{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:12:34Z","timestamp":1792725154938,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1023\/a:1020914026829","type":"journal-article","created":{"date-parts":[[2003,3,20]],"date-time":"2003-03-20T19:19:47Z","timestamp":1048187987000},"page":"381-385","source":"Crossref","is-referenced-by-count":37,"title":["Fibroblast Growth Factor Receptor 3 Mutations in Achondroplasia and Related Forms of Dwarfism"],"prefix":"10.1007","volume":"3","author":[{"given":"William A.","family":"Horton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Lunstrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"4","key":"5100486_CR1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00008480-199708000-00021","volume":"9","author":"WA Horton","year":"1997","unstructured":"Horton WA. Fibroblast growth factor receptor 3 and the human chondrodysplasias. Curr Opin Pediatr 1997;9(4):437\u2013442.","journal-title":"Curr Opin Pediatr"},{"key":"5100486_CR2","first-page":"641","volume-title":"Extracellular Matrix and Heritable Disorders of Connective Tissue","author":"WA Horton","year":"1993","unstructured":"Horton WA, Hecht JT. The chondrodysplasias. In: Royce PM, Steinman B, eds. Extracellular Matrix and Heritable Disorders of Connective Tissue. New York: Alan R. Liss, 1993:641\u2013676."},{"key":"5100486_CR3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","volume":"78","author":"R Shiang","year":"1994","unstructured":"Shiang R, Thompson LM, Zhu Y-Z, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 1994;78:335\u2013342.","journal-title":"Cell"},{"key":"5100486_CR4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/371252a0","volume":"371","author":"F Rousseau","year":"1995","unstructured":"Rousseau F, Bonaventure J, Legeal-Mallet L, Pelet A, Rozet J, Maroteaux P, Le Merrer M, Munnich A. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 1995;371:252\u2013254.","journal-title":"Nature"},{"key":"5100486_CR5","first-page":"368","volume":"56","author":"G Bellus","year":"1995","unstructured":"Bellus G, Hefferon T, Ortiz De Luna R, Hecht J, Horton W, Machado M, Kaitila I, McIntosh I, Francomano C. Achondroplasia is defined by recurrent G380R mutations in FGFR3. Am J Hum Genet 1995;56:368\u2013373.","journal-title":"Am J Hum Genet"},{"key":"5100486_CR6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0395-321","volume":"9","author":"P Tavormina","year":"1995","unstructured":"Tavormina P, Shiang R, Thompson L, Zhu Y, Wilkin D, Lachman R, Wilcox W, Rimoin D, Cohn D, Wasmuth J. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet 1995;9:321\u2013328.","journal-title":"Nat Genet"},{"issue":"4","key":"5100486_CR7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/hmg\/5.4.509","volume":"5","author":"F Rousseau","year":"1996","unstructured":"Rousseau F, El Ghouzzi V, Delezoide AL, Legeai-Mallet L, Le Merrer M, Munnich A, Bonaventure J. Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1). Hum Molec Genet 1996;5(4):509\u2013512.","journal-title":"Hum Molec Genet"},{"key":"5100486_CR8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng0795-357","volume":"10","author":"GA Bellus","year":"1995","unstructured":"Bellus GA, McIntosh I, Smith EA, Aylsworth AS, Kaitila I, Horton WA, Greenhaw GA, Hecht JT, Francomano CA. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat Genet 1995;10:357\u2013359.","journal-title":"Nat Genet"},{"issue":"3","key":"5100486_CR9","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1086\/302275","volume":"64","author":"PL Tavormina","year":"1999","unstructured":"Tavormina PL, Bellus GA, Webster MK, Bamshad MJ, Fraley AE, McIntosh I, Szabo J, Jiang W, Jabs EW, Wilcox WR, Wasmuth JJ, Donoghue DJ, Thompson LM, Francomano CA. A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. Am J Hum Genet 1999;64(3):722\u2013731.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"5100486_CR10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ng1096-174","volume":"14","author":"GA Bellus","year":"1996","unstructured":"Bellus GA, Gaudenz K, Zackai EH, Clarke LA, Szabo J, Francomano CA, Muenke M. Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes. Nat Genet 1996;14(2):174\u2013176.","journal-title":"Nat Genet"},{"issue":"3","key":"5100486_CR11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1086\/302000","volume":"63","author":"DJ Wilkin","year":"1998","unstructured":"Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, Mack ML, Kaitila I, Loughlin J, Munnich A, Sykes B, Bonaventure J, Francomano CA. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet 1998;63(3):711\u2013716.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"5100486_CR12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M","volume":"22","author":"DM Ornitz","year":"2000","unstructured":"Ornitz DM. FGFs, heparan sulfate and FGFRs: Complex interactions essential for development. Bioessays 2000;22(2):108\u2013112.","journal-title":"Bioessays"},{"issue":"2","key":"5100486_CR13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/mgme.1999.2915","volume":"68","author":"U Hehr","year":"1999","unstructured":"Hehr U, Muenke M. Craniosynostosis syndromes: From genes to premature fusion of skull bones. Mol Genet Metab 1999;68(2):139\u2013151.","journal-title":"Mol Genet Metab"},{"issue":"6","key":"5100486_CR14","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","volume":"84","author":"C Deng","year":"1996","unstructured":"Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996;84(6):911\u2013921.","journal-title":"Cell"},{"issue":"4","key":"5100486_CR15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","volume":"12","author":"JS Colvin","year":"1996","unstructured":"Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996;12(4):390\u2013397.","journal-title":"Nat Genet"},{"issue":"24","key":"5100486_CR16","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1242\/dev.125.24.4977","volume":"125","author":"MC Naski","year":"1998","unstructured":"Naski MC, Colvin JS, Coffin JD, Ornitz DM. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 1998;125(24):4977\u20134988.","journal-title":"Development"},{"issue":"2","key":"5100486_CR17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng0696-233","volume":"13","author":"MC Naski","year":"1996","unstructured":"Naski MC, Wang Q, Xu J, Ornitz DM. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 1996;13(2):233\u2013237.","journal-title":"Nat Genet"},{"issue":"25","key":"5100486_CR18","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","volume":"271","author":"DM Ornitz","year":"1996","unstructured":"Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. J Biol Chem 1996;271(25):15292\u201315297.","journal-title":"J Biol Chem"},{"issue":"9","key":"5100486_CR19","first-page":"3541","volume":"61","author":"JH Jang","year":"2001","unstructured":"Jang JH, Shin KH, Park JG. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 2001;61(9):3541\u20133543.","journal-title":"Cancer Res"},{"issue":"4","key":"5100486_CR20","first-page":"1265","volume":"61","author":"BW Van Rhijn","year":"2001","unstructured":"Van Rhijn BW, Lurkin I, Radvanyi F, Kirkels WJ, van der Kwast TH, Zwarthoff EC. The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001;61(4):1265\u20131268.","journal-title":"Cancer Res"},{"issue":"3","key":"5100486_CR21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood.V97.3.729","volume":"97","author":"M Chesi","year":"2001","unstructured":"Chesi M, Brents LA, Ely SA, Bais C, Robbiani DF, Mesri EA, Kuehl WM, Bergsagel PL. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 2001;97(3):729\u2013736.","journal-title":"Blood"},{"issue":"11","key":"5100486_CR22","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1101\/gad.13.11.1361","volume":"13","author":"M Sahni","year":"1999","unstructured":"Sahni M, Ambrosetti DC, Mansukhani A, Gertner R, Levy D, Basilico C. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 1999;13(11):1361\u20131366.","journal-title":"Genes Dev"},{"key":"5100486_CR23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/bj3420677","volume":"342","author":"NB Weksler","year":"1999","unstructured":"Weksler NB, Lunstrum GP, Reid ES, Horton WA. Differential effects of fibroblast growth factor (FGF) 9 and FGF2 on proliferation, differentiation and terminal differentiation of chondrocytic cells in vitro. Biochem J 1999;342 Pt 3(11):677\u2013682.","journal-title":"Biochem J"},{"issue":"11","key":"5100486_CR24","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1172\/JCI6690","volume":"104","author":"L Chen","year":"1999","unstructured":"Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng CX. