{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:15:22Z","timestamp":1791332122402,"version":"4.3.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1023\/a:1020702213099","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T15:53:36Z","timestamp":1048002816000},"page":"41-54","source":"Crossref","is-referenced-by-count":344,"title":["DMT1: A mammalian transporter for multiple metals"],"prefix":"10.1007","volume":"16","author":[{"given":"Michael D.","family":"Garrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Horbinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Porubcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille N.","family":"Hainsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay N.","family":"Umbreit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel E.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieska","family":"Lis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Singleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Garrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5094361_CR1","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","volume":"275","author":"S Abboud","year":"2000","unstructured":"Abboud S, Haile DJ. 2000 A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem\n275, 19906-19912.","journal-title":"J Biol Chem"},{"key":"5094361_CR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1182\/blood.V95.2.721","volume":"95","author":"X Alvarez-Hernandez","year":"2000","unstructured":"Alvarez-Hernandez X, Smith M, Glass J. 2000 Apo-transferrin is internalized and routed differently from Fe-transferrin by Caco-2 cells: a confocal microscopy study of vesicular transport in intestinal cells. Blood\n95, 721-723.","journal-title":"Blood"},{"key":"5094361_CR3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S1357-2725(99)00065-5","volume":"31","author":"NC. Andrews","year":"1999","unstructured":"Andrews NC. 1999 The iron transporter DMT1. Int J Biochem Cell Biol\n31, 991-994.","journal-title":"Int J Biochem Cell Biol"},{"key":"5094361_CR4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1021\/bi00216a003","volume":"30","author":"PK Bali","year":"1991","unstructured":"Bali PK, Zak O, Aisen P. 1991 A new role for the transferrin receptor in the release of iron from transferrin. Biochem\n30, 324-328.","journal-title":"Biochem"},{"key":"5094361_CR5","first-page":"227a","volume":"96","author":"C Beaumont","year":"2000","unstructured":"Beaumont C, Bourgeois M, Martin ME, Tchernitchko D. 2000 Expression of the two isoforms of the iron transporter Nramp2\/DMT1. Blood\n96, 227a.","journal-title":"Blood"},{"key":"5094361_CR6","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.1073\/pnas.151147098","volume":"98","author":"RH Broyles","year":"2001","unstructured":"Broyles RH, Belegu V, DeWitt CR, Shah SN, Stewart CA, Pye QN et al. 2001 Specific repression of \u03b2-globin promoter activity by nuclear ferritin. Proc Natl Acad Sci USA\n98, 9145-9150.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5094361_CR7","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1242\/jcs.114.12.2327","volume":"114","author":"CX Cai","year":"2001","unstructured":"Cai CX, Linsenmayer TF. 2001 Nuclear translocation of ferritin in corneal epithelial cells. J Cell Sci\n114, 2327-2334.","journal-title":"J Cell Sci"},{"key":"5094361_CR8","doi-asserted-by":"crossref","first-page":"12831","DOI":"10.1074\/jbc.272.19.12831","volume":"272","author":"CX Cai","year":"1997","unstructured":"Cai CX, Birk DE, Linsenmayer TF. 1997 Ferritin is a developmentally regulated nuclear protein of avian corneal epithelial cells. J Biol Chem\n272, 12831-12839.","journal-title":"J Biol Chem"},{"key":"5094361_CR9","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1091\/mbc.9.5.1037","volume":"9","author":"CX Cai","year":"1998","unstructured":"Cai CX, Cai CX, Birk DE, Linsenmayer TF. 1998 Nuclear ferritin protects DNA from UV damage in corneal epithelial cells. Mol Biol Cell\n9, 1037-1051.","journal-title":"Mol Biol Cell"},{"key":"5094361_CR10","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1182\/blood.V93.12.4406","volume":"93","author":"F Canonne-Hergaux","year":"1999","unstructured":"Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. 