{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:32:53Z","timestamp":1791160373812,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1023\/a:1022534217769","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T18:03:18Z","timestamp":1048874598000},"page":"19-24","source":"Crossref","is-referenced-by-count":128,"title":["Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulation"],"prefix":"10.1007","volume":"20","author":[{"given":"Garth L.","family":"Nicolson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Toh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5109482_CR1","first-page":"505","volume":"9","author":"A Moustafa","year":"1998","unstructured":"Moustafa A, Nicolson GL. Breast cancer metastasis-associated genes: Prognostic significance and therapeutic implications. Oncol Res 1998; 9:505\u201325.","journal-title":"Clinical & Experimental Metastasis"},{"issue":"4","key":"5109482_CR2","first-page":"441","volume":"6","author":"MT Debies","year":"2001","unstructured":"Debies MT, Welch D. Genetic basis of human breast cancer metastasis. J Mammary Gland Biol Neoplasia 2001; 6(4): 441\u201351.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR3","first-page":"200","volume":"80","author":"PS Steeg","year":"1998","unstructured":"Steeg PS, Bevilacqua G, Kopper L et al. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst1998; 80: 200\u20134.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR4","first-page":"1086","volume":"3","author":"A Ebralidze","year":"1989","unstructured":"Ebralidze A, Tulchinsky E, Grigorian M et al. Isolation and characterization of a gene specially expressed in different metastatic cells and whose deduced gene product has a high degree of homology to Ca2+ binding protein. Genes Dev 1989; 3: 1086\u201393.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR5","first-page":"5203","volume":"48","author":"TN Dear","year":"1988","unstructured":"Dear TN, Ramshaw IA, Kefford RF. Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells. Cancer Res 1988; 48: 5203\u20139","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR6","first-page":"5323","volume":"49","author":"TN Dear","year":"1989","unstructured":"Dear TN, McDonald DA, Kefford RF. Transcriptional downregulation of a rat gene, WDNM2, in metastatic DMBA-8 cells. Cancer Res 1989; 49: 5323\u20138.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR7","first-page":"199","volume":"82","author":"SM Phillips","year":"1990","unstructured":"Phillips SM, Bendall AJ, Ramshaw IA. Isolation of gene associated with high metastatic potential in rat mammary adenocarcinoma. J Natl Cancer Inst 1990; 82:199\u2013203.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR8","first-page":"699","volume":"348","author":"P. Bisset","year":"1990","unstructured":"Bisset P, Bellocq JP, Wolf C et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 1990; 348: 699\u2013704.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1126\/science.7754374","volume":"268","author":"JT Dong","year":"1995","unstructured":"Dong JT, Lamb PW, Rinker-Schaeffer CW et al. KAI1, a metastasis suppressor gene for prostate cancer of human chromosome 11p11.2. Science 1995; 268: 884\u20136.","journal-title":"Science"},{"key":"5109482_CR10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1023\/A:1013124725690","volume":"18","author":"RS Samant","year":"2000","unstructured":"Samant RS, Seraj MJ, Saunders MM et al. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metastasis 2000; 18: 683\u201393.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR11","first-page":"22958","volume":"269","author":"Y Toh","year":"1994","unstructured":"Toh Y, Pencil SD, Nicolson GL. A novel candidate metastasisassociated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. J Biol Chem 1994; 269: 22958\u201363.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR12","first-page":"99","volume":"159","author":"Y Toh","year":"1995","unstructured":"Toh Y, Pencil SD, Nicolson GL. Analysis of the complete sequence of the novel gene mta1 differentially expressed in highly metastatic mammary adenocarcinoma and breast cancer cell lines and clones. Gene 1995; 159: 99\u2013104.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR13","first-page":"165","volume":"25","author":"SD Pencil","year":"1993","unstructured":"Pencil SD, Toh Y, Nicolson GL. Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma. Breast Cancer Res Treat 1993; 25: 165\u201374.