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest 1999;104(11):1517\u20131525.","journal-title":"J Clin Invest"},{"issue":"8","key":"5100486_CR25","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.96.8.4455","volume":"96","author":"Y Wang","year":"1999","unstructured":"Wang Y, Spatz MK, Kannan K, Hayk H, Avivi A, Gorivodsky M, Pines M, Yayon A, Lonai P, Givol D. A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc Natl Acad Sci USA 1999;96(8):4455\u20134460.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"5100486_CR26","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1359\/jbmr.1999.14.11.1909","volume":"14","author":"S Garofalo","year":"1999","unstructured":"Garofalo S, Kliger-Spatz M, Cooke JL, Wolstin O, Lunstrum GP, Moshkovitz SM, Horton WA, Yayon A. Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice. J Bone Miner Res 1999;14(11):1909\u20131915.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"5100486_CR27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S1097-2765(00)00073-3","volume":"6","author":"J Schlessinger","year":"2000","unstructured":"Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M. Crystal structure of FGFR3 Mutations in Achondroplasia\n385 a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell 2000;6(3):743\u2013750.","journal-title":"Mol Cell"},{"issue":"2","key":"5100486_CR28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","volume":"103","author":"J Schlessinger","year":"2000","unstructured":"Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000;103(2):211\u2013225.","journal-title":"Cell"},{"issue":"15","key":"5100486_CR29","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1016\/S0021-9258(19)78170-8","volume":"269","author":"AT Chellaiah","year":"1994","unstructured":"Chellaiah AT, McEwen DG, Werner S, Xu J, Ornitz DM. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF\/FGF-1. J Biol Chem 1994;269(15):11620\u201311627.","journal-title":"J Biol Chem"},{"key":"5100486_CR30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/08977199509036882","volume":"12","author":"D Hecht","year":"1995","unstructured":"Hecht D, Zimmerman N, Bedford M, Avivi A, Yayon A. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGR receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors 1995;12:223\u2013233.","journal-title":"Growth Factors"},{"issue":"3","key":"5100486_CR31","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1074\/jbc.271.3.1726","volume":"271","author":"S Santos-Ocampo","year":"1996","unstructured":"Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM. Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem 1996;271(3):1726\u20131731.","journal-title":"J Biol Chem"},{"issue":"10","key":"5100486_CR32","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1074\/jbc.272.10.6621","volume":"272","author":"M Kanai","year":"1997","unstructured":"Kanai M, G\u00f6ke M, Tsunekawa S, Podolsky DK. Signal transduction pathway of human fibroblast growth factor receptor 3. J Biol Chem 1997;272(10):6621\u20136628.","journal-title":"J Biol Chem"},{"key":"5100486_CR33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.965602","volume":"16","author":"Z Liu","year":"2002","unstructured":"Liu Z, Xu J, Colvin JS, Ornitz DM. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Develop 2002;16:859\u2013869.","journal-title":"Genes Develop"},{"issue":"14","key":"5100486_CR34","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1074\/jbc.M003535200","volume":"276","author":"A Shimizu","year":"2001","unstructured":"Shimizu A, Tada K, Shukunami C, Hiraki Y, Kurokawa T, Magane N, Kurokawa-Seo M. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. J Biol Chem 2001;276(14):11031\u201311040.","journal-title":"J Biol Chem"},{"key":"5100486_CR35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(00)80131-2","volume":"86","author":"M Mohammadi","year":"1996","unstructured":"Mohammadi M, Schlessinger J, Hubbard SR. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 1996;86:577\u2013587.","journal-title":"Cell"},{"key":"5100486_CR36","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/386288a0","volume":"386","author":"W-CS Su","year":"1997","unstructured":"Su W-CS, Kitagawa M, Xue N, Xie B, Garofalo S, Cho J, Deng C, Horton WA, Fu X-Y. Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 1997;386:288\u2013291.","journal-title":"Nature"},{"issue":"21","key":"5100486_CR37","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1074\/jbc.273.21.13007","volume":"273","author":"L Legeai-Mallet","year":"1998","unstructured":"Legeai-Mallet L, Benoist-Lasselin C, Delezoide AL, Munnich A, Bonaventure J. Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J Biol Chem 1998;273(21):13007\u201313014.","journal-title":"J Biol Chem"},{"issue":"29","key":"5100486_CR38","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1038\/sj.onc.1203650","volume":"19","author":"KC Hart","year":"2000","unstructured":"Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 2000;19(29):3309\u20133320.","journal-title":"Oncogene"},{"key":"5100486_CR39","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1074\/jbc.M002959200","volume":"276","author":"DY Choi","year":"2001","unstructured":"Choi DY, Toledo-Aral JJ, Lin HY, Ischenko I, Medina L, Safo P, Mandel G, Levinson SR, Halegoua S, Hayman MJ. Fibroblast Growth Factor Receptor 3 induces gene expression primarily through Ras-independent signal transduction pathways. J Biol Chem 2001;276:5116\u20135122.","journal-title":"J Biol Chem"},{"issue":"1","key":"5100486_CR40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/hmg\/8.1.35","volume":"8","author":"C Li","year":"1999","unstructured":"Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX. A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 1999;8(1):35\u201344.","journal-title":"Hum Mol Genet"},{"issue":"43","key":"5100486_CR41","doi-asserted-by":"crossref","first-page":"30934","DOI":"10.1074\/jbc.274.43.30934","volume":"274","author":"DG McEwen","year":"1999","unstructured":"McEwen DG, Green RP, Naski MC, Towler DA, Ornitz DM. Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3', 5'-monophosphate. Identification of a chondrocytic regulatory element. J Biol Chem 1999;274(43):30934\u201330942.","journal-title":"J Biol Chem"},{"issue":"3","key":"5100486_CR42","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1073\/pnas.97.3.1113","volume":"97","author":"S Murakami","year":"2000","unstructured":"Murakami S, Kan M, McKeehan WL, de Crombrugghe B. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 2000;97(3):1113\u20131118.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"5100486_CR43","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/j.1460-2075.1996.tb00384.x","volume":"15","author":"MK Webster","year":"1996","unstructured":"Webster MK, Donoghue DJ. Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. EMBO J 1996;15(3):520\u2013527.","journal-title":"EMBO J"},{"issue":"2","key":"5100486_CR44","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/MCB.20.2.516-522.2000","volume":"20","author":"E Monsonego-Ornan","year":"2000","unstructured":"Monsonego-Ornan E, Adar R, Feferman T, Segev O, Yayon A. The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from downregulation. Mol Cell Biol 2000;20(2):516\u2013522.","journal-title":"Mol Cell Biol"},{"key":"5100486_CR45","unstructured":"Horton WA. (Unpublished observations) 2002."},{"key":"5100486_CR46","doi-asserted-by":"crossref","unstructured":"Sorokin A, Lemmon MA, Ullrich A, Schlessinger J. Stabilization of an active dimeric form of the epidermal growth factdor receptor by introduction of an inter-receptor disulfide bond. J Biol Chem 1994:9752\u20139759.","DOI":"10.1016\/S0021-9258(17)36947-8"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020914026829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1020914026829\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1020914026829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:30:30Z","timestamp":1754472630000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1020914026829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["5100486"],"URL":"https:\/\/doi.org\/10.1023\/a:1020914026829","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}