{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:57:00Z","timestamp":1793473020542,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1023\/a:1022520710570","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T23:03:18Z","timestamp":1048892598000},"page":"91-99","source":"Crossref","is-referenced-by-count":16,"title":["Lupus Manifestations in Severe Combined Immunodeficient (SCID) Mice and in Human\/Mouse Radiation Chimeras"],"prefix":"10.1007","volume":"23","author":[{"given":"Zev","family":"Sthoeger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidy","family":"Zinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Dekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Arditi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Reisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Mozes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"460774_CR1","first-page":"69","volume-title":"Dubois' Lupus Erythematosus","author":"BH Hahn","year":"1993","unstructured":"Hahn BH: An overviewof the pathogenesis of systemic lupus erythe-matosus. In Dubois' Lupus Erythematosus, DJ Wallace, BH Hahn (eds). Philadelphia; Williams and Wilkins, 1993, pp 69\u201376"},{"key":"460774_CR2","first-page":"1361","volume-title":"Arthritis and Allied Conditions","author":"RJ Winchester","year":"1996","unstructured":"Winchester RJ: Systemic lupus erythematosus pathogenesis. In Arthritis and Allied Conditions. Koopman WJ (ed). Birmingham, AL, Williams and Wilkins, 1996, pp 1361\u20131391"},{"key":"460774_CR3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.7326\/0003-4819-100-5-714","volume":"100","author":"AD Steinberg","year":"1984","unstructured":"Steinberg AD: Systemic lupus erythematosus: Insights from animal models. Ann Intern Med 100:714\u2013727, 1984","journal-title":"Ann Intern Med"},{"key":"460774_CR4","first-page":"121","volume-title":"Systemic Lupus Erythematosus","author":"AN Theofilopoulos","year":"1992","unstructured":"Theofilopoulos AN: Murine models of lupus. In Systemic Lupus Erythematosus, Lahita R. G. (ed.) New York, Churchill Livingston, 1992, pp 121\u2013194"},{"key":"460774_CR5","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1073\/pnas.85.7.2260","volume":"85","author":"S Mendlovic","year":"1988","unstructured":"Mendlovic S, Brocke S, Shoenfeld Y, Ben-Bassat M, Meshorer A, Bakimer R, Mozes E: Induction of a systemic lupus erythematosus like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci USA 85:2260\u20132264, 1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"460774_CR6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1084\/jem.158.3.718","volume":"158","author":"Y Shoenfeld","year":"1983","unstructured":"Shoenfeld Y, Isenberg DA, Rauch J, Madaio MP, Stollar BD, Schwartz RS: Idiotypic cross-reactions of monoclonal human lu-pus autoantibodies. J Exp Med 158:718\u2013730, 1983","journal-title":"J Exp Med"},{"key":"460774_CR7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/B978-044482824-8\/50015-4","volume-title":"The Decade of Autoimmunity","author":"E Mozes","year":"1999","unstructured":"Mozes E: Experimental systemic lupus erythematosus: From a pathogenic autoantibody to immunomodulating peptides. In The Decade of Autoimmunity, Shoenfeld Y (ed). Amsterdam, Elsevier Science B.V., 1999, pp 109\u2013117"},{"key":"460774_CR8","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1073\/pnas.94.9.4620","volume":"94","author":"A Waisman","year":"1997","unstructured":"Waisman A, Ruiz PJ, Israeli E, Eilat E, Konen-Waisman S, Zinger H, Dayan M, Mozes E: Modulation of murine systemic lupus erythe-matosus with peptides based on the complementarity determining regions of a pathogenic anti-DNA monoclonal antibody. Proc Natl Acad Sci USA 94:4620\u20134625, 1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"460774_CR9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1006663519132","volume":"20","author":"E Eilat","year":"2000","unstructured":"Eilat E, Zinger H, Nyska A, Mozes E: Prevention of systemic lupus erythematosus-like disease in (NZB \u00a3 NZW)F1mice by treating with CDR-1 and CDR-3 based peptides of a pathogenic autoantibody. J Clin Immunol 20:269\u2013278, 2000","journal-title":"J Clin Immunol"},{"key":"460774_CR10","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.98.3.1148","volume":"98","author":"E Eilat","year":"2001","unstructured":"Eilat E, Dayan M, Zinger H, Mozes: The mechanism by which a pep-tide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythe-matosus. Proc Natl Acad Sci USA 98:1148\u20131153, 2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"460774_CR11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/335256a0","volume":"335","author":"DE Mosier","year":"1988","unstructured":"Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Transfer of a func-tional human immune system to mice with severe combined immun-odeficiency. Nature 335:256\u2013259, 1988","journal-title":"Nature"},{"key":"460774_CR12","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.2971269","volume":"241","author":"JM