1999 Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood\n93, 4406-4417.","journal-title":"Blood"},{"key":"5094361_CR11","first-page":"3964","volume":"96","author":"F Canonne-Hergaux","year":"2000","unstructured":"Canonne-Hergaux F, Fleming MD, Levy JE, Gauthier S, Ralph T, Picard V et al. 2000 The Nramp2\/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood\n96, 3964-3970.","journal-title":"Blood"},{"key":"5094361_CR12","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1182\/blood.V97.4.1138","volume":"97","author":"F Canonne-Hergaux","year":"2001","unstructured":"Canonne-Hergaux F, Levy JE, Fleming MD, Montross LK, Andrews NC, Gros P. 2001 Expression of the DMT1 (NRAMP2\/DCT1) iron transporter in mice with genetic iron overload disorders. Blood\n97, 1138-1140.","journal-title":"Blood"},{"key":"5094361_CR13","first-page":"A397","volume":"14","author":"X Chen","year":"1999","unstructured":"Chen X, Peng J, Nelson N, Hediger MA. 1999 Uncoupled currents mediated by the H+-dependent divalent metal-ion transporters DCT1 and SMF1. FASEB J\n14, A397.","journal-title":"FASEB J"},{"key":"5094361_CR14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s003600050085","volume":"167","author":"A Chua","year":"1997","unstructured":"Chua A, Morgan EH. 1997 Manganese metabolism is impaired in the Belgrade laboratory rat. J Comp Physiol B\n167, 361-369.","journal-title":"J Comp Physiol B"},{"key":"5094361_CR15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000441-199910000-00002","volume":"318","author":"ME Conrad","year":"1999","unstructured":"Conrad ME, Umbreit JN, Moore EG. 1999 Iron absorption and transport. Am J Med Sci\n318, 213-229.","journal-title":"Am J Med Sci"},{"key":"5094361_CR16","doi-asserted-by":"crossref","first-page":"G767","DOI":"10.1152\/ajpgi.2000.279.4.G767","volume":"279","author":"ME Conrad","year":"2000","unstructured":"Conrad ME, Umbreit JN, Moore EG, Hainsworth LN, Porubcin M, Simovich MJ et al. 2000 Separate pathways for cellular uptake of ferric and ferrous iron. Am J Physiol Gastrointest Liver Physiol\n279, G767-G774.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5094361_CR17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","volume":"403","author":"A Donovan","year":"2000","unstructured":"Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J et al. 2000 Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (London)\n403, 776-781.","journal-title":"Nature (London)"},{"key":"5094361_CR18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3181\/00379727-141-36720","volume":"141","author":"JA Edwards","year":"1972","unstructured":"Edwards JA, Hoke JE. 1972 Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anemia. Proc Soc Exp Biol Med\n141, 81-84.","journal-title":"Proc Soc Exp Biol Med"},{"key":"5094361_CR19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1006\/bbrc.2001.5245","volume":"285","author":"F Elisma","year":"2001","unstructured":"Elisma F, Jumarie C. 2001 Evidence for cadmium uptake through Nramp2: Metal speciation studies with Caco-2 cells. Biochem Biophys Res Commun\n285, 662-668.","journal-title":"Biochem Biophys Res Commun"},{"key":"5094361_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajh.2830390104","volume":"39","author":"EA Farcich","year":"1992","unstructured":"Farcich EA, Morgan EH. 1992 Uptake of transferrin-bound and nontransferrin-bound iron by reticulocytes from the Belgrade laboratory rat: comparison with Wistar rat transferrin and reticulocytes. Am J Hematol\n39, 9-14.","journal-title":"Am J Hematol"},{"key":"5094361_CR21","doi-asserted-by":"crossref","first-page":"F803","DOI":"10.1152\/ajprenal.2001.280.5.F803","volume":"280","author":"CJ Ferguson","year":"2001","unstructured":"Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, Riccardi D. 2001 Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol\n280, F803-F814.","journal-title":"Am J Physiol Renal Physiol"},{"key":"5094361_CR22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng0897-383","volume":"16","author":"MD Fleming","year":"1997","unstructured":"Fleming MD, Trenor CI, Su MA, Foernzler D, Beier DR, Dietrich WF et al. 1997 Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet\n16, 383-386.","journal-title":"Nature Genet"},{"key":"5094361_CR23","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.95.3.1148","volume":"95","author":"MD Fleming","year":"1998","unstructured":"Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC. 1998 Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA\n95, 1148-1153.