57","doi-asserted-by":"crossref","DOI":"10.1002\/9783527613106","volume-title":"Handbook of Molecular Descriptors","author":"R. Todeschini","year":"2000","unstructured":"Todeschini, R. and Consonni, V. (2000b). Handbook of Molecular Descriptors . Weinheim, Germany: Wiley-VCH."},{"key":"5096178_CR58","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/qsar.19970160204","volume":"16","author":"R. Todeschini","year":"1997","unstructured":"Todeschini, R. and Gramatica, P. (1997). 3-D modelling and prediction by WHIM descriptors. Part 5 Theory development and chemical meaning of the WHIM descriptors. Quantitative Structure-Activity Relationships\n16 , 120\u20135.","journal-title":"Quantitative Structure-Activity Relationships"},{"key":"5096178_CR59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cem.1180080405","volume":"8","author":"R. Todeschini","year":"1994","unstructured":"Todeschini, R., Lasagni, M. and Marengo, E. (1994). New molecular descriptors for 2D and 3D structures theory. J. Chemomet.\n8 , 263\u201372.","journal-title":"J. Chemomet."},{"key":"5096178_CR60","volume-title":"Dokumentation wassergef\u00e4hrdender Stoffe\u2014Datenblattsammlung: Grundwerk mit 3. Erg\u00e4nzungslieferung","author":"UBA","year":"1999","unstructured":"UBA (Umweltbundesamt), (1999). Dokumentation wassergef\u00e4hrdender Stoffe\u2014Datenblattsammlung: Grundwerk mit 3. Erg\u00e4nzungslieferung. Stand: Juni 1998. Stuttgart, Hirzel."},{"key":"5096178_CR61","volume-title":"In-depth studies on health and environmental impacts of selected water pollutants","author":"U.S.-EPA","year":"1978","unstructured":"U.S.-EPA (Environmental Protection Agency) (1978). In-depth studies on health and environmental impacts of selected water pollutants. Contract No. 68\u201301\u20134646, Duluth, U.S. EPA."},{"key":"5096178_CR62","volume-title":"Kombinationswirkungen von Umweltchemikalien\u2014Zur Analyse der milieuabh\u00e4ngigen Mischungstoxizit\u00e4t von Kontaminanten mit unbekanntem Wirkungsmechanismus in umweltrelevanten Konzentrationen","author":"H. Walter","year":"2002","unstructured":"Walter, H. (2002). Kombinationswirkungen von Umweltchemikalien\u2014Zur Analyse der milieuabh\u00e4ngigen Mischungstoxizit\u00e4t von Kontaminanten mit unbekanntem Wirkungsmechanismus in umweltrelevanten Konzentrationen. Dissertation. Universit\u00e4t Halle-Wittenberg. Dev Andere Verlag, OsmaSr\u00fcck."}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020592802989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1020592802989\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020592802989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T20:33:27Z","timestamp":1753821207000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1020592802989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["5096178"],"URL":"https:\/\/doi.org\/10.1023\/a:1020592802989","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}