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR14","first-page":"202","volume":"79","author":"A Nawa","year":"2000","unstructured":"Nawa A, Nishimori K, Lin P et al.Tumor metastasis-associated human MTA1 gene: Its deduced protein sequence, localization and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J Cell Biochem 2000; 79: 202\u201312.","journal-title":"Clinical & Experimental Metastasis"},{"issue":"1","key":"5109482_CR15","first-page":"33","volume":"28","author":"A Nawa","year":"2000","unstructured":"Nawa A, Sawada H, Toh Y et al. Tumor metastasis-associated human MTA1 gene: Effects of antisense oligonucleotides on cell growth. Intern J Med Biol Environ 2000; 28(1): 33\u20139.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR16","first-page":"851","volume":"2","author":"Y Xue","year":"1989","unstructured":"Xue Y, Wong J, Moreno GT et al. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 1989; 2: 851\u201361.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR17","first-page":"279","volume":"95","author":"Y Zhang","year":"1998","unstructured":"Zhang Y, LeRoy G, Seelig HP et al. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 1998; 95: 279\u201389.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR18","first-page":"1157","volume":"259","author":"R Ren","year":"1993","unstructured":". Ren R, Mager BJ, Cicchetti P et al. Identification of a ten-amino acid proline-rich SH3 binding site. Science 1993; 259: 1157\u201361.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR19","first-page":"933","volume":"76","author":"H Yu","year":"1994","unstructured":"Yu H, Chen JK, Feng S et al. Structual basis for the binding of prolinerich peptides to SH3 domains. Cell 1994; 76: 933\u201345.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR20","first-page":"1886","volume":"4","author":"DIK Martin","year":"1990","unstructured":"Martin DIK, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1\/NF-E1\/Eryf. Genes Dev 1990; 4: 1886\u201398.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR21","first-page":"911","volume":"246","author":"CR Vinson","year":"1989","unstructured":"Vinson CR, Sigler PB, McKnight SL. Scissors-Grip model for DNA recognition by a family of leucine zipper proteins. Science 1989; 246: 911\u20136.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR22","first-page":"61","volume":"207","author":"M. Suzuki","year":"1989","unstructured":"Suzuki M. SPXX, a frequent sequence motif in gene regulatory proteins. J Mol Biol 1989; 207: 61\u201384.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR23","first-page":"87","volume":"21","author":"R. Aasland","year":"1996","unstructured":"Aasland R. The SANT domain: putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor NCoR and TFIIIB. Trends Biochem Sci 1996; 21: 87\u20138.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR24","first-page":"143","volume":"20","author":"CL Peterson","year":"1995","unstructured":"Peterson CL, Tamkun JW. The SWI-SNF complex: A chromatin remodeling machine? Trends Biochem Sci 1995; 20: 143\u20136.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR25","first-page":"1203","volume":"15","author":"J Horiuchi","year":"1995","unstructured":"Horiuchi J, Silverman N, Marcus GA et al. ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex. Mol Cell Biol 1995; 15: 1203\u20139.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR26","first-page":"397","volume":"377","author":"AJ Horlein","year":"1995","unstructured":"Horlein AJ, Naar AM, Heinzel T et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor. Nature 1995; 377: 397\u2013404.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR27","first-page":"9786","volume":"92","author":"GA Kassavetis","year":"1995","unstructured":"Kassavetis GA, Nguyen ST, Kobayashi R et al. Cloning, expression, and function of TFC5, the gene encoding the B\u2033 component of the Saccharomyces cervisiae RNA polymerase III transcription factor TFIIIB.Proc Natl Acad Sci USA 1995; 92: 9786\u201390.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR28","first-page":"683","volume":"335","author":"M. Ptashne","year":"1988","unstructured":"Ptashne M. How eukaryotic transcriptional activators work. Nature 1988; 335: 683\u20139.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR29","first-page":"717","volume":"50","author":"JE Price","year":"1990","unstructured":"Price JE, Polyzos A, Zhang RD et al. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 1990; 50: 717\u201321.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR30","first-page":"459","volume":"74","author":"Y Toh","year":"1997","unstructured":"Toh Y, Oki E, Oda S et al. Overexpression of MTA1 gene in colorectal and gastrointestinal carcinomas: Correlation with invasion and metastasis. Intern J Cancer 1997; 74: 459\u201363.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR31","first-page":"1723","volume":"79","author":"Y Toh","year":"1999","unstructured":"Toh Y, Kuwano H, Mori M et al. Overexpression of metastasisassociated MTA1 mRNA in invasive oesophageal carcinomas. Br J Cancer 1999; 79: 1723\u201326.