McCune","year":"1988","unstructured":"McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL: The SCID-hu mouse: Murine model for the analy-sis of human hematolymphoid differentiation and function. Science 241:1632\u20131639, 1988","journal-title":"Science"},{"key":"460774_CR13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1084\/jem.172.3.985","volume":"172","author":"MA Duchosal","year":"1990","unstructured":"Duchosal MA, McConahey PJ, Robinson CA, Dixon FJ: Transfer of human systemic lupus erythematosus in severe combined immun-odeficient (SCID) mice. J Exp Med 172:985\u2013988, 1990","journal-title":"J Exp Med"},{"key":"460774_CR14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2249.1992.tb03043.x","volume":"88","author":"D Ashany","year":"1992","unstructured":"Ashany D, Hines J, Gharavi A, Moiradian J, Elkon KB: Analysis of autoantibody production in SCID-systemic lupus erythematosus (SLE) chimeras. Clin Exp Immunol 88:84\u201390, 1992","journal-title":"Clin Exp Immunol"},{"key":"460774_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.1993.tb06488.x","volume":"93","author":"AO Vladutiu","year":"1993","unstructured":"Vladutiu AO: The severe combined immunodeficient (SCID) mouse as a model for the study of autoimmune diseases. Clin Exp Immunol 93:1\u20138, 1993","journal-title":"Clin Exp Immunol"},{"key":"460774_CR16","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.4049\/jimmunol.159.6.2658","volume":"159","author":"Y Kalechman","year":"1997","unstructured":"Kalechman Y, Gafter U, Da JP, Albeck M, Alarcon-Segovia D, Sredni B: Delay in the onset of systemic lupus erythematosus fol-lowing treatment with the immunomodulator AS101. J Immunol 159:2658\u20132667, 1997","journal-title":"J Immunol"},{"key":"460774_CR17","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1182\/blood.V83.8.2368.2368","volume":"83","author":"I Lubin","year":"1994","unstructured":"Lubin I, Segall H, Marcus H, David M, Kulova L, Steinitz M, Erlich P, Gan J, Reisner Y: Engraftment of human peripheral blood lym-phocytes in normal strains of mice. Blood 83:2368\u20132381, 1994","journal-title":"Blood"},{"key":"460774_CR18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0167-7799(98)01203-7","volume":"16","author":"Y Reisner","year":"1998","unstructured":"Reisner Y, Dagan S: The Trimera mouse: Generating human monoclonal antibodies and an animal model for human diseases. TIBTECH 16:242\u2013245, 1998","journal-title":"TIBTECH"},{"key":"460774_CR19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/sj.leu.2400645","volume":"11","author":"H Marcus","year":"1997","unstructured":"Marcus H, Shimoni A, Ergas D, Canaan A, Dekel B, Ben-David D, David M, Sigler E, Reisner Y, Berrebi A: Human\/mouse radiation chimera generated from PBMC of B chronic lymphocytic leukemia patients with autoimmune hemolytic anemia produce anti-human red cell antibodies. Leukemia 11:687\u2013693, 1997","journal-title":"Leukemia"},{"key":"460774_CR20","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1097\/00007890-199712150-00008","volume":"64","author":"B Dekel","year":"1997","unstructured":"Dekel B, Burakova T, Ben-Hur H, Marcus H, Oren R, Laufer J, Reisner Y: Engraftment of human kidney tissue in rat radiation chimera. Transplantation 64:1550\u20131558, 1997","journal-title":"Transplantation"},{"key":"460774_CR21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1365-2567.1998.00516.x","volume":"94","author":"B Dekel","year":"1998","unstructured":"Dekel B, Marcus H, Shekman B, Shimoni A, Shechter Y, Canaan A, Berrebi A, Varon D, Reisner Y: Human\/BALB\/c radiation chimera engrafted with splenocytes from patients with idiopathic thrombo-cytopenia purpura produce human platelet antibodies. Immunology 94:410\u2013416, 1998","journal-title":"Immunology"},{"key":"460774_CR22","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","volume":"25","author":"EM Tan","year":"1982","unstructured":"Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schallor JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arth Rheum 25:1271\u20131277, 1982","journal-title":"Arth Rheum"},{"key":"460774_CR23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4049\/jimmunol.141.1.91","volume":"141","author":"ZM Sthoeger","year":"1988","unstructured":"Sthoeger ZM, Chiorazzi N, Lahita RG: Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testos-terone on pokweed mitogen-induced human B cell differentiation. J Immunol 141:91\u201398, 1988","journal-title":"J Immunol"},{"key":"460774_CR24","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1182\/blood.V86.1.398.bloodjournal861398","volume":"86","author":"H Marcus","year":"1995","unstructured":"Marcus H, David M, Cnaan A, Kulova L, Lubin I, Segal H, Denis L, Erlich P, Galun E, Gan J, Laster M, Reisner Y: Human\/mouse radiation chimera are capable of mounting a human primary humoral response. Blood 86:398\u2013406, 