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5094361_CR24","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.96.6.3143","volume":"96","author":"RE Fleming","year":"1999","unstructured":"Fleming RE, Migas MC, Zhou XY, Jiang JX, Britton RS, Brunt EM et al. 1999 Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci USA\n96, 3143-3148.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5094361_CR25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jcp.1041460317","volume":"146","author":"LM Garrick","year":"1991","unstructured":"Garrick LM, Gniecko K, Hoke JE, Al-Nakeeb A, Ponka P, Garrick MD. 1991 Ferric-salicyaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat. J Cell Physiol\n146, 460-465.","journal-title":"J Cell Physiol"},{"key":"5094361_CR26","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1182\/blood.V81.12.3414.3414","volume":"81","author":"LM Garrick","year":"1993","unstructured":"Garrick LM, Gniecko K, Liu Y, Cohan DS, Grasso JA, Garrick MD. 1993a Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone. Blood\n81, 3414-3421.","journal-title":"Blood"},{"key":"5094361_CR27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1097-4652(199903)178:3<349::AID-JCP9>3.0.CO;2-R","volume":"178","author":"LM Garrick","year":"1999","unstructured":"Garrick LM, Dolan KG, Romano MA, Garrick MD. 1999 Nontransferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J Cell Physiol\n178, 349-358.","journal-title":"J Cell Physiol"},{"key":"5094361_CR28","first-page":"82a","volume":"111","author":"MD Garrick","year":"1990","unstructured":"Garrick MD, Gniecko K, Liu Y, Eckert B, Grasso JA, Garrick LM. 1990a Elevated endosomal pH in Belgrade rat reticulocytes. J Cell Biol\n111, 82a.","journal-title":"J Cell Biol"},{"key":"5094361_CR29","first-page":"8a","volume":"76","author":"MD Garrick","year":"1990","unstructured":"Garrick MD, Gniecko K, Liu Y, Cohan D, Eckert BS, Grasso JA et al. 1990b Defective endosomal acidification in Belgrade rat reticulocytes. Blood\n76, 8a.","journal-title":"Blood"},{"key":"5094361_CR30","doi-asserted-by":"crossref","first-page":"14867","DOI":"10.1016\/S0021-9258(18)82413-9","volume":"268","author":"MD Garrick","year":"1993","unstructured":"Garrick MD, Gniecko K, Liu Y, Cohan DS, Garrick LM. 1993b Transferrin and the transferrin cycle in Belgrade rat reticulocytes. J Biol Chem\n268, 14867-14874.","journal-title":"J Biol Chem"},{"key":"5094361_CR31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1018370804882","volume":"10","author":"M Garrick","year":"1997","unstructured":"Garrick M, Scott D, Walpole S, Finkelstein E, Whitbred J, Chopra S et al. 1997 Iron supplementation moderates but does not cure the Belgrade anemia. BioMetals\n10, 65-76.","journal-title":"BioMetals"},{"key":"5094361_CR32","first-page":"227a","volume":"96","author":"MD Garrick","year":"2000","unstructured":"Garrick MD, Horbinski C, Dolan KG, Feng L, Burdo J, Connor J et al. 2000 Factors associated with nuclear localization of the-IRE isoform of DMT1 (Nramp2\/DCT1). Blood\n96, 227a.","journal-title":"Blood"},{"key":"5094361_CR33","first-page":"141","volume-title":"Ultrastructure and Molecular Biology stet for oxidants and Antioxidants, Methods in Molecular Biology","author":"MD Garrick","year":"2002","unstructured":"Garrick MD, Dolan KG. 2002 An expression system for a transporter of iron and other metals. In: D. Armstrong (ed.): Ultrastructure and Molecular Biology stet for oxidants and Antioxidants, Methods in Molecular Biology, vol. 196. Totawa: Humana; pp. 141-154."},{"key":"5094361_CR34","unstructured":"Garrick M, Horbinski C, Dolan K, Higgins DL, Feng L, Lis A et al. 2001 Isoforms of divalent metal transporter (DMT1 aka DCT1 or Nramp2): what and where. BioIron (Cairns), 014."