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR32","first-page":"1119","volume":"1","author":"CA. Stein","year":"1995","unstructured":"Stein CA. Does antisense exist? Nat Med 1995; 1: 1119\u201321.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR33","first-page":"1023","volume":"41","author":"CF Bennett","year":"1992","unstructured":"Bennett CF, Chiang MY, Chan H et al. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 1992; 41: 1023\u201333.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR34","first-page":"67","volume":"3","author":"P Yaswen","year":"1993","unstructured":"Yaswen P, Stampfer MR, Ghosh K et al. Effect of sequence of thioated oligonucleotides on cultured human mammary epithelial cells. Antisense Res Dev 1993; 3: 67\u201377.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR35","first-page":"3928","volume":"49","author":"PG Cavanaugh","year":"1989","unstructured":"Cavanaugh PG, Nicolson GL. Purification and some properties of a lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung. Cancer Res 1989; 49: 3928\u201333.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR36","first-page":"296","volume-title":"Cell Biology: A Laboratory Handbook","author":"H Wakabayashi","year":"1997","unstructured":"Wakabayashi H, Nicolson GL. Transfilter cell invasion assays. In Celis JE (ed): Cell Biology: A Laboratory Handbook. New York: Academic Press 1997; 1: 296\u2013301."},{"key":"5109482_CR37","first-page":"2161","volume":"21","author":"MG Mahoney","year":"2002","unstructured":"Mahoney MG, Simpson A, JostM et al. Metastasis-associated protein (MTA)1 enhances migration, invasion and anchorage-independent survival of immortalized human keratinocytes. Oncogene 2002; 21: 2161\u201370.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR38","first-page":"105","volume":"19","author":"Y Toh","year":"2000","unstructured":"Toh Y, Kuninaka S, Endo H et al. Molecular analysis of a candidate metastasis associated gene MTA1: Interaction with histone deacetylase 1. J Exp Clin Cancer Res 2000; 19: 105\u201311.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR39","first-page":"654","volume":"418","author":"R Kumar","year":"2002","unstructured":"Kumar R, Wang RA, Mazumdar A et al. A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 2002; 418: 654\u20137.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR40","first-page":"122","volume":"177","author":"M Yoshida","year":"1998","unstructured":"Yoshida M, Beppu T. Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A. Exp Cell Res 1998; 177: 122\u201331.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR41","first-page":"597","volume":"391","author":"A Brehm","year":"1998","unstructured":"Brehm A, Miska EA, MaCane DJ et al. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 1998; 391: 597\u2013601.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR42","first-page":"463","volume":"92","author":"RX Luo","year":"1998","unstructured":". Luo RX, Postigo AA, Dean DC. Rb interacts with histone deacetylase to repress transcription. Cell 1998; 92: 463\u201373.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR43","first-page":"601","volume":"391","author":"L Magnaghi-Jaulin","year":"1998","unstructured":"Magnaghi-Jaulin L, Groisman R, Naguibneva I et al. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 1998; 391: 601\u20135.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR44","first-page":"595","volume":"90","author":"W Gu","year":"1997","unstructured":"Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997; 90: 595\u2013606.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR45","first-page":"5331","volume":"87","author":"YH Fu","year":"1990","unstructured":"Fu YH, Marzluf GA. nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc Natl Acad Sci USA 1990; 87: 5331\u20135.","journal-title":"Clinical & Experimental Metastasis"},{"key":"5109482_CR46","first-page":"6216","volume":"11","author":"PL Minehart","year":"1991","unstructured":"Minehart PL, Magasanik B. Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain. Mol Cell Biol 1991; 11: 6216\u201328.","journal-title":"Clinical & Experimental Metastasis"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022534217769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1022534217769\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022534217769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:04:32Z","timestamp":1752357872000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1022534217769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["5109482"],"URL":"https:\/\/doi.org\/10.1023\/a:1022534217769","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}