1995","journal-title":"Blood"},{"key":"460774_CR25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60836-6","volume":"33","author":"EM Tan","year":"1982","unstructured":"Tan EM:Antibodies to nuclear antigens: Their biology and medicine. Adv Immunol 33:167\u2013240, 1982","journal-title":"Adv Immunol"},{"key":"460774_CR26","first-page":"2231","volume":"21","author":"ZM Sthoeger","year":"1994","unstructured":"Sthoeger ZM, Bentwich Z, Zinger H, Mozes E: The beneficial effect of the estrogen antagonist, Tamoxifen, on experimental systemic lupus erythematosus. J Rheumatol 21:2231\u20132238, 1994","journal-title":"J Rheumatol"},{"key":"460774_CR27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF01533366","volume":"14","author":"BL Bermas","year":"1994","unstructured":"Bermas BL, Petri M, Goodlman D, Mittleman B, Miller MW, Stocks NI, Via CS, Shearer GM: T helper cell dysfunction in systemic lupus erythematosus (SLE): Relation of disease activity. J Clin Immunol 14:169\u2013177, 1994","journal-title":"J Clin Immunol"},{"key":"460774_CR28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1084\/jem.181.3.839","volume":"181","author":"L Llorente","year":"1995","unstructured":"Llorente L, Zou W, Levy Y, Richaud-Patin Y, Wijdenes J, Alcocer-Varela J, Morel-Fourrier B, Brouet J-C, Alarcon-Segovia D, Galanaud P, Emilie D: Role of interleukin 10 in the B lympho-cyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 181:839\u2013844, 1995.","journal-title":"J Exp Med"},{"key":"460774_CR29","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.4049\/jimmunol.165.10.5900","volume":"165","author":"Y Suzuki","year":"2000","unstructured":"Suzuki Y, Funato T, Munakata Y, Sato K, Hirabayashi Y, Ishii T, Takasawa N, Ootaka T, Saito T, Sasaki T: Chemically modified ri-bozyme to V gene inhibits anti-DNA production and the forma-tion of immune deposits caused by lupus lymphocytes. J Immunol 165:5900\u20135905, 2000","journal-title":"J Immunol"},{"key":"460774_CR30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/sj.bmt.1703206","volume":"28","author":"K Cwynarski","year":"2001","unstructured":"Cwynarski K, Goulding R, Pocock C, Dazzi F, Craddock C, Kaeda J, Olavarria E, Kanfer E, Apperley J, Lawler M, Goldman JM: Immune haemolytic anaemia following T cell-depleted allogeneic bone mar-row transplantation for chronic myeloid leukemia: Association with leukemic relapse and treatment with donor lymphocyte infusions. Bone Marrow Tranplant 28:581\u2013586, 2001","journal-title":"Bone Marrow Tranplant"},{"key":"460774_CR31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.410340110","volume":"34","author":"G Martino","year":"1993","unstructured":"Martino G, DuPont BL, Wollmann RL, Bongioanni P, Anastasi J, Quitans J, Arnason BGW, Grimaldi LME: The human-severe com-bined immunodeficiency myasthenic mouse model: Anewapproach for the study of myasthenia gravis. Ann Neurol 34:48\u201356, 1993","journal-title":"Ann Neurol"},{"key":"460774_CR32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0090-1229(83)90053-3","volume":"27","author":"S Hoch","year":"1983","unstructured":"Hoch S, Schur PH, Schwaber J: Frequency of anti-DNA antibody producing cells from normals and patients with systemic lupus ery-thematosus. Clin Immunol Immunopathol 27:28\u201337, 1983","journal-title":"Clin Immunol Immunopathol"},{"key":"460774_CR33","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.161.3.1274","volume":"161","author":"J-M Lecerf","year":"1998","unstructured":"Lecerf J-M, Chen Y, Richalet-S\u00e9cordel P, Wang X, Stollar BD: Au-toreactivity of human VH domains from cDNA libraries: Analysis with a bacterial expression vector. J Immunol 161:1274\u20131283, 1998","journal-title":"J Immunol"},{"key":"460774_CR34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1084\/jem.164.2.614","volume":"164","author":"Y Naparstek","year":"1986","unstructured":"Naparstek Y, Andr\u00e9-Schwartz J, Manser T, Wysocki T, Breitman L, Stollar BD, Gefter M, Schwartz RS: A single germ line VH gene segment of normal A\/J mice encodes autoantibodies characteristic of systemic lupus erythematosus. J Exp Med 164:614\u2013626, 1986","journal-title":"J Exp Med"},{"key":"460774_CR35","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/art.10254","volume":"46","author":"K Andreassen","year":"2002","unstructured":"Andreassen K, Bendiksen S, Kjeldsen E, Van Ghelue M, Moens U, Arnesen E, Petter Rekvig O: T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system. Arth Rheum 46:1270\u20131281, 2002","journal-title":"Arth Rheum"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022520710570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1022520710570\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022520710570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:03:34Z","timestamp":1751281414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1022520710570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["460774"],"URL":"https:\/\/doi.org\/10.1023\/a:1022520710570","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}