},{"key":"5094361_CR35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/B978-0-12-008303-9.50016-5","volume":"3","author":"LA Greene","year":"1982","unstructured":"Greene LA, Tischler AS. 1982 PC12 pheochromocytoma cultures in neurobiological research. Adv Cell Neurobiol\n3, 373-414.","journal-title":"Adv Cell Neurobiol"},{"key":"5094361_CR36","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1053\/gast.2001.24050","volume":"120","author":"W Griffiths","year":"2001","unstructured":"Griffiths W, Sly WS, Cox TM. 2001 Intestinal iron uptake determined by divalent metal transporter is enhanced in hfe-deficient mice with hemochromatosis. Gastroenterology\n120, 1420-1429.","journal-title":"Gastroenterology"},{"key":"5094361_CR37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","volume":"388","author":"H Gunshin","year":"1997","unstructured":"Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF et al. 1997 Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature (London)\n388, 482-488.","journal-title":"Nature (London)"},{"key":"5094361_CR38","doi-asserted-by":"crossref","first-page":"13616","DOI":"10.1074\/jbc.271.23.13616","volume":"271","author":"SA Gurgueira","year":"1996","unstructured":"Gurgueira SA, Meneghini R. 1996 An ATP-dependent iron transport system in isolated rat liver nuclei. J Biol Chem\n271, 13616-13620.","journal-title":"J Biol Chem"},{"key":"5094361_CR39","unstructured":"Hubert N, Hentze MW. 2001 Regulation of the iron transporter DMT1 in Caco2 cells. BioIron (Cairns), P146."},{"key":"5094361_CR40","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0006-3495(00)76343-0","volume":"79","author":"M Kn\u00f6pfel","year":"2000","unstructured":"Kn\u00f6pfel M, Schulthess G, Funk F, Hauser H. 2000 Characterization of an integral protein of the brush border membrane mediating the transport of divalent metal ions. Biophys J\n79, 874-884.","journal-title":"Biophys J"},{"key":"5094361_CR41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/bcmd.1998.0186","volume":"24","author":"PL Lee","year":"1998","unstructured":"Lee PL, Gelbart T, Halloran C, Beutler E. 1998 The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis\n24, 199-215.","journal-title":"Blood Cells Mol Dis"},{"key":"5094361_CR42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood.V94.1.9.413a43_9_11","volume":"94","author":"JE Levy","year":"1999","unstructured":"Levy JE, Montross LK, Cohen DE, Fleming MD, Andrews NC. 1999 The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood\n94, 9-11.","journal-title":"Blood"},{"key":"5094361_CR43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/jnr.490340507","volume":"34","author":"W Lin","year":"1993","unstructured":"Lin W, Higgins D, Pacheco M, Aletta J, Perrini S, Marcucci KA et al. 1993 Manganese induces spreading and process outgrowth in rat pheocromocytoma (PC12) cells. J Neurosci Res\n34, 546-561.","journal-title":"J Neurosci Res"},{"key":"5094361_CR44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","volume":"5","author":"AT McKie","year":"2000","unstructured":"McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D et al. 2000 A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell\n5, 299-309.","journal-title":"Mol Cell"},{"key":"5094361_CR45","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.1057206","volume":"291","author":"AT McKie","year":"2001","unstructured":"McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E et al. 2001 An iron-regulated ferric reductase associated with the absorption of dietary iron. Science\n291, 1755-1759.","journal-title":"Science"},{"key":"5094361_CR46","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1016\/S0021-9258(19)39205-1","volume":"265","author":"MT Nu\u00f1ez","year":"1990","unstructured":"Nu\u00f1ez MT, Gaete V, Watkins JA, Glass J. 1990 Mobilization of iron from endocytic vesicles. The effects of acidification and reduction. J Biol Chem\n265, 6688-6692.","journal-title":"J Biol Chem"},{"key":"5094361_CR47","doi-asserted-by":"crossref","first-page":"19425","DOI":"10.1074\/jbc.272.31.19425","volume":"272","author":"MT Nu\u00f1ez","year":"1997","unstructured":"Nu\u00f1ez MT, Nu\u00f1ez-Millacura C, Beltran M, Tapia V, Alvarez HX. 1997 Apotransferrin and holotransferrin undergo different endocytic cycles in intestinal epithelia (Caco-2) cells. J Biol Chem\n272, 19425-19428.","journal-title":"J Biol Chem"},{"key":"5094361_CR48","doi-asserted-by":"crossref","first-page":"C1085","DOI":"10.1152\/ajpcell.1999.276.5.C1085","volume":"276","author":"MT Nu\u00f1ez","year":"1999","unstructured":"Nu\u00f1ez MT, Tapia V. 1999 Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cells. Am J Physiol Cell Physiol\n276, C1085-C1090.","journal-title":"Am J Physiol Cell Physiol"},{"key":"5094361_CR49","doi-asserted-by":"crossref","first-page":"G826","DOI":"10.1152\/ajpgi.1996.270.5.G826","volume":"270","author":"PS Oates","year":"1996","unstructured":"Oates PS, Morgan EH. 1996 Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am J Physiol Gastrointest Liver Physiol\n270, G826-G832.