{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:47:11Z","timestamp":1780105631420,"version":"3.54.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1023\/a:1020695110648","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T20:27:35Z","timestamp":1048019255000},"page":"527-536","source":"Crossref","is-referenced-by-count":21,"title":["Protective effect of adrenomedullin in mannitol-induced apoptosis"],"prefix":"10.1007","volume":"7","author":[{"given":"Won","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ok","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jeong","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gou Young","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kwang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5100234_CR1","first-page":"639","volume":"13","author":"R Bullock","year":"1996","unstructured":"Bullock R, Chestnut RM, Clifton G, et al Guidelines for the management of severe head injury. Brain Trauma 1996; 13: 639\u2013734.","journal-title":"Brain Trauma"},{"key":"5100234_CR2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ki.1997.409","volume":"52","author":"OS Better","year":"1997","unstructured":"Better OS, Rubinstein I, Winaver JM, Knochel JP Mannitol therapy revisited. Kidney Int 1997; 52: 886\u2013894.","journal-title":"Kidney Int"},{"key":"5100234_CR3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/excr.1997.3476","volume":"231","author":"L Shapiro","year":"1997","unstructured":"Shapiro L, Dinarello CA Hyperosmotic stress as a stimulant for proinflammatory cytokine production. Exp Cell Res 1997; 231: 354\u2013362.","journal-title":"Exp Cell Res"},{"key":"5100234_CR4","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.STR.29.12.2631","volume":"29","author":"AM Malek","year":"1998","unstructured":"Malek AM, Goss GG, Jiang L, Izumo S, Alper SL Mannitol at clinical concentrations activates multiple signaling pathways and induce apoptosis in endothelial cells. Stroke 1998; 29: 2631\u20132640.","journal-title":"Stroke"},{"key":"5100234_CR5","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0006-291X(90)91557-9","volume":"172","author":"S Araki","year":"1990","unstructured":"Araki S, Simada Y, Kaji K, Hayashi H Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum depleted endothelial cells. Biochem Biophys Res Commun 1990; 172: 1081\u20131085.","journal-title":"Biochem Biophys Res Commun"},{"key":"5100234_CR6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.HYP.30.5.1198","volume":"30","author":"M Shichiri","year":"1997","unstructured":"Shichiri M, Kato H, Marumo F, Hirata Y Endothelin-1 as an autocrine\/paracrine apoptosis survival factor for endothelial cells. Hypertension 1997; 30: 1198\u20131203.","journal-title":"Hypertension"},{"key":"5100234_CR7","doi-asserted-by":"crossref","first-page":"13313","DOI":"10.1074\/jbc.273.21.13313","volume":"273","author":"HP Gerber","year":"1998","unstructured":"Gerber HP, Dixit V, Ferrara N Vascular endothelial growth factor induces expression of the antiapoptotic proteins bcl-2 and A1 in vascular endothelial cells. J Biol Chem 1998; 273: 13313\u201313316.","journal-title":"J Biol Chem"},{"key":"5100234_CR8","doi-asserted-by":"crossref","first-page":"30336","DOI":"10.1074\/jbc.273.46.30336","volume":"273","author":"HP Gerber","year":"1988","unstructured":"Gerber HP, McMurtrey A, Kowalski J, et al Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3\u2032-kinase\/Akt signal transduction pathway. J Biol Chem 1988; 273: 30336\u201330343.","journal-title":"J Biol Chem"},{"key":"5100234_CR9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-5793(99)00378-6","volume":"448","author":"HJ Kwak","year":"1999","unstructured":"Kwak HJ, So JN, Lee SJ, Kim I, Koh GY Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett 1999; 448: 249\u2013253.","journal-title":"FEBS Lett"},{"key":"5100234_CR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","volume":"192","author":"K Kitamura","year":"1993","unstructured":"Kitamura K, Kangawa K, Kawamoto M, et al Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192: 553\u2013560.","journal-title":"Biochem Biophys Res Commun"},{"key":"5100234_CR11","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1210\/endo.138.6.5197","volume":"138","author":"H Kato","year":"1997","unstructured":"Kato H, Shichiri M, Marumo F, Hirata Y Adrenomedullin as an autocrine\/paracrine apoptosis survival factor for rat endothelial cells. Endocrinology 1997; 138: 2615\u20132620.","journal-title":"Endocrinology"},{"key":"5100234_CR12","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/01.CIR.101.19.2317","volume":"101","author":"HJ Kwak","year":"2000","unstructured":"Kwak HJ, Lee SJ, Lee YH, et al Angiopoietin-1 inhibits irradiation-and mannitol-induced apoptosis in endothelial cells. Circulation 2000; 101: 2317\u20132324.","journal-title":"Circulation"},{"key":"5100234_CR13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-2952(01)00860-7","volume":"63","author":"KB Kwon","year":"2002","unstructured":"Kwon