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5094361_CR50","doi-asserted-by":"crossref","first-page":"G930","DOI":"10.1152\/ajpgi.2000.278.6.G930","volume":"278","author":"PS Oates","year":"2000","unstructured":"Oates PS, Thomas C, Freitas E, Callow MJ, Morgan EH. 2000 Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats. Am J Physiol Gastrointest Liver Physiol\n278, G930-G936.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5094361_CR51","doi-asserted-by":"crossref","first-page":"C793","DOI":"10.1152\/ajpcell.2001.281.3.C793","volume":"281","author":"L Olivi","year":"2001","unstructured":"Olivi L, Sisk, J, Bressler, J. 2001 Involvement of DMT1 in uptake of Cd in MDCK cells: Role of protein kinase C. Am J Physiol Gastrointest Cell Physiol\n281, C793-C800.","journal-title":"Am J Physiol Gastrointest Cell Physiol"},{"key":"5094361_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V89.1.1","volume":"89","author":"P. Ponka","year":"1997","unstructured":"Ponka P. 1997 Tissue-specific regulation of iron metabolism and heme synthesis: Distinct control mechanisms in erythroid cells. Blood\n89, 1-18.","journal-title":"Blood"},{"key":"5094361_CR53","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1523\/JNEUROSCI.20-20-07595.2000","volume":"20","author":"JA Roth","year":"2000","unstructured":"Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, Garrick MD. 2000 Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J Neurosci\n20, 7595-7601.","journal-title":"J Neurosci"},{"key":"5094361_CR54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jnr.10207","volume":"68","author":"JA Roth","year":"2002","unstructured":"Roth JA, Feng L, Dolan KG, Lis A, Garrick MD. 2002a Effect of the iron chelator, desferrioximine, on manganese-induced toxicity of rat pheochromocytoma (PC12) cells. J Neurosci Res, 68, 76-83.","journal-title":"J Neurosci Res"},{"key":"5094361_CR55","doi-asserted-by":"crossref","unstructured":"Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. 2002b Mechanism of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. NeuroToxicology\n81, in press.","DOI":"10.1016\/S0161-813X(01)00077-8"},{"key":"5094361_CR56","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1242\/jeb.204.6.1053","volume":"204","author":"A Sacher","year":"2001","unstructured":"Sacher A, Cohen A, Nelson N. 2001 Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus Laevis oocytes. J Exp Biol\n204, 1053-1061.","journal-title":"J Exp Biol"},{"key":"5094361_CR57","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1016\/S0021-9258(18)92931-5","volume":"266","author":"DM Sipe","year":"1991","unstructured":"Sipe DM, Murphy RF. 1991 Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH. J Biol Chem\n266, 8002-8007.","journal-title":"J Biol Chem"},{"key":"5094361_CR58","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1182\/blood.V92.6.2157","volume":"92","author":"MA Su","year":"1998","unstructured":"Su MA, Trenor CI, Fleming JC, Fleming MD, Andrews NC. 1998 The G185R mutation disrupts functions of the iron transporter Nramp2. Blood\n92, 2157-2163.","journal-title":"Blood"},{"key":"5094361_CR59","doi-asserted-by":"crossref","first-page":"22220","DOI":"10.1074\/jbc.M001478200","volume":"275","author":"M Tabuchi","year":"2000","unstructured":"Tabuchi M, Yoshimori T, Yamaguchi K, Yoshida T, Kishi F. 2000 Human NRAMP2\/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem\n275, 22220-22228.","journal-title":"J Biol Chem"},{"key":"5094361_CR60","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0378-4274(01)00363-0","volume":"122","author":"J Tallkvist","year":"2001","unstructured":"Tallkvist J, Bowlus CL, L\u00f6nnerda, B. 2001 DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett\n122, 171-177.","journal-title":"Toxicol Lett"},{"key":"5094361_CR61","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1074\/jbc.275.2.1023","volume":"275","author":"S Tandy","year":"2000","unstructured":"Tandy S, Williams M, Leggett A, Lopez JM, Dedes M, Ramesh B et al. 2000 Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem\n275, 1023-1029.","journal-title":"J Biol Chem"},{"key":"5094361_CR62","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/gut.46.2.270","volume":"46","author":"D Trinder","year":"2000","unstructured":"Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH. 2000 Localisation of divalent metal transporter I (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut\n46, 270-276.","journal-title":"Gut"},{"key":"5094361_CR63","doi-asserted-by":"crossref","unstructured":"Umbreit JN, Conrad ME, Hainswort, LN, Simovich M. 2002 The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin.","DOI":"10.1152\/ajpgi.00199.2001"},{"key":"5094361_CR64","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF00352405","volume":"6","author":"SM Vidal","year":"1995","unstructured":"Vidal SM, Belouchi A, Cellier M, Bewaty B, Gros P. 1995 Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mammal Genome\n6, 224-230.","journal-title":"Mammal Genome"},{"key":"5094361_CR65","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/5979","volume":"21","author":"CD Vulpe","year":"1999","unstructured":"Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N et al. 1999 Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nature Genet\n21, 195-199.","journal-title":"Nature Genet"},{"key":"5094361_CR66","doi-asserted-by":"crossref","unstructured":"Wang X, Ghio AJ, Yang F, Dolan KG, Garrick MD, Piantadosi CA. 2002 Iron uptake and Nramp2\/DMT1\/DCT1 in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol, in press.","DOI":"10.1152\/ajplung.00253.2001"},{"key":"5094361_CR67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01871413","volume":"119","author":"JA Watkins","year":"1991","unstructured":"Watkins JA, Nunez MT, Gaete V, Alvarez O, Glass J. 1991 Kinetics of iron passage through subcellular compartments of rabbit reticulocytes. J Membr Biol\n119, 141-149.","journal-title":"J Membr Biol"},{"key":"5094361_CR68","doi-asserted-by":"crossref","first-page":"A38","DOI":"10.1042\/bst030a038","volume":"30","author":"KN White","year":"2001","unstructured":"White KN, Graham DC, Bomford A. 2001 Nuclear localisation of iron regulatory proteins. Biochem Soc Trans\n30, A38.","journal-title":"Biochem Soc Trans"},{"key":"5094361_CR69","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-5793(01)02953-2","volume":"507","author":"S Yamaji","year":"2001","unstructured":"Yamaji S, Tennant J, Tandy S, Williams M, Srai SKS, Sharp P. 2001 Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco-2 cells. FEBS Lett\n507, 137-141.","journal-title":"FEBS Lett"},{"key":"5094361_CR70","doi-asserted-by":"crossref","first-page":"G1070","DOI":"10.1152\/ajpgi.2000.279.5.G1070","volume":"279","author":"KY Yeh","year":"2000","unstructured":"Yeh KY, Yeh M, Watkins JA, Rodriguez PJ, Glass J. 2000 Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol\n279, G1070-G1079.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"5094361_CR71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng0395-267","volume":"9","author":"K Yoshida","year":"1995","unstructured":"Yoshida K, Furihata K, Takeda S, Nakamura A, Yamamoto K, Morita H et al. 1995 A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nature Genet\n9, 267-272.","journal-title":"Nature Genet"},{"key":"5094361_CR72","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/S0140-6736(98)11179-0","volume":"353","author":"H Z\u00f6ller","year":"1999","unstructured":"Z\u00f6ller H, Pietrangelo A, Vogel W, Weiss G. 1999 Duodenal metaltransporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis. Lancet\n353, 2120-2123.","journal-title":"Lancet"},{"key":"5094361_CR73","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1053\/gast.2001.24033","volume":"120","author":"H Z\u00f6ller","year":"2001","unstructured":"Z\u00f6ller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G et al. 2001 Expression of the duodenal iron transporters divalentmetal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology\n120, 1412-1419.","journal-title":"Gastroenterology"}],"container-title":["Biometals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020702213099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1020702213099\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020702213099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:17:36Z","timestamp":1749561456000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1020702213099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["5094361"],"URL":"https:\/\/doi.org\/10.1023\/a:1020702213099","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}