KB, Yoo SJ, Ryu DG, et al Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem Pharmacol 2002; 63: 41\u201347.","journal-title":"Biochem Pharmacol"},{"key":"5100234_CR14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.RES.86.1.24","volume":"86","author":"I Kim","year":"2000","unstructured":"Kim I, Kim HG, So JN, Kim JH, Kwak HJ, Koh GY Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3\u2032-Kinase\/Akt signal transduction pathway. Circ Res 2000; 86: 24\u201329.","journal-title":"Circ Res"},{"key":"5100234_CR15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000045725","volume":"86","author":"A Amore","year":"2000","unstructured":"Amore A, Coppo R Role of apoptosis in pathogenesis and progression of renal diseases. Nephron 2000; 86: 99\u2013104.","journal-title":"Nephron"},{"key":"5100234_CR16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","volume":"393","author":"LM McLatchie","year":"1998","unstructured":"McLatchie LM, Fraser NJ, Main MJ, et al RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998; 393: 333\u2013339.","journal-title":"Nature"},{"key":"5100234_CR17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(99)00358-0","volume":"448","author":"S Kamitani","year":"1999","unstructured":"Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T The RAMP2\/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. FEBS Lett 1999; 448: 111\u2013114.","journal-title":"FEBS Lett"},{"key":"5100234_CR18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-5793(95)01427-6","volume":"378","author":"DJ Withers","year":"1996","unstructured":"Withers DJ, Coppock HA, Seufferlein T, Smith DM, Bloom SR, Rozengurt E Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells. FEBS Lett 1996; 378: 83\u201387.","journal-title":"FEBS Lett"},{"key":"5100234_CR19","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1074\/jbc.270.9.4412","volume":"270","author":"Y Shimekake","year":"1995","unstructured":"Shimekake Y, Nagata K, Ohta S, et al Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells. J Biol Chem 1995; 270: 4412\u20134417.","journal-title":"J Biol Chem"},{"key":"5100234_CR20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0006-8993(97)01430-3","volume":"786","author":"Y Uezono","year":"1998","unstructured":"Uezono Y, Shibuya I, Ueda Y, et al Adrenomedullin increases intracellular Ca2+ and inositol 1,4,5-trisphosphate in human oligodendroglial cell line KG-1C. Brain Res 1998; 786: 230\u2013234.","journal-title":"Brain Res"},{"key":"5100234_CR21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000045427","volume":"83","author":"A Osajima","year":"1999","unstructured":"Osajima A, Kato H, Uezono Y, et al Adrenomedullin inhibits transmural pressure induced mesangial cell proliferation through activation of protein kinase A. Nephron 1999; 83: 352\u2013357.","journal-title":"Nephron"},{"key":"5100234_CR22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00004872-200103001-00012","volume":"19","author":"A Semplicini","year":"2001","unstructured":"Semplicini A, Ceolotto G, Baritono E, et al Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinasedependent cascade. J Hypertens 2001; 19: 599\u2013602.","journal-title":"J Hypertens"},{"key":"5100234_CR23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/mend.13.8.0324","volume":"13","author":"M Shichiri","year":"1999","unstructured":"Shichiri M, Kato H, Doi M, Marumo F, Hirata Y Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Mol Endocrinol 1999; 13: 1353\u20131363.","journal-title":"Mol Endocrinol"},{"key":"5100234_CR24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.82.11.1111","volume":"82","author":"A Haunstetter","year":"1998","unstructured":"Haunstetter A, Izumo S Apoptosis: Basic mechanisms and implications for cardiovascular disease. Circ Res 1998; 82: 1111\u20131129.","journal-title":"Circ Res"},{"key":"5100234_CR25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.HYP.36.1.83","volume":"36","author":"M Sata","year":"2000","unstructured":"Sata M, Kakoki M, Nagata D, et al Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism. Hypertension 2000; 36: 83\u201388.","journal-title":"Hypertension"},{"key":"5100234_CR26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/hh1301.092498","volume":"89","author":"H Nishimatsu","year":"2001","unstructured":"Nishimatsu H, Suzuki E, Nagata D, et al Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase\/Akt-dependent pathway in rat aorta. Circ Res 2001; 89: 63\u201370.","journal-title":"Circ Res"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020695110648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1020695110648\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020695110648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T15:40:48Z","timestamp":1747582848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1020695110648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["5100234"],"URL":"https:\/\/doi.org\/10.1023\/a:1020695110648","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}